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Loss Of Glycosaminoglycan Receptor Binding After Mosquito Cell Passage Reduces Chikungunya Virus Infectivity, Amber M. Paul, Dhiraj Acharya, John F. Anderson, Faqing Huang, Fengwei Bai

Publications

Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that can cause fever and chronic arthritis in humans. CHIKV that is generated in mosquito or mammalian cells differs in glycosylation patterns of viral proteins, which may affect its replication and virulence. Herein, we compare replication, pathogenicity, and receptor binding of CHIKV generated in Vero cells (mammal) or C6/36 cells (mosquito) through a single passage. We demonstrate that mosquito cell derived CHIKV (CHIKVmos) has slower replication than mammalian cell derived CHIKV (CHIKVvero), when tested in both human and murine cell lines. Consistent with this, CHIKVmos infection in both cell lines produce less cytopathic …

Defending The Black Sheep Of The Forensic Dna Family: The Case For Implementing Familial Dna Searches In Minnesota, Amy Liberty

Hamline Law Review

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Computational Analysis Of The Stereoselective Synthesis Of Substituted Pyrrolidines, Diamond T. Jones

McNair Scholars Research Journal

In this work we use computational methods to study the aza-Cope-Mannich tandem reaction of a substituted oxazolidine to form a formyl pyrrolidine. Pyrrolidine structural motifs are found in natural products, pharmaceutical compounds, and chiral catalysts. Often only one stereoisomer of these compounds is active, while the others are inactive or toxic. Our goal is to determine reaction conditions and substrate characteristics that lead to one stereoisomer preferentially over the others. We focus on an oxazolidine starting material with an electron-withdrawing group at the nitrogen center and a bulky substituent at the alpha position. The long-term objective is to delineate the …

Queering Asexuality: Asexual-Inclusion In Queer Spaces, Dominique A. Canning

McNair Scholars Research Journal

Discussions about emerging sexual identities are prevalent in today’s society. As our recognition of the diversity of sexual identities grows, so does our need to define these identities and to better understand how they represent the human experience. One such identity is asexuality, which is defined by the Asexual Visibility and Education Network (AVEN) as a “person who experiences no sexual attraction” (“Overview” n.d.). In this research, I will analyze the debate over whether asexual individuals should be considered “queer.” This analysis will examine previous research that focuses on identity, discourse, and boundaries between identities. The goal of this research …

Examining Differences In Middle School Student Achievement On A State Mandated Examination: Does A Full Year Of Agriscience Really Make A Difference?, Sarah Hicks, Dennis W. Duncan, Myra Womble, Robert Branch

Online Journal for Workforce Education and Development

Early agricultural education programs in the United States existed to promote new methods and techniques to further agricultural production. Today, extending integration, general knowledge, appreciation, and literacy about agriculture is the goal, especially at the middle school level. Not only is agricultural education designed to encompass academics, but science and technology, literacy, and career preparedness are parts of the total agricultural education program. Since the passage of No Child Left Behind Act (NCLB), more pressure has been put on teachers to generate increased student academic performance and improvement of test scores. The purpose of this research study was to determine …

The First Amendment, Homosexual Unions, And "Newspeak": Has The Language Surrounding The Marriage Debate Altered The Nature Of Marriage Itself, Or Affected The Truth Of The Issues Inherent In Alternative Marriage Demands?, Lynne Marie Kohm

Liberty University Law Review

No abstract provided.

Homosexuality: Innate And Immutable? What Science Can And Cannot Say, A. Dean Byrd

Liberty University Law Review

No abstract provided.

Problems Of Classification, William C. Duncan

Liberty University Law Review

No abstract provided.

The Fallacy Of Neutrality From Beginning To End: The Battle Between Religious Liberties And Rights Based On Homosexual Conduct, Rena M. Lindevaldsen

Liberty University Law Review

No abstract provided.

Richard L. Bready Mount Hope Bay Sailing And Education Center 'Puts Rwu On The Map', Melissa A. Patricio

Featured News Story

Multifunction facility to serve as a home for top ranked sailing team and a resource for STEM education.

Volume 51 - Issue 06 - October 19, 2015, Rose Thorn Staff

The Rose Thorn Archive

The Rose Thorn, Rose-Hulman's independent student newspaper.

Curricular Affairs Committee Minutes October 19, 2015, University Of Rhode Island Faculty Senate

Faculty Senate Committee Reports and Appendices

No abstract provided.

Case Study: Identification, Characterization And Mitigation Of Growth Inhibitory Leachable Compound From Disposable Plastic Vessels, Zara Melkounian

Single-Use Technologies: Bridging Polymer Science to Biotechnology Applications

The inhibition of CHO cell growth was observed in culture medium incubated in disposable plastic vessel, but not in a control glass vessel. Gamma irradiation of vessels during terminal sterilization step was required to produce the growth inhibitory leachable, as unsterilized vessels showed no inhibition of cell growth. Also, the growth inhibition was cell line specific in that some CHO cells were more sensitive than others, and some were not sensitive at all.

Using chromatographic and spectroscopic methods we were able to identify and characterize a single leachable responsible for this growth inhibition in some CHO cells. By understanding the …

Final Program, Ekta Mahajan, Gary Lye

Single-Use Technologies: Bridging Polymer Science to Biotechnology Applications

No abstract provided.

A Modern Gate For Ezells Cave, Texas, Jim "Crash" Kennedy

National Cave and Karst Management Symposia

No abstract provided.

Cave Research Projects Help Promote Diversity In The Geosciences, De'etra Young, Shannon Trimboli, Thomas Bly

National Cave and Karst Management Symposia

No abstract provided.

An Education Is Not All Derived From Textbooks”: A Century Of Interactions Between Mammoth Cave And Western Kentucky University, Chris Groves, Deana Groves, Weldon Hawkins

National Cave and Karst Management Symposia

No abstract provided.

Genus-Wide Assessment Of Bactrurus (Amphipoda: Crangonyctidae) Informs Conservation And Management Of Groundwater Habitats, Matthew L. Niemiller, Steven J. Taylor

National Cave and Karst Management Symposia

No abstract provided.

Cave And Karst Resource Management At Joint Base San Antonio-Camp Bullis, Chris Thibodaux

National Cave and Karst Management Symposia

No abstract provided.

Karst Wreckage: Subterranean Fauna As Collateral Damage, Julian J. Lewis, Salisa L. Lewis

National Cave and Karst Management Symposia

No abstract provided.

Ada News - 10/19/2015, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

The Utah Statesman, October 19, 2015, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

October 19, 2015, James Madison University

The Breeze, 2010-2019

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

Managing The Spread Of Pseudogymnoascus Destructans And Conserving Bats Threatened By White-Nose Syndrome In North America, Jeremy Coleman, Jonathan D. Reichard, Richard Geboy, Christopher Servheen, Christina Kocer, Mike Armstrong

National Cave and Karst Management Symposia

No abstract provided.

Strip Adaptive Cluster Sampling With Application To Cave Crickets, Kurt Lewis Helf

National Cave and Karst Management Symposia

No abstract provided.

Monitoring In-Cave Resources With Reduced Impact And Increased Quantitative Capacity: Developing Photogrammetry Methodologies For In Cave Environments, Robyn L. Henderek, John R. Wood, Benjamin W. Tobin

National Cave and Karst Management Symposia

No abstract provided.

The Extirpation Of A Population Of The Endangered Illinois Cave Amphipod (Gammarus Acherondytes) By An Exotic Species: The Wednesday Cave Debacle, Julian J. Lewis, Salisa L. Lewis

National Cave and Karst Management Symposia

No abstract provided.

White-Nose Syndrome Response At Mammoth Cave National Park, Rickard S. Toomey

National Cave and Karst Management Symposia

No abstract provided.

Improving Stormwater Treatment Efficiency Based On Runoff Properties At Mammoth Cave National Park, Hung-Wai Ho, Rickard Toomey

National Cave and Karst Management Symposia

No abstract provided.

The Statesman, V. 59, I. 8, Stony Brook University

Stony Brook Statesman-Sucolian

v. 59;i. 8