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Curcumin: A Multi-Dimensional Approach To Pancreatic Cancer Targeting Cell Death And Exosomes, Carlos J. Diaz Osterman

Loma Linda University Electronic Theses, Dissertations & Projects

Pancreatic cancer is currently one of the most difficult diseases to treat due to difficulty of detection and the aggressive nature of the disease. In addition, pancreatic cancer has the highest mortality rates compared to other cancer types. These mortality rates are attributable in part to increasing resistance to cancer therapy. Cancer therapy resistance is caused by adaptations that favor survival within cancer cells and their environment, termed the tumor microenvironment. Intracellular adaptations include the overexpression of resistance-linked genes, such as the inhibitor of apoptosis (IAP) family of proteins and overall resistance to cell death. Adaptations in the tumor microenvironment …

Reproductive Ecology And Hatchling Behavior Of Olive Ridley Sea Turtles In Honduras, Noemi Duran Royo

Loma Linda University Electronic Theses, Dissertations & Projects

In this dissertation, I investigated the reproductive ecology and hatchling behavior of the olive ridley (Lepidochelys olivacea) sea turtle population nesting in Pacific Honduras. I begin by reviewing olive ridley reproduction, human use of this species, and past and present conservation on nesting beaches. I also propose a conservation strategy to improve nesting beach conservation programs in developing countries. In the first of four empirical studies, I used microsatellite markers to assess multiple paternity levels of the Honduran population, and found evidence for multiple paternity in 75% of the nests examined. This rate, higher than expected for a population of …

Treatment Of Petroleum Hydrocarbons In Oil-Based Drill Cutting Mud Using Biowish Bioaugmentation Products, Diego Jose Cardenas Zepeda

Master's Theses

The efficacy of BiOWiSHTM-Thai Aqua, a commercially discontinued microbial product, in remediating oil based drill-cutting mud (DCM) was researched in this study. Experimentation was performed directly on DCM and on sand contaminated with oil extracted from DCM. A gas chromatograph-mass spectrometrer and a respirometer were used for analysis of total petroleum hydrocarbons (TPH) and CO2 production respectively. Five experiments were analyzed by TPH extraction and analysis; four experiments were analyzed by respirometric analysis. The specific microcosm conditions tested in the experiments were control, nutrient-only control, and bioaugmentation product.

This study concluded that there might be potential for bioaugmentation of TPH …

A Finite Element Analysis On The Viscoelasticity Of Postmenopausal Compact Bone Utilizing A Complex Collagen D-Spacing Model, Austin C. Cummings

Master's Theses

The nanoscale dimension known as D-spacing describes the staggering of collagen molecules, which are fundamental to the biphasic makeup of bone tissue. This dimension was long assumed to be constant, but recent studies have shown that the periodicity of collagen is variable. Given that the arrangement of collagen molecules is closely related to the degree of bone mineralization, recent studies have begun to look at D-spacing as a potential factor in the ongoing effort to battle postmenopausal osteoporosis. The theoretical models presented by previous studies have only opted to model a single collagen-hydroxyapatite period, so the creation of an intricate …

The Effects Of Injury And Displacement On Typhoon Yolanda Survivors, Crystel N. Chaparro, Alexis L. Mitchell

Electronic Theses, Projects, and Dissertations

This study was conducted with a group Filipino survivors of Typhoon Yolanda. It examines the effects of being injured or displaced as a result of the natural disaster on the effectiveness of a pilot project addressing depression, anxiety and hope. Eight adults (N = 8) completed a series of five workshops along with a pre and post questionnaire. Those that were displaced, exhibited a reduction in depression (24%), a reduction in anxiety (12.8%), and an increase in hope (14.78%) after completing the workshops. Furthermore, the individuals that were injured experienced a reduction in anxiety (22.7%), an increase in depression (28.48%), …

Effects Of Attachment Styles Of Foster And Adoptive Parents On The Relational Interactions Of Their Foster And Adoptive Children, Taylor Paige Mountjoy, Elyssa Noel Vanlandingham

Electronic Theses, Projects, and Dissertations

Children enter the Child Welfare System for a variety of complex reasons.

These reasons often point towards parents’ inability to provide appropriate

protection and safety for their children. After removal, many children are placed in

foster homes of relatives, non-related extended family members, group homes,

and county or private foster homes. A child who is removed from their original

home is likely to experience difficulties in the areas of attachment with caregivers

and other adults throughout their development.

This study examined the attachment styles of 37 foster and adoptive parents in

three separate private Foster Family Agencies in both San …

The Secret Language Of The Desert: Poetry, Loss, And Awakening, Elisha P. Holt

Electronic Theses, Projects, and Dissertations

The speaker of The Desert Survival Guide is seeking to reconcile his own disconnection, from the natural world, the cosmos, his family, and from his sense of his own humanity. The poems in The Desert Survival Guide are a healing ceremony, to come to a place of acceptance regarding the loss of my father. The semi-autobiographical speaker of these poems has lost the immediate physical presence of his father in his life but still retains a deep memory imprint of the father and an unresolved need to process the absence of the father. He is gradually establishing a new connection …

The Relationship Between Attachment And Depression: The Mediational Role Of Shame, Self-Esteem, And Social Support, Evelyn Estela Ayala

Electronic Theses, Projects, and Dissertations

According to the American College Health Association 31.3% of college students reported feeling depressed. Early parental attachment forms an internal working model that is used as reference for later relationships and experiences. Past research suggests that parental attachment is associated with depression. Low self-esteem was found to mediate the relationship between parental bonding (low care and overprotection) and depression. The cognitive schemas of defectiveness and shame were found to meditate the relationship between poor parental bonding and depression. Among cancer patients the relationship between anxious attachment and symptoms of depression was mediated by perceived social support.

Research is necessary to …

Consumer Evaluation: The Link Between Body Mass Index, Reward Sensitivity, Product Liking And Emotion, Malori Comer

Master's Theses

The objectives of this study were: (1) to evaluate consumer acceptance of cheeses varying in fat and sodium levels, (2) to determine if sensitivity to reward and body mass index has an effect on product liking based on fat or salt content, (3) to evaluate the use of FaceReader technology during consumer evaluation and, (4) to determine if consumer’s self-selected, conscious emotions matched with the expressed, subconscious emotions acquired by FaceReader.

Consumer acceptance testing (n=108) was conducted on two medium cheddar cheeses with varying fat levels and two low-moisture part-skim mozzarella cheeses varying in sodium levels. Attributes were measured using …

Ecg Classification With An Adaptive Neuro-Fuzzy Inference System, Brad Thomas Funsten

Master's Theses

Heart signals allow for a comprehensive analysis of the heart. Electrocardiography (ECG or EKG) uses electrodes to measure the electrical activity of the heart. Extracting ECG signals is a non-invasive process that opens the door to new possibilities for the application of advanced signal processing and data analysis techniques in the diagnosis of heart diseases. With the help of today’s large database of ECG signals, a computationally intelligent system can learn and take the place of a cardiologist. Detection of various abnormalities in the patient’s heart to identify various heart diseases can be made through an Adaptive Neuro-Fuzzy Inference System …

Screening Of Biocontrol Organisms For The Management Of Phytopathogenic Fungi And Foodborne Pathogens On Produce, Antoinette Boyee De Senna

Master's Theses

The multibillion dollar agricultural industry is an important part of the United States economy, and the management of factors that affect crop and human health is imperative to maintaining this economic sector. The fungi Botrytis cinerea, Fusarium pallidoroseum, and Fusarium moniliforme are the causative agents of several plant diseases and can cause significant crop loss both before and after harvest in commodities such as strawberries, lettuce, citrus, and grains. Fungicides are employed to control these phytopathogens, but the use of these chemicals has led to an increase in fungicide resistance and may negatively affect the environment and human …

Investigation Of Larval Sensory Systems In The Marine Bryozoan, Bugula Neritina, Heather Leigh Price

Master's Theses

Bugula neritina is a sessile marine bryozoan with a pelagic larval stage. Larvae frequently settle on boat hulls, facilitating the introduction of B. neritina to bays and estuaries worldwide. Adrenergic agonists, such as the vertebrate hormone noradrenaline, inhibit larval settlement in a variety of marine invertebrate species, including B. neritina. Light also inhibits B. neritina larval settlement, yet the underlying mechanisms by which light and adrenergic compounds exert their effects on larvae are not well understood. Octopamine is considered the invertebrate analog of noradrenaline, and may be an endogenous hormone involved in larval settlement pathways. I observed the effects of …

Transcriptional Regulatory Networks In Hepatitis C Virus_Induced Hepatocellular Carcinoma, Marwa Zahra

Theses and Dissertations

HCV is an epidemic affecting an estimated 160 million individuals worldwide or approximately 2.35% of the world’s population.(1) This is partly because HCV exhibits high genetic variation which thereby characterizes each region with its own genetic prevalence. Therefore, understanding the transcriptional regulatory elements that influence the progression of liver disease in the presence of HCV infection is thereby crucial for diagnostic and therapeutic purposes. Systems biology provides a road map by which these elements may be easily identified. In this study 124 microarray samples were assessed in order to determine differentially expressed genes for 4 tissue types/conditions (normal, cirrhosis, cirrhosis …

Experience Of Kurdistan Province Of Iraq In Light Of The Development Of Economic And Social Indicators For Sustainable Development, Abd Aljabaar Fatah Al-Obaidid, Ayub Anwar Hamad

Journal of Economics and Administrative Sciences

Reflect the sustainable development of the interaction of three key elements are the economic component and the social component and the environmental component while focusing economic component to achieve economic growth and focuses social element to achieve social justice in the distribution of income and achieve prosperity, the environmental component related fields and including emphasizes the protection of the environment and to ensure the continuation and sustainability of resources physical, biological and form in which it believes the interaction required for development process real and effective and sustainable, and is considered the province of Kurdistan Iraq of important areas where …

Climatic Variation And Seed Persistence: Freeze-Thaw Cycles Lower Survival Via The Joint Action Of Abiotic Stress And Fungal Pathogens, Brian M. Connolly, John L. Orrock

Biology Faculty Scholarship

Global climate change is altering thermal cycles in soils during late winter, a transition that may directly threaten seed survival via abiotic stress, facilitate infection by soil-borne pathogens, or both. Using field-collected soil and seeds of the perennial bunchgrass Elymus canadensis, we tested the hypothesis that soil freeze–thaw events limit survival within the soil through direct effects on seed persistence and amplification of soil pathogen attack using a factorial experiment that manipulated freeze–thaw cycles (constant freeze vs. freeze–thaw) and fungicide addition. Freeze–thaw treatment resulted in lower seedling emergence and delayed emergence time relative to constant-freeze controls. Fungicide-treated soils had …

Montclair Magazine (Spring/Summer 2015), Montclair State University

Montclair: The magazine of Montclair State University

No abstract provided.

String Lights, Amanda Jennifer Pleau Mfa

All Student Scholarship

String Lights is a nonfictional, creative exploration of relationships. Themes in this collection include digital communication, the cultural influence of music and music retailers, coming of age, sex, love, true crime, and travel.

Irisin Evokes Bradycardia By Activating Cardiac-Projecting Neurons Of Nucleus Ambiguus., Eugen Brailoiu, Elena Deliu, Romeo A Sporici, Gabriela Cristina Brailoiu

College of Pharmacy Faculty Papers

Irisin is a newly identified hormone induced in muscle and adipose tissues by physical activity. This protein and its encoding gene have been identified in the brain; in addition, the precursor for irisin, FNDC5, can cross the blood-brain barrier. The fact that irisin is secreted during exercise together with the lower resting heart rate in athletes prompted us to investigate the effect of irisin on cardiac-projecting vagal neurons of nucleus ambiguus, a key regulatory site of heart rate. In vitro experiments in cultured nucleus ambiguus neurons indicate that irisin activates these neurons, inducing an increase in cytosolic Ca(2+) concentration and …

2015/2016 University Of The Pacific General Catalog, University Of The Pacific

Catalogue, Bulletin, Catalog

No abstract provided.

Does Video Game Content Matter? An Examination Of Two Competing Ideas, Nathan J. Smith

Theses and Dissertations

The current paper addresses the associations between video game content (i.e., physically aggressive, relationally aggressive, and prosocial) and physical aggression, relational aggression, and prosocial behavior in two distinct developmental periods. The purpose of the paper is to test whether playing video games with a particular type of content influences behaviors over time, or whether individuals who have higher levels of physical aggression, relational aggression, or prosocial behavior prefer to play games with similar content. Two theories will be simultaneously examined and tested in order to determine the relative merit in using each in research examining the relationships between video game …

Bioinformatics For The Comparative Genomic Analysis Of The Cotton (Gossypium) Polyploid Complex, Justin Thomas Page

Theses and Dissertations

Understanding the composition, evolution, and function of the cotton (Gossypium) genome is complicated by the joint presence of two genomes in its nucleus (AT and DT genomes). Specifically, read-mapping (a fundamental part of next-generation sequence analysis) cannot adequately differentiate reads as belonging to one genome or the other. These two genomes were derived from progenitor A-genome and D-genome diploids involved in ancestral allopolyploidization. To better understand the allopolyploid genome, we developed PolyCat to categorize reads according to their genome of origin based on homoeo-SNPs that differentiate the two genomes. We re-sequenced the genomes of extant diploid relatives of tetraploid cotton …

Finnishness And Colonization In Akseli Gallen-Kallela's Representations Of Africa, Camille Kathryn Richey

Theses and Dissertations

Akseli Gallen-Kallela is often discussed as the national painter of Finland, as one who helped define Finnishness when Finland was still a colonized area of Russia. However, his trip to Africa from 1909-1911 shows where Gallen-Kallela acts as a pictorial colonizer himself, not only sympathizing with the Africans but representing them through a European cosmopolitan lens, as purer and closer to nature, but still inferior. The assumptions inherent in his representations of Africa reveal that Gallen-Kallela is not only a colonized subject but a colonizer of his own country.

Interactions Between Social Support, Acculturationand Health Among Mexican Immigrants, Christopher D. Anderson

Theses and Dissertations

The impact of acculturation and poor social support as potential risk factors for cardiovascular and metabolic disease amongst Mexican immigrants to the United States (U.S.) is a developing area of research. One theory is that acculturation to U.S. society is negatively associated with health due to the stress of immigration as well as the less healthy diet and lifestyle in the U.S. It is also theorized that positive social support is associated with better health during immigration due to the buffering effect relationships have on stress. Despite these theories, mixed findings have been found regarding the associations between acculturation and …

Electrophysiological Endophenotypes In Autism Spectrum Disorder: A Family Study, Ann Clawson

Theses and Dissertations

Autism spectrum disorder (ASD) is a highly heritable neurodevelopmental disorder associated with altered neural connectivity and deficits in self-monitoring, response inhibition, and planning. One promising avenue of research to improve understanding of the symptoms and heritable nature of ASD may be the identification of neural endophenotypes of ASD. The error-related negativity (ERN) and post-error positivity (Pe), scalp-recorded event-related potentials (ERPs), reflect performance monitoring processes and may qualify as candidate endophenotypes of ASD. We collected ERP and behavioral data (error rates, response times) from 18 ASD probands and their families (mother, father, sibling) and 38 control youth and their parents to …

Geographically Isolated Wetlands: Rethinking A Misnomer, David M. Mushet, Aram J. K. Calhoun, Laurie C. Alexander, Matthew J. Cohen, Edward S. Dekeyser, Laurie Fowler, Charles R. Lane, Mark C. Rains, Susan C. Walls

School of Geosciences Faculty and Staff Publications

We explore the category “geographically isolated wetlands” (GIWs; i.e., wetlands completely surrounded by uplands at the local scale) as used in the wetland sciences. As currently used, the GIW category (1) hampers scientific efforts by obscuring important hydrological and ecological differences among multiple wetland functional types, (2) aggregates wetlands in a manner not reflective of regulatory and management information needs, (3) implies wetlands so described are in some way “isolated,” an often incorrect implication, (4) is inconsistent with more broadly used and accepted concepts of “geographic isolation,” and (5) has injected unnecessary confusion into scientific investigations and discussions. Instead, we …

Peninsular Florida Stream Systems: Guidance For Their Classification And Restoration, John H. Kiefer, Joann Mossa, Kristen B. Nowak, William R. Wise, Kenneth M. Portier, Thomas Crisman

School of Geosciences Faculty and Staff Publications

This project was performed to improve understanding of key physical and ecological attributes of natural streams in peninsular Florida in order to derive a practical process-based classification system; and also to provide design aids to assist with stream restoration in rural settings. Fifty-six of the best remaining stream systems in the peninsula were selected for monitoring of more than 120 quantitative variables known to associate with key stream system processes. The sites covered a wide range of physical gradients including soil drainage condition, drainage area, and valley slope, and were observed at watershed, valley, channel and patch scales. Hierarchical cluster …

Notes: Are Land-Use Changes Reflected In Diets Of Mourning Doves (Zenaida Macroura) In Eastern South Dakota, Joshua B. Smith, Troy W. Grovenburg, Matthew A. Perrion, Jason M. Augspurger, Trevor W. Bultje, Anna M. Robinson, Brandi L. Crider, Datta Shubham, Jonathan A. Jenks

The Prairie Naturalist

Food habits of the mourning dove (Zenaida macroura) have been extensively studied in the southern United States (McClure 1943, Korschgen 1958, Carpenter 1971) and consist primarily of vegetable matter throughout their range (Beckwith 1959). Diet studies in several states have indicated agricultural crops, specifically corn and wheat, were the most readily consumed plant seeds (Korshgen 1958, Carpenter 1971). Similarities observed in diets of doves were dependent on the agricultural crops available within the area. For example, in Missouri, some seasonal variability was documented suggesting doves forage based on food availability as much as by food preference (Korschgen 1958). However, in …

A New Species Of Euscorpius (Scorpiones: Euscorpiidae) From Southern Bulgaria, Gioele Tropea, Victor Fet, Aristeidis Parmakelis, Panayiota Kotsakiozi, Iasmi Stathi

Biological Sciences Faculty Research

A new scorpion species, Euscorpius drenskii sp. nov., is described from the Western Rhodope Mts. in southern Bulgaria. It is characterized by an oligotrichous trichobothrial pattern, which shows a conspicuous loss of one trichobothrium in the external median patellar series (em = 3), also observed in E. carpathicus (Linnaeus, 1767) and the subgenus Alpiscorpius Gantenbein, Fet, Largiadèr & Scholl, 1999. Phylogenetic analysis of 16S rDNA marker sequences does not show any close relationship between these three groups, suggesting that the observed loss of a trichobothrium is an independent event.

Examining The Toxicity, Exposure, And Regulatory Approach To Potential Human Health Risks Of The Algal Toxin Domoic Acid, Thomas H. Angus

Graduate Doctoral Dissertations

Domoic acid is a neurotoxin produced by the marine diatom genus Pseudo-nitzschia and causes cell death primarily in the area of the brain responsible for long-term memory. The resulting severe illness has been termed amnesic shellfish poisoning. Domoic acid accumulates in shellfish and planktivorous fish that consume Pseudo-nitzschia, resulting in exposure to humans through consumption of planktivorous seafood. A regulatory standard in seafood was developed shortly after its discovery in 1987 to protect against acute effects. This regulatory standard has not been revised despite significant recent data in the scientific literature.

This dissertation is divided into four sections: (1) …

Fluxes Of Dissolved Organic Carbon During Storm Events In The Neponset River Watershed, Keith Thomas Cialino

Graduate Doctoral Dissertations

The transport of dissolved organic carbon (DOC) and chromophoric dissolved organic matter (CDOM) from land to coastal environments strongly influences coastal ecosystems. The presence of first flush phenomena due to rainwater runoff traveling from land into waterways can greatly affect carbon fluxes to coastal areas. This research utilizes sensors, autosamplers, and standard watershed sampling in order to assess for the presence of first flush and its significance. A rainfall simulator was built in order to collect runoff on two land use types. Time series data suggest that first flush of dissolved organic carbon was present for all rainfall intensities simulated …