Digital Commons Network^™

Identification And Analysis Of Pathogenic Bacteria From Imported Frozen Tilapia, Halley Purkey

Student Research and Creative Projects 2015-2016

Tilapia is one of the most commonly eaten fish in the United States, yet little is known about the bacteria that it could carry. Because the vast majority of tilapia are raised and processed outside the United States, it is possible that there is less control of its bacterial content due to a higher chance of exposure to environments that could lead to the retention and/or introduction of pathogenic bacterial species. Therefore, it is important to determine if the tilapia sold commercially in the United States carry pathogenic bacteria that could pose a significant health risk to consumers. To address …

The Energy Benefits Of The Pantograph Wing Mechanism In Flapping Flight: Case Study Of A Gull, Gene D. Sattler

Faculty Publications and Presentations

Bird wings generally contain a 4-bar pantograph mechanism in the forearm that enables the wrist joint to be actuated from the elbow joint thus reducing the number of wing muscles and hence reducing the wing inertia and inertial drag. In this paper we develop a theoretical model of inertial power for flapping flight to estimate the advantage of the 4-bar pantograph mechanism by comparing the inertial power required for the case where wrist muscles are present in the forearm with the case where wrist muscles are not present in the forearm. It is difficult to predict how wrist muscles would …

Community Involvement To Address A Long-Standing Invasive Species Problem: Aspects Of Civic Ecology In Practice, Rebecca W. Dolan, Kelly Harris, Mark Adler

Scholarship and Professional Work - LAS

Invasive non-native species (INS) are found in every city around the globe, but their impacts in urban settings as biological agents of visual pollution that block views of natural landscapes and disconnect citizens from nature are not as often addressed as comprehensively as their impacts in natural areas or agricultural settings. The multiple impacts of INS in cities make them ideal candidates for aspects of Civic Ecology Practice, where local environmental stewardship action is taken to enhance green infrastructure and community well-being in urban and other human-dominated systems. We present details of a community driven program focused on removal of …

Soil Nitrogen Affects Phosphorus Recycling: Foliar Resorption And Plant–Soil Feedbacks In A Northern Hardwood Forest, Craig R. See, Ruth D. Yanai, Melany C. Fisk, Matthew A. Vadeboncoeur, Braulio A. Quintero, Timothy J. Fahey

All Materials

Previous studies have attempted to link foliar resorption of nitrogen and phosphorus to their respective availabilities in soil, with mixed results. Based on resource optimization theory, we hypothesized that the foliar resorption of one element could be driven by the availability of another element. We tested various measures of soil N and P as predictors of N and P resorption in six tree species in 18 plots across six stands at the Bartlett Experimental Forest, New Hampshire, USA. Phosphorus resorption efficiency (P , 0.01) and proficiency (P ¼ 0.01) increased with soil N content to 30 cm depth, suggesting that …

Development Of A Technology-Based Behavioral Vaccine To Prevent Adolescent Depression: A Health System Integration Model, Benjamin W. Van Voorhees, Tracy Gladstone, Stephanie Cordel, Monika Marko-Holguin, William Beardslee, Sachiko Kuwabara, Mark Allan Kaplan, Joshua Fogel, Anne Diehl, Chris Hansen, Carl Bell

Publications and Research

Efforts to prevent depression have become a key health system priority. Currently, there is a high prevalence of depression among adolescents, and treatment has become costly due to the recurrence patterns of the illness, impairment among patients, and the complex factors needed for a treatment to be effective. Primary care may be the optimal location to identify those at risk by offering an Internet-based preventive intervention to reduce costs and improve outcomes. Few practical interventions have been developed. The models for Internet intervention development that have been put forward focus primarily on the Internet component rather than how the program …

Services Gone Wild: Has Wildlife Services' Predator Control Program Gone Too Far?, Alison J. Russell

Villanova Environmental Law Journal (1991 - )

No abstract provided.

The Generation-Skipping Transfer Tax And Sociological Shifts In Generational Length: Proposing A Generation-Inflation Index For Taxation, Alyssa A. Dirusso

ACTEC Law Journal

No abstract provided.

A Gene-Based Association Method For Mapping Traits Using Reference Transcriptome Data, Eric R. Gamazon, Heather Wheeler, Kaanan P. Shah, Sahar V. Mozaffari, Keston Aquino-Michaels, Robert J. Carroll, Anne E. Eyler, Joshua C. Denny, Gtex Consortium, Dan L. Nicolae, Nancy J. Cox, Hae Kyung Im

Bioinformatics Faculty Publications

Genome-wide association studies (GWAS) have identified thousands of variants robustly associated with complex traits. However, the biological mechanisms underlying these associations are, in general, not well understood. We propose a gene-based association method called PrediXcan that directly tests the molecular mechanisms through which genetic variation affects phenotype. The approach estimates the component of gene expression determined by an individual’s genetic profile and correlates ‘imputed’ gene expression with the phenotype under investigation to identify genes involved in the etiology of the phenotype. Genetically regulated gene expression is estimated using whole-genome tissue-dependent prediction models trained with reference transcriptome data sets. PrediXcan enjoys …

The Current Volume 26 : Issue 3, Nova Southeastern University

Student Newspapers

No abstract provided.

Green Infrastructure Principles: An Opportunity For Streamlined Stormwater And Floodplain Planning The West, Emily A. Dowd

Water Law Review

No abstract provided.

An Exploration Of The Generalization Of Conversational Social Skills For Students With Autism Spectrum Disorder Within A Self-Contained Educational Setting, Sara L. Parmeley

Dissertations

The researcher taught students with autism 14 years in a public school. For years, her students were part of a social language class and a recess playgroup with typical peers. Though the therapists facilitating those groups observed progress, the researcher witnessed no real-life application outside of class. Students with high-functioning autism had a diagnosis that included poor or lacking social skills and a language delay. Research stated that students on the autism spectrum must be taught social skills and could not be expected to ‘pick up’ skills through simple observation. In order for people to have relationships, go to college, …

The Spirit Molecule: Dmt, Brains, And A Theoneurological Model To Explain Spiritual Experiences, Shaun Smith

Masters Theses

This thesis attempts to address the philosophical implications of the N, N-Dimethyltryptamine (DMT) research of Dr. Rick Strassman. Strassman concludes that the psychedelic properties of DMT represent a proper biological starting point for discussing spiritual and near-death experiences. My research attempts to incorporate philosophical elements from the philosophy of mind and philosophy of religion/mysticism to give an accurate account of some of the philosophical issues worth exploring for future research. One of the essential patterns in this thesis is to trace the research and conclusions of Strassman, compare them with the philosophical issues in the contemporary philosophy of mind and …

September 2015 News Releases, University Of Montana--Missoula. Office Of University Relations

University of Montana News Releases, 1928, 1956-present

No abstract provided.

Erbb3-Erbb2 Complexes As A Therapeutic Target In A Subset Of Wild-Type Braf/Nras Cutaneous Melanomas., Claudia Capparelli, Sheera Rosenbaum, Lisa D. Berman-Booty, Amel Salhi, Nadège Gaborit, Tingting Zhan, Inna Chervoneva, Jason Roszik, Scott E. Woodman, Michael A. Davies, Yulius Y. Setiady, Iman Osman, Yosef Yarden, Andrew E. Aplin

Department of Cancer Biology Faculty Papers

The treatment options remain limited for patients with melanoma who are wild-type for both BRAF and NRAS (WT/WT). We demonstrate that a subgroup of WT/WT melanomas display high basal phosphorylation of ErbB3 that is associated with autocrine production of the ErbB3 ligand neuregulin-1 (NRG1). In WT/WT melanoma cells displaying high levels of phospho-ErbB3, knockdown of NRG1 reduced cell viability and was associated with decreased phosphorylation of ErbB3, its coreceptor ErbB2, and its downstream target, AKT. Similar effects were observed by targeting ErbB3 with either siRNAs or the neutralizing ErbB3 monoclonal antibodies huHER3-8 and NG33. In addition, pertuzumab-mediated inhibition of ErbB2 …

Rac1 P29s Regulates Pd-L1 Expression In Melanoma., Ha Linh Vu, Sheera Rosenbaum, Timothy J. Purwin, Michael A. Davies, Andrew E. Aplin

Department of Cancer Biology Faculty Papers

Whole exome sequencing of cutaneous melanoma has led to the detection of P29 mutations in RAC1 in 5-9% of samples, but the role of RAC1 P29 mutations in melanoma biology remains unclear. Using reverse phase protein array analysis to examine the changes in protein/phospho-protein expression, we identified cyclin B1, PD-L1, Ets-1, and Syk as being selectively upregulated with RAC1 P29S expression and downregulated with RAC1 P29S depletion. Using the melanoma patient samples in TCGA, we found PD-L1 expression to be significantly increased in RAC1 P29S patients compared to RAC1 WT as well as other RAC1 mutants. The finding that PD-L1 …

Expression Of The Il-11 Gene In Metastatic Cells Is Supported By Runx2-Smad And Runx2-Cjun Complexes Induced By Tgfβ1., Xuhui Zhang, Hai Wu, Jason R. Dobson, Gillian Browne, Deli Hong, Jacqueline Akech, Lucia R. Languino, Gary S. Stein, Jane B. Lian

Department of Cancer Biology Faculty Papers

In tumor cells, two factors are abnormally increased that contribute to metastatic bone disease: Runx2, a transcription factor that promotes expression of metastasis related and osteolytic genes; and IL-11, a secreted osteolytic cytokine. Here, we addressed a compelling question: Does Runx2 regulate IL-11 gene expression? We find a positive correlation between Runx2, IL-11 and TGFβ1, a driver of the vicious cycle of metastatic bone disease, in prostate cancer (PC) cell lines representing early (LNCaP) and late (PC3) stage disease. Further, like Runx2 knockdown, IL-11 knockdown significantly reduced expression of several osteolytic factors. Modulation of Runx2 expression results in corresponding changes …

The Use Of Journaling To Assess Student Learning And Acceptance Of Evolutionary Science, Lawrence C. Scharmann, Wilbert Butler Jr.

Department of Teaching, Learning, and Teacher Education: Faculty Publications

Journal writing was introduced as a means to assess student learning and acceptance of evolutionary science in a nonmajors’ biology course taught at a community college. Fourteen weeks of instruction were performed, each initiated by student-centered, in-class activities and culminated by a discussion, to elucidate tentative conclusions based on evidence from in-class activities. Students (N = 31) engaged in explicit and reflective writing (i.e., journaling) at four points during the semester, providing responses to the following questions: (a) what influence did the recent inclass activities and discussion have on your understanding of evolution (b) has your view (of evolution) changed …

Reduced Toxicity Conditioning And Allogeneic Hematopoietic Progenitor Cell Transplantation For Recessive Dystrophic Epidermolysis Bullosa, Mark B. Geyer, Kavita Radhakrishnan, Roger Giller, Noriko Umegaki, Sivan Harel, Maija Kiuru, Kimberly D. Morel, Nicole Leboeuf, Jessica Kandel, Anna Bruckner, Sandra Fabricatore, Mei Chen, David Woodley, John Mcgrath, Leeann Baxter-Lowe, Jouni Uitto, Angela M. Christiano, Mitchell S. Cairo

NYMC Faculty Publications

Recessive dystrophic epidermolysis bullosa is a severe, incurable, inherited blistering disease caused by COL7A1 mutations. Emerging evidence suggests hematopoietic progenitor cells (HPCs) can be reprogrammed into skin; HPC-derived cells can restore COL7 expression in COL7-deficient mice. We report two children with recessive dystrophic epidermolysis bullosa treated with reduced-toxicity conditioning and HLA-matched HPC transplantation.

Short Communication: Lack Of Association Between Mthfr Gene Polymorphisms And Response To Methotrexate Treatment In Pakistani Patients With Rheumatoid Arthritis, Mohammad Perwaiz Iqbal, Azra Arif Ali, Naseema Mehboobali, Khalida Iqbal

Department of Biological & Biomedical Sciences

Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms have been reported to be associated with response to methotrexate (MTX) in certain populations of patients with rheumatoid arthritis (RA). This study aims at investigating any relationship of two single nucleotide polymorphisms (SNPs) in MTHFR gene, C677T and A1298C with response to therapy with MTX in Pakistani RA patients. Allelic frequencies of the two polymorphisms (C677T and A1298C) were determined in 67 RA patients (9 males and 58 females; mean age 42.87 ± 13.5 years) who had previously participated in a prospective clinical trial. Fifty-one patients had received MTX and were followed up for response …

Eating Disorder Risk, Exercise Dependence, And Body Weight Dissatisfaction Among Female Nutrition And Exercise Science University Majors, Natalie Harris, David Gee, Debra D'Acquisto, Dana Ogan, Kelly Pritchett

All Faculty Scholarship for the College of the Sciences

Background and Aims: Past research has examined eating disorder risk among college students majoring in Nutrition and has suggested an increased risk, while other studies contradict these results. Exercise Science majors, however, have yet to be fully examined regarding their risk for eating disorders and exercise dependence. Based on pressures to fit the image associated with careers related to these two disciplines, research is warranted to examine the potential risk for both eating disorder and exercise dependence. The purpose of this study is to compare eating disorder risk, exercise dependence, and body weight dissatisfaction (BWD) between Nutrition and Exercise Science …

A Moving Target: Literacy Development In Situations Of Diglossia And Bilingualism, Lotfi Sayahi

Languages, Literatures and Cultures Faculty Scholarship

The present paper analyzes the challenges of literacy development in cases of classical diglossia and bilingualism. The main argument is that the diverse levels of proficiency in the varieties present in a given linguistic market have implications for and are shaped by processes of literacy development, feelings of linguistic insecurity, and the overall outlook for educational and socioeconomic success. With a special focus on Tunisia, where diglossia and bilingualism are part of the students’ linguistic reality, this paper argues that surmounting the initial marginalization of the native vernacular in favor of literacy in Standard Arabic does not seem to be …

Doing It Again: Repeating Methodology From Published Literature To Learn Field Biology, Laurie Eberhardt

Biology Faculty Publications

Repeatability underpins a basic assumption in science which students must learn in order to evaluate others’ research findings as well as to communicate the results of their own research. By attempting to repeat the methods of published studies, students learn the importance of clear written communication, while at the same time developing research skills. I describe three examples of published field studies that can be used as the basis for course exercises on the repeatability of methodology, as well as field sampling techniques, all grounded in the overall topic of environmental change. Two of the exercises returned students to the …

Human Ips Cell-Derived Astrocyte Transplants Preserve Respiratory Function After Spinal Cord Injury., Ke Li, Elham Javed, Daniel Scura, Tamara J. Hala, Suneil Seetharam, Aditi Falnikar, Jean-Philippe Richard, Ashley Chorath, Nicholas J. Maragakis, Megan C. Wright, Angelo C. Lepore

Department of Neuroscience Faculty Papers

Transplantation-based replacement of lost and/or dysfunctional astrocytes is a promising therapy for spinal cord injury (SCI) that has not been extensively explored, despite the integral roles played by astrocytes in the central nervous system (CNS). Induced pluripotent stem (iPS) cells are a clinically-relevant source of pluripotent cells that both avoid ethical issues of embryonic stem cells and allow for homogeneous derivation of mature cell types in large quantities, potentially in an autologous fashion. Despite their promise, the iPS cell field is in its infancy with respect to evaluating in vivo graft integration and therapeutic efficacy in SCI models. Astrocytes express …

2015-September-01-Aaron Woodruff, University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.

2015-September-01-Research Team Studies Reptilian Embryonic Nutrient Pathways, University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.

2015-September-01-Research Team Studies Reptilian Embryonic Nutrient Pathways, University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.

Nebraska Bird Review (September 2015) 83(3), Whole Issue

Nebraska Bird Review

Summer Field Report, June–July 2015 ... 102

2014 (26th) Report of the NOU Records Committee ... 125

First Nesting Record and Status Review of the Glossy Ibis in Nebraska … 139

In Memory of Roland E. Barth … 149

Subscription and Organization Information ... 151

Summer Field Report, June–July 2015, W. Ross Silcock

Nebraska Bird Review

This summer was very wet over most of the state. Breeding Bird Survey operators noted impassible roads, especially in the western Sandhills. The benefits to water birds in the Rainwater Basin were obvious, however, with notable breeding records for Ruddy Duck and White-faced Ibis, as well as the first documented breeding in the state of Glossy Ibis, and the first Rainwater Basin breeding for Double-crested Cormorant and third for Eared Grebe.

Additional notable breeding records were led by Osprey; after 7 years of trying at various locations, success came with a bang, as at least 3 nests successfully fledged young, …

How Social Activity Affects Exercise In A Rat Model Of Depression Proneness, Jacqueline Rojas

Modern Psychological Studies

With depression rising worldwide, finding effective, affordable relief is a pressing global public health need. Social activity and physical activity both function as natural depression remedies, but depression can interfere with these activities. This study explores whether an increase in social activity can simultaneously increase voluntary exercise. If so, a single remedy could potentially yield two benefits. Rats were singly or paired housed to model social activity, and voluntary wheel running was measured. Depression proneness was modeled with Occidental Low-Saccharin- Consuming (LoS) rats; relative to high-saccharin-consuming (HiS) rats, LoS rats are more anxious and vulnerable to stress, both of which …

Climate-Suitable Planting As A Strategy For Maintaining Forest Productivity And Functional Diversity, Matthew Joshua Duveneck, Robert M. Scheller

Environmental Science and Management Faculty Publications and Presentations

Within the time frame of the longevity of tree species, climate change will change faster than the ability of natural tree migration. Migration lags may result in reduced productivity and reduced diversity in forests under current management and climate change. We evaluated the efficacy of planting climate-suitable tree species (CSP), those tree species with current or historic distributions immediately south of a focal landscape, to maintain or increase aboveground biomass, productivity, and species and functional diversity. We modeled forest change with the LANDIS-II forest simulation model for 100 years (2000–2100) at a 2-ha cell resolution and five-year time steps within …