Digital Commons Network^™

Toxic Oligomeric Alpha-Synuclein Variants Present In Human Parkinson’S Disease Brains Are Differentially Generated In Mammalian Cell Models, Wei Xin, Sharareh Emadi, Stephanie Williams, Qiang Liu, Philip Schulz, Ping He, Now Bahar Alam, Jie Wu, Michael R. Sierks

Translational Neuroscience

Misfolding and aggregation of α-synuclein into toxic soluble oligomeric α-synuclein aggregates has been strongly correlated with the pathogenesis of Parkinson’s disease (PD). Here, we show that two different morphologically distinct oligomeric α-synuclein aggregates are present in human post-mortem PD brain tissue and are responsible for the bulk of α-synuclein induced toxicity in brain homogenates from PD samples. Two antibody fragments that selectively bind the different oligomeric α-synuclein variants block this α-synuclein induced toxicity and are useful tools to probe how various cell models replicate the α-synuclein aggregation pattern of human PD brain. Using these reagents, we show that mammalian cell …

Transboundary Capital And Pollution Flows And The Emergence Of Regional Inequalities, Anastasios Xepapadeas, Simon Levin

Fondazione Eni Enrico Mattei Working Papers

We seek to explain the emergence of spatial heterogeneity regarding development and pollution on the basis of interactions associated with the movement of capital and polluting activities from one economy to another. We use a simple dynamical model describing capital accumulation along the lines of a fixed-savings-ratio Solow-type model capable of producing endogenous growth and convergence behavior, and pollution accumulation in each country with pollution diffusion between countries or regions. The basic mechanism underlying the movements of capital across space is the quest for locations where the marginal productivity of capital is relatively higher than the productivity at the location …

07-22-2015 Swosu Students Complete Degrees, Southwestern Oklahoma State University

THE BARK ARCHIVE 2015

A total of 159 students at Southwestern Oklahoma State University complete requirements for either associate, bachelor’s or master’s degrees this summer on the Weatherford campus.

Geo-Referenced, Abundance Calibrated Ocean Distribution Of Chinook Salmon (Oncorhynchus Tshawytscha) Stocks Across The West Coast Of North America, M. Renee Bellinger, Michael A. Banks, Sarah J. Bates, Eric D. Crandall, John Carlos Garza, Gil Sylvia, Peter W. Lawson

School of Natural Sciences Faculty Publications and Presentations

Understanding seasonal migration and localized persistence of populations is critical for effective species harvest and conservation management. Pacific salmon (genus Oncorhynchus) forecasting models predict stock composition, abundance, and distribution during annual assessments of proposed fisheries impacts. Most models, however, fail to account for the influence of biophysical factors on year-to-year fluctuations in migratory distributions and stock-specific survival. In this study, the ocean distribution and relative abundance of Chinook salmon (O. tshawytscha) stocks encountered in the California Current large marine ecosystem, U.S.A were inferred using catch-per-unit effort (CPUE) fisheries and genetic stock identification data. In contrast to stock distributions estimated through …

Diffusion Tensor Imaging Of Dolphin Brains Reveals Direct Auditory Pathway To Temporal Lobe, Gregory S. Berns, Peter F. Cook, Sean Foxley, Saad Jbabdi, Karla L. Miller, Lori Marino

Veterinary Science and Medicine Collection

The brains of odontocetes (toothed whales) look grossly different from their terrestrial relatives. Because of their adaptation to the aquatic environment and their reliance on echolocation, the odontocetes’ auditory system is both unique and crucial to their survival. Yet, scant data exist about the functional organization of the cetacean auditory system. A predominant hypothesis is that the primary auditory cortex lies in the suprasylvian gyrus along the vertex of the hemispheres, with this position induced by expansion of ‘associative0 regions in lateral and caudal directions. However, the precise location of the auditory cortex and its connections are still unknown. Here, …

Summer Internship Counting Plants In The Wetland, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Volume 52, Number 49: July 22, 2015, University Of North Dakota

University Letter Archive

No abstract provided.

The Alestle - Vol. 67 No. 47 - 07/22/2015, Southern Illinois University Edwardsville

The Alestle

Vol. 67 No. 47

Sistrunk Triplets Finally Ready To Attend Um, Nathan Weber

University of Mississippi News

Dr. and Mrs. William Sistrunk met at UM and now see their children take the next step at their alma mater.

Keep Up Or Drown: Adjustment Of Western Pacific Coral Reefs To Sea-Level Rise In The 21st Century, Robert Van Woesik, Yimnang Golbuu, George Roff

Ocean Engineering and Marine Sciences Faculty Publications

Since the Mid-Holocene, some 5000 years ago, coral reefs in the Pacific Ocean have been vertically constrained by sea level. Contemporary sea-level rise is releasing these constraints, providing accommodation space for vertical reef expansion. Here, we show that Porites microatolls, from reef-flat environments in Palau (western Pacific Ocean), are ‘keeping up’ with contemporary sea-level rise. Measurements of 570 reef-flat Porites microatolls at 10 locations around Palau revealed recent vertical skeletal extension (78±13 mm) over the last 6–8 years, which is consistent with the timing of the recent increase in sea level. We modelled whether microatoll growth rates will potentially ‘keep …

Efficacy Of Galactose And Adalimumab In Patients With Resistant Focal Segmental Glomerulosclerosis: Report Of The Font Clinical Trial Group., Howard Trachtman, Suzanne Vento, Emily Herreshoff, Milena Radeva, Jennifer Gassman, Daniel T. Stein, Virginia J. Savin, Mukut Sharma, Jochen Reiser, Changli Wei, Michael Somers, Tarak Srivastava, Debbie S. Gipson

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Patients with resistant focal segmental glomerulosclerosis (FSGS) who are unresponsive to corticosteroids and other immunosuppressive agents are at very high risk of progression to end stage kidney disease. In the absence of curative treatment, current therapy centers on renoprotective interventions that reduce proteinuria and fibrosis. The FONT (Novel Therapies for Resistant FSGS) Phase II clinical trial (NCT00814255, Registration date December 22, 2008) was designed to assess the efficacy of adalimumab and galactose compared to standard medical therapy which was comprised of lisinopril, losartan, and atorvastatin.

METHODS: Key eligibility criteria were biopsy confirmed primary FSGS or documentation of a causative …

Population Genetic Structure Of The Dwarf Seahorse (Hippocampus Zosterae) In Florida, Nathan Fedrizzi, Melanie L. J. Stiassny, J. T. Boehm, Eric R. Dougherty, George Amato, Martin Mendez

Publications and Research

The dwarf seahorse (Hippocampus zosterae) is widely distributed throughout near-shore habitats of the Gulf of Mexico and is of commercial significance in Florida, where it is harvested for the aquarium and curio trades. Despite its regional importance, the genetic structure of dwarf seahorse populations remains largely unknown. As an aid to ongoing conservation efforts, we employed three commonly applied mtDNA markers (ND4, DLoop and CO1) to investigate the genetic structuring of H. zosterae in Florida using samples collected throughout its range in the state. A total of 1450 bp provided sufficient resolution to delineate four populations of dwarf seahorses, as …

Students Interning In Asia Share Experiences, University Communications Illinois Wesleyan University

News and Events (Discontinued Series)

No abstract provided.

Cosm News, Georgia Southern University

College of Science & Mathematics: News & Publications (2012-2022)

• Coral Reproduction Workshop

The Relationship Between Affective Teaching And Teacher Effectiveness In Rural Teachers In Tennessee, Ricky Catlett

Electronic Theses and Dissertations Archive

The purpose of this study was to investigate the relationship between affective teachers and teacher effectiveness amoung teachers in rural Tennessee. The philosophical belief of the study is embedded in the classical conditioning theory where the classroom is perceived as the instructional construct, which is characterized by the generation of stimuli and response. A sample of 259 rural teachers in Tennessee located in elementary, middle, and high schools participated in the study. Data were collected using a survey containing elements of motivation, emotionality, planning, stability, commitment, and competence. Data were analyzed using regression analysis, descriptive statistics, and correlations. Results showed …

Attentional Guidance And Media Presentation During Explicit Instruction, Whitney Layne Cade

Electronic Theses and Dissertations Archive

While much is known about how certain types of images influence learning in multimedia educational systems, comparatively little work has been done on how different image types compare to each other in terms of the types of knowledge conveyed and transfer of knowledge. Two popular types of media found in many multimedia environments, pictures and concept maps, are capable of blending verbal information (such as in picture labels or node/link labels) and visual information (such as structural information) into a single image, which may result in increased exposure to vocabulary (improving learning) or may create split attention (decreasing learning). Both …

Genome-Wide Meta-Analysis In Alopecia Areata Resolves Hla Associations And Reveals Two New Susceptibility Loci, Regina C. Betz, Lynn Petukhova, Stephan Ripke, Hailiang Huang, Androniki Menelaou, Silke Redeler, Tim Becker, Stefanie Heilmann, Tarek Yamany, Madeleine Duvic, Maria Hordinsky, David Norris, Vera H. Price, Julian Mackay-Wiggan, Annemieke De Jong, Gina M. Destefano, Susanne Moebus, Markus Böhm, Ulrike Blume-Peytavi, Hans Wolff, Gerhard Lutz, Roland Kruse, Li Bian, Christopher I. Amos

Dartmouth Scholarship

Alopecia areata (AA) is a prevalent autoimmune disease with ten known susceptibility loci. Here we perform the first meta-analysis in AA by combining data from two genome-wide association studies (GWAS), and replication with supplemented ImmunoChip data for a total of 3,253 cases and 7,543 controls. The strongest region of association is the MHC, where we fine-map 4 independent effects, all implicating HLA-DR as a key etiologic driver. Outside the MHC, we identify two novel loci that exceed statistical significance, containing ACOXL/BCL2L11(BIM) (2q13); GARP (LRRC32) (11q13.5), as well as a third nominally significant region SH2B3(LNK)/ ATXN2 (12q24.12). Candidate susceptibility gene expression …

Polyq-Dependent Rna–Protein Assemblies Control Symmetry Breaking, Changhwan Lee, Patricia Occhipinti, Amy S. Gladfelter

Dartmouth Scholarship

Dendritic growth in fungi and neurons requires that multiple axes of polarity are established and maintained within the same cytoplasm. We have discovered that transcripts encoding key polarity factors including a formin, Bni1, and a polarisome scaffold, Spa2, are nonrandomly clustered in the cytosol to initiate and maintain sites of polarized growth in the fungus Ashbya gossypii. This asymmetric distribution requires the mRNAs to interact with a polyQ-containing protein, Whi3, and a Pumilio protein with a low-complexity sequence, Puf2. Cells lacking Whi3 or Puf2 had severe defects in establishing new sites of polarity and failed to localize Bni1 protein. Interaction …

Fetal Interests Vs. Maternal Rights: Is The State Going Too Far?, Robin M. Trindel

Akron Law Review

Part One of this Comment traces the historical development and examines the current status of fetal rights. Part Two discusses the implications that the courts' recognition of fetal rights has spawned upon womens' lives. This Comment concludes that forcing women to undergo medical treatment to benefit their fetuses both ignores legal precedent and violates the woman's right to privacy and bodily integrity. The use of civil and criminal sanctions to punish women for prenatal conduct greatly affects all women while accomplishing nothing in furtherance of state goals.

Someone To Watch Over Me: Medical Decision-Making For Hopelessly Ill Incompetent Adult Patients, Debra L. Dippel

Akron Law Review

This comment focuses on the predicament of the hopelessly ill incompetent adult patient. The comment first discusses the legal framework for medical decision-making in general. Next, it examines the legal and medical distinctions between competent and incompetent patients, and the implications of those distinctions. The comment then explores the options in caring for hopelessly ill incompetent adult patients, and the persons who may or should be responsible for exercising those options. The comment also considers the bases upon which the options may be exercised. Finally, the comment contains an examination of the current state of opinion and the law on …

Hate Speech, Free Speech And The University, Robert W. Mcgee

Akron Law Review

Students and faculty face possible retribution for expressing unpopular ideas, making statements that may be offensive to someone, or even for asking legitimate questions that deal with race, sex, ethnicity or sexual preference. A "thought police" mentality has infested the university, just as McCarthyism did in the 1950s. This article explores the current state of this mentality and discusses the problems inherent in trying to preserve and protect the right of free speech in the university

July 21, 2015 Special Finance & Facilities (F&F) Committee Meeting, Evp For Administration

Finance and Facilities Committee

Documents related to the July 21, 2015 Special Meeting of the Board of Regents' Finance and Facilities Committee. (Agenda, Minutes, eBook, Notice)

Applying Systems Theory As A Lens On Teacher And Student Perceptions Of Assessment And Feedback In An Intensive English Program, Thomas A. Germain

MA TESOL Collection

The goal of this project was to apply systems theory, or more generally, systems thinking as a lens on the perceptions of teachers, students, and administrators who work together at an intensive English program (IEP). This goal necessitated a two-part project: a review of pertinent literature on systems theory and a limited qualitative study situated at the IEP. Sixteen participants, including seven teachers (more than half of the current faculty), two teacher/administrators, and seven students from different levels within the program, were invited to participate. The primary focus of the study was on participants’ awareness of and attitudes about two …

What You Gotta Know To Play Good In The Iterated Prisoner’S Dilemma, Ethan Akin

Mathematics and Statistics Faculty Research & Creative Works

For the iterated Prisoner's Dilemma there exist good strategies which solve the problem when we restrict attention to the long-term average payoff. When used by both players, these assure the cooperative payoff for each of them. Neither player can benefit by moving unilaterally to any other strategy, i.e., these provide Nash equilibria. In addition, if a player uses instead an alternative which decreases the opponent's payoff below the cooperative level, then his own payoff is decreased as well. Thus, if we limit attention to the long-term payoff, these strategies effectively stabilize cooperative behavior. The existence of such strategies follows from …

Efficacy Of Visual Surveys For White-Nose Syndrome At Bat Hibernacula, A. F. Janicki, W. F. Frick, A. M. Kilpatrick

KIP Articles

White-Nose Syndrome (WNS) is an epizootic disease in hibernating bats caused by the fungus Pseudogymnoascus destructans. Surveillance for P. destructans at bat hibernacula consists primarily of visual surveys of bats, collection of potentially infected bats, and submission of these bats for laboratory testing. Cryptic infections (bats that are infected but display no visual signs of fungus) could lead to the mischaracterization of the infection status of a site and the inadvertent spread of P. destructans. We determined the efficacy of visual detection of P. destructans by examining visual signs and molecular detection of P. destructans on 928 bats of six …

Ocean Acidification To Lead The Way For Food Chain Changes, Staff

Browse All News

No abstract provided.

Exposure To Deepwater Horizon Crude Oil Burnoff Particulate Matter Induces Pulmonary Inflammation And Alters Adaptive Immune Response, Sridhar Jaligama, Zaili Chen, Jordy Saravia, Nikki Yadav, Slawomir M. Lomnicki, Tammy R. Dugas, Stephania A. Cormier

Faculty Publications

© 2015 American Chemical Society. The "in situ burning" of trapped crude oil on the surface of Gulf waters during the 2010 Deepwater Horizon (DWH) oil spill released numerous pollutants, including combustion-generated particulate matter (PM). Limited information is available on the respiratory impact of inhaled in situ burned oil sail particulate matter (OSPM). Here we utilized PM collected from in situ burn plumes of the DWH oil spill to study the acute effects of exposure to OSPM on pulmonary health. OSPM caused dose-and time-dependent cytotoxicity and generated reactive oxygen species and superoxide radicals in vitro. Additionally, mice exposed to OSPM …

Smoking Duration, Respiratory Symptoms, And Copd In Adults Aged ≥45 Years With A Smoking History, Yong Liu, Roy A. Pleasants, Janet B. Croft, Anne G. Wheaton, Khosrow Heidari, Ann M. Malarcher, Jill A. Ohar, Monica Kraft, David M. Mannino, Charlie Strange

Preventive Medicine and Environmental Health Faculty Publications

BACKGROUND: The purpose of this study was to assess the relationship of smoking duration with respiratory symptoms and history of chronic obstructive pulmonary disease (COPD) in the South Carolina Behavioral Risk Factor Surveillance System survey in 2012.

METHODS: Data from 4,135 adults aged ≥45 years with a smoking history were analyzed using multivariable logistic regression that accounted for sex, age, race/ethnicity, education, and current smoking status, as well as the complex sampling design.

RESULTS:The distribution of smoking duration ranged from 19.2% (1-9 years) to 36.2% (≥30 years). Among 1,454 respondents who had smoked for ≥30 years, 58.3% were current …

Quantitative Sequencing For The Determination Of Kdr-Type Resistance Allele (V419l,L925i, I936f) Frequencies In Common Bed Bug, Cimex Lectularius L., (Hemiptera: Cimicidae) Populations Collected From Israel, Daniel J. Palencar, Kyle J. Gellatly, Kyong-Sup Yoon, Kosta Y. Mumcuoglu, Uri Shalom, J Marshall Clark

SIUE Faculty Research, Scholarship, and Creative Activity

Human bed bug infestations have dramatically increased worldwide since the mid-1990s. A similar phenomenon was also observed in Israel since 2005, when infestations were reported from all over the country. Two single nucleotide polymorphisms (V419L and L925I) in the bed bug voltage sensitive sodium channel confer kdr-type resistance to pyrethroids. Using quantitative sequencing (QS), the resistance allele frequencies of Israeli bed bug populations from across the country were determined. Genomic DNA was extracted from samples of 12 populations of bed bugs collected from Israel and DNA fragments containing the V419L or L925I and I936F mutations sites were PCR amplified. The …

Mossing Left Lasting Mark At Um, Katie Morrison

University of Mississippi News

No abstract provided.