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The Paradox Of The Serrated Sickle Erythrocyte: The Importance Of The Red Blood Cell Membrane Topography., Samir K. Ballas, Philippe Connes

Cardeza Foundation for Hematologic Research

Red blood cell rheology and adhesiveness play a key role in the occurrence of vaso-occlusive like events in sickle cell anemia. The present paper reviews counter-intuitive findings supporting that rigid and serrated sickle red blood cells do not initiate vaso-occlusion. Instead, the less rigid red blood cells could initiate vaso-occlusion because of their increased adhesiveness to the vascular wall. We suspect that stiffness of sickle erythrocytes and the topography of RBC membrane are factors affecting adhesion to the endothelium.

From Within To Between, Ds Maranan

School of Art, Design and Architecture

Somaesthetics is an approach advanced by Richard Shusterman (2000, 2006, 2008) in which bodily experience plays the central role in aesthetic appreciation, production, and analysis. Somaesthetics draws from a variety of epistemological approaches, including the philosophies of twentieth-century thinkers such as as Merleau-Ponty (1962), de Beauvoir (1997), Foucault (1986), and Wittgenstein; pragmatist philosophies of William James and John Dewey; and theoretical and practice-based contributions of somatic practitioners such as Moshe Feldenkrais and Frederick Alexander. It is an ameliorative approach that encourages heightened awareness of the body leading to an improved “use of the self” (Shusterman, 2008, p. 8). As a …

A Phenomic Scan Of The Norfolk Island Genetic Isolate Identifies A Major Pleiotropic Effect Locus Associated With Metabolic And Renal Disorder Markers, Miles C. Benton, Rodney A. Lea, Donia Macartney-Coxson, Michelle Hanna, David A. Eccles, Melanie A. Carless, Claire Bellis, Harald H. H. Goring, Joanne E. Curran, John Blangero

School of Medicine Publications

Multiphenotype genome-wide association studies (GWAS) may reveal pleiotropic genes, which would remain undetected using single phenotype analyses. Analysis of large pedigrees offers the added advantage of more accurately assessing trait heritability, which can help prioritise genetically influenced phenotypes for GWAS analysis. In this study we performed a principal component analysis (PCA), heritability (h2) estimation and pedigree-based GWAS of 37 cardiovascular disease -related phenotypes in 330 related individuals forming a large pedigree from the Norfolk Island genetic isolate. PCA revealed 13 components explaining >75% of the total variance. Nine components yielded statistically significant h2 values ranging from 0.22 to 0.54 (P<0.05). The most heritable component was loaded with 7 phenotypic measures reflecting metabolic and renal dysfunction. A GWAS of this composite phenotype revealed statistically significant associations for 3 adjacent SNPs on chromosome 1p22.2 (P<1x10-8). These SNPs form a 42kb haplotype block and explain 11% of the genetic variance for this renal function phenotype. Replication analysis of the tagging SNP (rs1396315) in an independent US cohort supports the association (P = 0.000011). Blood transcript analysis showed 35 genes were associated with rs1396315 (P<0.05). Gene set enrichment analysis of these genes revealed the most enriched pathway was purine metabolism (P = 0.0015). Overall, our findings provide convincing evidence for a major pleiotropic effect locus on chromosome 1p22.2 influencing risk of renal dysfunction via purine metabolism pathways in the Norfolk Island population. Further studies are now warranted to interrogate the functional relevance of this locus in terms of renal pathology and cardiovascular disease risk.

Ocean Acoustics And The Environment, Michael D. Vera

Interdisciplinary Investigations

Sound in the ocean can travel for long distances, particularly at relatively low frequencies. Electromagnetic waves, such as visible light or radar signals, are strongly damped in the marine environment.

Man-made sounds in the ocean can therefore be both a useful probe of the environment and an environmental concern. Since the speed of sound in water depends on the temperature, long-range transmissions can be used as a way to measure the average temperature of a large region of the ocean.

This type of data is extremely useful in studying climate, both in short-term weather prediction and in long-term assessment of …

Reverse Engineering Tumor Invasion And Resistance Using Micro/Nano Technologies, Ian Y. Wong

Amgen Seminar Series in Chemical Engineering

Tumor invasion and metastasis, as well as the emergence of drug resistance, confound existing anti-cancer therapies and result in over 9 out of 10 cancer-related fatalities. However, this complex and emergent phenomenon remains poorly understood, particularly from a physical and mechanical perspective. Engineering approaches based on micro/nano technologies may enable new insights into cancer biology and their translation for preclinical drug testing. Here, I describe the use of engineered microenvironments to profile single cell invasion and drug resistance. These behaviors can be comprehensively analyzed in space and time using computer vision, revealing an unexpected analogy with phase transitions during binary …

Hawk On The High Seas: Emma Wightman ’17 To Sail Across The Atlantic With Sea Semester, Public Affairs, Roger Williams University

Featured News Story

Upper-level science undergrads from across the country will investigate global climate change while aboard a 134-foot brigantine en route from the Canary Islands to St. Croix.

Guide To The Dr. Jane Claire Dirks-Edmunds Papers, Linfield College Archives

Linfield Archives Finding Aids

This collection reflects the life work of Dr. Jane Claire Dirks-Edmunds, a student and professor of Linfield College. A dedicated and scrupulous woman, the majority of the collection consists of her research, teaching materials, and correspondence. The collection also includes research and correspondence by Dr. Jane Claire Dirks-Edmunds’s mentor, Dr. James A. Macnab.

Time-Specific Fear Acts As A Non-Photic Entraining Stimulus Of Circadian Rhythms In Rats, Blake A. Pellman, Earnest S. Kim, Melissa Reilly, James Kashima, Oleksiy Motch, Horacio O. De La Iglesia, Jeansok J. Kim

Faculty Publications - Psychology Department

Virtually all animals have endogenous clock mechanisms that “entrain” to the light-dark (LD) cycle and synchronize psychophysiological functions to optimal times for exploring resources and avoiding dangers in the environment. Such circadian rhythms are vital to human mental health, but it is unknown whether circadian rhythms “entrained” to the LD cycle can be overridden by entrainment to daily recurring threats. We show that unsignaled nocturnal footshock caused rats living in an “ethological” apparatus to switch their natural foraging behavior from the dark to the light phase and that this switch was maintained as a free-running circadian rhythm upon removal of …

The Tiger Vol. 109 Issue 41 2015-10-15, Clemson University

Tiger Newspapers 2015

No abstract provided.

Otter Realm, October 15, 2015, California State University, Monterey Bay

The Otter Realm

OtterMedia vote just as confusing as the issue -- Chancellor White visits CSUMB: A question & answer with the CSU chancellor -- Marina movie theater open for the public -- Hispanic Heritage Month celebrations -- Majoring in Math as easy as Pi -- College of Business adds major and reviews programs -- College of Education offers Multiple Subject Teacher Credential program -- Marina purchases Preston Park for $35 million: Marina apartments will now support local economy -- Defense spending high while other branches suffer -- Christianity and equality: Shedding light on our differences -- Get a clue, know your news! …

Sustainability | Art + Science Course Seeks Creative Solutions To Problems Posed By World Scientists, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

The Utah Statesman, October 15, 2015, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

Pursuing Links Between Inflammation And Parkinson's, In Lab And Clinic, Jeff Hansen

Browse All News

No abstract provided.

The Daily Gamecock, Thursday, October 15, 2015, The University Of South Carolina, Office Of Student Media

October

No abstract provided.

The Murray Ledger And Times, October 15, 2015, The Murray Ledger And Times

The Murray Ledger & Times

No abstract provided.

Shaw, Clifford, The Jack Roller, Richard Tewksbury

Qualitative Criminology (QC)

"Learn from the classics. Understand where you came from. Know the past so you won’t repeat it. Be informed about those that have preceded you. Find the foundation your own work is based upon. All of these are viable, valuable, and unfortunately, often unheeded pearls of wisdom. I, for one, can admit that while I’ve espoused these lessons many times, I have not adhered to my own advice. Although we all are well versed (at least for an undergraduate level lecture or two) on the history of our field and the influential scholars and works of the field, unfortunately far …

Daily Eastern News: October 15, 2015, Eastern Illinois University

October

No abstract provided.

Maturity Characteristics Of Pacific Saury During Fishing Season In The Northwest Pacific, Wen-Bin Huang, Yu-Chun Huang

Journal of Marine Science and Technology–Taiwan

Pacific saury is a commercially important fish in the Northwest Pacific. This study examined the maturity characteristics, gonadosomatic index (GSI), condition factor (CF), and ovarian developmental stage of the saury stock in three months of the fishing season (from May to December) in the Northwest Pacific. The maturity characteristics of saury varied among these three months (May, July, and October) in 2009. In May, large GSI and CF values with advanced ovarian developmental stages but small knob lengths (KnL) and body weights (BW) were found. Also in this month, the large-sized saury (> 29 cm) possessed large GSI values and …

Molecular Phylogenetics Reveals Convergent Evolution In Lower Congo River Spiny Eels, S. Elizabeth Alter, Bianca Brown, Melanie L. J. Stiassny

Publications and Research

Background The lower Congo River (LCR) is a region of exceptional species diversity and endemism in the Congo basin, including numerous species of spiny eels (genus Mastacembelus). Four of these exhibit distinctive phenotypes characterized by greatly reduced optic globes deeply embedded into the head (cryptophthalmia) and reduced (or absent) melanin pigmentation, among other characteristics. A strikingly similar cryptophthalmic phenotype is also found in members of a number of unrelated fish families, strongly suggesting the possibility of convergent evolution. However, little is known about the evolutionary processes that shaped diversification in LCR Mastacembelus, their biogeographic origins, or when colonization of the …

Bulletin, Dmacc Marketing

Bulletin

No abstract provided.

Ethanol Enhances Arsenic-Induced Cyclooxygenase-2 Expression Via Both Nfat And Nf-Κb Signalings In Colorectal Cancer Cells, Lei Wang, John Andrew Hitron, James T.F. Wise, Young Ok Son, Ram Vinod Roy, Donghern Kim, Jin Dai, Poyil Pratheeshkumar, Zhuo Zhang, Mei Xu, Jia Luo, Xianglin Shi

Faculty Publications

Arsenic is a known carcinogen to humans, and chronic exposure to environmental arsenic is a worldwide health concern. As a dietary factor, ethanol carries a well-established risk for malignancies, but the effects of co-exposure to arsenic and ethanol on tumor development are not well understood. In the present study, we hypothesized that ethanol would enhance the function of an environmental carcinogen such as arsenic through increase in COX-2 expression. Our in vitro results show that ethanol enhanced arsenic-induced COX-2 expression. We also show that the increased COX-2 expression associates with intracellular ROS generation, up-regulated AKT signaling, with activation of both …

2015-2016 Common Data, Morehead State University. Institutional Research & Analysis.

Office of Institutional Research & Analysis Publication Archive

2015-2016 issue of the Common Data.

Suppression Of Locomotor Activity In Female C57bl/6j Mice Treated With Interleukin-1Β: Investigating A Method For The Study Of Fatigue In Laboratory Animals, David R. Bonsall, Hyunji Kim, Awa Ndiaye, Abbey Petronzio, Grace Mckay-Corkum, Penny C. Molyneux, Thomas E. Scammell, Mary E. Harrington

Psychology: Faculty Publications

Fatigue is a disabling symptom in patients with multiple sclerosis and Parkinson’s Disease, and is also common in patients with traumatic brain injury, cancer, and inflammatory disor- ders. Little is known about the neurobiology of fatigue, in part due to the lack of an approach to induce fatigue in laboratory animals. Fatigue is a common response to systemic challenge by pathogens, a response in part mediated through action of the pro-inflammatory cytokine interleukin-1 beta (IL-1β). We investigated the behavioral responses of mice to IL-1β. Female C57Bl/6J mice of 3 ages were administered IL-1β at various doses i.p. Interleukin-1β reduced locomotor …

An In Vitro Assessment Of Liposomal Topotecan Simulating Metronomic Chemotherapy In Combination With Radiation In Tumor-Endothelial Spheroids, Amar Jyoti, Kyle Daniel Fugit, Pallavi Sethi, Ronald C. Mcgarry, Bradley D. Anderson, Meenakshi Upreti

Pharmaceutical Sciences Faculty Publications

Low dose metronomic chemotherapy (LDMC) refers to prolonged administration of low dose chemotherapy designed to minimize toxicity and target the tumor endothelium, causing tumor growth inhibition. Topotecan (TPT) when administered at its maximum tolerated dose (MTD) is often associated with systemic hematological toxicities. Liposomal encapsulation of TPT enhances efficacy by shielding it from systemic clearance, allowing greater uptake and extended tissue exposure in tumors. Extended release of TPT from liposomal formulations also has the potential to mimic metronomic therapies with fewer treatments. Here we investigate potential toxicities of equivalent doses of free and actively loaded liposomal TPT (LTPT) and compare …

Bis(Spirolactam) 1,3-Double-Armed Calix[4]Arene Compounds And Their Application As Extractants For The Determination Of Heavy Metal Ions, Fintan Kelleher, Mary Deasy, James Ward, Li Li, Fiona Regan

Articles

A number of double-armed calix[4]arene compounds, with proline-derived spirolactam ligating groups on the lower rim, have been synthesised and investigated as extractants of toxic heavy metal ions from aqueous solution. Pedersen’s extraction technique was employed to determine the capability of these new 1,3-distal derived calix[4]arene spiroalactams to extract selected heavy metal ions (e.g. Pb²⁺, Cd²⁺, Zn²⁺, Cu²⁺, Ni²⁺, Co²⁺) from an aqueous phase into an organic phase. The percentage extraction was calculated using UV-vis spectroscopy. All of the compounds synthesised demonstrated good selectivity for the heavy metals selected …

Incorporation Of Fibrin Into A Collagen–Glycosaminoglycan Matrix Results In A Scaffold With Improved Mechanical Properties And Enhanced Capacity To Resist Cell-Mediated Contraction, Claire Brougham, Tanya J. Levingstone, Stefan Jockenhoevel, Thomas C. Flanagan, Fergal J. O'Brien

Articles

Fibrin has many uses as a tissue engineering scaffold, however many in vivo studies have shown a reduction in function resulting from the susceptibility of fibrin to cell-mediated contraction. The overall aim of the present study was to develop and characterise a reinforced natural scaffold using fibrin, collagen and glycosaminoglycan (FCG), and to examine the cell-mediated contraction of this scaffold in comparison to fibrin gels. Through the use of an injection loading technique, a homogenous FCG scaffold was developed. Mechanical testing showed a sixfold increase in compressive modulus and a thirtyfold increase in tensile modulus of fibrin when reinforced with …

Sex Offender Residency Restrictions: Government Regulation Of Public Health, Safety, And Morality, John Kip Cornwell

William & Mary Bill of Rights Journal

Sex offender residency restrictions have proliferated throughout the United States over the past decade. A number of commentators have likened these laws to medieval banishment, when political outcasts and undesirables are exiled to remote areas where they cannot threaten civilized society. This Article argues first that likening modern residency restrictions to “banishment” largely misconstrues this practice as it has been practiced historically. Instead, these statutory initiatives are better understood as an assertion of governments’ police power to protect public health, safety, and morality. Seen through this lens, this Article evaluates the laws’ constitutional sufficiency with attention to their allegedly punitive …

The Alestle - Vol. 68 No. 8 - 10/15/2015, Southern Illinois University Edwardsville

The Alestle

Vol. 68 No. 8

Chemometric And Bioinformatic Analyses Of Cellular Biochemistry, Bradley Worley

Department of Chemistry: Dissertations, Theses, and Student Research

The amount of information collected and analyzed in biochemical and bioanalytical research has exploded over the last few decades, due in large part to the increasing availability of analytical instrumentation that yields information-rich spectra. Datasets from Nuclear Magnetic Resonance (NMR), Mass Spectrometry (MS), infrared (IR) or Raman spectroscopy may easily carry tens to hundreds of thousands of potentially correlated variables observed from only a few samples, making the application of classical statistical methods inappropriate, if not impossible. Drawing useful biochemical conclusions from these unique sources of data requires the use of specialized multivariate data handling techniques.

Unfortunately, proper implementation of …

Minutes, Graduate Council Meeting, October 15, 2015, University Of South Florida St. Petersburg. Graduate Council

USF St. Petersburg Graduate Council Meetings

Minutes of the October 15, 2015, meeting of the University of South Florida St. Petersburg's Graduate Council.