Digital Commons Network^™

A Patient-Specific Model Of The Biomechanics Of Hip Reduction For Neonatal Developmental Dysplasia Of The Hip: Investigation Of Strategies For Low To Severe Grades Of Developmental Dysplasia Of The Hip, Victor Huayamave, Christopher Rose, Sheila Serra, Brendan Jones, Eduardo Divo, Faissal Moslehy, Alain J. Kassab, Charles T. Price

Publications

A physics-based computational model of neonatal Developmental Dysplasia of the Hip (DDH) following treatment with the Pavlik Harness (PV) was developed to obtain muscle force contribution in order to elucidate biomechanical factors influencing the reduction of dislocated hips. Clinical observation suggests that reduction occurs in deep sleep involving passive muscle action. Consequently, a set of five (5) adductor muscles were identified as mediators of reduction using the PV. A Fung/Hill-type model was used to characterize muscle response. Four grades (1–4) of dislocation were considered, with one (1) being a low subluxation and four (4) a severe dislocation. A three-dimensional model …

Insight Into The Function Of X-Linked Lymphocyte Regulated 3 (Xlr3) And The Mechanism Regulating Its Imprinted Expression, Robert James Foley

Doctoral Dissertations

Insight into the Function of X-linked Lymphocyte Regulated 3 (XLR3) and the Mechanism Regulating its Imprinted Expression

Robert J. Foley

University of Connecticut

2015

Abstract

The Synaptonemal Complex Protein 3 (SYCP3), a key component of the synaptonemal complex in mammalian meiosis, has many closely related X-linked homologs on the X chromosome of which the functions are unclear. In rodentia, these genes comprise the Xlr superfamily of proteins and studies elucidating spatial and temporal profiles of these homologs reveal primarily testis specific function. The following study provides evidence for murine testis and ovary function of a newly discovered Xlr superfamily protein, …

Does Market Integration Buffer Risk, Erode Traditional Sharing Practices And Increase Inequality? A Test Among Bolivian Forager-Farmers, Michael Gurven, Adrian V. Jaeggi, Christopher Von Rueden, Paul L. Hooper, Hillard Kaplan

ESI Publications

Sharing and exchange are common practices for minimizing food insecurity in rural populations. The advent of markets and monetization in egalitarian indigenous populations presents an alternative means of managing risk, with the potential impact of eroding traditional networks. We test whether market involvement buffers several types of risk and reduces traditional sharing behavior among Tsimane Amerindians of the Bolivian Amazon. Results vary based on type of market integration and scale of analysis (household vs. village), consistent with the notion that local culture and ecology shape risk management strategies. Greater wealth and income were unassociated with the reliance on others for …

Forest Structure From Terrestrial Laser Scanning – In Support Of Remote Sensing Calibration/Validation And Operational Inventory, David Kelbe

Theses

Forests are an important part of the natural ecosystem, providing resources such as timber and fuel, performing services such as energy exchange and carbon storage, and presenting risks, such as fire damage and invasive species impacts. Improved characterization of forest structural attributes is desirable, as it could improve our understanding and management of these natural resources.

However, the traditional, systematic collection of forest information – dubbed “forest inventory” – is time-consuming, expensive, and coarse when compared to novel 3-D measurement technologies. Remote sensing estimates, on the other hand, provide synoptic coverage, but often fail to capture the fine- scale structural …

Achilles Tendons From Decorin- And Biglycan-Null Mouse Models Have Inferior Mechanical And Structural Properties Predicted By An Image-Based Empirical Damage Model., Joshua A. Gordon, Benjamin R. Freedman, Andrey Zuskov, Renato V. Iozzo, David E. Birk, Louis J. Soslowsky

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Achilles tendons are a common source of pain and injury, and their pathology may originate from aberrant structure function relationships. Small leucine rich proteoglycans (SLRPs) influence mechanical and structural properties in a tendon-specific manner. However, their roles in the Achilles tendon have not been defined. The objective of this study was to evaluate the mechanical and structural differences observed in mouse Achilles tendons lacking class I SLRPs; either decorin or biglycan. In addition, empirical modeling techniques based on mechanical and image-based measures were employed. Achilles tendons from decorin-null (Dcn(-/-)) and biglycan-null (Bgn(-/-)) C57BL/6 female mice (N=102) were used. Each tendon …

Registered Report: Biomechanical Remodeling Of The Microenvironment By Stromal Caveolin-1 Favors Tumor Invasion And Metastasis, Steven Fiering, Lay-Hong Ang, Judith Lacoste, Tim D. Smith, Erin Griner

Dartmouth Scholarship

The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by conducting replicating selected results from a number of high-profile papers in the field of cancer biology. The papers, which were published between 2010 and 2012 were selected on the basis of citations and Altimetric scores (Errington et al., 2014). This Registered report describes the proposed replication plan of key experiments from ‘Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis’ by Goetz and colleagues, published in Cell in 2011 (Goetz et al., 2011). The key experiments …

A Critical Race Analysis Of Travel For Transformation: Pedagogy For The Privileged Or Vehicle For Socio-Cultural Transformation?, James Arthur Gambrell

Dissertations and Theses

Transformative learning theory (TLT) describes the process of reframing discriminative, untenable worldviews with a more inclusive, permeable, and reflective epistemology. Although TLT has been around for more than 50 years, few studies empirically engage critical theoretical frameworks to move beyond personal learning to identify the impacts of transformation on society. Through a critical race theory (CRT) framework, this study analyzed how the participants' socio-cultural identities (race, class, gender, sexuality, and heritage language) impacted the transformative learning of eight study-abroad students from a medium-sized, rural Midwestern university. Focusing on the extent to which the participants experienced the elements of transformative …

Volume 35, Issue 1: Full Issue, Manuscripts Staff

Manuscripts

No abstract provided.

Government By Gus, Dave Head

Manuscripts

No abstract provided.

The First Bloom, Jean Ann Mccain

Manuscripts

No abstract provided.

Computational Analysis And Monte Carlo Simulation Of Wave Propagation, Jun Qin

Articles

No abstract provided.

Mns Faculty/Student Team Transforms Audubon Society's Bristol Aquarium, Public Affairs, Roger Williams University

Featured News Story

New setup at Audubon's Environmental Education Center in Bristol surpasses standards for today’s public aquariums in areas of energy efficiency, exhibit design, water quality and animal care.

Weekly News Digest 07/15/2015, Jenna Ray

Weekly Bulletin Archive

In This Issue:

● Campus Hosts WCSA All-School Reunion

● Morris Names Director of Admissions

● Team Presents at Cambio de Colores Conference

● CST Featured in MinnPost and Minneapolis Star Tribune

The Multifactorial Role Of The 3rs In Shifting The Harm-Benefit Analysis In Animal Models Of Disease, Melanie L. Graham, Mark J. Prescott

Biomedical Research and Alternative Methods Collection

Ethics on animal use in science in Western society is based on utilitarianism, weighing the harms and benefits to the animals involved against those of the intended human beneficiaries. The 3Rs concept (Replacement, Reduction, Refinement) is both a robust framework for minimizing animal use and suffering (addressing the harms to animals) and a means of supporting high quality science and translation (addressing the benefits). The ambiguity of basic research performed early in the research continuum can sometimes make harm-benefit analysis more difficult since anticipated benefit is often an incremental contribution to a field of knowledge. On the other hand, benefit …

Students, Alumnus Collaborate On Ant Research, July 15, 2015, University Of South Florida St. Petersburg Office Of University Advancement.

USF St. Petersburg Campus News and Press Releases

No abstract provided.

An Elmo2-Rhog-Ilk Network Modulates Microtubule Dynamics, Bradley C. Jackson, Iordanka A. Ivanova, Lina Dagnino

Paediatrics Publications

ELMO2 belongs to a family of scaffold proteins involved in phagocytosis and cell motility. ELMO2 can simultaneously bind integrin-linked kinase (ILK) and RhoG, forming tripartite ERI complexes. These complexes are involved in promoting β1 integrin-dependent directional migration in undifferentiated epidermal keratinocytes. ELMO2 and ILK have also separately been implicated in microtubule regulation at integrin-containing focal adhesions. During differentiation, epidermal keratinocytes cease to express integrins, but ERI complexes persist. Here we show an integrin-independent role of ERI complexes in modulation of microtubule dynamics in differentiated keratinocytes. Depletion of ERI complexes by inactivating the Ilk gene in these cells reduces microtubule growth …

Nos Inhibition Modulates Immune Polarization And Improves Radiation-Induced Tumor Growth Delay, Lisa A. Ridnour, Robert Y.S. Cheng, Jonathan M. Weiss, Sukhbir Kaur, David R. Soto-Pantoja, Debashree Basudhar, Julie L. Heinecke, C. Andrew Stewart, William Degraff, Anastasia L. Sowers, Angela Thetford, Aparna H. Kesarwala, David D. Roberts, Howard A. Young, James B. Mitchell, Giorgio Trinchieri, Robert H. Wiltrout, David A. Wink

United States Public Health Resources

Nitric oxide synthases (NOS) are important mediators of progrowth signaling in tumor cells, as they regulate angiogenesis, immune response, and immune-mediated wound healing. Ionizing radiation (IR) is also an immune modulator and inducer of wound response. We hypothesized that radiation therapeutic efficacy could be improved by targeting NOS following tumor irradiation. Herein, we show enhanced radiation-induced (10 Gy) tumor growth delay in a syngeneic model (C3H) but not immunosuppressed (Nu/Nu) squamous cell carcinoma tumor-bearing mice treated post-IR with the constitutive NOS inhibitor NG-nitro-L-arginine methyl ester (L-NAME). These results suggest a requirement of T cells for improved radiation tumor response. In …

Cdc6 Degradation Requires Phosphodegron Created By Gsk-3 And Cdk1 For Scfcdc4 Recognition In Saccharomyces Cerevisiae, Amr Al-Zain, Lea Schroeder, Alina Sheglov, Amy E. Ikui

Publications and Research

DNA replication has to be tightly regulated to ensure genome integrity such that DNA replication takes place only once per cell cycle. The Cdc6 sequential phosphorylation by GSK-3 and Cdk1 creates a binding site for Cdc4 ubiquitin ligase to promote Cdc6 degradation.

Fall Enrollment 2014-15, Southwestern Oklahoma State University

IPEDS

IPEDS Report created by the SWOSU Office of Institutional Research

Completions 2014-15, Southwestern Oklahoma State University

IPEDS

IPEDS Report created by the SWOSU Office of Institutional Research

Framing In Crime News, Gabriele Ward

Theses and Dissertations

The purpose of this study was to investigate if televised news programs overrepresent or underrepresent certain races as perpetrators or victims. Three weeks of crime news programming were surveyed. The races of perpetrators and victims were identified and coded. Those findings were then compared to 2014 crime statistics obtained from the Philadelphia Police Department. It was hypothesized that (a) Blacks would be overrepresented as perpetrators, (b) Blacks would be underrepresented as victims, (c) Whites would be overrepresented as victims, (d) Whites would be underrepresented as perpetrators, (e) Hispanics would neither be underrepresented or overrepresented as perpetrators, and (f) Hispanics would …

Biological Aggregation Driven By Social And Environmental Factors: A Nonlocal Model And Its Degenerate Cahn-Hilliard Approximation, Andrew Bernoff, Chad M. Topaz

All HMC Faculty Publications and Research

Biological aggregations such as insect swarms and bird flocks may arise from a combination of social interactions and environmental cues. We focus on nonlocal continuum equations, which are often used to model aggregations, and yet which pose significant analytical and computational challenges. Beginning with a particular nonlocal aggregation model [Topaz et al., Bull. Math. Bio., 2006], we derive the minimal well-posed long-wave approximation, which is a degenerate Cahn-Hilliard equation. Energy minimizers of this reduced, local model retain many salient features of those of the nonlocal model, especially for large populations and away from an aggregation's boundaries. Using the Cahn-Hilliard model …

2014-2015 Common Data Set, Southwestern Oklahoma State University

Common Data Sets

This document contains data compiled by the SWOSU Office of Institutional Research for the 2014-2015 academic year.

Macromolecular Crystallography For Synthetic Abiological Molecules: Combining Xmdff And Phenix For Structure Determination Of Cyanostar Macrocycles, Abhishek Singharoy, Balasubramanian Venkatakrishnan, Yun Liu, Christopher G. Mayne, Semin Lee, Chun Hsing Chen, Adam Zlotnick, Klaus Schulten, Amar H. Flood

Faculty Publications

© 2015 American Chemical Society. Crystal structure determination has long provided insight into structure and bonding of small molecules. When those same small molecules are designed to come together in multimolecular assemblies, such as in coordination cages, supramolecular architectures and organic-based frameworks, their crystallographic characteristics closely resemble biological macromolecules. This resemblance suggests that biomacromolecular refinement approaches be used for structure determination of abiological molecular complexes that arise in an aggregate state. Following this suggestion we investigated the crystal structure of a pentagonal macrocycle, cyanostar, by means of biological structure analysis methods and compared results to traditional small molecule methods. Cyanostar …

Crystal Structure Of O-Methyltransferase Calo6 From The Calicheamicin Biosynthetic Pathway: A Case Of Challenging Structure Determination At Low Resolution, Oleg V. Tsodikov, Caixia Hou, Christopher T. Walsh, Sylvie Garneau-Tsodikova

Pharmaceutical Sciences Faculty Publications

BACKGROUND: Calicheamicins (CAL) are enedyine natural products with potent antibiotic and cytotoxic activity, used in anticancer therapy. The O-methyltransferase CalO6 is proposed to catalyze methylation of the hydroxyl moiety at the C2 position of the orsellinic acid group of CAL.

RESULTS: Crystals of CalO6 diffracted non-isotropically, with the usable data extending to 3.4 Å. While no single method of crystal structure determination yielded a structure of CalO6, we were able to determine its structure by using molecular replacement-guided single wavelength anomalous dispersion by using diffraction data from native crystals of CalO6 and a highly non-isomorphous mercury derivative. The structure …

Numerical Analysis Of Bubble Dynamics In Electrohydraulic And Electromagnetic Shock Wave Lithotripsy, Jun Qin

Articles

This study numerically investigated the bubble dynamics in electrohydraulic (EH) and electromagnetic (EM) shock wave lithotripsy (SWL). The acoustic pressure generated by a typical EH (i.e., Dornier HM-3) and EM (i.e., Siemens Modularis) lithotripters has been measured. The dynamics of cavitation bubbles in SWL has been numerically simulated using the Gilemore formulation coupled with zero-order gas diffusion. The pressure measurement results showed that both the peak positive and negative pressure of the Modularis at E4.0 are slightly higher than the corresponding values of the HM-3 at 20 kV. However, the pressure waveforms generated by an EH lithotripter is different from …

Plant Species' Origin Predicts Dominance And Response To Nutrient Enrichment And Herbivores In Global Grasslands, Eric W. Seabloom, Elizabeth T. Borer, Yvonne M. Buckley, Elsa E. Cleland, Kendi F. Davies, Jennifer Firn, W. Stanley Harpole, Yann Hautier, Eric M. Lind, Andrew S. Macdougall, John L. Orrock, Suzanne M. Prober, Peter B. Adler, T. Michael Anderson, Jonathan D. Bakker, Lori A. Biederman, Dana M. Blumenthal, Cynthia S. Brown, Lars A. Brudvig, Marc Cadotte, Chengjin Chu, Kathryn L. Cottingham, Michael J. Crawley, Ellen I. Damschen, Carla M. Dantonio, Nicole M. Decrappeo, Guozhen Du, Philip A. Fay, Paul Frater, Daniel S. Gruner, Nicole Hagenah, Andy Hector, Helmut Hillebrand, Kirsten S. Hofmockel, Hope C. Humphries, Virginia L. Jin, Adam Kay, Kevin P. Kirkman, Julia A. Klein, Johannes M. H. Knops, Kimberly J. La Pierre, Laura Ladwig, John G. Lambrinos, Qi Li, Wei Li, Robin Marushia, Rebecca L. Mcculley, Brett A. Melbourne, Charles E. Mitchell, Joslin L. Moore, John Morgan, Brent Mortensen, Lydia R. O'Halloran, David A. Pyke, Anita C. Risch, Mahesh Sankaran, Martin Schuetz, Anna Simonsen, Melinda D. Smith, Carly J. Stevens, Lauren Sullivan, Elizabeth Wolkovich, Peter D. Wragg, Justin Wright, Louie Yang

Plant and Soil Sciences Faculty Publications

Exotic species dominate many communities; however the functional significance of species' biogeographic origin remains highly contentious. This debate is fuelled in part by the lack of globally replicated, systematic data assessing the relationship between species provenance, function and response to perturbations. We examined the abundance of native and exotic plant species at 64 grasslands in 13 countries, and at a subset of the sites we experimentally tested native and exotic species responses to two fundamental drivers of invasion, mineral nutrient supplies and vertebrate herbivory. Exotic species are six times more likely to dominate communities than native species. Furthermore, while experimental …

The Alestle - Vol. 67 No. 46 - 07/15/2015, Southern Illinois University Edwardsville

The Alestle

Vol. 67 No. 46

Severe White Pine Blister Rust Infection In Whitebark Pine Alters Mountain Pine Beetle (Coleoptera: Curculionidae) Attack Density, Emergence Rate, And Body Size, Edith Mary Dooley, Diana Six

Ecosystem and Conservation Sciences Faculty Publications

Exotic tree pathogens can cause devastating ecological effects on forests that can be exacerbated when infections increase the likelihood of attack by insects. Current high rates of mortality of whitebark pine (Pinus albicaulis Engelm.) are due to white pine blister rust caused by the exotic fungus, Cronartium ribicola J.C. Fisch, and the native mountain pine beetle (Dendroctonus ponderosae Hopkins). These two mortality agents interact in whitebark pine; mountain pine beetle preferentially selects white pine blister rust-infected whitebark pine over healthy trees, and likelihood of attack has been observed to increase with infection severity. We examined attack and emergence …

Impact Of Maternal Incarceration On The Criminal Justice Involvement Of Adult Offspring: A Research Note, Lisa Muftic, Leana A. Bouffard, Gaylene Armstrong

Criminology and Criminal Justice Faculty Publications

Objectives:

Methods:

Results: