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Flyer News, Vol. 63, No. 5 (Oct. 21, 2015), University Of Dayton

Flyer News

Student-run newspaper of the University of Dayton.

Um Professor Aids In Discovery Of New Species Of Giant Tortoise, Edwin Smith

University of Mississippi News

Ryan Garrick among co-authors of peer-reviewed paper published in journal PLoS ONE

Human Library Catalog

Materials for the 4th Annual Human Library

No abstract provided.

The First Whole Genome And Transcriptome Of The Cinereous Vulture Reveals Adaptation In The Gastric And Immune Defense Systems And Possible Convergent Evolution Between The Old And New World Vultures, Oksung Chung, Seondeok Jin, Yun Sung Cho, Jeongheui Lim, Hyunho Kim, Sungwoong Jho, Hak-Min Kim, Jehoon Jun, Hyejin Lee, Alvin Chon, Junsu Ko, Jeremy Edwards, Jessica A. Weber, Kyudong Han, Stephen J. O'Brien, Andrea Manica, Jong Bhak, Woon Kee Paek

Biology Faculty Articles

Background: The cinereous vulture, Aegypius monachus, is the largest bird of prey and plays a key role in the ecosystem by removing carcasses, thus preventing the spread of diseases. Its feeding habits force it to cope with constant exposure to pathogens, making this species an interesting target for discovering functionally selected genetic variants. Furthermore, the presence of two independently evolved vulture groups, Old World and New World vultures, provides a natural experiment in which to investigate convergent evolution due to obligate scavenging.

Results: We sequenced the genome of a cinereous vulture, and mapped it to the bald …

Wintering North Pacific Black-Legged Kittiwakes Balance Spatial Flexibility And Consistency, Rachael Orben, Rosana Paredes, Daniel Roby, David Irons, Scott A. Shaffer

Faculty Publications, Biological Sciences

Background Marine environments are inherently dynamic, yet marine predators are often long-lived and employ strategies where consistency, individual specialization, routine migrations, and spatial memory are key components to their foraging and life-history strategies. Intrinsic determinates of animal movements are linked to physiological and life-history traits (e.g. sex, colony, experience), while extrinsic influences occur as the result of an animal’s interactions with either other animals or the environment (e.g. prey availability, weather, competition). Knowledge of the factors affecting animal movements is critical to understand energetic bottlenecks and population dynamics. Here, we attempt to understand the interaction of some of these factors …

Ca2+/Calmodulin Regulates Kvβ1.1-Mediated Inactivation Of Voltage-Gated K+ Channels, Sandip M. Swain, Nirakar Sahoo, Sophie Dennhardt, Roland Schönherr, Stefan H. Heinemann

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

A-type K+ channels open on membrane depolarization and undergo subsequent rapid inactivation such that they are ideally suited for fine-tuning the electrical signaling in neurons and muscle cells. Channel inactivation mostly follows the so-called ball-and-chain mechanism, in which the N-terminal structures of either the K+ channel’s α or β subunits occlude the channel pore entry facing the cytosol. Inactivation of Kv1.1 and Kv1.4 channels induced by Kvβ1.1 subunits is profoundly decelerated in response to a rise in the intracellular Ca2+ concentration, thus making the affected channel complexes negative feedback regulators to limit neuronal overexcitation. With electrophysiological and biochemical experiments we …

Diabetic Ketoacidosis: Pathophysiology And Treatment, Laura E. Mumme

The Kabod

The pathophysiology of DKA in patients with T1D is addressed, followed by a discussion of proper emergency treatment for this life-threatening condition.

Keynote - Why The Rapidly Changing Arctic Matters To Science, Hon. Fran Ulmer

Penn State Symposium on the Arctic

Fran Ulmer is chair of the U.S. Arctic Research Commission, where she has served since being appointed by President Barack Obama in March 2011. In June 2010, Obama appointed her to the National Commission on the BP Deepwater Horizon Oil Spill and Offshore Drilling. From 2007 to 2011, Ulmer was chancellor of Alaska's largest public university, the University of Alaska Anchorage (UAA). Prior to that, she was a Distinguished Visiting Professor of Public Policy and director of the Institute of Social and Economic Research at UAA. She is a member of the Arctic Council chairmanship, the global board of The …

Open Your Research Without Opening Your Wallet, Janelle L. Wertzberger

Open Access Week at Gettysburg College

Open scholarship promotes sharing and collaboration, increases readership, and amplifies impact. It is gaining traction as institutions, professional associations, and funding agencies encourage or require broad sharing of research results. Yet many authors believe that the only way to open their work is to pay publishers thousands of dollars for the privilege. Luckily for us, that just isn’t the case. Come hear about a range of ways to open your research without paying for the privilege!

Lunch provided.

(Limited seating, RSVP to [email protected])

The Legacy, October 20, 2015, Lindenwood University

The Legacy (2007-2018)

Student Newspaper of Lindenwood University

Sensors For Continuous Monitoring Of Disposable Bioreactors, Kenneth Reardon

Single-Use Technologies: Bridging Polymer Science to Biotechnology Applications

Continuous monitoring of biotechnological processes is important for control and optimization of quality and productivity. Typically, samples must be removed from the cultivation and analyzed in a laboratory to determine the concentrations of substrates and products. These time-delayed data cannot be used for real-time process control. The Process Analytical Technology initiative of the FDA supports the use of on-line measurement techniques for process development, production, and quality. Single-use systems are increasingly used in biotechnological applications, and face at least as many challenges as their stainless steel counterparts for process monitoring because the range of available sensors is limited to temperature, …

Preventing Leaks In A Single Use System, Trishna Ray-Chaudhuri

Single-Use Technologies: Bridging Polymer Science to Biotechnology Applications

Assurance of the integrity of a single use system is important to ensure process fluids are contained and to limit the potential for a sterility breach. This discussion will describe an approach for the technical assessment of single use systems (SUS) for a specific biopharmaceutical process step. The presentation considers the key properties that need to be evaluated to ensure the integral components of a single use assembly are able to meet the performance attributes for the process step.

Understanding the polymer properties associated with the plastic materials used in single use system (SUS) ensures that the system will be …

Single Use Bioreactors: Geometry Does Matter, Colin Jaques, Anthony Beaney

Single-Use Technologies: Bridging Polymer Science to Biotechnology Applications

The first generation of single use bioreactors (SUBs) departed from conventional stirred tank bioreactor (STR) geometry in terms of impeller number, and orientation and sparger hole diameter. Moreover, one marked feature of SUB bioreactors was that they could be operated at lower volumes than conventional STRs, bringing considerable operational flexibility. This practice, however, further negates the principle of geometric similarity. Whilst some processes may be able to remain within a SUB for the whole product life cycle, many products will require scale up to larger-scale vessels as demand for the product increases. This poster considers the implications of changing reactor …

Implementation And Characterization Of Solvent Detergent Viral Inactivation In Single Use Bags, Michael Cunningham, Ven Raman, Nitin Sood, Jessica Shea, Lori Mullin, Eric Youssef, Pedro Almeida, Elizabeth Goodrich

Single-Use Technologies: Bridging Polymer Science to Biotechnology Applications

Biomanufacturing of recombinant products from mammalian cell culture systems and plasma derived products requires at least two orthogonal virus reduction steps to comply with regulatory pathogen safety risk mitigation guidelines. Solvent detergent viral inactivation (SD VI) has historically been effectively utilized for the inactivation of lipid-enveloped viruses from plasma derived products, yet only recently have process development activities focused on implementation of SD VI in single use systems. The adoption of single-use technologies for bioproduction continues to progress, driven predominantly by the benefits of operational flexibility, speed of implementation, lower capital investment, and elimination of cross contamination concerns. However, the …

Single-Use Capacitance Measurement Of Cell Viability, Dan Kopec, Stuart Tindal, Marcus Weise, Sven Grob, Henry Weichert, Thomas Schnitzler, Manfred Biselli, Mario Becker

Single-Use Technologies: Bridging Polymer Science to Biotechnology Applications

The biomanufacture of complex biologics continues to expand and develop with no end foreseen and in order to build on the industries rapid adoption of single use technology an ethos of what is measured and controlled in stainless steel can be, and should be transferable to plastic. The realization of this continues to be a challenge but one of the key critical parameters in cell cultivation; in-situ viable biomass is now quantifiable using single use capacitance measurement. A single-use sensor patch is fully integrated in a 5L Rocking Motion Bioreactor bag, gamma sterilized and applied to CHO DG44 and Hybridoma …

Independent - Oct. 20, 2015, Rut Ortiz

The Independent (1988-present)

No abstract provided.

Daily Minority Stress And Affect Among Gay And Bisexual Men: A 30-Day Diary Study, Adam I. Eldahan, John E. Pachankis, H. Jonathan Rendina, Ana Ventuneac, Christian Grov, Jeffrey T. Parsons

Publications and Research

Background. This study examined the time-variant association between daily minority stress and daily affect among gay and bisexual men. Tests of time-lagged associations allow for a stronger causal examination of minority stress-affect associations compared with static assessments. Multilevel modeling allows for comparison of associations between minority stress and daily affect when minority stress is modeled as a between-person factor and a within-person time-fluctuating state.

Methods. 371 gay and bisexual men in New York City completed a 30-day daily diary, recording daily experiences of minority stress and positive affect (PA), negative affect (NA), and anxious affect (AA). Multilevel analyses examined …

Loss Of Glycosaminoglycan Receptor Binding After Mosquito Cell Passage Reduces Chikungunya Virus Infectivity, Dhiraj Acharya, Amber M. Paul, John F. Anderson, Faqing Huang, Fengwei Bai

Faculty Publications

Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that can cause fever and chronic arthritis in humans. CHIKV that is generated in mosquito or mammalian cells differs in glycosylation patterns of viral proteins, which may affect its replication and virulence. Herein, we compare replication, pathogenicity, and receptor binding of CHIKV generated in Vero cells (mammal) or C6/36 cells (mosquito) through a single passage. We demonstrate that mosquito cell-derived CHIKV (CHIKV_mos) has slower replication than mammalian cell-derived CHIKV (CHIKV_vero), when tested in both human and murine cell lines. Consistent with this, CHIKV_mos infection in both cell lines …

The Parthenon, October 20, 2015, Jocelyn Gibson

The Parthenon

The Parthenon, Marshall University’s student newspaper, was published by students Monday through Friday during the regular semester and weekly on Thursdays during the summer. Due to budgetary constraints, beginning with the 2015 Fall semester, the newspaper is only published four days a week. There is no issue on Mondays, physical issues are printed on Tuesdays and Fridays, and online issues only are published on Wednesdays and Thursdays. The editorial staff is responsible for the news and the editorial content.

2015-October-20-Leading Global Expert On Crisis Communication To Speak, University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.

Decadal Patterns Of Westerly Winds, Temperatures, Ocean Gyre Circulations And Fish Abundance: A Review, Candace A. Oviatt, Leslie Smith, M. Conor Mcmanus, Kimberly Hyde

Graduate School of Oceanography Faculty Publications

The purpose of this review is to describe the global scope of the multidecadal climate oscillations that go back at least, through several hundred years. Literature, historic data, satellite data and global circulation model output have been used to provide evidence for the zonal and meridional jet stream patterns. These patterns were predominantly zonal from the 1970s to 1990s and switched since the 1990s to a meridional wind phase, with weakening jet streams forming Rossby waves in the northern and southern hemispheres. A weakened northern jet stream has allowed northerly winds to flow down over the continents in the northern …

The Current Volume 26 : Issue 9, Nova Southeastern University

Student Newspapers

No abstract provided.

Identification Of The Substrate Access Portal Of 5-Lipoxygenase, Sunayana Mitra, Sue G. Bartlett, Marcia E. Newcomer

Faculty Publications

© 2015 American Chemical Society. The overproduction of inflammatory lipid mediators derived from arachidonic acid contributes to asthma and cardiovascular diseases, among other pathologies. Consequently, the enzyme that initiates the synthesis of pro-inflammatory leukotrienes, 5-lipoxygenase (5-LOX), is a target for drug design. The crystal structure of 5-LOX revealed a fully encapsulated active site; thus the point of substrate entry is not known. We asked whether a structural motif, a "cork" present in 5-LOX but absent in other mammalian lipoxygenases, might be ejected to allow substrate access. Our results indicate that reduction of cork volume facilitates access to the active site. …

Use Of Cactus Mucilage As A Dispersant And Absorbant For Oil In Oil-Water Mixtures, Norma A. Alcantar, Dawn I. Fox, Sylvia Thomas, Ryan G. Toomey

USF Patents

Despite advances in off-shore oil exploration and drilling technology, accidental oil spills do occur. Depending on their magnitude and location, irreparable damage may be inflicted on marine and coastal ecosystems. Emulsification of a water/surfactant/oil system results in the production of oil droplets and this depends on the formulation and composition variables, mixing characteristics and system preparation. Thus, research is ongoing on improving methods of cleaning up oil spills. Cactus mucilage was used to disperse and absorb oil from a simulated oil slick in different salt concentrations. Results show correlations between emulsion properties and interfacial characteristics of mucilage as function of …

Pop2: Nkκb-Inhibiting Polypeptides, Nucleic Acids And Methods Of Use, Jonathan A. Harton, Felipe Bedoya, Laurel L. Sandler

USF Patents

This invention provides a novel pyrin-only protein (POP2), polypeptides, and nucleic acids encoding them and methods for making and using them. POP2 is a 294 nt single exon gene located on human chromosome 3 encoding a 97 amino acid protein with sequence and predicted structural similarity to other pyrin domains. Highly similar to pyrin domains in CATERPILLER (CLR, NLR, NALP) family proteins, POP2 is less like the prototypic Pyrin and ASC pyrin domains. POP2 is expressed principally in peripheral blood leukocytes and displays both cytoplasmic and nuclear expression patterns in transfected cells. TNFα-stimulated and p65 (RelA) induced NF-κB-dependent gene transcription …

Kenyon Collegiate - October 20, 2015

Kenyon Collegiate

No abstract provided.

The Daily Gamecock, Tuesday, October 20, 2015, The University Of South Carolina, Office Of Student Media

October

No abstract provided.

The Sun Star Vol 35 No 8 ( October 20th, 2015), N/A N/A

Sun Star

No abstract provided.

The Sun Star, Vol. 35 No. 08 (October 20, 2015), Various Authors

Sun Star

No abstract provided.

The Prospector, October 20, 2015, Utep Student Publications

The Prospector

Headline: "We Have a Right to a Gun-Free Campus!"