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2015

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The Cestode Community In Northern Fur Seals (Callorhinus Ursinus) On St. Paul Island, Alaska, Tetiana A Kuzmina, Jesús S. Hernández-Orts, Eugene T. Lyons, Terry R Spraker, Vadym V. Kornyushyn, Roman Kuchta Aug 2015

The Cestode Community In Northern Fur Seals (Callorhinus Ursinus) On St. Paul Island, Alaska, Tetiana A Kuzmina, Jesús S. Hernández-Orts, Eugene T. Lyons, Terry R Spraker, Vadym V. Kornyushyn, Roman Kuchta

Veterinary Science Faculty Publications

The diversity and ecology of cestodes from the northern fur seals, Callorhinus ursinus (NFS), were examined using newly collected material from 756 humanely harvested subadult males between 2011 and 2014. NFSs were collected from five different haul-outs on St. Paul Island, Alaska. A total of 14,660 tapeworms were collected with a prevalence of 98.5% and intensity up to 107 cestodes per host (mean intensity 19.7 ± 16.5 SD). Three species of tapeworms were found: Adenocephalus pacificus (Diphyllobothriidea) was the most prevalent (prevalence 97.4%), followed by Diplogonoporus tetrapterus (49.7%), and 5 immature specimens of Anophryocephalus cf. ochotensis (Tetrabothriidea) (0.5%). Most of …


Spatiotemporal Dynamics Of Coarse Woody Debris In An Old-Growth Temperate Deciduous Forest, Jessica G. Davis, Julia I. Chapman, Shuang-Ye Wu, Ryan W. Mcewan Aug 2015

Spatiotemporal Dynamics Of Coarse Woody Debris In An Old-Growth Temperate Deciduous Forest, Jessica G. Davis, Julia I. Chapman, Shuang-Ye Wu, Ryan W. Mcewan

Biology Faculty Publications

No abstract provided.


Water Transport And The Functional Dynamics Of Aquaporins In Osmoregulatory Organs Of Fishes, Steffen S. Madsen, Morton B. Engelund, Christopher P. Cutler Aug 2015

Water Transport And The Functional Dynamics Of Aquaporins In Osmoregulatory Organs Of Fishes, Steffen S. Madsen, Morton B. Engelund, Christopher P. Cutler

Biology: Faculty Publications

Aquaporins play distinct roles for water transport in fishes as they do in mammals—both at the cellular, organ, and organismal levels. However, with over 32,000 known species of fishes inhabiting almost every aquatic environment, from tidal pools, small mountain streams, to the oceans and extreme salty desert lakes, the challenge to obtain consensus as well as specific knowledge about aquaporin physiology in these vertebrate clades is overwhelming. Because the integumental surfaces of these animals are in intimate contact with the surrounding milieu, passive water loss and uptake represent two of the major osmoregulatory challenges that need compensation. However, neither obligatory …


Ltc Newsletter, University Of Dayton. Ryan C. Harris Learning Teaching Center Aug 2015

Ltc Newsletter, University Of Dayton. Ryan C. Harris Learning Teaching Center

LTC Newsletter

Fall 2015


Engineering Plant Biomass Lignin Content And Composition For Biofuels And Bioproducts, Cassie Marie Welker, Vimal Kumar Balasubramanian, Carloalberto Petti, Krishan Mohan Rai, Seth Debolt, Venugopal Mendu Aug 2015

Engineering Plant Biomass Lignin Content And Composition For Biofuels And Bioproducts, Cassie Marie Welker, Vimal Kumar Balasubramanian, Carloalberto Petti, Krishan Mohan Rai, Seth Debolt, Venugopal Mendu

Horticulture Faculty Publications

Lignin is an aromatic biopolymer involved in providing structural support to plant cell walls. Compared to the other cell wall polymers, i.e., cellulose and hemicelluloses, lignin has been considered a hindrance in cellulosic bioethanol production due to the complexity involved in its separation from other polymers of various biomass feedstocks. Nevertheless, lignin is a potential source of valuable aromatic chemical compounds and upgradable building blocks. Though the biosynthetic pathway of lignin has been elucidated in great detail, the random nature of the polymerization (free radical coupling) process poses challenges for its depolymerization into valuable bioproducts. The absence of specific …


Phosphinimine Zinc Complexes And Neutral Phosphinimines For Ring Opening Polymerization Of Lactides., Rajesh Thapa Aug 2015

Phosphinimine Zinc Complexes And Neutral Phosphinimines For Ring Opening Polymerization Of Lactides., Rajesh Thapa

Electronic Theses and Dissertations

Achiral arenesulfonates ligands having a (NNN) or (NNO) side arm have been developed (Chapter 2) and their respective zinc ethyl complexes, NNNZnEt 3.2 and NNOZnEt 3.3, have been synthesized and characterized using spectroscopic methods (Chapter 3). NNNZnEt as well as NNOZnEt complexes are stable under nitrogen atmosphere. In the NNOZnEt 3.3 complex the protons associated with the pendant (dimethylamino)ethyl arm are broad indicating that a fluxional process is operative, most likely dissociation of the (dimethylamino)ethyl arm at 25 °C in CD2Cl2. The fluxional behavior present in the 1H NMR spectrum of 3.2 could be arrested by cooling the CD2Cl2 solution …


Residential Proximity To Major Roadways Is Associated With Increased Levels Of Ac133+ Circulating Angiogenic Cells, Dejarnett Natasha, Ray Yeager, Daniel J. Conklin, Jongmin Lee, Timothy E. O’Toole, James Mccracken, Wes Abplanalp, Sanjay Srivastava, Daniel W. W. Riggs, Jasmit Shah Aug 2015

Residential Proximity To Major Roadways Is Associated With Increased Levels Of Ac133+ Circulating Angiogenic Cells, Dejarnett Natasha, Ray Yeager, Daniel J. Conklin, Jongmin Lee, Timothy E. O’Toole, James Mccracken, Wes Abplanalp, Sanjay Srivastava, Daniel W. W. Riggs, Jasmit Shah

Brain and Mind Institute

Objectives: Previous studies have shown that residential proximity to a roadway is associated with increased cardiovascular disease risk. Yet, the nature of this association remains unclear, and its effect on individual cardiovascular disease risk factors has not been assessed. The objective of this study was to determine whether residential proximity to roadways influences systemic inflammation and the levels of circulating angiogenic cells.

Approach and Results: In a cross-sectional study, cardiovascular disease risk factors, blood levels of C-reactive protein, and 15 antigenically defined circulating angiogenic cell populations were measured in participants (n=316) with moderate-to-high cardiovascular disease risk. Attributes of roadways surrounding …


Benthic Collector And Grazer Communities Are Threatened By Hemlock Woolly Adelgid-Induced Eastern Hemlock Loss, Joshua K. Adkins, Lynne K. Rieske Aug 2015

Benthic Collector And Grazer Communities Are Threatened By Hemlock Woolly Adelgid-Induced Eastern Hemlock Loss, Joshua K. Adkins, Lynne K. Rieske

Entomology Faculty Publications

Eastern hemlock (Tsuga canadensis (L.) is a foundation species in eastern North America where it is under threat from the highly invasive, exotic hemlock woolly adelgid (Adelges tsugae). Eastern hemlock is especially important in riparian areas of Central and Southern Appalachia, so we compared the spatial and temporal composition of benthic collector-gatherers, collector-filterers, and grazers in headwater streams with hemlock-dominated riparian vegetation to those with deciduous tree-dominated riparian vegetation to evaluate the extent to which adelgid-induced hemlock loss could influence composition and abundance of these two functional feeding groups. We found differences in benthic invertebrate abundance and …


The Dynamics Of Human And Rattlesnake Conflict In Southern California, Aaron Grant Corbit Aug 2015

The Dynamics Of Human And Rattlesnake Conflict In Southern California, Aaron Grant Corbit

Loma Linda University Electronic Theses, Dissertations & Projects

Human-rattlesnake conflict occurs when rattlesnakes are discovered in human-dominated areas and are deemed to pose an unacceptable risk to humans because of their venomous bite. In this dissertation, I investigated the nature of this conflict from the perspectives of both the behavioral and survival risks posed to rattlesnakes and the medical risks posed to humans. In the first of three studies, I investigated the effects of short- and long-distance translocation (SDT and LDT) of nuisance wildlife as a way of mitigating conflict between humans and naturally occurring Red Diamond Rattlesnakes (Crotalus ruber) near residential development in southern California. Snake activity …


Improving Attenuation Correction In Hybrid Positron Emission To Mography, Hua Asher Ai Aug 2015

Improving Attenuation Correction In Hybrid Positron Emission To Mography, Hua Asher Ai

Dissertations and Theses (Open Access)

Hybrid positron emission tomography imaging techniques such as PET/CT and PET/MR have undergone significant developments over the last two decades and have played increasingly more important roles both in research and in the clinic. A unique advantage PET has over other clinical imaging modalities is its capability of accurate quantification. However, as the most critical component of PET quantification, attenuation correction in hybrid PET systems is challenged in several different aspects, including the spatial- temporal mismatch between the PET emission images and the associated attenuation images provided by the complementary modality, and the difficulty in bone identification in the MR-based …


Breast Cancer/Stromal Cells Coculture On Polyelectrolyte Films Emulates Tumor Stages And Mirna Profiles Of Clinical Samples, Amita Daverey, Karleen M. Brown, Srivatsan Kidambi Aug 2015

Breast Cancer/Stromal Cells Coculture On Polyelectrolyte Films Emulates Tumor Stages And Mirna Profiles Of Clinical Samples, Amita Daverey, Karleen M. Brown, Srivatsan Kidambi

Department of Chemical and Biomolecular Engineering: Faculty Publications

In this study, we demonstrate a method for controlling breast cancer cells adhesion on polyelectrolyte multilayer (PEM) films without the aid of adhesive proteins/ ligands to study the role of tumor and stromal cell interaction on cancer biology. Numerous studies have explored engineering coculture of tumor and stromal cells predominantly using transwell coculture of stromal cells cultured onto coverslips that were subsequently added to tumor cell cultures. However, these systems imposed an artificial boundary that precluded cell−cell interactions. To our knowledge, this is the first demonstration of patterned coculture of tumor cells and stromal cells that captures the temporal changes …


The European Union And The United Nations Convention On The Law Of The Sea, Esa Paasivirta Aug 2015

The European Union And The United Nations Convention On The Law Of The Sea, Esa Paasivirta

Fordham International Law Journal

This Essay comments on EU participation in UNCLOS and its implementation. It addresses first the nature of the EU as a contracting party and outlines the modalities for its participation. It then reviews the international implementation of the UNCLOS obligations and the implementation/status of the Convention under EU law.


Eu External Relations: Exclusive Competence Revisited, Allan Rosas Aug 2015

Eu External Relations: Exclusive Competence Revisited, Allan Rosas

Fordham International Law Journal

This Article will focus on the question of exclusive competence in the field of EU external relations, especially in the light of recent developments. After a brief discussion on the origins and development of exclusive competence, a distinction will be made between common commercial policy, which has traditionally been the most important area of an explicit “a priori” exclusive competence, and what is often called an implicit exclusive competence, which, as it is today based on some general criteria enshrined in TFEU Article 3(2), may be called “supervening” exclusive competence. With regard to both categories, the main focus will be …


Sustaining The Saco Estuary: Final Report 2015, Christine B. Feurt Ph D, Pamela A. Morgan, Mark D. O. Adams, Anna L. Bass, Carrie J. Byron, Michael C. Daley, Michael O. Esty, Noah G. Perlut, Kayla Smith, Tyler Spillane, Michelle M. Steen-Adams, James Sulikowski, Stephan I. Zeeman, Jacob Aman, Michele Dionne, Jeremy Miller, Kristin Wilson Aug 2015

Sustaining The Saco Estuary: Final Report 2015, Christine B. Feurt Ph D, Pamela A. Morgan, Mark D. O. Adams, Anna L. Bass, Carrie J. Byron, Michael C. Daley, Michael O. Esty, Noah G. Perlut, Kayla Smith, Tyler Spillane, Michelle M. Steen-Adams, James Sulikowski, Stephan I. Zeeman, Jacob Aman, Michele Dionne, Jeremy Miller, Kristin Wilson

Environmental Studies Faculty Publications

This study focuses on the Saco estuary, the tidal portion of the Saco River, which drains the largest watershed in southern Maine. With headwaters in the White Mountains of New Hampshire, the watershed encompasses more than 4,400 km2, and provides clean healthy drinking water to over 100,000 people living and working in communities in southern Maine.

When the study began in 2009, very little was known about the ecology of the Saco estuary. Researchers at the University of New England and the Wells National Estuarine Research Reserve employed the process of collaborative learning to bring together people who …


Quantification Of Variable Rate Irrigation Benefits And Spatial Variability In Root Zone Water Holding Capacity, Tsz Him Lo Aug 2015

Quantification Of Variable Rate Irrigation Benefits And Spatial Variability In Root Zone Water Holding Capacity, Tsz Him Lo

Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research

Variable rate irrigation (VRI) investment decisions require field-specific knowledge of benefits. The objective of this research was to help producers and consultants consider and quantify potential benefits of VRI. First, a conceptual model was developed for evaluating the public and/or private gain from adopting VRI where irrigation water supply is non-restrictive. Potential benefits were classified into three categories and were attributed to ten reasons. In the Central Plains at current prices, a small improvement in corn (maize) yield would make a large contribution to VRI profitability. Second, the potential irrigation withdrawal reduction from adapting VRI to spatial heterogeneity of root …


An Analysis Of The Correlation Between Act Scores And One-To-One Computing, Jeffrey Brian Heath Aug 2015

An Analysis Of The Correlation Between Act Scores And One-To-One Computing, Jeffrey Brian Heath

Dissertations

This study examined whether a relationship exists between one-to-one computing and student achievement, specifically ACT scores. This study also examined whether relationships exist among teachers’ perceptions of one-to-one computing, teachers’ years of experience, subjects taught by teachers, teachers’ skill level in the use of a computer for instruction, and teachers’ perceptions of changes in ACT scores. The results of this study could help policymakers and educators with decisions regarding implementation of one-to-one computing programs.

The sample of schools for investigating the relationship between one-to-one computing and ACT scores consisted of 33 secondary public schools with one-to-one computing programs located in …


Predictors Of Binge Eating In College Women, Emily E. Prather Aug 2015

Predictors Of Binge Eating In College Women, Emily E. Prather

Dissertations

Binge eating has received increased attention in the psychological literature, as the health consequences are becoming increasingly well known. The prevalence of subclinical binge eating (i.e., binge eating that is not associated with a diagnosable eating disorder) is elevated among college women, some of whom will go on to develop more serious problems. Thus, improved understanding of subclinical binge eating in this population can help to inform prevention and intervention strategies.

In a sample of 472 college women this study evaluated the relationships among four theoretically relevant factors hypothesized to predict binge eating: trait anger, anger suppression, impulsivity, and emotion …


What Concerns Are Secondary Mathematics Teachers Experiencing With The Implementation Of The Common Core State Standards For Mathematics And Is There A Relationship Between The Concerns And Professional Development Received?, Suzanne Therez Jennings Aug 2015

What Concerns Are Secondary Mathematics Teachers Experiencing With The Implementation Of The Common Core State Standards For Mathematics And Is There A Relationship Between The Concerns And Professional Development Received?, Suzanne Therez Jennings

Dissertations

Using the Concerns Based Adoption Model (CBAM) as the theoretical framework, this mixed-methods study utilized three research methods, quantitative, profile interpretation, and qualitative to answer the research questions to investigate the concerns teachers were experiencing during the first year of implementing the Common Core State Standards for Mathematics (CCSSM) and to determine if professional development affected those concerns. The Stage of Concern questionnaire which included two open-ended questions was employed to survey 88 secondary Mississippi mathematics teachers. MANOVA was used to investigate any differences in the means of the relative levels of intensity present within the subgroups which are inconclusive. …


Assessing Awareness, Interest, And Knowledge Of Fractal Geometry Among Secondary Mathematics Teachers In The United States And China, Suanrong Chen Aug 2015

Assessing Awareness, Interest, And Knowledge Of Fractal Geometry Among Secondary Mathematics Teachers In The United States And China, Suanrong Chen

Dissertations

Fractal geometry has gained great attention from mathematicians and scientists in the past three decades (Fraboni, & Moller, 2008). As a new geometry language and subject, fractal geometry has significant value in teaching and learning secondary mathematics. The present study focused on investigating the current state of mathematics teachers’ awareness, interest, and knowledge of fractal geometry in the U.S. and China, as well as the factors that influence them.

The instrument of the study included a survey and a test designed by the researcher and validated by five experts. The results of the study indicated that secondary math teachers in …


Unique And Combined Contributions Of Callous-Unemotional Traits And Parental Incarceration On Juvenile Delinquency In An At-Risk Sample, Lacey Loy Herrington Aug 2015

Unique And Combined Contributions Of Callous-Unemotional Traits And Parental Incarceration On Juvenile Delinquency In An At-Risk Sample, Lacey Loy Herrington

Dissertations

The current study examined the interrelations among callous-unemotional (CU) traits, a history of parental incarceration, and juvenile delinquency. More specifically, although research suggests that both CU traits and parental incarceration are predictors of juvenile delinquent behaviors, their interaction in influencing such behaviors had yet to be investigated. Two-hundred thirteen (213) adolescents (201 males, 12 females) who were enlisted in a residential program designed for adolescents that dropped out of school participated in this study. Participants ranged in age from 16 to 19 (M = 16.92; SD = .77). Higher levels of overall CU traits reported by the adolescent significantly …


Regulation Of Vancomycin Resistance And Stress Response By The Msaabcr Operon In Staphylococcus Aureus, Dhritiman Samanta Aug 2015

Regulation Of Vancomycin Resistance And Stress Response By The Msaabcr Operon In Staphylococcus Aureus, Dhritiman Samanta

Dissertations

Staphylococcus aureus is the predominant cause of public health problems around the world. Vancomycin has been an important antibiotic against Methicillin Resistant Staphylococcus aureus (MRSA) infections. However, Vancomycin Intermediate S. aureus (VISA) strains have been reported. These strains are characterized by thick cell walls, reduced autolytic rate, reduced PBP4 activity, and increased amount of D-Ala-D-Ala termini in the cell wall. In this study, we show that the msaABCR operon regulates vancomycin resistance in two clinical VISA strains. Deletion of the msaABCR operon in strains Mu50 and HIP6297 resulted in a significant decrease in the minimum inhibitory concentration (MIC) for vancomycin. …


Investigating How Students Communicate Tree-Thinking, Carrie Jo Boyce Aug 2015

Investigating How Students Communicate Tree-Thinking, Carrie Jo Boyce

Dissertations

Learning is often an active endeavor that requires students work at building conceptual understandings of complex topics. Personal experiences, ideas, and communication all play large roles in developing knowledge of and understanding complex topics. Sometimes these experiences can promote formation of scientifically inaccurate or incomplete ideas. Representations are tools used to help individuals understand complex topics. In biology, one way that educators help people understand evolutionary histories of organisms is by using representations called phylogenetic trees. In order to understand phylogenetics trees, individuals need to understand the conventions associated with phylogenies.

My dissertation, supported by the Tree-Thinking Representational Competence and …


August 2015 Quicknotes, Southern Adventist University Aug 2015

August 2015 Quicknotes, Southern Adventist University

QuickNotes – Advancement e-Newsletter

QuickNotes is an e-newsletter that comes from Advancement at Southern Adventist University. August 2015 edition features the article "Enrollment Numbers Create Opportunities".


Design, Fabrication, And Optimization Of Miniaturized Devices For Bioanalytical Applications, Suresh Kumar Aug 2015

Design, Fabrication, And Optimization Of Miniaturized Devices For Bioanalytical Applications, Suresh Kumar

Theses and Dissertations

My dissertation work integrates the techniques of microfabrication, micro/nanofluidics, and bioanalytical chemistry to develop miniaturized devices for healthcare applications. Semiconductor processing techniques including photolithography, physical and chemical vapor deposition, and wet etching are used to build these devices in silicon and polymeric materials. On-chip micro-/nanochannels, pumps, and valves are used to manipulate the flow of fluid in these devices. Analytical techniques such as size-based filtration, solid-phase extraction (SPE), sample enrichment, on-chip labeling, microchip electrophoresis (µCE), and laser induced fluorescence (LIF) are utilized to analyze biomolecules. Such miniaturized devices offer the advantages of rapid analysis, low cost, and lab-on-a-chip scale integration …


Streptomycin Induced Stress Response In Salmonella Enterica Serovar Typhimurium Shows Distinct Colony Scatter Signature, Atul K. Singh, Rishi Drolia, Xingjian Bai, Arun K. Bhunia Aug 2015

Streptomycin Induced Stress Response In Salmonella Enterica Serovar Typhimurium Shows Distinct Colony Scatter Signature, Atul K. Singh, Rishi Drolia, Xingjian Bai, Arun K. Bhunia

Department of Food Science Faculty Publications

We investigated the streptomycin-induced stress response in Salmonella enterica serovars with a laser optical sensor, BARDOT (bacterial rapid detection using optical scattering technology). Initially, the top 20 S. enterica serovars were screened for their response to streptomycin at 100 μg/mL. All, but four S. enterica serovars were resistant to streptomycin. The MIC of streptomycin-sensitive serovars (Enteritidis, Muenchen, Mississippi, and Schwarzengrund) varied from 12.5 to 50 μg/mL, while streptomycin-resistant serovar (Typhimurium) from 125-250 μg/mL. Two streptomycin-sensitive serovars (Enteritidis and Mississippi) were grown on brain heart infusion (BHI) agar plates containing sub-inhibitory concentration of streptomycin (1.25-5 μg/mL) and a streptomycin-resistant serovar (Typhimurium) …


Prefrontal Cortex Activity During Attentional Bias Conditioning With Fearful Faces: A Near-Infrared Spectroscopy Analysis, Robert D. Torrence Aug 2015

Prefrontal Cortex Activity During Attentional Bias Conditioning With Fearful Faces: A Near-Infrared Spectroscopy Analysis, Robert D. Torrence

All NMU Master's Theses

Observing a fearful facial expression elicits an automatic orienting of attention. Past research focusing on fear conditioning has used an unconditioned stimulus that the participant directly experiences (e.g. shock). Other research has focused on observational fear learning where the participant watches another individual receive the stimulus. The aim of this study was to condition a colored square with a fearful face in the dot-probe task. Orienting toward and disengagement from fearful faces was also examined using the dot-probe task. In addition, hemodynamic responses in the prefrontal cortex (PFC) were measured using near-infrared spectroscopy (NIRS). It was hypothesized that after pairing …


Altering The Movement: Learning Effects In Beginning And Well-Practiced Flute Players, Andrea Savord Aug 2015

Altering The Movement: Learning Effects In Beginning And Well-Practiced Flute Players, Andrea Savord

All NMU Master's Theses

This project looks at the extent to which musicians at varying stages of expertise are able to adapt to changes in motor movement (specifically the kinesthetic sense) while playing an instrument. Eight well-practiced and five beginning flute players were tested on playing a major scale on both a modified flute and a traditional flute. The modified flute had altered key positions so that the participants’ right hands were on the same side of the instrument as their left hands. The two modified conditions involved either playing the modified flute with the same fingers as one would play on a traditional …


Evaluation And Application Of Population Size Estimators To Assess Brook Trout (Salvelinus Fontinalis) Response To A Non-Native Salmonid Removal In A Small Michigan Coldwater Stream, Joseph P. Gerbyshak Aug 2015

Evaluation And Application Of Population Size Estimators To Assess Brook Trout (Salvelinus Fontinalis) Response To A Non-Native Salmonid Removal In A Small Michigan Coldwater Stream, Joseph P. Gerbyshak

All NMU Master's Theses

Non-native salmonids have been stocked into the Great Lakes since the 1870s and now naturalized populations use tributary environments to reproduce and for their juvenile life stage. Historically, brook trout were the only salmonid to inhabit the tributary environment and numerous studies suggest that exotic salmonids negatively affect brook trout by competing for limited resources. Other studies have been successful at removing non-native salmonids and the native populations increased. During this project 5,320 exotic salmonids were removed from a tributary of Lake Superior from 2008 to 2010 significantly reducing their density and young-of-year brook trout density increased by 260% the …


The Tumor-Suppressive Properties Of Neural Stem Cells, Ryan Passino Aug 2015

The Tumor-Suppressive Properties Of Neural Stem Cells, Ryan Passino

All NMU Master's Theses

Glioblastoma multiforme (GBM) is an aggressive central nervous system malignancy that commonly causes immune suppression in patients to avoid immune recognition and clearance. This complicates treatment options and limits the effectiveness of immunotherapy strategies. Interestingly, GBM formation can stimulate the neurogenic subventricular zone of the cerebral cortex and causes the proliferation and migration of neural stem cells (NSCs) towards the tumor. This migration reflects the NSC wound repair response following CNS injury. Studies using NSCs surgically implanted into GBM tumors showed decreased tumor growth and increased animal survival in mice; however, the mechanisms underlying these anti-tumor properties of NSCs are …


Gene Regulation By A Novel Two-Component System Conserved Among Gammaproteobacteria, Kristin M. Jacob Aug 2015

Gene Regulation By A Novel Two-Component System Conserved Among Gammaproteobacteria, Kristin M. Jacob

All NMU Master's Theses

Two-component systems are common gene regulatory pathways seen in bacteria. Gene expression is controlled by these systems through a series of phosphorylation events between two proteins, a membrane bound sensor kinase and a cytoplasmic response regulator. Activation of a two-component system can be caused by biological or environmental stimuli, resulting in altered gene expression. A conserved two-component system was recently discovered in entomopathogenic bacteria, including our model organisms Pseudomonas entomophila and Pseudomonas aeruginosa, and is homologous to the recently identified two-component system, CrbRS, in Vibrio cholerae. In V. cholerae CrbRS regulates acetate metabolism and controls virulence. The aim of this …