Digital Commons Network^™

Administration Of Panobinostat Is Associated With Increased Il-17a Mrna In The Intestinal Epithelium Of Hiv-1 Patients, Ane Bjerg Christensen, Anders Dige, Johan Vad-Nielsen, Christel R. Brinkmann, Mia Bendix, Lars Østergaard, Martin Tolstrup, Ole S. Søgaard, Thomas A. Rasmussen, Jens Randel Nyengaard, Jørgen Agnholt, Paul W. Denton

Biology Faculty Publications

Intestinal CD4+ T cell depletion is rapid and profound during early HIV-1 infection.This leads to a compromised mucosal barrier that prompts chronic systemic inflammation.The preferential loss of intestinal T helper 17 (Th17) cells in HIV-1 disease is a driver of the damage within the mucosal barrier and of disease progression.Thus, understanding the effects of new therapeutic strategies in the intestines has high priority. Histone deacetylase (HDAC) inhibitors (e.g., panobinostat) are actively under investigation as potential latency reversing agents in HIV eradication studies. These drugs have broad effects that go beyond reactivating virus, including modulation of immune pathways. We examined colonic …

Allyship To The Intersex Community On Cosmetic, Non-Consensual Genital "Normalizing" Surgery, Robert Hupf

William & Mary Journal of Race, Gender, and Social Justice

No abstract provided.

Toward A Socially Responsible Application Of The Criminal Law To The Problem Of Street Harassment, Maeve Olney

William & Mary Journal of Race, Gender, and Social Justice

No abstract provided.

Married On Sunday, Fired On Monday: Approaches To Federal Lgbt Civil Rights Protections, Lisa Bornstein, Megan Bench

William & Mary Journal of Race, Gender, and Social Justice

No abstract provided.

Fibronectin Signals Through Integrin Α5Β1 To Regulate Cardiovascular Development In A Cell Type-Specific Manner., Dongying Chen, Xia Wang, Dong Liang, Julie Gordon, Ashok Mittal, Nancy Manley, Karl Degenhardt, Sophie Astrof

Department of Medicine Faculty Papers

Fibronectin (Fn1) is an evolutionarily conserved extracellular matrix glycoprotein essential for embryonic development. Global deletion of Fn1 leads to mid-gestation lethality from cardiovascular defects. However, severe morphogenetic defects that occur early in embryogenesis in these embryos precluded assigning a direct role for Fn1 in cardiovascular development. We noticed that Fn1 is expressed in strikingly non-uniform patterns during mouse embryogenesis, and that its expression is particularly enriched in the pharyngeal region corresponding with the pharyngeal arches 3, 4, and 6. This region bears a special importance for the developing cardiovascular system, and we hypothesized that the localized enrichment of Fn1 in …

A Primer: Air And Water Environmental Quality Standards In The United States, Jason J. Czarnezki, Siu Tip Lam, Nadia B. Ahmad

William & Mary Environmental Law and Policy Review

No abstract provided.

Effects Of The Craft Beer Boom In Virginia: How Breweries, Regulators, And The Public Can Collaborate To Mitigate Environmental Impacts, Hannah Fish

William & Mary Environmental Law and Policy Review

No abstract provided.

Monitoring For Adverse Events Post Marketing Approval Of Drugs, Karl E. Peace, Macaulay Okwuokenye

Biostatistics: Faculty Publications

This brief communication provides information to those developing monitoring plans for serious adverse events (SAE’s) following regulatory approval of a new drug. In addition, we (1) illustrate how many patients would need to be treated in order to have high confidence of seeing at least 1 pre-specified SAE, (2) show that absence of proof of a SAE is not proof of absence of that SAE, and (3) identify statistical methodology that could be used for formal statistical monitoring of SAE’s.

Emerging Immunopharmacological Targets In Multiple Sclerosis., Mojtaba Farjam, Guang-Xian Zhang, Bogoljub Ciric, Abdolmohamad Rostami

Department of Neurology Faculty Papers

Inflammatory demyelination of the central nervous system (CNS) is the hallmark of multiple sclerosis (MS), a chronic debilitating disease that affects more than 2.5 million individuals worldwide. It has been widely accepted, although not proven, that the major pathogenic mechanism of MS involves myelin-reactive T cell activation in the periphery and migration into the CNS, which subsequently triggers an inflammatory cascade that leads to demyelination and axonal damage. Virtually all MS medications now in use target the immune system and prevent tissue damage by modulating neuroinflammatory processes. Although current therapies such as commonly prescribed disease-modifying medications decrease the relapse rate …

Offshore Discoveries, Michelle Morrissey

UNH Today Archive

No abstract provided.

Environmental Temperatures, Artificial Nests, And Incubation Of Cassin's Auklet, Emma Kelsey, Russell Bradley, Pete Warzybok, Jamie Jahncke, Scott A. Shaffer

Faculty Publications, Biological Sciences

Hatching success in birds is influenced by the temperature and turning rate of the egg, but our understanding of the environmental factors that effect incubation temperatures and egg turning rates in birds is limited. Especially little is known of these effects for species that nest in burrows or crevices, such as the Cassin's auklet. On Southeast Farallon Island, California, USA, a subset of the Cassin's auklet (hereafter auklet) population nest in artificial nest boxes. The nest boxes are above ground and made out of a single layer of plywood. Temperatures in unshaded nest boxes can increase significantly with high ambient …

Now, We Hear Through A Voice Darkly: New Media And Narratology In Cinematic Art, James Anthony Ricci

USF Tampa Graduate Theses and Dissertations

This dissertation explores the intersection of new media and narrative, as it is presented through a cinematic aesthetic. The narrative language of film is analyzed through the theoretical framework of Bakhtin’s concepts of Heteroglossia, Chronotope, and Dialogism. Bakhtin’s ideas of classifying language act as strong tools for demonstrating how cinematic narrative can inform and alter the perception of its spectators. Lev Manovich’s principles of New Media, specifically Variability, Modularity, and Automation are also utilized to demonstrate how cinema is a constantly evolving paradigm.

Chapter one focuses on the theoretical terminology, outlining the conceptual definitions and illustrating their relevance in precise …

Antioxidative Capacity And Electrolyte Leakage In Healthy Versus Phytoplasma Infected Tissues Of Euphorbia Coerulescens And Orbea Gigantean, Yh Dewir, Mahrouk Me El, Hz Rihan, Ca Sáez, Mp Fuller

School of Biological and Marine Sciences

The present study reports on reactive oxygen species (ROS), antioxidant enzyme activities, electrolyte leakage and levels of abscisic acid (ABA) in healthy and phytoplasma infected (PI) tissues of Euphorbia coerulescens and Orbea gigantea. Histochemical staining for ROS indicated that PI tissues possess higher levels of hydrogen peroxide (H2O2) rather than superoxide (O2 ·-) as compared with healthy tissues in both plant species. The results indicated that superoxide dismutase (SOD) is not playing an important role in eliminating O2− in PI tissues. This was confirmed by a significantly decreased activity of SOD and a non-significant difference in O2 ·- content in …

Relationships Of Haemosporidian Parasites To Populations Of Their Avian Hosts In Eastern North America, Vincenzo Alexander Ellis

Dissertations

Avian Haemosporida are common, vector-transmitted blood parasites of birds throughout the world. During my dissertation research, I explored how multiple host species respond immunologically to natural infections in the wild (Chapter 1) and to experimental infections in the laboratory (Chapter 2). Despite their tractability as a model host-parasite system and a burgeoning literature on avian Haemosporida, little is known about how their populations interact across large areas (hereafter “regions”). I present data from parasite surveys of birds across eastern North America suggesting that continental parasite populations track host populations across the region, but also that the host breadth of a …

Microrna Molecular Profiling From Matched Tumor And Bio-Fluids In Bladder Cancer, David A. Armstrong, Benjamin B. Green, John D. Seigne, Alan R. Schned, Carmen Marsit

Dartmouth Scholarship

MicroRNAs have been identified as potential cancer biomarkers due to their presence and stability in many body fluids including urine and plasma, but the relationship of the pattern of expression of these messengers across various biological media has not been addressed and could provide important information in order to translate these biomarkers for epidemiologic or clinical use. We analyzed microRNA of matched FFPE-tumor tissue, plasma, urine exosomes (n = 16) and WBCs (n = 11) from patients with bladder cancer, using Nanostring miRNA assays and droplet digital PCR for validation. Pearson correlations were used to compare expression between …

Filtering With A Drill Pump: An Efficient And Cost Effective Method To Collect Suspended Sediment And Filtrate, Julia E. Kelso, Michelle A. Baker

Biology Faculty Publications

Water quality monitoring programs across multiple disciplines use total suspended solids (TSS), and volatile suspended solids (VSS), to assess potential impairments of surface water and groundwater. While previous methods for instream filtering have been developed, the need for rapid, cost-effective, high volume sampling has increased with the need to verify and supplement data produced by sondes and instantaneous data loggers. We present an efficient method to filter water instream with a portable drill pump that results in reduced sample processing time, and potentially reduced error associated with sample transportation, preservation, contamination, and homogenization. This technical note outlines the advantages of …

Growing In This Place: A Place-Based Guide To Edible Wild Plants And Wildcrafting In Minnesota, Kelly Shaun Knott

School of Education and Leadership Student Capstone Theses and Dissertations

The main research question explored in this curriculum capstone is what are some simple things that children could know about where they live and what edible wilds grow around them that would enrich their sense of place? A goal of this project is to get children outside with an adult companion exploring natural settings by way of foraging for wild edibles. The purpose of this wild edibles guide is to give novice foragers the basic tools necessary to ensure wildcrafting success. The guide highlights fourteen easy to identify common wild edibles growing in Minnesota and concludes with fourteen simple recipes …

The Unfolding Legal Dilemma Created By Honor And Apostasy Crimes In The United States, Meredith I. Biggs

Liberty University Law Review

No abstract provided.

Holding Schools Accountable For Their Sex-Ed Curricula, Rena M. Lindevaldsen

Liberty University Law Review

No abstract provided.

The Roles Of Geographic Isolation And Gene Flow In The Diversification Of The Rufous Fantail Rhipidura Rufifrons, Douglas E. Weidemann

Open Access Theses

Studies of divergence and speciation patterns in island systems have played an important role in the development and establishment of the allopatric speciation model. However, recent empirical support for divergence and speciation with gene flow means the importance of isolation for divergence in island systems needs to be re-examined. Here I explore the roles of geographic isolation and gene flow in the early stages of divergence of evolutionarily independent replicate populations of the Rufous Fantail Rhipidura rufifrons on satellite islands in southeastern Solomon Islands. These populations differ in the extent of morphological divergence from the main island, providing a unique …

Renewal Of Five-Year Grant Will Continue Winthrop's Stem Initiative, Winthrop University

Winthrop News 2015

• Winthrop was one of only 40 Noyce awards made nationwide from the 118 proposals submitted to the funding agency in the spring, according to Beth Greene Costner, associate dean of the Richard W. Riley College of Education and co-director of the Winthrop Initiative for STEM Educators, called WISE.
• This second award for more than $1 million includes a stronger partnership with nearby York Technical College with eight internship spots and 10 scholarships set to be awarded to students that begin their college career there.

Full Steam Ahead: Education Students Develop Custom Exhibit Proposals For Herreshoff Marine Museum, Sabrina Polin

Featured News Story

Interactive exhibits combine sailing basics with lessons in science, technology, engineering, art and math.

Developing Human Capacity For Marine Scientific Research In Myanmar, Roxane S. De Waegh

Open Access Theses

Scientists worldwide believe that sustainable resource management must be based on results derived from successful research (Strigl, 2003). Therefore, scientists are constantly engaged in research projects in order to obtain more results and create new knowledge. In this constant pursuit of knowledge, the international scientific community is minimally participating in the development of human capacity, especially when their research is based in low-income countries (LIC) (Strigl, 2003). This research-based agenda benefits scientific societies in developed countries, as they continuously add value to their knowledge-based economy, while the local communities’ education levels remain stagnant. LIC’s needs in education and science are …

Recidivism Recourse: Cracking Down On Florida's Sexually Violent Predators, Nicole Canha

Barry Law Review

No abstract provided.

Mol-Pcr For Snp Based Detection And Characterization Of Stec Non-O157 Strains, Heather M. Mendez

Biomedical Engineering ETDs

Shiga toxin-producing Escherichia coli (STEC) strains are important food-borne pathogens that have been linked to human illness. In the United States, STEC O157:H7 strains have been attributed to the majority of disease and outbreaks; however, the frequency of disease associated with STEC non-O157 strains have also increased and is often under recognized due to diagnostic limitations. In 2012, the Food Safety and Inspection Service (FSIS) implemented mandatory testing for non-O157 STEC serogroups O26, O45, O103, O111, O121, and O145. Single nucleotide polymorphisms (SNPs) have been identified in the O-antigen gene cluster for each of the non-O157 STEC serogroups that can …

November 13-14, 2015, Vs. Miami, University Of North Dakota

UND Athletics Publications: Men's Hockey

Program for the November 13-14, 2015, weekend series against the Miami RedHawks.

Development Of 11-Plex Assay For The Rapid Screening Of Samples For Detection Of Shiga Toxin-Producing E. Coli, Travis Woods

Biomedical Engineering ETDs

Shiga toxin-producing Escherichia coli (STEC) have been identified by the USDA as a serious threat to the nations health stemming from contaminations in the food supply, specifically, the beef chain. I have developed an assay that is able to screen samples for STEC in a rapid and multiplexed format. Multiplex oligonucleotide ligation-PCR (MOL- PCR) is a nucleic acid based assay patented at Los Alamos National Laboratory (LANL) that uses flow cytometry and multiplex microsphere arrays for detection of nucleic acid based signatures. By using MOL-PCR for detecting unique STEC DNA signatures in samples from the beef supply chain (farm to …

Umm Curriculum Program Changes 11/13/2015, Curriculum Committee

Curriculum Committee Reports

No abstract provided.

Checking In

NASIG Newsletter

No abstract provided.

Ecuadoran Government Climate Change Discourse: Just Lip Service?, Luis ÁNgel Saavedra

NotiSur

No abstract provided.