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2015

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Selective Impact Of Cdk4/6 Suppression On Patient-Derived Models Of Pancreatic Cancer., Agnieszka K Witkiewicz, Nicholas A Borja, Jorge Franco, Jonathan Brody, Md, Charles Yeo, John Mansour, Michael A Choti, Peter Mccue, Erik S Knudsen Jun 2015

Selective Impact Of Cdk4/6 Suppression On Patient-Derived Models Of Pancreatic Cancer., Agnieszka K Witkiewicz, Nicholas A Borja, Jorge Franco, Jonathan Brody, Md, Charles Yeo, John Mansour, Michael A Choti, Peter Mccue, Erik S Knudsen

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Pancreatic ductal adenocarcinoma (PDA) harbors an exceedingly poor prognosis, and is generally considered a therapy-recalcitrant disease due to poor response to conventional chemotherapy coupled with non-actionable genetic drivers (e.g. KRAS mutations). However, PDA frequently loses p16ink4a, thereby leading to deregulation of CDK4/6. Surprisingly, in established cell models and xenografts, CDK4/6 inhibition has a modest effect on proliferation and resistance develops rapidly. To determine if such weak response was an intrinsic feature of PDA, we developed primary tumor explants that maintain the tumor environment and recapitulate feuture of primary PDA. The CDK4/6 inhibitor PD-0332991 was highly efficient at suppressing proliferation in …

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The Status Of Fishes In The Missouri River, Nebraska: Emerald Shiner (Notropis Atherinoides), Red Shiner (Cyprinella Lutrensis), River Shiner (N. Blennius), Sand Shiner N. Stramineus), Spotfin Shiner (C. Spiloptera), Thad W. Huenemann, Kirk D. Steffensen, Gerald Mestl, Dane A. Shuman, Sam Stukel Jun 2015

The Status Of Fishes In The Missouri River, Nebraska: Emerald Shiner (Notropis Atherinoides), Red Shiner (Cyprinella Lutrensis), River Shiner (N. Blennius), Sand Shiner N. Stramineus), Spotfin Shiner (C. Spiloptera), Thad W. Huenemann, Kirk D. Steffensen, Gerald Mestl, Dane A. Shuman, Sam Stukel

Transactions of the Nebraska Academy of Sciences and Affiliated Societies

Despite major anthropogenic modification to the Missouri River system, relative abundance of five shiner species within Nebraska’s reach of the Missouri River has increased since the 1940’s. The combined abundance of five species: Red Shiner Cyprinella lutrensis, Spotfin Shiner C. spilopterus, Emerald Shiner Notropis atherinoides, River Shiner N. blennius, Sand Shiner N. stramineus, represented > 50% of the small fish community in the Missouri River over the past ten years (2003-2012). More than 3,600 mini-fyke nets were deployed, resulting in over 158,600 shiners collected from the Missouri River along Nebraska’s eastern border between 2003 and 2012. Past literature …

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Novel Cross Talk Between Igf-Ir And Ddr1 Regulates Igf-Ir Trafficking, Signaling And Biological Responses., Roberta Malaguarnera, Maria Luisa Nicolosi, Antonella Sacco, Alaide Morcavallo, Veronica Vella, Concetta Voci, Michela Spatuzza, Shi-Qiong Xu, Renato V Iozzo, Riccardo Vigneri, Andrea Morrione, Antonino Belfiore Jun 2015

Novel Cross Talk Between Igf-Ir And Ddr1 Regulates Igf-Ir Trafficking, Signaling And Biological Responses., Roberta Malaguarnera, Maria Luisa Nicolosi, Antonella Sacco, Alaide Morcavallo, Veronica Vella, Concetta Voci, Michela Spatuzza, Shi-Qiong Xu, Renato V Iozzo, Riccardo Vigneri, Andrea Morrione, Antonino Belfiore

Kimmel Cancer Center Faculty Papers

The insulin-like growth factor-I receptor (IGF-IR), plays a key role in regulating mammalian development and growth, and is frequently deregulated in cancer contributing to tumor initiation and progression. Discoidin domain receptor 1 (DDR1), a collagen receptor tyrosine-kinase, is as well frequently overexpressed in cancer and implicated in cancer progression. Thus, we investigated whether a functional cross-talk between the IGF-IR and DDR1 exists and plays any role in cancer progression.Using human breast cancer cells we found that DDR1 constitutively associated with the IGF-IR. However, this interaction was enhanced by IGF-I stimulation, which promoted rapid DDR1 tyrosine-phosphorylation and co-internalization with the IGF-IR. …

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Tooth Retrospective Dosimetry Using Electron Paramagnetic Resonance: Influence Of Irradiated Dental Composites, Céline M. Desmet, Andrej Djurkin, Ana Maria Dos Santos-Goncalvez, Ruhong Dong, Maciej M. Kmiec, Kyo Kobayashi, Kevin Rychert, Sébastien Beun, Julian G. Leprince, Gaëtane Leloup, Philippe Levêque, Bernard Gallez Jun 2015

Tooth Retrospective Dosimetry Using Electron Paramagnetic Resonance: Influence Of Irradiated Dental Composites, Céline M. Desmet, Andrej Djurkin, Ana Maria Dos Santos-Goncalvez, Ruhong Dong, Maciej M. Kmiec, Kyo Kobayashi, Kevin Rychert, Sébastien Beun, Julian G. Leprince, Gaëtane Leloup, Philippe Levêque, Bernard Gallez

Dartmouth Scholarship

In the aftermath of a major radiological accident, the medical management of overexposed individuals will rely on the determination of the dose of ionizing radiations absorbed by the victims. Because people in the general population do not possess conventional dosimeters, after the fact dose reconstruction methods are needed. Free radicals are induced by radiations in the tooth enamel of victims, in direct proportion to dose, and can be quantified using Electron Paramagnetic Resonance (EPR) spectrometry, a technique that was demonstrated to be very appropriate for mass triage. The presence of dimethacrylate based restorations on teeth can interfere with the dosimetric …

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Marine Governance In The English Channel (La Manche): Linking Science And Management., G. Glegg, R. Jefferson, S. Fletcher Jun 2015

Marine Governance In The English Channel (La Manche): Linking Science And Management., G. Glegg, R. Jefferson, S. Fletcher

School of Biological and Marine Sciences

The English Channel is one of the world's busiest sea areas with intense shipping and port activity juxtaposed with recreation, communications and important conservation areas. Opportunities for marine renewable energy vie with existing activities for space. The current governance of the English Channel is reviewed and found to lack integration between countries, sectors, legislation and scientific research. Recent developments within the EU's marine management frameworks are significantly altering our approach to marine governance and this paper explores the implications of these new approaches to management of the English Channel. Existing mechanisms for cross-Channel science and potential benefits of an English …

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Nutrient Addition Effects On Tropical Dry Forests: A Mini-Review From Microbial To Ecosystem Scales., J S. Powers, K K. Becklund, M G. Gei, S B. Iyengar, R Meyer, C S. O'Connell, E M. Schilling, C M. Smith, Bonnie G. Waring, L K. Werden Jun 2015

Nutrient Addition Effects On Tropical Dry Forests: A Mini-Review From Microbial To Ecosystem Scales., J S. Powers, K K. Becklund, M G. Gei, S B. Iyengar, R Meyer, C S. O'Connell, E M. Schilling, C M. Smith, Bonnie G. Waring, L K. Werden

Biology Faculty Publications

Humans have more than doubled inputs of reactive nitrogen globally and greatly accelerated the biogeochemical cycles of phosphorus and metals. However, the impacts of increased element mobility on tropical ecosystems remain poorly quantified, particularly for the vast tropical dry forest biome. Tropical dry forests are characterized by marked seasonality, relatively little precipitation, and high heterogeneity in plant functional diversity and soil chemistry. For these reasons, increased nutrient deposition may affect tropical dry forests differently than wet tropical or temperate forests. Here, we review studies that investigated how nutrient availability affects ecosystem and community processes from the microsite to ecosystem scales …

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Educating Illinois Progress Report, Fiscal Year 2015, Illinois State University Jun 2015

Educating Illinois Progress Report, Fiscal Year 2015, Illinois State University

Educating Illinois (2000-2018)

Illinois State University’s mission, vision, values, goals, and strategies presented in Educating Illinois have provided a road map for the University that has led to its current level of distinction. This report reflects how the University community embodies the strategic plan as highlighted through the programs and activities initiated and the recognitions received during the second full year of implementation of Educating Illinois 2013-2018: Individualized Attention, Shared Aspirations.

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The Status Of Philippine Lake Studies: Scholarly Deficit In Social Science And Small-Lake Research, Bing Baltazar C. Brillo Jun 2015

The Status Of Philippine Lake Studies: Scholarly Deficit In Social Science And Small-Lake Research, Bing Baltazar C. Brillo

Asia-Pacific Social Science Review

This study surveys the literature on Philippine lake studies using a representative sample from the library databases of the three leading universities in the country. The paper proceeds as follows: firstly, it categorizes the existing lake studies by scholarly orientation (natural science perspective or social science perspective) and by physical size of the particular lake under study (big lake or small lake); secondly, it charts and assesses the overall trajectory of lake studies in the country. The paper concludes that Philippine lake studies are dominated by the natural science-based studies and heavily concentrated on big-lake research. This finding illustrates the …

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Perceptions Of Preservice Teachers’ E-Portfolios For Hiring Decisions, Molly Zhou, Marilyn M. Helms Jun 2015

Perceptions Of Preservice Teachers’ E-Portfolios For Hiring Decisions, Molly Zhou, Marilyn M. Helms

Georgia Educational Researcher

Preservice teachers often build E-portfolios of their work prior to graduation, but their use beyond the college classroom is not clear. To identify if E-portfolios are used during the teacher hiring process, 170 administrators from 84 (K-12) schools in eight North Georgia districts were surveyed regarding their use of E-portfolio materials. Based on the mixed methods used, E-portfolios were not strongly favored for use in decision-making. To increase their usefulness, preservice teachers should actively provide access to artifacts valued by potential employers including certification documents, classroom management plans, evidence of work with Individualized Educational Plan (IEP) students, ability to work …

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Exploring Publication Productivity In The Philippines: A 10-Year Gendered Analysis Of Six Academic Disciplines, Charisse N. Reyes, Joseph Anthony L. Reyes Jun 2015

Exploring Publication Productivity In The Philippines: A 10-Year Gendered Analysis Of Six Academic Disciplines, Charisse N. Reyes, Joseph Anthony L. Reyes

Asia-Pacific Social Science Review

This article presents a gendered analysis exploring publication productivity in the Philippines using bibliometric data from the Web of Science. It investigates the temporal pattern of journal article publications for six disciplines, its gendered distribution, differences between disciplines, patterns of authorship and collaboration, and how much women authors contribute and participate in research collaboration. Statistical analyses revealed that although overall publication productivity increased in number from 2003 to 2012, the percentage of female contribution and participation remained almost unchanged. Significant differences were also found among disciplines using logistic regression. Implications of the results in relation to the contemporary environment of …

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A Multivariate Analysis Of Suicide Ideation Among University Students In The Philippines, Madelene A. Sta. Maria, Romeo B. Lee, Susana Estanislao, Cristina Rodriguez, Jianli Wang, Yan Liu Jun 2015

A Multivariate Analysis Of Suicide Ideation Among University Students In The Philippines, Madelene A. Sta. Maria, Romeo B. Lee, Susana Estanislao, Cristina Rodriguez, Jianli Wang, Yan Liu

Asia-Pacific Social Science Review

Suicide ideation is a robust predictor of suicide completion. Research into the extent of and the factors related to suicide ideation is thus important. Findings can help inform the development of prevention programs. Despite the increasing suicide cases among the youth in the Philippines, substantive local studies on suicide ideation are sparse. This survey determined the prevalence and associated factors of suicide ideation among university students in Manila, Philippines. A questionnaire containing items on suicide ideation and risk factors was administered among 2,450 students enrolled at a private university. As the criterion variable, suicide ideation, which was originally measured using …

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Two New Species Of Madicolous Water Beetle From South Africa (Coleoptera: Hydraenidae), David T. Bilton Jun 2015

Two New Species Of Madicolous Water Beetle From South Africa (Coleoptera: Hydraenidae), David T. Bilton

School of Biological and Marine Sciences

Coelometopon glenavoni sp. n. and Oomtelecopon disjunctum sp. n., two madicolous hydraenid beetles are described from the Eastern and Western Cape provinces of South Africa respectively. Diagnostic notes are provided for both species, together with a discussion of the ecology and biogeography of the two genera.

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Southern Free Women Of Color In The Antebellum North: Race, Class, And A "New Women's Legal History", Bernie D. Jones Jun 2015

Southern Free Women Of Color In The Antebellum North: Race, Class, And A "New Women's Legal History", Bernie D. Jones

Akron Law Review

This article develops Welke’s theme and proposes that in the field of legal history, the analyses can not be limited to “race, gender, or class,” but that matrices of race, gender, and class must be considered at their intersections, “race, and gender, and class,” where they might shed light on the significance of shifting legal modalities. It explores how race, gender, and class as legal policy in the 19th century could be crucial for the formation of family and marital relationships in the private sphere. The focus here is upon free women of color living in the antebellum North who …

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Copulemus In Pace: A Meditation On Rape, Affirmative Consent To Sex, And Sexual Autonomy, Dan Subotnik Jun 2015

Copulemus In Pace: A Meditation On Rape, Affirmative Consent To Sex, And Sexual Autonomy, Dan Subotnik

Akron Law Review

Social change, to be sure, is not necessarily bad. But what if affirmative consent is not biologically or psychologically sound and, for that reason, women do not even desire it? Questioning the idea that increasing women’s power will be desirable even if not founded on the “the truth,” I ask: Can and should women — to say nothing of men — say “no” to affirmative consent? I examine this question in two parts. Part I evaluates the sexual environment today from which affirmative consent has arisen. Part II deals specifically with affirmative consent.

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Wilson V. Wilson: The Effect Of Qdros On Appealing Divorce Decrees, Joshua A. Dean Jun 2015

Wilson V. Wilson: The Effect Of Qdros On Appealing Divorce Decrees, Joshua A. Dean

Akron Law Review

In most divorces today, the largest asset held by the divorcing couple is a retirement fund belonging to one of the spouses. Courts invery state must decide how to divide a married couple’s property in order to provide each spouse his or her proper share. But when there are no assets large enough to offset the value of the retirement pension, divorce courts must find a way to “equitably distribute” the proceeds of the plan. Dealing with this large asset presented problems in the past as Congress sought to limit the ability to assign proceeds of retirement plans to anyone …

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Neuroscience And Health Law: An Integrative Approach, Stacey A. Tovino J.D., Ph.D. Jun 2015

Neuroscience And Health Law: An Integrative Approach, Stacey A. Tovino J.D., Ph.D.

Akron Law Review

Neuroscience is one of the fastest growing scientific fields in terms of the numbers of scientists and the knowledge being gained. In recent years, both the scope of neuroscience and the methodologies employed by neuroscientists have broadly expanded, from biochemical and genetic analysis of individual nerve cells and their molecular constituents, to the imaging of brain structure and function. Perhaps the most significant recent neuroscientific achievement is the ability of neuroimaging technologies, including functional magnetic resonance imaging (fMRI), to image brain function. Clinicians and scientists use fMRI not only to map sensory, motor, and cognitive function, but also to study …

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Remarks: Neuroscience, Gender, And The Law, Stacey A. Tovino Jd, Phd Jun 2015

Remarks: Neuroscience, Gender, And The Law, Stacey A. Tovino Jd, Phd

Akron Law Review

n my recent research, I have been exploring the legal impact of advances in the neuroscience of gender, such as whether and how stakeholders are using recent studies finding structural and functional differences between male and female brains in an attempt to influence the law. I also have been examining whether and how stakeholders are using the neuroscience of both gender-specific and gender-prevalent health conditions to influence the interpretation of civil and regulatory health law. Today, I am going to explore how stakeholders are using advances in the neuroscience of three gender-specific and genderprevalent conditions (the postpartum mood disorders, premenstrual …

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Asperger's Disorder, High-Functioning Autism, And Guardianship In Ohio, Michael E. Bloom Jun 2015

Asperger's Disorder, High-Functioning Autism, And Guardianship In Ohio, Michael E. Bloom

Akron Law Review

Early in the 1940s, two men, worlds apart and unaware of each other’s work, used the term “autism” to describe children that had remarkably similar characteristics, namely core impairments in socialization, communication, and imagination. In the United States in 1943, Leo Kanner published an account of “early infantile autism,” describing children with impaired social interaction, impaired communication, and stereotyped behaviors and interests.Kanner’s children seemed to relate better to objects than people. In Austria in 1944, Hans Asperger used the term “autistic psychopathy” to describe children with impaired social interaction, behavioral oddities, and poor coordination. Asperger’s children, who displayed no delay …

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Neuroscience And Juvenile Justice, Jay D. Aronson Jun 2015

Neuroscience And Juvenile Justice, Jay D. Aronson

Akron Law Review

Recent advances in the field of neuroscience, especially improved magnetic resonance imaging (MRI) techniques, are providing scientists and decision-makers with an increasingly complex understanding of how our brains develop from birth to adulthood. While these studies are still in their infancy, they have already made it clear that the brain typically continues to develop long after the point at which an individual becomes a legal adult (i.e., at age 18), and that the slow maturation process that plays out in the social context is mirrored by a slow maturation process at the neural level. Despite the tentative nature and unsettled …

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"His Brain Has Been Mismanaged With Great Skill": How Will Jurors Respond To Neuromimaging Testimony In Insanity Defense Cases?, Michael L. Perlin Jun 2015

"His Brain Has Been Mismanaged With Great Skill": How Will Jurors Respond To Neuromimaging Testimony In Insanity Defense Cases?, Michael L. Perlin

Akron Law Review

A review of the literature on neuroimaging, predictably, reveals a broad array of positions, promises and prophecies. Carter Snead argues that the ambition of cognitive neuroscientists is “to use the claims of their discipline and the new powers conferred by neuroimaging to overthrow retributive justice as a legitimate justification for criminal sanctions.” In this paper, I do not take sides on this debate. Rather, I discuss a related, but distinctly separate issue: which of these positions will jurors think is right, especially in the context of deciding insanity defense cases. The primary and robust debate that has taken place so …

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The Right To Silence As Protecting Mental Control, Dov Fox Jun 2015

The Right To Silence As Protecting Mental Control, Dov Fox

Akron Law Review

This Article examines the idea that individuals have a moral and constitutional right of control over the use of their thoughts vis-à-vis the state. As a point of departure, I consider the prospect of a forensic neuroimaging device that was capable of eliciting recall and recognition from a criminal suspect without the suspect’s having even to answer an interrogator’s question. Reflection on government access to this sort of interrogation technique suggests that the state should be prohibited from either extracting a person’s thoughts without her consent or making use of her compelled thoughts to lay criminal blame upon her. Though …

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Law And The Revolution In Neuroscience: An Early Look At The Field, Henry T. Greely Jun 2015

Law And The Revolution In Neuroscience: An Early Look At The Field, Henry T. Greely

Akron Law Review

Several of the articles in this symposium consider different aspects of the intersection of neuroscience and testing for deception. Professor Joelle Moreno’s article provides an important philosophic link for those thinking about the role of the academy in evaluating novel scientific evidence such as neuroscience. Noting that “profound validity questions divide cognitive neuroscientists,” Professor Moreno cautions against ready admission of cognitive neuroscience evidence, recognizing that the images presented may be far more persuasive to judges and juries than they legitimately should be. Quoting studies on the effect of neuroscience evidence in forming opinions, she reminds readers that cognitive neuroscience evidence …

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Waiting For Good Dough: Litigation Funding Comes To Law, Stephen Gillers Jun 2015

Waiting For Good Dough: Litigation Funding Comes To Law, Stephen Gillers

Akron Law Review

In this Article, I want to examine Rancman. The court’s treatment of one issue it raised—the question of champerty —is myopic, hostile, and superficial. The resolution of this issue on the facts before the court promotes injustice. The court introduced the issue into the case without the benefit of briefing. The Ohio legislature has since overruled Rancman. There is reason to believe that the Ohio Supreme Court will defer to the legislation, although we cannot know for certain until it addresses the question, as discussed.

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Functional Characterization Of Fmr4, A Trans- Acting Long Non-Coding Rna Associated With The Fragile X Locus, Veronica J. Peschansky Jun 2015

Functional Characterization Of Fmr4, A Trans- Acting Long Non-Coding Rna Associated With The Fragile X Locus, Veronica J. Peschansky

Open Access Dissertations

CGG repeat expansions in the Fragile X mental retardation 1 (FMR1) gene are responsible for a family of associated disorders characterized by either intellectual disability and autism (Fragile X Syndrome, FXS), or adult-onset neurodegeneration (Fragile X-associated Tremor/Ataxia Syndrome, FXTAS). However, the FMR1 locus is complex and encodes several long noncoding RNAs (lncRNAs), whose expression is altered by repeat expansion mutations. The role of these lncRNAs is thus far unknown; therefore we investigated the functionality of FMR4, which we previously identified. “Full”-length expansions of the FMR1 triplet repeat cause silencing of both FMR1 and FMR4, thus we are interested in potential …

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Local And Regional Determinants Of An Uncommon Functional Group In Freshwater Lakes And Ponds, Michael James Mccann Jun 2015

Local And Regional Determinants Of An Uncommon Functional Group In Freshwater Lakes And Ponds, Michael James Mccann

Ecology & Evolution Faculty Publications

A combination of local and regional factors and stochastic forces is expected to determine the occurrence of species and the structure of communities. However, in most cases, our understanding is incomplete, with large amounts of unexplained variation. Using functional groups rather than individual species may help explain the relationship between community composition and conditions. In this study, I used survey data from freshwater lakes and ponds to understand factors that determine the presence of the floating plant functional group in the northeast United States. Of the 176 water bodies surveyed, 104 (59.1%) did not contain any floating plant species. The …

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Gsu View, 2015-06-29, Office Of Marketing And Communications Jun 2015

Gsu View, 2015-06-29, Office Of Marketing And Communications

GSU View

Newsletter published by Governors State University 2007-current.

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Summer Internship Week 1 At Old Woman Creek National Estuarine Reserve, Ohio University College Of Arts & Sciences Jun 2015

Summer Internship Week 1 At Old Woman Creek National Estuarine Reserve, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

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Taranis Functions With Cyclin A And Cdk1 In A Novel Arousal Center To Control Sleep In Drosophila., Dinis J.S. Afonso, Die Liu, Daniel R. Machado, Huihui Pan, James E.C. Jepson, Dragana Rogulja, Kyunghee Koh Jun 2015

Taranis Functions With Cyclin A And Cdk1 In A Novel Arousal Center To Control Sleep In Drosophila., Dinis J.S. Afonso, Die Liu, Daniel R. Machado, Huihui Pan, James E.C. Jepson, Dragana Rogulja, Kyunghee Koh

Department of Neuroscience Faculty Papers

Sleep is an essential and conserved behavior whose regulation at the molecular and anatomical level remains to be elucidated. Here, we identify TARANIS (TARA), a Drosophila homolog of the Trip-Br (SERTAD) family of transcriptional coregulators, as a molecule that is required for normal sleep patterns. Through a forward-genetic screen, we isolated tara as a novel sleep gene associated with a marked reduction in sleep amount. Targeted knockdown of tara suggests that it functions in cholinergic neurons to promote sleep. tara encodes a conserved cell-cycle protein that contains a Cyclin A (CycA)-binding homology domain. TARA regulates CycA protein levels and genetically …

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Potential Drug Lessens Neurodegeneration In Parkinson's Disease Mode, Jeff Hansen Jun 2015

Potential Drug Lessens Neurodegeneration In Parkinson's Disease Mode, Jeff Hansen

Browse All News

No abstract provided.

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A Phenomenological Multi-Case Study About Social Success Skills, Aspirations, And Related Media Experiences, Darnel Degand Jun 2015

A Phenomenological Multi-Case Study About Social Success Skills, Aspirations, And Related Media Experiences, Darnel Degand

The Qualitative Report

The social success skills valued and ultimately acquired by youth during their formative years can be better understood by examining the social spaces, processes, and interactions that are related to their personal aspirations and related media experiences. Using a phenomenological approach, I conducted a year-long multi-case study about two Black male high school students’ thoughts on social success, their aspirations, their social experiences, and their experiences with media. The participants were selected using purposeful sampling. I collected data through semi-structured interviews, focus groups, and observations. I performed analyses by using the hermeneutic cycle which requires one to repeatedly read text, …

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