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Species Identification And Habitat Assessment Of The South Texas Siren, Taylor C. Lafortune Jul 2015

Species Identification And Habitat Assessment Of The South Texas Siren, Taylor C. Lafortune

Theses and Dissertations - UTB/UTPA

At least one species of siren is endemic to the Rio Grande Valley of Texas, yet very little is known about the populations of the region. Texas Parks and Wildlife refers to the populations of Siren spp. in South Texas as the “South Texas siren (large form Siren sp. 1),” and recognizes these populations as a threatened species, yet their current population status remains unclear. The species identification of the South Texas siren has been hampered by similarity in morphology across species, and by the lack of complete siren genetic sequences in the NCBI GenBank database. In addition to species …


Alumni Matter, Summer 2015, Women's, Gender, And Sexuality Studies Program Jul 2015

Alumni Matter, Summer 2015, Women's, Gender, And Sexuality Studies Program

Alumni Matter (2009-2022)

A bulletin of Illinois State University’s Women’s, Gender, and Sexuality Studies program, Summer 2015.


Economic Literacy: Measuring The Economic Human Capital Of Arkansas K-12 Teachers, June Marie Freund Jul 2015

Economic Literacy: Measuring The Economic Human Capital Of Arkansas K-12 Teachers, June Marie Freund

Graduate Theses and Dissertations

Economic literacy is recognized as a deficit quality in the United States, no more prevalent than during the last great recession. It is paramount the K-12 educational system lead the movement to educate the public on economic content and issues, as it is the one institution that has direct contact with all citizens. The question then must be asked, how economic literate are teachers entrusted with the responsibility of imparting economic knowledge to his/her K-12 grade level student. A sample of Arkansas teachers at each grade level K – 12 were tested using national normed economic literacy tests designed to …


Association Mapping For Elemental Concentration Resulting From Vegetative Stage Soil Waterlogging Stress In Wheat (Triticum Aestivum L.), Maria Nelly Arguello-Blanco Jul 2015

Association Mapping For Elemental Concentration Resulting From Vegetative Stage Soil Waterlogging Stress In Wheat (Triticum Aestivum L.), Maria Nelly Arguello-Blanco

Graduate Theses and Dissertations

Soil waterlogging (WL) affects wheat production worldwide, including the southern of the U.S. Little is known about the genetics of tolerance mechanisms to WL, particularly of potentially toxic elements such as aluminum, iron and sodium. The objectives of this study were to use association mapping (AM) to identify SNP associated with the EC in the vegetative tissue of a set of 240 diverse soft winter wheat genotypes (AM panel) grown under field WL and to determine the impact of WL on wheat yield (GY) and yield components in a set 28 adapted cultivars (YT)

YT study showed reductions in GY …


Phenology And Diversity Of Arthropod Communities In Leaf Litter, Fredericka Hamilton Jul 2015

Phenology And Diversity Of Arthropod Communities In Leaf Litter, Fredericka Hamilton

Graduate Theses and Dissertations

Temperate deciduous forests produce a layer of leaf litter on the forest floor annually. This layer is dynamic, and both the composition and depth change throughout the year. The leaf litter layer is an important habitat to many arthropods since they utilize it for food, shelter from adverse environmental conditions, and protection from predators.

Two commonly encountered and diverse taxa found in the litter layer are the ground beetles (Coleoptera: Carabidae) and the ground spiders (Araneae: Gnaphosidae). Carabidae and Gnaphosidae were collected and identified on a monthly basis from April 2014 to March 2015 from the Ozark Mountains of Arkansas …


Asymmetric Synthesis And Transition Metal-Catalyzed Cross-Coupling Arylations Of Selected Organolithiums, Barry Kyle Sharp Jul 2015

Asymmetric Synthesis And Transition Metal-Catalyzed Cross-Coupling Arylations Of Selected Organolithiums, Barry Kyle Sharp

Graduate Theses and Dissertations

My former boss, Dr. Gawley, always loved to say, “The world is chiral” (à la Pasteur). From DNA and proteins to hands and feet, it is obviously true. Also, a wide variety of chemical products exist as single enantiomers. Advances in chemical technology have greatly accelerated asymmetric synthesis in the past quarter century, and namely, organolithiums, have been shown to provide a versatile route to chiral natural products and biologically active molecules. Versatility arises from the array of methods that produce a chiral organolithium. Dynamic thermodynamic resolution (DTR) is considered one of the most practical methods, but among the others …


Effect Of Feeding Regimen And Age On Lipid Metabolism In Broiler Breeder Hens And Progeny, Nirun Boonsinchai Jul 2015

Effect Of Feeding Regimen And Age On Lipid Metabolism In Broiler Breeder Hens And Progeny, Nirun Boonsinchai

Graduate Theses and Dissertations

Age of hens and feed allocation can affect egg yolk lipid compositions which in turn directly relate to chick quality. A series of experiments were conducted to determine the effects of age and feeding programs on lipid metabolism in breeder hens and progeny. In the first trial, the rate of yolk absorption and fatty acid profiles in the yolk were compared among 28, 35, and 49wk old hens. The results revealed that the rate of yolk absorption was higher, but the absolute amount of fatty acids absorbed was lower in young hens than in the old hens. The second trial …


Reducing Nutrient Runoff From Poultry Production Facilities Using Locally-Sourced Iron And Aluminum Byproducts, Sheri Lynn Herron Jul 2015

Reducing Nutrient Runoff From Poultry Production Facilities Using Locally-Sourced Iron And Aluminum Byproducts, Sheri Lynn Herron

Graduate Theses and Dissertations

Phosphorus (P) inputs to fresh waters can accelerate the eutrophication process. Agricultural nutrient runoff has been shown to be a contributor of P and nitrogen (N). Broiler production areas were evaluated for their potential to contribute P and N to runoff. Broiler house dust (BHD) samples were analyzed and compared to broiler litter (BL), rainfall simulations were conducted on plots adjacent to broiler house fans to evaluate nutrient enrichment in runoff from deposited dust, and runoff was automatically sampled at two culverts draining the land around broiler houses. Following this, an on-farm byproduct containment and nutrient removal structure was designed …


Physiological Responses Of Cotton Genotypes To Water-Deficit Stress During Reproductive Development, Cristiane Pilon Jul 2015

Physiological Responses Of Cotton Genotypes To Water-Deficit Stress During Reproductive Development, Cristiane Pilon

Graduate Theses and Dissertations

Drought stress is one of the major abiotic factors affecting crop growth and limiting production worldwide. Cotton genotypes vary in drought tolerance, and the effects of drought stress on the anatomy and physiology of cotton leaves and roots have been reported. However, information on physiological and metabolic processes of leaves and flowers of modern cotton cultivars under water-deficit stress during reproductive development is not well elucidated. It was hypothesized that water-deficit stress during squaring and flowering stages would impair stomatal conductance and photosynthetic efficiency of leaves, which consequently would result in osmotic adjustment through accumulation of compatible solutes, increased activity …


Grass Finishing Systems For Lambs, Erin Leigh Smyth Jul 2015

Grass Finishing Systems For Lambs, Erin Leigh Smyth

Graduate Theses and Dissertations

There is strong interest in sustainably produced meat. Grass-fed lamb could fulfill this market by reducing off-farm inputs. The objective was to examine the effect of grass-finishing or minimal supplementation on performance of lambs in the southeastern US. Katahdin lambs born in October 2013 and 2014 and February 2014 were weaned in January 2014/2015 and May 2014, respectively. Lambs were blocked by gender (fall; winter included only ram lambs) and randomly assigned to receive no (NON) or grain co-product supplement (SUP; 15% CP) at 0.5% of BW/d. Lambs were rotationally grazed on predominantly grass. Body weight, fecal egg counts (FEC), …


Lidar And Machine Learning Estimation Of Hardwood Forest Biomass In Mountainous And Bottomland Environments, Bowei Xue Jul 2015

Lidar And Machine Learning Estimation Of Hardwood Forest Biomass In Mountainous And Bottomland Environments, Bowei Xue

Graduate Theses and Dissertations

Light detection and ranging (lidar) has been applied in various forest applications, such as to retrieve forest structural information, to build statistical models for identification of tree species, and to monitor forest growth. However, despite significant progress in these areas, the choice of regression approach and parameter tuning remains an ongoing critical question. This study focused on choosing the right spatial generalization level to transform lidar point clouds to 2D images which can be further processed by mature image processing and pattern recognition approaches. It also compared the prediction ability of popular machine learning algorithms applied to aboveground forest biomass …


The Spectacle Of Orphanhood: Reimagining Orphans In Postbellum Fiction, Afrin Zeenat Jul 2015

The Spectacle Of Orphanhood: Reimagining Orphans In Postbellum Fiction, Afrin Zeenat

Graduate Theses and Dissertations

Orphan iconography has always been deployed in American literature and culture, but nineteenth-century American literature, fiction in particular, abounds in orphans, both real and imaginary. The orphan’s amphibious nature is hailed and demonized as the epitome of individualism and unbridled freedom, and also as the location of society’s anxiety. This complicated and conflicted construction of orphans animates the Social and cultural realm in postbellum America, foregrounding issues of class, race, and gender.


Capillary Electrophoresis For Analysis Of Aβ1-42 Adsorption And Photo-Crosslinking, Jennifer Lynn Kurtz Jul 2015

Capillary Electrophoresis For Analysis Of Aβ1-42 Adsorption And Photo-Crosslinking, Jennifer Lynn Kurtz

Graduate Theses and Dissertations

The accumulation of amyloid-beta (Aβ) oligomers is believed to be the driving force behind Alzheimer’s disease (AD) pathogenesis. Due to the metastable nature of Aβ oligomers, the knowledge of Aβ aggregation and accumulation is not well understood. Here, we use capillary electrophoresis (CE) and photo-induced crosslinking of unmodified proteins (PICUP) to learn about the aggregation of Aβ.

First, we explore the effect of capillary coating on Aβ1-42 protein loss using CE. The dynamic coatings tested were PHEA and 50 kDa, 2000 kDa, 5000 kDa, and 8000 kDa PEO. The covalent coating tested was PVA. The results indicated that 2000 kDa …


Temperature In The Cotton (Gossypium Hirsutum L.) Canopy And Effects On Cotton Leaf And Boll Growth, Maria Soledad Berlangieri Costa Jul 2015

Temperature In The Cotton (Gossypium Hirsutum L.) Canopy And Effects On Cotton Leaf And Boll Growth, Maria Soledad Berlangieri Costa

Graduate Theses and Dissertations

Cotton development and yield are negatively influenced by extremes temperatures, mainly during reproductive stage. Ambient air temperature is used to evaluate temperature stress effect on yield under field conditions; however, there is evidence that actual temperatures in the canopy where bolls develop are different. In terms of cotton responses, there is limited research about the effects of elevated day and night temperatures upon boll carbohydrate content, size, and boll respiration. Field and growth chamber experiments were performed during 2014-2015 using the cotton (Gossypium hirsutum L.) cultivar DP0912B2RF. Field studies for determining temperature gradients through the canopy consisted of two planting …


The Ability Of Select Probiotics To Reduce Enteric Campylobacter Colonization In Broiler Chickens, Sandip Shrestha Jul 2015

The Ability Of Select Probiotics To Reduce Enteric Campylobacter Colonization In Broiler Chickens, Sandip Shrestha

Graduate Theses and Dissertations

Campylobacter is the leading cause of foodborne illness worldwide and is often associated with consumption and/or mishandling of contaminated poultry products. Probiotic use in poultry has been an effective strategy in reducing other enteric foodborne pathogens but not consistently for Campylobacter. As Campylobacter resides and utilizes intestinal mucin for growth, isolates selected on the basis of mucin utilization might be a strategy to screen for efficacious probiotic bacterium. In this study, bacterial isolates demonstrating increased growth rates in mucin, in vitro (trials 1 or 2), or isolates demonstrating a reduction of Campylobacter counts when co-incubated with mucin, in vitro (trials …


2015 July, Office Of Communications & Marketing, Morehead State University. Jul 2015

2015 July, Office Of Communications & Marketing, Morehead State University.

Morehead State Press Release Archive, 1961 to the Present

Press releases for July of 2015.


Perceived Discrimination And Markers Of Cardiovascular Risk Among Low-Income African American Youth, Bridget J. Goosby, Sarah Malone, Elizabeth A. Richardson, Jacob Cheadle, Deadric T. Williams Jul 2015

Perceived Discrimination And Markers Of Cardiovascular Risk Among Low-Income African American Youth, Bridget J. Goosby, Sarah Malone, Elizabeth A. Richardson, Jacob Cheadle, Deadric T. Williams

Department of Sociology: Faculty Publications

Objectives: Our study examines the relationship between perceived discrimination and levels of C-reactive protein and blood pressure in low-income youth ages 10215 years old.

Methods: Data were collected from 10 to 15 year old focal children and their mothers. Face-to-face interviews were implemented to collect data on stressors including experiences of everyday discrimination from youth. High sensitivity CRP in dried blood spot samples and diastolic and systolic blood pressure were also collected at the time of the interview.

Results: Perceived discrimination among youth was significantly associated with higher levels of CRP, systolic, and diastolic blood pressure. CRP, systolic, and diastolic …


Inhibition Of Cell Differentiation In Bacillus Subtilis By Pseudomonas Protegens, Matthew J. Powers, Edgardo Sanabria-Valentín, Albert A. Bowers, Elizabeth A. Shanka Jul 2015

Inhibition Of Cell Differentiation In Bacillus Subtilis By Pseudomonas Protegens, Matthew J. Powers, Edgardo Sanabria-Valentín, Albert A. Bowers, Elizabeth A. Shanka

Publications and Research

Interspecies interactions have been described for numerous bacterial systems, leading to the identification of chemical compounds that impact bacterial physiology and differentiation for processes such as biofilm formation. Here, we identified soil microbes that inhibit biofilm formation and sporulation in the common soil bacterium Bacillus subtilis. We did so by creating a reporter strain that fluoresces when the transcription of a biofilm-specific gene is repressed. Using this reporter in a coculture screen, we identified Pseudomonas putida and Pseudomonas protegens as bacteria that secrete compounds that inhibit biofilm gene expression in B. subtilis. The active compound produced by P. protegens was …


Science And Charity: Rival Catholic Visions For Humanitarian Practice At The End Of French Rule In Cameroon, Charlotte Walker-Said Jul 2015

Science And Charity: Rival Catholic Visions For Humanitarian Practice At The End Of French Rule In Cameroon, Charlotte Walker-Said

Publications and Research

This paper explores the conflict between local expressions of Christian charity and new theories of scientific humanitarianism in the final years of French rule in Africa. Compassionate phenomena inspired by Catholic social organizing had transformed everyday life throughout French Cameroon’s cities and villages in the interwar and postwar years, and yet, in 1950, poverty, crime, poor public health, and social tensions remained prevalent. Seeking a more deeply transformative approach to social rehabilitation, ecclesiastical leaders in the Catholic Church in Europe and French foreign missionary societies in Africa partnered with international medical and scientific organizations in order to invigorate charity with …


Iron-Mediated Stabilization Of Soil Carbon Amplifies The Benefits Of Ecological Restoration In Degraded Lands, Lucas C. R. Silva, Timothy A. Doane, Rodrigo S. Correa, Vinicius Valverde, Engil Isadora Pujol Pereira, William R. Horwath Jul 2015

Iron-Mediated Stabilization Of Soil Carbon Amplifies The Benefits Of Ecological Restoration In Degraded Lands, Lucas C. R. Silva, Timothy A. Doane, Rodrigo S. Correa, Vinicius Valverde, Engil Isadora Pujol Pereira, William R. Horwath

School of Earth, Environmental, & Marine Sciences Faculty Publications

Recent observations across a 14‐year restoration chronosequence have shown an unexpected accumulation of soil organic carbon in strip‐mined areas of central Brazil. This was attributed to the rapid plant colonization that followed the incorporation of biosolids into exposed regoliths, but the specific mechanisms involved in the stabilization of carbon inputs from the vegetation remained unclear. Using isotopic and elemental analyses, we tested the hypothesis that plant‐derived carbon accumulation was triggered by the formation of iron‐coordinated complexes, stabilized into physically protected (occluded) soil fractions. Confirming this hypothesis, we identified a fast formation of microaggregates shortly after the application of iron‐rich biosolids, …


Striatal Activity And Reduced White Matter Increase Frontal Activity In Youths With Family Histories Of Alcohol And Other Substance-Use Disorders Performing A Go/No-Go Task, Ashley Acheson, Malle A. Tagamets, Anderson M. Winkler, Laura M. Rowland, Charles W. Mathias, Susan N. Wright, L. Elliot Hong, Peter Kochunov, Donald M. Dougherty Jul 2015

Striatal Activity And Reduced White Matter Increase Frontal Activity In Youths With Family Histories Of Alcohol And Other Substance-Use Disorders Performing A Go/No-Go Task, Ashley Acheson, Malle A. Tagamets, Anderson M. Winkler, Laura M. Rowland, Charles W. Mathias, Susan N. Wright, L. Elliot Hong, Peter Kochunov, Donald M. Dougherty

School of Medicine Publications

Introduction: Youths with a family history of alcohol and other drug use disorders (FH+) are at greater risk of developing substance-use disorders relative to those with no such family histories (FH-). We previously reported that FH+ youths have elevated activity in the supplementary motor area (SMA) and dorsal striatum while performing go/no-go tasks and have reduced frontal white matter integrity. A better understanding of relationships between these variables would provide insight into how frontostriatal circuitry is altered in FH+ youths, which may be an important contributor to their elevated risk.

Methods: In this study, we used structural equation modeling (SEM) …


Stemchecker: A Web-Based Tool To Discover And Explore Stemness Signatures In Gene Sets, José P. Pinto, Ravi K. Kalathur, Daniel V. Oliveira, Tânia Barata, Rsr Machado, S Machado, Ivette Pacheco-Leyva, Isabel Duarte, Matthias E. Futschik Jul 2015

Stemchecker: A Web-Based Tool To Discover And Explore Stemness Signatures In Gene Sets, José P. Pinto, Ravi K. Kalathur, Daniel V. Oliveira, Tânia Barata, Rsr Machado, S Machado, Ivette Pacheco-Leyva, Isabel Duarte, Matthias E. Futschik

School of Biomedical Sciences

No abstract provided.


Bioresponsive Antisense Dna Gold Nanobeacons As A Hybrid In Vivo Theranostics Platform For The Inhibition Of Cancer Cells And Metastasis, Chenchen Bao, Joao Conde, James Curtin, Daxiang Cui, Furong Tian, Natalie Artzi Jul 2015

Bioresponsive Antisense Dna Gold Nanobeacons As A Hybrid In Vivo Theranostics Platform For The Inhibition Of Cancer Cells And Metastasis, Chenchen Bao, Joao Conde, James Curtin, Daxiang Cui, Furong Tian, Natalie Artzi

Articles

Gold nanobeacons can be used as a powerful tool for cancer theranostics. Here, we proposed a nanomaterial platform based on gold nanobeacons to detect, target and inhibit the expression of a mutant Kras gene in an in vivo murine gastric cancer model. The conjugation of fluorescently-labeled antisense DNA hairpin oligonucleotides to the surface of gold nanoparticles enables using their localized surface plasmon resonance properties to directly track the delivery to the primary gastric tumor and to lung metastatic sites. The fluorescently labeled nanobeacons reports on the interaction with the target as the fluorescent Cy3 signal is quenched by the gold …


Active Semi-Supervised Approach For Checking App Behavior Against Its Description, Ma Siqi, Shaowei Wang, David Lo, Deng, Robert H., Cong Sun Jul 2015

Active Semi-Supervised Approach For Checking App Behavior Against Its Description, Ma Siqi, Shaowei Wang, David Lo, Deng, Robert H., Cong Sun

Research Collection School Of Computing and Information Systems

Mobile applications are popular in recent years. They are often allowed to access and modify users' sensitive data. However, many mobile applications are malwares that inappropriately use these sensitive data. To detect these malwares, Gorla et al. Propose CHABADA which compares app behaviors against its descriptions. Data about known malwares are not used in their work, which limits its effectiveness. In this work, we extend the work by Gorla et al. By proposing an active and semi-supervised approach for detecting malwares. Different from CHABADA, our approach will make use of both known benign and malicious apps to predict other malicious …


Modification Of Traffic-Related Respiratory Response By Asthma Control In A Population Of Car Commuters, Maria C. Mirabelli, Rachel Golan, Roby Greenwald, Amit U. Raysoni, Fernando Holguin, Priya Kewada, Andrea Winquist, W Dana Flanders, Jeremy A. Sarnat Jul 2015

Modification Of Traffic-Related Respiratory Response By Asthma Control In A Population Of Car Commuters, Maria C. Mirabelli, Rachel Golan, Roby Greenwald, Amit U. Raysoni, Fernando Holguin, Priya Kewada, Andrea Winquist, W Dana Flanders, Jeremy A. Sarnat

School of Earth, Environmental, & Marine Sciences Faculty Publications

Background: Effects of traffic-related exposures on respiratory health are well documented, but little information is available about whether asthma control influences individual susceptibility. We analyzed data from the Atlanta Commuter Exposure study to evaluate modification of associations between rush-hour commuting, in- vehicle air pollution, and selected respiratory health outcomes by asthma control status.

Methods: Between 2009 and 2011, 39 adults participated in Atlanta Commuter Exposure, and each conducted two scripted rush-hour highway commutes. In-vehicle particulate components were measured during all commutes. Among adults with asthma, we evaluated asthma control by questionnaire and spirometry. Exhaled nitric oxide, forced expiratory volume in …


Moving Ahead And Looking Back, Tia Patsavas '16 Jul 2015

Moving Ahead And Looking Back, Tia Patsavas '16

Illinois Wesleyan University Magazine, 2002-2017

This spring, we polled several graduating seniors about their IWU experience, from post-college plans to best memories and biggest sources of inspiration. Their answers, excerpted for this article, provide telling glimpses of these students’ college journeys, just as the next chapter of their lives was about to begin.


Vocal Classification Of Vocalizations Of A Pair Of Asian Small-Clawed Otters To Determine Stress, Peter M. Scheifele, Michael T. Johnson, Michelle Fry, Benjamin Hamel, Kathryn Laclede Jul 2015

Vocal Classification Of Vocalizations Of A Pair Of Asian Small-Clawed Otters To Determine Stress, Peter M. Scheifele, Michael T. Johnson, Michelle Fry, Benjamin Hamel, Kathryn Laclede

Electrical and Computer Engineering Faculty Research and Publications

Asian Small-Clawed Otters (Aonyx cinerea) are a small, protected but threatened species living in freshwater. They are gregarious and live in monogamous pairs for their lifetimes, communicating via scent and acoustic vocalizations. This study utilized a hidden Markov model (HMM) to classify stress versus non-stress calls from a sibling pair under professional care. Vocalizations were expertly annotated by keepers into seven contextual categories. Four of these—aggression, separation anxiety, pain, and prefeeding—were identified as stressful contexts, and three of them—feeding, training, and play—were identified as non-stressful contexts. The vocalizations were segmented, manually categorized into broad vocal type call types, and analyzed …


Ua64/2 The Challenge: Magazine For The Center For Gifted Studies (No. 37, Summer 2015), Center For Gifted Studies, Tracy Inman Editor Jul 2015

Ua64/2 The Challenge: Magazine For The Center For Gifted Studies (No. 37, Summer 2015), Center For Gifted Studies, Tracy Inman Editor

Gifted Studies Publications

No abstract provided.


In Silico Molecular Docking Analysis To Predict The Role Of Metal Ions In The Function Of Drug Targeted Proteins, S. M. A. Shahid, Qazi M. S. Jamal, J. M. Arif, Fahad M. Al-Khodairy, Anupam Dhasmana, Mohtashim Lohani Jul 2015

In Silico Molecular Docking Analysis To Predict The Role Of Metal Ions In The Function Of Drug Targeted Proteins, S. M. A. Shahid, Qazi M. S. Jamal, J. M. Arif, Fahad M. Al-Khodairy, Anupam Dhasmana, Mohtashim Lohani

School of Medicine Publications

Metal ions are required for many critical functions in living systems. Scarcity of some metal ions can lead to disease. A characteristic of metals is that they easily lose electrons from the familiar elemental or metallic state to form positively charged ions which tend to be soluble in biological fluids. Role of zinc, calcium and copper ions in the catalytic mechanism of drug targeted proteins such as Farnesyltransferase, Neuraminidase and Thioredoxin are analyzed using molecular docking, respectively. The docking results show that inhibitors have low Binding, docking and internal energies with proteins in the presence of Zn, Ca and Cu …


Gene Expression In Experimental Aortic Coarctation And Repair: Candidate Genes For Therapeutic Intervention?, John F. Ladisa Jr., Serdar Bozdag, Jessica Olson, Ramani Ramchandran, Judy R. Kersten, Thomas J. Eddinger Jul 2015

Gene Expression In Experimental Aortic Coarctation And Repair: Candidate Genes For Therapeutic Intervention?, John F. Ladisa Jr., Serdar Bozdag, Jessica Olson, Ramani Ramchandran, Judy R. Kersten, Thomas J. Eddinger

Biomedical Engineering Faculty Research and Publications

Coarctation of the aorta (CoA) is a constriction of the proximal descending thoracic aorta and is one of the most common congenital cardiovascular defects. Treatments for CoA improve life expectancy, but morbidity persists, particularly due to the development of chronic hypertension (HTN). Identifying the mechanisms of morbidity is difficult in humans due to confounding variables such as age at repair, follow-up duration, coarctation severity and concurrent anomalies. We previously developed an experimental model that replicates aortic pathology in humans with CoA without these confounding variables, and mimics correction at various times using dissolvable suture. Here we present the most comprehensive …