Digital Commons Network^™

Research Finds Males And Females Process Chronic Pain Differently, Staff

Browse All News

No abstract provided.

Maoa Genotype X Environment Interaction And Influence On Monoamine Neurotransmitter Functioning In Rhesus Macaques (Macaca Mulatta), Daniel Loveland, Dr. J. Dee Higley

Journal of Undergraduate Research

Original Project Title: Why can’t we all just get along? MAOa genotype variation is associated with aggressive temperaments in nonhuman primates

In place of studying behavior differences among rhesus monkeys with differing MAOa genotypes, my research group and I chose to analyze the effects of genes and the environment on brain chemistry.

The 2014 Farm Bill: Farm Subsidies And Food Oppression, Andrea Freeman

Seattle University Law Review

The 2014 Farm Bill ushered in some significant and surprising changes. One of these was that it rendered the identity of all the recipients of farm subsidies secret. Representative Larry Combest, who is now a lobbyist for agribusiness, first introduced a secrecy provision into the bill in 2000. The provision, however, only applied to subsidies made in the form of crop insurance. Until 2014, the majority of subsidies were direct payments and the identity of the people who received them was public information. In fact, the Environmental Working Group’s release of the list of recipients led to a series of …

Gene Expression During The First 28 Days Of Axolotl Limb Regeneration I: Experimental Design And Global Analysis Of Gene Expression, S. Randal Voss, Alex Palumbo, Radha Nagarajan, David M. Gardiner, Ken Muneoka, Arnold J. Stromberg, Antony T. Athippozhy

Biology Faculty Publications

While it is appreciated that global gene expression analyses can provide novel insights about complex biological processes, experiments are generally insufficiently powered to achieve this goal. Here we report the results of a robust microarray experiment of axolotl forelimb regeneration. At each of 20 post-amputation time points, we estimated gene expression for 10 replicate RNA samples that were isolated from 1 mm of heterogeneous tissue collected from the distal limb tip. We show that the limb transcription program diverges progressively with time from the non-injured state, and divergence among time adjacent samples is mostly gradual. However, punctuated episodes of transcription …

Today - June 29, 2015, Loma Linda University Health

TODAY

Inside this issue:

-- Loma Linda University celebrates 1,480 newest alumni
-- University celebrates honorees during ceremonies
-- Safe Kids and Children's Hospital host media event for water safety awareness
-- Zipcar, which brought car sharing to Loma Linda University Health, may expand
-- Kids learn to trust care providers during teddy bear clinic
-- Annual Celebration of Life provides heartfelt laughter, inspiration and hope
-- Food and family are important to LLUMC - Murrieta chef
-- Official negotiations begin for affiliation with San Gorgonio Memorial Hospital
-- Study finds increasing respiratory risks for children living near major rail yards …

Arctic Domain Awareness Center: Biographies, N/A University Of Alaska Anchorage

June 2015

No abstract provided.

E2e Program, Don Spalinger, Luann Piccard, Charlie Stuart, George Kamberov

June 2015

No abstract provided.

Deletion Of Nfnab In Thermoanaerobacterium Saccharolyticum And Its Effect On Metabolism, Jonathan Lo, Tianyong Zheng, Daniel G. Olson, Natalie Ruppertsberger, Shital Tripathi, Adam Guss, Lee Lynd

Dartmouth Scholarship

NfnAB catalyzes the reversible transfer of electrons from reduced ferredoxin and NADH to 2 NADP⁺. The NfnAB complex has been hypothesized to be the main enzyme for ferredoxin oxidization in strains of Thermoanaerobacterium saccharolyticum engineered for increased ethanol production. NfnAB complex activity was detectable in crude cell extracts of T. saccharolyticum. Activity was also detected using activity staining of native PAGE gels. The nfnAB gene was deleted in different strains of T. saccharolyticum to determine its effect on end product formation. In wild-type T. saccharolyticum, deletion of nfnAB resulted in a 46% increase in H₂ formation but …

Metagenome Sequencing Of The Hadza Hunter-Gatherer Gut Microbiota, Simone Rampelli, Stephanie L. Schnorr, Clarissa Consolandi, Silvia Turroni, Marco Severgnini, Clelia Peano, Patrizia Brigidi, Alyssa N. Crittenden, Amanda G. Henry, Marco Candela

Anthropology Faculty Research

Through human microbiome sequencing, we can better understand how host evolutionary and ontogenetic history is reflected in the microbial function. However, there has been no information on the gut metagenome configuration in hunter-gatherer populations, posing a gap in our knowledge of gut microbiota (GM)-host mutualism arising from a lifestyle that describes over 90% of human evolutionary history. Here, we present the first metagenomic analysis of GM from Hadza hunter-gatherers of Tanzania, showing a unique enrichment in metabolic pathways that aligns with the dietary and environmental factors characteristic of their foraging lifestyle. We found that the Hadza GM is adapted for …

Familiarity With And Preferences For Oral And Long-Acting Injectable Hiv Pre-Exposure Prophylaxis (Prep) In A National Sample Of Gay And Bisexual Men In The U.S., Jeffrey T. Parsons, H. Jonathan Rendina, Thomas H.F. Whitfield, Christian Grov

Publications and Research

Objectives: We sought to determine preferences for oral versus long-acting injectable (LAI) PrEP among gay and bisexual men (GBM).

Methods: We surveyed a national U.S. sample of 1,071 GBM about forms of PrEP.

Results: Overall, 46.0% preferred LAI, 14.3% oral, 21.7% whichever was most effective, 10.1% had no preference, and 7.8% would not take PrEP. There were no differences in PrEP preferences by race/ethnicity, income, region of residence, or relationship status. Those unwilling to take PrEP were significantly older than those who preferred LAI PrEP and those who would take either. Those who preferred the most effective …

Pleiotropic Effects Of Bitter Taste Receptors On [Ca2+]I Mobilization, Hyperpolarization, And Relaxation Of Human Airway Smooth Muscle Cells., Blanca Camoretti-Mercado, Susan H Pauer, Hwan Mee Yong, Dan'elle C Smith, Deepak A. Deshpande, Phd, Steven S An, Stephen B Liggett

Center for Translational Medicine Faculty Papers

Asthma is characterized by airway inflammation and airflow obstruction from human airway smooth muscle (HASM) constriction due to increased local bronchoconstrictive substances. We have recently found bitter taste receptors (TAS2Rs) on HASM, which increase [Ca2+]i and relax the muscle. We report here that some, but not all, TAS2R agonists decrease [Ca2+]i and relax HASM contracted by G-protein coupled receptors (GPCRs) that stimulate [Ca2+]i. This suggests both a second pathway by which TAS2Rs relax, and, a heterogeneity of the response phenotype. We utilized eight TAS2R agonists and five procontractile GPCR agonists in cultured HASM cells. We find that heterogeneity in the …

Exogenous 17-Β Estradiol Administration Blunts Progression Of Established Angiotensin Ii-Induced Abdominal Aortic Aneurysms In Female Ovariectomized Mice, Sean E. Thatcher, Xuan Zhang, Shannon Woody, Yu Wang, Yasir Alsiraj, Richard Charnigo, Alan Daugherty, Lisa A. Cassis

Saha Cardiovascular Research Center Faculty Publications

BACKGROUND: Abdominal aortic aneurysms (AAAs) occur predominately in males. However, AAAs in females have rapid growth rates and rupture at smaller sizes. Mechanisms contributing to AAA progression in females are undefined. We defined effects of ovariectomy, with and without 17-β estradiol (E2), on progression of established angiotensin II (AngII)-induced AAAs in female mice.

METHODS: We used neonatal testosterone exposures at 1 day of age to promote susceptibility to AngII-induced AAAs in adult female Ldlr^-/- mice. Females were infused with AngII for 28 days to induce AAAs, and then stratified into groups that were sham, ovariectomized (Ovx, vehicle), or Ovx …

Randy Wadkins Named Inaugural Bps Congressional Fellow, Edwin Smith

University of Mississippi News

UM associate professor of chemistry to study, lecture in nation's capital

A Case Study Of Laser Wind Sensor Performance Validation By Comparison To An Existing Gage, Charles R. Standridge Ph.D., David Zeitler, Erik E. Nordman, T. Arnold Boezaart, James Edmonson, Yeni Nieves, T. J. Turnage, Reo Phillips, Graham Howe, Guy Meadows, Aline Cotel, Frank Marsik

Peer Reviewed Articles

A case study concerning validation of wind speed measurements made by a laser wind sensor mounted on a 190 square foot floating platform in Muskegon Lake through comparison with measurements made by pre-existing cup anemometers mounted on a met tower on the shore line is presented. The comparison strategy is to examine the difference in measurements over time using the paired-t statistical method to identify intervals when the measurements were equivalent and to provide explanatory information for the intervals when the measurements were not equivalent. The data was partitioned into three sets: not windy (average wind speed measured by the …

Enhancing Interferon Regulatory Factor 7 Mediated Antiviral Responses And Decreasing Nuclear Factor Kappa B Expression Limit Hiv-1 Replication In Cervical Tissues, Christiane Rollenhage, Sherrill L. Macura, Melissa J. Lathrop, Todd A. Mackenzie, Gustavo F. Doncel, Susana N. Asin

Dartmouth Scholarship

Establishment of a productive HIV-1 infection in the female reproductive tract likely depends on the balance between anti-viral and pro-inflammatory responses leading to activation and proliferation of HIV target cells. Immune modulators that boost anti-viral and depress pro-inflammatory immune responses may decrease HIV-1 infection or replication. Polyinosinic: polycytidylic [Poly (I:C)] has been reported to down-regulate HIV-1 replication in immune cell subsets and lymphoid tissues, yet the scope and mechanisms of poly (I:C) regulation of HIV-1 replication in the cervicovaginal mucosa, the main portal of viral entry in women remain unknown. Using a relevant, underexplored ex vivo cervical tissue model, we …

Novel Imidazopyridine Derivatives Possess Anti-Tumor Effect On Human Castration-Resistant Prostate Cancer Cells., Matthew A. Ingersoll, Anastesia S. Lyons, Sakthivel Muniyan, Napoleon D'Cunha, Tashika Robinson, Kyle Hoelting, Jennifer G. Dwyer, Xiu R. Bu, Surinder K. Batra, Ming-Fong Lin

Journal Articles: Biochemistry & Molecular Biology

Prostate cancer (PCa) is the second leading cause of cancer-related death afflicting United States males. Most treatments to-date for metastatic PCa include androgen-deprivation therapy and second-generation anti-androgens such as abiraterone acetate and enzalutamide. However, a majority of patients eventually develop resistance to these therapies and relapse into the lethal, castration-resistant form of PCa to which no adequate treatment option remains. Hence, there is an immediate need to develop effective therapeutic agents toward this patient population. Imidazopyridines have recently been shown to possess Akt kinase inhibitory activity; thus in this study, we investigated the inhibitory effect of novel imidazopyridine derivatives HIMP, …

Week Of June 29, 2015, New York Medical College

InTouch

• New Campus Walkway is Now Open
• NYMC School of Medicine Pilots "The Healer's Art" Program
• Dr. Halperin Hosts Chancellor's Circle Reception
• Dr. Miller Hosts Special Dean's Lecture
• Department of Family and Community Medicine Hosts Annual Faculty Development and Appreciation Dinner
• Office of Medical Education Hosts Preceptor Appreciation Banquet
• NYMC Welcomes Class of 2018 D.P.T. Students
• Students Take a Study Break with Leonard

A Developmental Model Of Research Mentoring, Renata A. Revelo, Michael Loui

School of Engineering Education Faculty Publications

We studied mentoring relationships between undergraduate and graduate students in a summer undergraduate research program, over three years. Using a grounded theory approach, we created a model of research mentoring that describes how the roles of the mentor and the student can change. Whereas previous models of research mentoring ignored student roles and treated mentor roles as static, our model focuses on the development of the mentoring relationship over time. Our model explains how conflicts can occur if the mentor role does not match the maturity level of the student.

The Myb36 Transcription Factor Orchestrates Casparian Strip Formation, Takehiro Kamiya, Monica Borghi, Peng Wang, John M. C. Danku, Lothar Kalmbach, Prashant S. Hosmani, Sadaf Naseer, Toru Fujiwara, Niko Geldner, David E. Salt

Biology Faculty Publications

The endodermis in roots acts as a selectivity filter for nutrient and water transport essential for growth and development. This selectivity is enabled by the formation of lignin-based Casparian strips. Casparian strip formation is initiated by the localization of the Casparian strip domain proteins (CASPs) in the plasma membrane, at the site where the Casparian strip will form. Localized CASPs recruit Peroxidase 64 (PER64), a Respiratory Burst Oxidase Homolog F, and Enhanced Suberin 1 (ESB1), a dirigent-like protein, to assemble the lignin polymerization machinery. However, the factors that control both expression of the genes encoding this biosynthetic machinery and its …

My News

My News (2014-2020)

• "Jurassic World" at Georgia Southern
• Georgia Southern graduate selected as Woodrow Wilson Teaching Fellow
• Georgia Southern professor brings national attention to dangerous new drug trend
• Retired professor Don Armel rides crosscountry for community food bank
• BIG opportunity for student entrepreneurs
• Georgia Southern signs agreement with OTC for logistics degree students

Interferon-Γ Regulates Cellular Metabolism And Mrna Translation To Potentiate Macrophage Activation, Xiaodi Su, Yingpu Yu, Yi Zhong, Eugenia Giannopoulou, Xiaoyu Hu, Hui Liu, Justin R. Cross, Gunnar Rätsch, Charles M. Rice, Lionel B. Ivashkiv

Publications and Research

Interferon-γ (IFN-γ) primes macrophages for enhanced inflammatory activation by Toll-like receptors (TLRs) and microbial killing, but little is known about the regulation of cell metabolism or mRNA translation during priming. We found that IFN-γ regulates human macrophage metabolism and translation by targeting the kinases mTORC1 and MNK that both converge on the selective regulator of translation initiation eIF4E. Physiological downregulation of mTORC1 by IFN-γ was associated with autophagy and translational suppression of repressors of inflammation such as HES1. Genome-wide ribosome profiling in TLR2-stimulated macrophages revealed that IFN-γ selectively modulates the macrophage translatome to promote inflammation, further reprogram metabolic pathways, and …

Longitudinal Effects Of School Climate On Middle-School Students' Academic, Social-Emotional And Behavioral Outcomes, Jennifer Lynn Engelland-Schultz

Theses and Dissertations

Millions of youth are at risk for low academic achievement, school dropout, risky behavior, bullying, and mental health concerns, especially those living in rural areas. Protective factors can reduce the likelihood of children and adolescents experiencing these negative outcomes. Research shows that positive school climate is a powerful protective factor for youth. The present study investigated the longitudinal relations between middle school students' school climate perceptions and their academic, social-emotional, and behavioral development over two years. Specifically, 510 students in grades 5-9 from six rural schools rated their support and influence at school as well as their internalizing problems, personal …

Nutrient Addition Effects On Tropical Dry Forests: A Mini-Review From Microbial To Ecosystem Scales, Jennifer S. Powers, Kristen K. Becklund, Maria G. Gei, Siddharth B. Iyengar, Rebecca Meyer, Christine S. O'Connell, Erik M. Schilling, Christina M. Smith, Bonnie G. Waring, Leland K. Werden

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Humans have more than doubled inputs of reactive nitrogen globally and greatly accelerated the biogeochemical cycles of phosphorus and metals. However, the impacts of increased element mobility on tropical ecosystems remain poorly quantified, particularly for the vast tropical dry forest biome. Tropical dry forests are characterized by marked seasonality, relatively little precipitation, and high heterogeneity in plant functional diversity and soil chemistry. For these reasons, increased nutrient deposition may affect tropical dry forests differently than wet tropical or temperate forests. Here, we review studies that investigated how nutrient availability affects ecosystem and community processes from the microsite to ecosystem scales …

Willful Understanding: Avicenna’S Philosophy Of Action And Theory Of The Will, Jon Mcginnis, Anthony Ruffus

Philosophy Faculty Works

In this study, we look at two interpretive puzzles associated with the thought of Avicenna that are still of intrinsic philosophical interest today. The first concerns to what extent, if at all, Avicenna’s deity can be said to act freely. The second concerns to what extent, if at all, humans within Avicenna’s philosophical system can be said to act freely. It is our contention that only through a careful analysis of Avicenna’s theory of action can one begin to assess his position concerning the status of the will and so provide a satisfactory response to these two interpretative issues. We …

Recipes For Success: Comparing Ala-Accredited Mlis Programs, Mandi Goodsett

Michael Schwartz Library Publications

Discussion about the MLIS degree and what could be done to produce well-prepared new librarians for the workforce abounds in the current literature. As the ALA Committee on Accreditation re-evaluates its standards, and frustrated librarians continue to add to the over 150 comments on the Library Journal editorial "Can We Talk about the MLS?" by Michael Kelley, the time to re-evaluate the MLIS degree has arrived. In order to effectively move forward, however, a gap in the literature must be addressed: an overview of the MLIS as it currently stands is needed. This dataset presents information about the current requirements, …

Morphometry And Average Temperature Affect Lake Stratification Responses To Climate Change, Benjamin Kraemer, Orlane Anneville, Sudeep Chandra, Margaret Dix, Esko Kuusisto, David M. Livingstone, Alon Rimmer, S. Geoffrey Schladow, Eugene Silow, Lewis M. Sitoki, Rashid Tamatamah, Yvonne Vadeboncoeur, Peter B. Mcintyre

Biological Sciences Faculty Publications

Climate change is affecting lake stratification with consequences for water quality and the benefits that lakes provide to society. Here we use long-term temperature data (1970–2010) from 26 lakes around the world to show that climate change has altered lake stratification globally and that the magnitudes of lake stratification changes are primarily controlled by lake morphometry (mean depth, surface area, and volume) and mean lake temperature. Deep lakes and lakes with high average temperatures have experienced the largest changes in lake stratification even though their surface temperatures tend to be warming more slowly. These results confirm that the nonlinear relationship …

Identification Of Microorganisms In Traditional Sausage Using Molecular Methods, Li Bingchao, Hu Weidong, Tang Wencai, Li Xingling, Zhong Qiang, Li Zaixin, Zhang Zhi

Food and Machinery

To explore the mechanism of the microbial flora in fermented sausage, traditional methods of microbiological plate dilution and biochemical detection were performed to isolate and culture yeast, E. coli., lactic acid bacteria and other microorganisms. DNA of these suspected strains were extracted, and 16S rDNA and ITS were amplified using PCR technique, and then the amplification products were sequenced. After the obtained gene sequences were compared with those in GenBank by sequence homology comparison, three high abundance suspected strains were identified as: Debaryomyces, Staphylococcus saprophyticus strain YSY1-6 and Lactobacillus delbrueckii subsp respectively.

On-Line Detection Research Of Apple’S Soluble Solids Content Of Diffuse Transmission Technology Based On Near Infrared Spectroscopy, Lu Huishan, Chen Pengqiang, Yan Hongwei, Gao Qiang, Wang Fujie

Food and Machinery

To study on internal quality of the fruit, in order to improve the detection speed and robustness, near infrared spectral diffuse transmission is applied to on-line detection research, using partial least squares regression (PLSR) algorithm combined with different pre-processing methods to establish the quantitative models of soluble solids content (SSC) of internal quality of the apple. The results of final model were achieved as follow: the model was stability which was used by first derivative combined with multiplicative signal correction (MSC), rootmean square errors of calibration and rootmean square errors of prediction are 0.17 and 0.39, respectively, the correlation coefficient …

Effects Of Two Different Fans Arrangement On Stacking Cargo In Cold Store Based On Numerical Simulation, Du Zizheng, Xie Jing, Zhu Jinlin

Food and Machinery

Two different cold store models, one with downward blowing fans and the other with back blowing fans, based on a medium practical cold storage were established to investigate the influence of different fans arrangement on airflow in the cold store (24.3 m×21.6 m×7.2 m). Steady-state simulation was performed by using fluent software and stacking cargos were considered as porous medium. Darcy-Forchheimer and ergun equations were used to describe the parameter of stacking cargo combined with former research. Essential analysis and comparison were also performed. The influence of different fans arrangement on stacking cargo and air flow in the cold store …

Effects Of Hot-Air Drying Temperatures On Quality Of Green Peppers, Zheng Qingyun, Wang Dan, Ma Yue, Tong Junmao, Zhao Xiaoyan

Food and Machinery

The characteristics of green peppers were investigated after treated with hot-air drying at temperatures of 55, 60, 65 and 70 ℃. Then the qualities of dried peppers were analyzed and compared. The results showed that the drying rate and decline of water activity (a_w) were faster as the hot-air drying at higher temperature. Compared with other dried peppers, the treatment dried at 70 ℃ displayed higher the preservation of chlorophyll, Vc, rehydration radio, the hardness and toughness. However, the drying time was too long when peppers dried at 55 ℃, which could cause high production costs. Considered the …