Digital Commons Network^™

Designing Novel Abstraction Networks For Ontology Summarization And Quality Assurance, Christopher Ochs

Dissertations

Biomedical ontologies are complex knowledge representation systems. Biomedical ontologies support interdisciplinary research, interoperability of medical systems, and Electronic Healthcare Record (EHR) encoding. Ontologies represent knowledge using concepts (entities) linked by relationships. Ontologies may contain hundreds of thousands of concepts and millions of relationships. For users, the size and complexity of ontologies make it difficult to comprehend “the big picture” of an ontology's content. For ontology editors, size and complexity make it difficult to uncover errors and inconsistencies. Errors in an ontology will ultimately affect applications that utilize the ontology.

In prior studies abstraction networks (AbNs) were developed to provide a …

Information Filtering By Multiple Examples, Mingzhu Zhu

Dissertations

A key to successfully satisfy an information need lies in how users express it using keywords as queries. However, for many users, expressing their information needs using keywords is difficult, especially when the information need is complex. Search By Multiple Examples (SBME), a promising method for overcoming this problem, allows users to specify their information needs as a set of relevant documents rather than as a set of keywords.

Most of the studies on SBME adopt the Positive Unlabeled learning (PU learning) techniques by treating the user's provided examples (denoted as query examples) as positive set and the entire data …

Development Of Flexible Batteries Using Nano-Carbons And Polymers, Zhiqian Wang

Dissertations

Flexible electronics such as wearable equipment, displays, cell phones and smart cards require flexible power sources like batteries. In this thesis, the development of flexible batteries and supercapacitors are presented. Different types of flexible batteries including zinc carbon batteries, primary alkaline batteries, secondary alkaline batteries and zinc air cells are presented, These were designed, fabricated and improved using polymers and nano-carbons like carbon nanotubes (CNTs). CNTs are found to be effective as conductive additives compared to the traditional graphite. Purification is important to remove impurities that lead to side reactions/ corrosions. However, further treatment like carboxylation lead to higher electric …

Piezoelectric Scaffolds For Osteochondral Defect Repair, Sita Mahalakshmi Damaraju

Dissertations

Osteoarthritis is one of the most prevalent causes of disability affecting nearly 27 million Americans. Osteoarthritis is caused when extensive damage occurs to the articular cartilage later spreading to the underlying subchondral bone, resulting in osteochondral defects. The current clinical therapies aim at regenerating the hyaline cartilage, but instead fibrocartilage forms at the osteochondral defect site, which is inferior in structure and function and fails to integrate with the surrounding tissue. A biomimetic scaffold, which can provide cues similar to the native extracellular matrix, may facilitate osteochondral defect repair. Articular cartilage and bone extracellular matrix have been shown to produce …

Constructed Treatment Wetland In Rose-Hulman Greenhouse, Ila Creekbaum

Rose-Hulman Undergraduate Research Publications

As more impervious materials and buildings takeover natural environments, creeks and rivers become more polluted. When it rains the water collects pollutants because the water flows over parking lots, buildings, and agricultural land. The water can collect oil, nitrogen, phosphorus, and small particles. These pollutants decrease the water quality in surrounding water bodies. Natural wetlands are excellent at removing pollutants from the water that flows through the filter media and are relatively inexpensive. Our objective this summer was to replicate the biological processes by constructing a treatment wetland in the greenhouse on the Rose-Hulman campus. Then we would test the …

An Efficient Boundary Integral Method For Stiff Fluid Interface Problems, Oleksiy Varfolomiyev

Dissertations

The purpose of this thesis is to formulate and investigate a boundary integral method for the solution of the internal waves/Rayleigh-Taylor problem. This problem describes the evolution of the interface between two immiscible, inviscid, incompressible, irrotational fluids of different density in three dimensions. A mathematical model of this interfacial flow problem in 3D is derived. The motion of the interface and fluids is driven by the action of a gravity force, surface tension at the interface, elastic bending and/or a prescribed far-field pressure gradient. The presented models include derived equations for the evolution of the interface and dipole density on …

The Consequences Of Plan Colombia: Domestic Drug Policies In Colombia, Brittany T. Reid

Standard Theses

None

Admissions Report - Detailed Data - May 2015, Office Of Institutional Research & Effectiveness, Wright State University

Admissions Reports

Detailed report of applicants to Wright State including data on county of residency, intended major, and ethnicity for Fall Semester 2015.

An Extended Duration Operation For Solid Hollow Fiber Cooling Crystallization Method, Chi Jin

Theses

As recently demonstrated by Chen et al. [1], the solid hollow fiber cooling crystallization method to achieve continuous polymer coating/encapsulation of submicrometer particles, has advantages of no problem with high pressure, easy scale-up and production of free-flowing coated particles. There is a concern whether this crystallization method can be applied for an extended duration coating process; it was not investigated in the previous study. Therefore, in order to examine this problem, in this work, the duration of the whole crystallization coating process has been greatly extended from 5 min to 60 min and 120 min. For the purpose of being …

Principles And Applications Of Mechanical Dry Coating - Review And State-Of-The-Art, Sayani Bhaumik

Theses

Dry Coating of powders to form composite particulates has been firmly established and has garnered interest both in academia and industry due to its myriad applications. This thesis work is an attempt to map the progress of the dry coating technology from its incipient years in the '80s to the thriving practice in the present day. Dry coating is a relatively simple approach to coat powders with specific guest particles via mechanical means to produce composites with desired tailor-made properties, without the constraints of harmful emissions or huge capital investment. Composite particulates with enhanced flowability, high-temperature resistant properties, and modified …

The Kinetics Of Drug Dissolution In Polymers During Hot-Melt Extrusion, Huayang Fang

Theses

Extrusion has been a most important and widely used continuous process in polymer processing for over one hundred and fifty years. However, it has only been recently applied and adopted by the pharmaceutical industry to prepare solid oral dosage formulations with increased bioavailability for the poorly-water soluble drugs and controlled release characteristics for the water-soluble drugs. In pharmaceutical Hot-melt extrusion poorly water soluble drug particulates are mixed with water soluble polymer excipient particulates and fed in the extruder, where the polymer is melted, after which the drug particulates begin to dissolve into the polymer melt. Extrusion-generated mixing accelerates dissolution process. …

Design, Construction And Characterization Of A Wind Tunnel, Chang Ge

Theses

The wind tunnel is the most fundamental test equipment for aircraft testing and studying aerodynamics. Because of the complexity of the test-subject's geometry, it is difficult to study the aerodynamic pattern simply based on theoretical calculations. Most of the aerodynamics experiments still use wind tunnels. The progress of the wind tunnel is highly related to the advancements in air crafts. Aircraft manufacturing has pushed the wind tunnel technology forward. Wind tunnels can be categorized by the wind speed limit differences, which are controlled by the mechanism of the driving methods, structure applications, etc. In this case, we built a small …

Unsupervised Gene Regulatory Network Inference On Microarray Data, Nidhi Radia

Theses

Obtaining gene regulatory networks (GRNs) from expression data is a challenging and crucial task. Many computational methods and algorithms have been developed to infer gene networks for gene expression data, which are usually obtained from microarray experiments. A gene network is a method to depict the relation among clusters of genes. To infer gene networks, the unsupervised method is used in this study. The two types of data used are time-series data and steady-state data. The data is analyzed using various tools containing different algorithms and concepts. GRNs from time-series data tools are obtained using the Time-delayed Algorithm for the …

Experimental Determination Of The Agitation Requirements For Solids Suspension In Dissolution Systems Using A Mini Paddle Apparatus, Yang Song

Theses

Dissolution testing is a critical step in quality control of manufactured final products in the pharmaceutical industry. The United State Pharmacopeia (USP) Dissolution Testing Apparatus 2 (paddle) is the most widely used dissolution test devices in the pharmaceutical industry to formulate solid drug dosage forms and to develop quality control specifications for its manufacturing process.

Mini vessels and mini paddle dissolution testing systems are smaller versions of the USP 2 Apparatus. The concept of the mini paddle apparatus is similar to that of the USP 2 setup but it is scaled down about to 1/5 of the volume and 40% …

Effect Of Impeller Submergence On Power Dissipation And Solids Suspension In Mixing Systems Equipped With Pitch-Blade Turbines, Yufeng Song

Theses

Mixing and dispersion of solids in a liquid is a process frequently encountered in the pharmaceutical industry and often conducted in cylindrical baffled tanks stirred by mechanical impellers. In operations where the liquid level is decreased (as often which emptying the tank) the process must be stopped when the solids are no longer suspended. In this work, the minimum agitation to suspend solids (Njs) when the liquid level was lowered, and the impeller submergence S_b changed as a result were determined for the case of a six-blade, pitch-blade turbine (6-PBT) impeller. The power consumed by the impeller …

Identifying Modifier Genes In Sma Model Mice, Weiting Xu

Theses

Spinal Muscular Atrophy (SMA) involves the loss of nerve cells called motor neurons in the spinal cord and is classified as a motor neuron disease, it affects 1 in 5000-10000 newborns, one of the leading genetic causes of infant death in USA. Mutations in the SMN1, UBA1, DYNC1H1 and VAPB genes cause spinal muscular atrophy. Extra copies of the SMN2 gene modify the severity of spinal muscular atrophy. Mutations in SMN1 (Motor Neuron 1) mainly causes SMA (Autosomal recessive inheritance). SMN1 gene mutations lead to a shortage of the SMN protein and SMN protein forms SMN complex …

Bio-Medicinal Application For Plasma Electrolytic Oxidation Of Metals, Zunjian Yang

Theses

Plasma electrolytic oxidation (PEO), a novel method for forming ceramic coatings on metals, has been researched extensively in recent times. By applying high voltage between dielectric thin films, a plasma micro-arc is induced through penetration of breakdown in film boiling layer. Such a method takes advantage of high processing time, low equipment requirement and advanced coating performance.

Titanium alloys, Ti-6Al-4V and pure Titanium Grade 2, are two of most common Titanium alloys in daily use. Both of such Titanium alloys show great potential utilization in bio-medicinal application, especially in implants, for its excellent biocompatibility, high tensile strength, and high elastic …

Swift Fox Abundance Along The Heartland Expressway Corridor In Nebraska, Marc Albrecht

Nebraska Department of Transportation: Research Reports

No abstract provided.

The Freshman 15: The 15 Most Important Things I Learned Freshman Year, Megan Clark

UNH Today Archive

No abstract provided.

Banning Neonicotinoids: Ban First, Ask Questions Later, Evan Jensen

Seattle Journal of Environmental Law

No abstract provided.

The International Tribunal For E-Waste: Ending The Race Towards Lethal Fallout, Erin Mcintire

Seattle Journal of Environmental Law

No abstract provided.

Can Sharks Be Saved? A Global Plan Of Action For Shark Conservation In The Regime Of The Convention On Migratory Species, James Kraska, Leo Chan Gaskins

Seattle Journal of Environmental Law

Shark populations throughout the world are at grave risk; some spe-cies have declined by 95 percent. The most recent IUCN (Interna-tional Union for the Conservation of Nature) assessment by the Shark Specialist Group (SSG) found that one-fourth of shark and ray spe-cies face the prospect of extinction. This article proposes an engage-ment plan to accelerate efforts by states and international organiza-tions to conserve and protect sharks worldwide. Sharks are found throughout all of the world’s oceans, and collec-tively they occupy an indispensable niche as apex predators at the top of the ocean trophic ecosystem. These fish function as an im-portant …

Cemaran Mikroba Escherichia Coli Dan Total Bakteri Koliform Pada Air Minum Isi Ulang, Rolan Sudirman Pakpahan, Intje Picauly, I Nyoman W. Mahayasa

Kesmas

Jumlah layanan air minum melalui depot air minum di Kota Kupang meningkat dengan rata-rata 1,44 setiap tahun sejak 2010, sementara tidakterdapat jaminan kualitas air minum isi ulang memenuhi syarat setiap saat. Hasil pemeriksaan sampel air minum isi ulang di Kota Kupang tahun 2013 menunjukkan 37,5% tercemar mikroba. Tujuan penelitian ini adalah menganalisis cemaran mikroba dan mengetahui determinan cemaran Escherichia coli (E. coli) dan total koliform pada air minum isi ulang. Penelitian ini menggunakan desain studi potong lintang periode Januari Maret 2015. Populasi penelitian berjumlah 51 depot air minum yang ditentukan menggunakan teknik total sampling. Analisis data dilakukan secara univariat, analisis …

Pengaruh Teknik Marmet Terhadap Kelancaran Air Susu Ibu Dan Kenaikan Berat Badan Bayi, Anita Widiastuti, Siti Arifah, Wiwin Renny Rachmawati

Kesmas

Bayi lahir cukup bulan memiliki naluri menyusu 20 - 30 menit setelah dilahirkan. Namun, fakta menunjukkan produksi dan ejeksi air susu ibu (ASI) yang sedikit di hari-hari pertama menyebabkan banyak ibu yang mengalami ketidakefektifan proses menyusui. Tidak terproduksinya ASI diakibatkan karena kurangnya rangsangan hormon prolaktin. Teknik marmet merupakan perpaduan memerah dan memijat payudara pada ibu nifas yang dapat merangsang hormon pada proses menyusui. Penelitian ini bertujuan untuk mengetahui perbedaan pengaruh teknik marmet dengan masase payudara pada ibu nifas tiga hari postpartum terhadap kelancaran ASI dan kenaikan berat badan bayi. Penelitian ini menggunakan desain pre-experimental bentuk perbandingan kelompok statistik yang dilakukan …

Pola Konsumsi Dengan Terjadinya Sindrom Metabolik, Suhaema Suhaema, Herta Masthalina

Kesmas

Terjadinya sindrom metabolik diduga berhubungan dengan pergeseran gaya hidup masyarakat yang berubah menuju masyarakat modern, dari mengonsumsi makanan tradisional beralih ke makanan instan dan kebaratbaratan. Penelitian ini bertujuan untuk mengetahui prevalensi sindrom metabolik dan determinannya dari pola konsumsi, meliputi konsumsi sayur dan buah serta pola makan makanan manis, asin, berlemak, lauk hewani berpengawet, dan penggunaan penyedap. Penelitian ini merupakan bagian dari analisis lanjut data Riset Kesehatan Dasar tahun 2013 dengan desain potong lintang. Jumlah sampel setelah pembobotan adalah 1.878.578 orang dengan kriteria berusia 18 tahun ke atas. Pengumpulan data pola konsumsi, antropometri, klinis, dan biomedis telah dilakukan. Analisis data menggunakan …

Behavior Of Deformed Dermal Fibroblasts Seeded On A Silicon Membrane Under High Levels Of Strain, Laura Osorno

Theses

The main objective of this thesis is to understand, from a molecular perspective, the morphological and functional abnormalities of human dermal fibroblasts as a response to deformation produced by a normal force that can lead to the potential formation of stretch marks in pregnant women, adolescents, and people with Cushing's syndrome. The main function of dermal fibroblasts is to produce the essential fibrous components of the extracellular matrix (ECM) of the skin.

In order to study the mechanism of stretch mark formation, neonatal human dermal fibroblasts were seeded on a silicon membrane for controlled deformation. Upon reaching a confluence of …

Experimental Determination Of Solids Suspension With Angled Impeller In A Pharmaceutical Mixing Vessel, Yingxi Tang

Theses

Angled-mounted impellers are commonly used in a number of pharmaceutical industry applications, from laboratory reactors to full-scale tanks. In these systems, the impeller is not centrally and vertically mounted, as in most stirred vessels, but it enters the vessel, and is therefore immersed in the fluid, at an angle from the vertical. This arrangement provides some baffling effects that would not otherwise exist if the impeller was centrally mounted.

One common requirement for such systems is that they are capable of suspending small solids dispersed in the liquid. Therefore, it is critical to know the value of the minimum agitation …

2015 Rose-Hulman Institute Of Technology : One-Hundred And Thirty-Seventh Commencement, Rose-Hulman

Commencement Programs

No abstract provided.

Comparative Analysis Of Pesticide Effects On Natural Enemies In Western Orchards: A Synthesis Of Laboratory Bioassay Data, Nicholas J. Mills, Elizabeth H. Beers, Peter W. Shearer, Thomas R. Unruh, Kaushalya G. Amarasekare

Agricultural and Environmental Sciences Faculty Research

Pesticides are commonly used for pest management in apple, pear and walnut orchards in the western U.S. and may disrupt biological control of secondary pests in these crops. A comparative analysis was made of results obtained from a series of laboratory bioassays of acute mortality and life table response experiments to estimate lethal and sublethal effects of eight pesticides on seven natural enemy species through use of stage-structured population models. Even though a number of the pesticides tested were reduced-risk products, all of them with the exception of copper plus mancozeb and chlorantraniliprole, caused more than 80% acute mortality of …

May 30, 2015 (Pages 2581-2694), Pennsylvania Legislative Reference Bureau

Volume 45 (2015)

No abstract provided.