Digital Commons Network^™

Human Papillomavirus: A Potential Risk Factor For Colorectal Carcinoma?, Ufuk Berber, Alpaslan Tanoğlu, Ahmet Zi̇ya Balta

Turkish Journal of Medical Sciences

No abstract provided.

Caffeic Acid Phenethyl Ester Protects Lung Alveolar Epithelial Cellsfrom Cigarette Smoke-Induced Damage, Firat Bariş Barlas, Suat Erdogan

Turkish Journal of Medical Sciences

Background/aim: To evaluate the influence of caffeic acid phenethyl ester (CAPE) on cigarette smoke (CS)-induced cell damage, oxidative stress, and inflammation in human alveolar epithelial cells. Materials and methods: A549 alveolar epithelial cells were divided into control, CS exposure, CAPE, and CS+CAPE treatment groups. Undiluted CS-exposed medium (100%) and three dilutions (50%, 25%, and 10%) of CS-exposed media were applied to cultured A549 cells, which were analyzed after 3 h of incubation. Viability was measured by MTT assay, the gene expressions were evaluated by real-time PCR, and spectrophotometric techniques were used for biochemical assessments. Results: While CS exposure markedly reduced …

Effect Of Pioglitazone, Quercetin, And Hydroxy Citric Acid On Vascular Endothelial Growth Factor Messenger Rna (Vegf Mrna) Expression In Experimentally Induced Nonalcoholic Steatohepatitis (Nash)*, Surapaneni Krishna Mohan, Vishnu Priya Veeraraghavan, Mallika Jainu

Turkish Journal of Medical Sciences

Background/aim: Vascular endothelial growth factor (VEGF) is associated with various ischemic and inflammatory diseases, and plays an important role in the development of liver fibrosis and hepatocarcinogenesis in nonalcoholic steatohepatitis (NASH). In this study, the comparative effect of pioglitazone, quercetin, and hydroxy citric acid on VEGF mRNA in experimentally induced NASH was investigated. Materials and methods: The experimental protocol consisted of five groups: control, NASH, NASH + pioglitazone, NASH + quercetin, and NASH + hydroxy citric acid. The VEGF mRNA expression was evaluated by reverse transcription polymerase chain reaction (RT-PCR) analysis for all experimental groups, and the levels of VEGF …

Comparison Of The Contamination Rates Of Culture Media Used For Isolation And Identification Of Dermatophytes, Ramazan Gümral, Ayli̇n Döğen, Mehmet Maci̇t İlki̇t

Turkish Journal of Medical Sciences

Background/aim: Mycological media that promote spore production are essential for the diagnosis of dermatophytosis. However, these culture media frequently become contaminated by multiple fungal or bacterial species during culture. The aim of this study was to compare the contamination rates of 6 culture media used for the isolation and identification of dermatophytes, including Borelli's lactritmel agar (BLA), brain-heart infusion agar (BHIA), Lowenstein-Jensen agar (LJA), malt extract agar (MEA), potato dextrose agar (PDA), and Sabouraud glucose agar (SGA). Materials and methods: Agar plates were inoculated with 43 well-characterized dermatophyte strains, belonging to the genera Arthroderma, Epidermophyton, Microsporum, or Trichophyton. The agar …

Elevated Serum Matrix Metalloproteinase-2 And -9 And Their Correlationswith Severity Of Disease In Patients With Community-Acquired Pneumonia, Haci Ahmet Bi̇rcan, Müni̇re Çakir, İlkay Yilmazer Kapulu, Recep Sütcü, Selçuk Kaya, Önder Öztürk

Turkish Journal of Medical Sciences

Background/aim: To determine the role of matrix metalloproteinases (MMPs) and their relationship with the clinical course of community-acquired pneumonia (CAP). Materials and methods: Sixty-two consecutively hospitalized patients with CAP were enrolled and their pneumonia severity index (PSI), time to clinical stability (TCS), treatment response, and complications were recorded. The pre- and posttreatment serum concentrations of MMPs and their inhibitors were analyzed by ELISA. The activities of MMPs were evaluated by gelatin zymography. Results: MMP-2 and -9 serum levels and their activities were higher in CAP patients than controls (P < 0.001 and P < 0.001, respectively). Low-risk patients had lower levels of MMP-2 and TIMP-1 than high-risk patients (P = 0.044, P = 0.001, respectively). Pretreatment serum TIMP-1 level was higher in patients with TCS of >3 days (P = 0.004) and was correlated with oxygenation and …

Sp1 Binding Site Polymorphism Of A Collagen Gene (Rs 1800012) In Womenaged 45 And Over And Its Association With Bone Density, Morteza Dehghan, Razieh Pourahmad-Jaktaji

Turkish Journal of Medical Sciences

Background/aim: Sp1 polymorphism of type I collagen genes is accompanied with bone c??ollagen disorders and severe clinical phenotypes such as osteogenesis imperfecta. The aim of this study was to study the association between COLIA1 Sp1 polymorphism and bone density rate. Materials and methods: In this descriptive, analytical study conducted in 2013 in southwestern Iran, 200 blood samples, per the Cochran sample size formula, were taken from women aged 45 and older. DNA was extracted from the samples using the phenol-chloroform method and the genomic fragments in question were proliferated using the polymerase chain reaction (PCR) method. Results: The genotype distribution …

Efficacy Of Diffusion-Weighted Magnetic Resonance Imaging In The Evaluation Of Extrahepatic Cholestasis-Related Hepatic Fibrosis, Süleyman Ayvaz, Sedat Alpaslan Tuncel, Güray Can, Beki̇r Çağli, Turan Karaca, Seli̇m Demi̇rtaş, Muhammed Elmaoğlu, Mehmet Ercüment Ünlü, Mehmet Pul

Turkish Journal of Medical Sciences

Background/aim: To investigate the efficacy of diffusion-weighted magnetic resonance imaging (DWI) in the diagnosis and staging of fibrosis induced by experimental bile duct ligation (BDL). Materials and methods: Twenty-four rats were divided randomly into four groups: control, BDL - 3 days, BDL - 2 weeks, and BDL - 4 weeks. DWI was performed with b-values of 100 and 500 on the rats from control group at day zero, on the rats from the BDL - 3 days group at the end of day 3, on the rats from the BDL - 2 weeks group at the end of day 14, …

Multidrug Resistance And Integron Carriage In Clinical Isolates Ofpseudomonas Aeruginosa In Tehran, Iran, Somayeh Moazami Goudarzi, Fereshteh Eftekhar

Turkish Journal of Medical Sciences

Background/aim: Pseudomonas aeruginosa is the cause of 10% of hospital-acquired infections. The organisms are often multidrug-resistant, mediated mostly by antibiotic-resistant integrons. The aim of this research was to study integron carriage and its association with multidrug resistance in burn and nonburn clinical isolates of P. aeruginosa. Materials and methods: A total of 112 P. aeruginosa clinical isolates were collected from the Motahari and Shohadaye Tajrish hospitals in Tehran between July and December 2011. Antibiotic susceptibility to 13 antibiotics was determined by disk diffusion. Detection of integron classes 1 and 2 and amplifications of internal variable regions (IVRs) of class 1 …

The Effects Of Aspirin, Flurbiprofen, And No-Donating Acetylsalicylic Acid(Ncx 4016) On Mice Models Of Endotoxic And Septic Shock, Nadi̇r Ulu, Alper Bektaş İski̇t, Cenk Sökmensüer, Mustafa Oğuz Güç

Turkish Journal of Medical Sciences

Background/aim: Nitric oxide-donating nonsteroidal antiinflammatory drugs (NO-NSAIDs) are a promising new class of antiinflammatory agents, which are obtained by adding NO-donating moieties to the existing conventional NSAID molecules. The aim of this study was to investigate the effects of aspirin, flurbiprofen, and NO-donating acetylsalicylic acid (NCX 4016) on cecal ligation and puncture (CLP) and endotoxin-induced septic shock (LPS) models in mice. Materials and methods: Overall survival and spleen and liver weights were monitored in LPS and CLP models. Histopathological examinations of liver and spleen were performed at the end of the experimental protocols. Results: NCX 4016 was able to reverse …

The Risk Of Tumor Cell Dissemination In Mediastinoscopy: A Cytological Study, Yasemi̇n Bi̇lgi̇n Büyükkarabacak, Ayşen Taslak Şengül, Bi̇lge Can Meydan, Burçi̇n Çeli̇k, Mehmet Gökhan Pi̇rzi̇renli̇, Selçuk Gürz, Zeynep Peli̇n Sürücü, Ahmet Başoğlu

Turkish Journal of Medical Sciences

Background/aim: Mediastinoscopy is an invasive procedure that is used in the diagnosis of mediastinal diseases and in staging lung cancer. Tumor cell seeding during mediastinoscopy along the mediastinum and the incision line is a very rare complication. This study aimed to test the safety of mediastinoscopy in terms of tumor seeding by cytological evaluation of mediastinal lavage samples taken before and after biopsy. Materials and methods: The patients who underwent mediastinoscopy in our hospital between 2011 and 2014 were studied prospectively. Seventy-three patients with a diagnosis of lung or mediastinal malignancy were included in the study. All patients underwent classical …

Acute Tuberculosis In The Intensive Care Unit, Kazim Rollas, Ati̇la Kara, Nazmi̇ye Ebru Ortaç Ersoy, Kezban Özmen Süner, Mehmet Nezi̇r Güllü, Serpi̇l Öcal, Arzu Topeli̇

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to determine mortality rates and to evaluate clinical features of patients with active tuberculosis (TB) requiring intensive care unit (ICU) admission. Materials and methods: The medical records of active TB patients requiring ICU admission were retrospectively reviewed over a 5-year period. Results: Sixteen patients with active TB admitted to the ICU were included in the study. Seven (43.8%) patients died in the ICU. The cause of mortality was septic shock in 5 patients and respiratory failure in 2 patients. The Acute Physiology and Chronic Health Evaluation II (APACHE II) and Sequential Organ Failure …

The Relation Between Oxidative Stress Parameters, Ischemic Stroke,And Hemorrhagic Stroke, Ferhat İçme, Özcan Erel, Akkan Avci̇, Sali̇m Satar, Müge Gülen, Selen Acehan

Turkish Journal of Medical Sciences

Background/aim: The aims of this study were to investigate the significance of oxidative stress parameters in the pathogenesis of ischemic stroke and hemorrhagic stroke and to investigate their effects on stroke severity using the National Institutes of Health Stroke Scale (NIHSS). Materials and methods: A total of 92 patients, including 74 with ischemic stroke and 18 with hemorrhagic stroke, and 75 volunteers were enrolled in the study. Total oxidant status (TOS), total antioxidant status (TAS), paraoxonase, stimulating paraoxonase, arylesterase, and thiol levels were measured in both the patient and volunteer groups. NIHSS and oxidative stress index (OSI) scores were calculated. …

Investigation Of The Effect Of Changes In Muscle Strength In Gestational Ageupon Fear Of Falling And Quality Of Life, Emrah Atay, Fatma Başalan İz

Turkish Journal of Medical Sciences

Background/aim: The aim of this study is the investigation of the effect of changes in muscle strength in gestational age upon fear of falling and quality of life. Materials and methods: This longitudinal, descriptive study included a sample of 37 pregnant women who volunteered to participate. The research data were collected at 20 and 32 weeks of gestation. Data collection instruments included a newly developed questionnaire form, the Tinetti Falls Efficacy Scale, a visual analog scale, and the Turkish language version of the WHO Quality of Life Scale. Upper body flexibility was measured by the back scratch test, while muscle …

Alzheimer Disease, Inflammation, And Novel Inflammatory Marker: Resistin, Muhammet Cemal Kizilarslanoğlu, Özgür Kara, Yusuf Yeşi̇l, Mehmet Emi̇n Kuyumcu, Zeynel Abi̇di̇n Öztürk, Mustafa Cankurtaran, Samed Rahatli, Nagehan Pakaşti̇çali, Esat Çinar, Meltem Gülhan Hali̇l, Burçi̇n Şener, Eylem Şahi̇n Cankurtaran, Servet Arioğul

Turkish Journal of Medical Sciences

Background/aim: Inflammation may play an important role in Alzheimer disease (AD) pathogenesis. A growing amount of evidence indicates that resistin has hallmark regulatory functions such as inflammatory states. The aim of this study was to determine whether plasma resistin levels would be useful in the diagnosis of patients with AD and to investigate the relationships between resistin and other inflammatory markers such as hs-CRP and TNF-α. Materials and methods: In this cross-sectional study, 38 AD patients and 32 control subjects with normal cognitive function aged 65 years and over were included. The diagnosis of AD was made according to DSM-IV …

Plasma 8-Isopgf2? And Serum Melatonin Levels In Patients With Minimal Cognitive Impairment And Alzheimer Disease, Fevzi̇ye Burcu Şi̇ri̇n, Duygu Kumbul Doğuç, Hüseyi̇n Vural, İbrahi̇m Eren, İkbal İnanli, Recep Sütcü, Namik Deli̇baş

Turkish Journal of Medical Sciences

Background/aim: F2α-isoprostane is accepted as an oxidative stress indicator and melatonin shows neuroprotective effects by antioxidative and antiamyloidogenic influences. By measuring these in patients diagnosed with minimal cognitive impairment (MCI) and Alzheimer-type dementia, we intended to demonstrate whether the measurement of these markers contributes to early diagnosis of Alzheimer disease (AD) in the MCI stage or not. Materials and methods: Three groups (n = 63) were created: the AD group, MCI group, and control group. Serum melatonin levels were measured by radioimmunoassay method, and plasma total 8-isoPGF2α levels were measured by enzyme immunoassay method. Results: Significant differences were observed in …

The Effects And Interactions Of Apoe And Aph-1a Polymorphisms In Alzheimer Disease, Burcu Acar Çi̇nleti̇, Ni̇lgül Yardimci, Zübeyde Aytürk, Ati̇lla İlhan, Gülhan Kaya, Muradi̇ye Acar, Emi̇ne Rabi̇a Koç, Esra Gündüz, Mehmet Gündüz

Turkish Journal of Medical Sciences

Background/aim: Alzheimer disease (AD) is characterized by the accumulation of senile plaques composed of amyloid β-peptide, which is derived from β-amyloid precursor protein through degradation by β-secretase and γ-secretase complexes. One of the major components of γ-secretase complex, anterior pharynx-defective-1 (APH-1), is responsible for the activity of the γ-secretase complex. In this study, we searched for not only the most known common genetic risk factor, APOE, but also the APH-1a gene polymorphism in AD patients in a Turkish population. Materials and methods: In this study, 49 AD patients and 45 healthy controls were included. The genetic polymorphisms and allele frequencies …

Effect Of Capparis Spinosa L. On Cognitive Impairment Induced By D-Galactosein Mice Via Inhibition Of Oxidative Stress, Nergi̇z Hacer Turgut, Haki̇ Kara, Emre Arslanbaş, Derya Güli̇z Mert, Bektaş Tepe, Hüseyi̇n Güngör

Turkish Journal of Medical Sciences

Background/aim: To determine the phenolic acid levels and DNA damage protection potential of Capparis spinosa L. seed extract and to investigate the effect of the extract on cognitive impairment and oxidative stress in an Alzheimer disease mice model. Materials and methods: Thirty BALB/c mice divided into 5 groups (control??, D-galactose, D-galactose + C. spinosa 50, D-galactose + C. spinosa 100, D-galactose + C. spinosa 200) were used. Mice were administered an injection of D-galactose (100 mg/kg, subcutaneous) and orally administered C. spinosa (50, 100, or 200 mg/kg) daily for 8 weeks. Results: Syringic acid was detected and the total amount …

Molecular Docking And Ex Vivo And In Vitro Anticholinesterase Activity Studies Ofsalvia Sp. And Highlighted Rosmarinic Acid, Lütfi̇ye Ömür Demi̇rezer, Peri̇han Gürbüz, Emi̇ne Peli̇n Keli̇cen Uğur, Mi̇ne Bodur, Nadi̇re Özenver, Ayşe Uz, Zühal Güvenalp

Turkish Journal of Medical Sciences

Background/aim: To evaluate acetylcholinesterase (AChE) inhibitory activity and antioxidant capacity of the major molecule from Salvia sp., rosmarinic acid, as a drug candidate molecule for treatment of Alzheimer disease (AD). Materials and methods: The AChE inhibitory activity of different extracts from Salvia trichoclada, Salvia verticillata, and Salvia fruticosa was determined by the Ellman and isolated guinea pig ileum methods, and the antioxidant capacity was determined with DPPH. The AChE inhibitory activity of the major molecule rosmarinic acid was determined by in silico docking and isolated guinea pig ileum methods. Results: The methanol extract of Salvia trichoclada showed the highest inhibition …

Fcs 1800 : Lifespan Human Development, Fcs

Approved Course Proposals

No abstract provided.

Chm 3300 : Survey Of Biochemistry, Chemistry And Biochemistry

Approved Course Proposals

No abstract provided.

Investigation Of The Protective Effect Of Erdosteine Against Cyclosporine-Inducedinjury In Rat Liver With Histological And Biochemical Methods, Ahmet Nacar, İhsan Karaboğa, Hamza Mali̇k Okuyan, Nebi̇hat Kaplan Sefi̇l, Emel Nacar, Sedat Motor, Seçki̇n Akküçük, Orhan Veli̇ Özkan

Turkish Journal of Medical Sciences

Background/aim: In the present study, the protective effect of erdosteine against cyclosporine-induced injury in rat liver was investigated with histological and biochemical methods. Materials and methods: Thirty-two Wistar albino male rats were randomly divided into 4 groups: control (n = 8), cyclosporine (n = 8, 20 mg kg-1 day-1 i.p.), cyclosporine + erdosteine (n = 8, erdosteine 12 mg kg-1 day-1 orally), and erdosteine (n = 8). At the end of day 12, liver tissues were removed for histological and biochemical analysis. After liver tissues were fixed in 10% buffered neutral formalin, routine histological processes were applied and tissue sections …

Developing A Framework For Stigmergic Human Collaboration With Technology Tools: Cases In Emergency Response, Janet Hinda Watkins Marsden

Dissertations - ALL

Information and Communications Technologies (ICTs), particularly social media and geographic information systems (GIS), have become a transformational force in emergency response. Social media enables ad hoc collaboration, providing timely, useful information dissemination and sharing, and helping to overcome limitations of time and place. Geographic information systems increase the level of situation awareness, serving geospatial data using interactive maps, animations, and computer generated imagery derived from sophisticated global remote sensing systems. Digital workspaces bring these technologies together and contribute to meeting ad hoc and formal emergency response challenges through their affordances of situation awareness and mass collaboration. Distributed ICTs that enable …

Practical Identity And Meaninglessness, Kirsten Egerstrom

Dissertations - ALL

While research on meaningfulnesss in life is becoming increasingly popular in analytic philosophy, there is still a dearth of literature on the topic of meaninglessness. This is surprising, given that a better understanding of the nature of meaninglessness may help to illuminate features of meaningfulness previously unobserved or misunderstood. Additionally, the topic of meaninglessness is interesting in its own right - independent of what it can tell us about meaningfulness. In my dissertation, I construct and defend my own conception of meaninglessness.

I adopt Thaddeus Metz's (2013) analysis of meaninglessness presented in his new book, Meaning in Life: An Analytic …

"The Terror Within:" Neoliberalism And The Rhetoric Of The Obesity Crisis, Anna Hensley

Dissertations - ALL

This dissertation focuses on specific discourses within the rhetoric of the "obesity crisis" that position the fat body as a threat to U.S. military power and national identity. Since 9/11, there has been a growing rhetoric that frames obesity as a threat to national security that is weakening U.S. military forces and straining the U.S. economy through increased health care costs and lower worker productivity. Drawing on research from rhetorical studies, transnational feminism, and disability studies that highlight the way that discourses surrounding the body are used to limit access to citizenship and rhetorical agency, this research analyzes the material …

Collective Phenomena In Active Systems, Xingbo Yang

Dissertations - ALL

This dissertation investigates collective phenomena in active systems of biological relavance across length scales, ranging from intracellular actin systems to bird flocks. The study has been conducted via theoretical modeling and computer simulations using tools from soft condensed matter physics and non-equilibrium statistical mechanics. The work has been organized into two parts through five chapters. In part one (chapter 2 to 3), continuum theories have been utilized to study pattern formation in bacteria suspensions, actomyosin systems and bird flocks, whose dynamics is described generically within the framework of polar active fluids. The continuum field equations have been written down phenomenogically …

Designing Core/Alloy Nanoparticles By Manipulation Of Interfacial Oxidation And Atomic Diffusion, Rahiem Davon Slaton

Dissertations - ALL

Alloying presents a unique opportunity to combine the chemical and physical properties of two or more metals into one material. This phenomenon can also be used for multi-metallic nanoparticles (NPs), where in conjunction with the size effects induced by quantum confinement, new properties or phase behavior can emerge. The properties of nanoalloys are highly dependent on their composition and morphology, which are contingent upon the method in which they are synthesized. Finding ways to control, or even design, the composition and morphology of nanoalloys could potentially open the door for a standardized approach for creating nanomaterials with unique and desirable …

A Private Right Of Action For Informed Consent In Research, Valerie Gutmann Koch

Seton Hall Law Review

No abstract provided.

Hst 3500 : Human Sexuality, Health Studies

Approved Course Proposals

No abstract provided.

Fcs 2850 : Child Development, Fcs

Approved Course Proposals

No abstract provided.

Bct 5000 : Techniques In Biotechnology, Biological Sciences

Approved Course Proposals

No abstract provided.