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2015

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Diagnostic And Prognostic Value Of Procalcitonin And Strem-1 Levels In Sepsis*, Hali̇m Bayram, Özlem Tünger, Melek Çi̇vi̇, Müni̇p Hakan Yüceyar, Cevval Ulman, Gönül Di̇nç Horasan, Çi̇ğdem Banu Çeti̇n Jan 2015

Diagnostic And Prognostic Value Of Procalcitonin And Strem-1 Levels In Sepsis*, Hali̇m Bayram, Özlem Tünger, Melek Çi̇vi̇, Müni̇p Hakan Yüceyar, Cevval Ulman, Gönül Di̇nç Horasan, Çi̇ğdem Banu Çeti̇n

Turkish Journal of Medical Sciences

Background/aim: Sepsis is still a major cause of morbidity and mortality despite the improvements in diagnosis and treatment. The aim of this study was to investigate the values of procalcitonin and soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in the differential diagnosis of patients with sepsis and noninfectious systemic inflammatory response syndrome (NI-SIRS) and measure their importance in the prognosis of patients with sepsis. Materials and methods: This prospective study included 41 NI-SIRS and 33 sepsis patients hospitalized in Celal Bayar University Hospital, Manisa, Turkey. Blood samples were taken from NI-SIRS patients on days 0 and 3 and from …


Correlation Between Antibiotic Resistance And Virulence Ofpseudomonas Aeruginosa Clinical Isolates, Fatma Ibrahim Sonbol, Maha Abd El Fattah Khalil, Abdelfattah Badr Mohamed, Sameh Samir Ali Jan 2015

Correlation Between Antibiotic Resistance And Virulence Ofpseudomonas Aeruginosa Clinical Isolates, Fatma Ibrahim Sonbol, Maha Abd El Fattah Khalil, Abdelfattah Badr Mohamed, Sameh Samir Ali

Turkish Journal of Medical Sciences

Background/aim: Virulent Pseudomonas aeruginosa is frequently life-threatening and often challenging to treat, and the emergence of multidrug-resistant isolates presents a critical problem for patients. The aim of the study was concerned with molecular analysis of the virulence factors and antimicrobial resistance profile of multidrug-resistant P. aeruginosa (MDRPA). Materials and methods: Out of 44 MDRPA isolates, 12 isolates representing different resistance profiles and sources of samples were selected for further molecular studies. Polymerase chain reaction (PCR) approaches were applied to identify the genes implicated in antimicrobial resistance or virulence factors in the selected MDRPA isolates. Results: Multidrug-resistance (pstS), ß-lactamase (IMP7, IMP10, …


Effects Of Grape Seed Extract On Oxidative Stress And Antioxidant Defensemarkers In Streptozotocin-Induced Diabetic Rats, Muaz Belvi̇ranli, Hakki Gökbel, Ni̇lsel Okudan, Sadik Büyükbaş Jan 2015

Effects Of Grape Seed Extract On Oxidative Stress And Antioxidant Defensemarkers In Streptozotocin-Induced Diabetic Rats, Muaz Belvi̇ranli, Hakki Gökbel, Ni̇lsel Okudan, Sadik Büyükbaş

Turkish Journal of Medical Sciences

Background/aim: To evaluate the effects of grape seed extract (GSE) supplementation on oxidative stress and antioxidant markers in streptozotocin (STZ)-induced diabetic rats. Materials and methods: Thirty-six male rats were divided into the following four groups: control, GSE-supplemented control, diabetic, and GSE-supplemented diabetic. Beginning on day 7 after STZ injection, the rats were administered GSE (100 mg kg-1 day-1) in drinking water for 6 weeks. At the end of week 6, rats were sacrificed by cardiac puncture. Plasma nitric oxide (NO) levels and xanthine oxidase (XO), adenosine deaminase (ADA), and glutathione peroxidase (GPx) activities were analyzed. Results: Both XO and ADA …


In Vitro Efficacy Of Frozen Erythrocytes: Implementation Of New Strategicblood Stores To Alleviate Resource Shortage (Issue Revisited), Riza Aytaç Çeti̇nkaya, Soner Yilmaz, İbrahi̇m Eker, Ayteki̇n Ünlü, Meti̇n Uyanik, Serkan Tapan, Ahmet Pekoğlu, Ali̇ye Aysel Pekel, Zerri̇n Ertaş, Orhan Gürsel, Uğur Haci̇ Muşabak, Sebahatti̇n Yilmaz, İsmai̇l Yaşar Avci, Ahmet Türker Çeti̇n, Can Polat Eyi̇gün Jan 2015

In Vitro Efficacy Of Frozen Erythrocytes: Implementation Of New Strategicblood Stores To Alleviate Resource Shortage (Issue Revisited), Riza Aytaç Çeti̇nkaya, Soner Yilmaz, İbrahi̇m Eker, Ayteki̇n Ünlü, Meti̇n Uyanik, Serkan Tapan, Ahmet Pekoğlu, Ali̇ye Aysel Pekel, Zerri̇n Ertaş, Orhan Gürsel, Uğur Haci̇ Muşabak, Sebahatti̇n Yilmaz, İsmai̇l Yaşar Avci, Ahmet Türker Çeti̇n, Can Polat Eyi̇gün

Turkish Journal of Medical Sciences

Background/aim: Currently, the provision of blood products largely depends on walking blood banks and limited amounts of stored blood with short shelf lives. We aimed to compare the efficacy of erythrocyte concentrate (ECs) by pre- and postfreezing in vitro tests. Materials and methods: In our study, 10 ECs were glycerolized, frozen, thawed, and then deglycerolized using the Naval Blood Research Laboratory method. In addition to using the standard tests, ATP and 2,3-DPG levels and the viability of erythrocytes were also determined. Results: The prefreezing mean viability rates of erythrocytes changed from 89.7 ± 13.7% to 98.6 ± 1.8% after thawing …


Comparison Of Endometrial Biopsies Of Fertile Women And Womenwith Repeated Implantation Failure At The Ultrastructural Level, Leyla Bahar, Semra Kahraman, Nazan Eras, Caroline Pirkevi Jan 2015

Comparison Of Endometrial Biopsies Of Fertile Women And Womenwith Repeated Implantation Failure At The Ultrastructural Level, Leyla Bahar, Semra Kahraman, Nazan Eras, Caroline Pirkevi

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to compare the cellular properties of endometrial tissues from fertile patients and patients having at least 3 previous in vitro fertilization failures, during the implantation window. The ultrastructural evaluation of the endometrium in the implantation window may shed light on the complexity of the implantation failure paradigm. Materials and methods: The study involved 23 women, 14 infertile with a clinical diagnosis of repeated implantation failure (RIF) and 9 fertile, defined as the control group. Endometrial samples were examined by transmission electron microscopy (TEM). Results: In the control group, secretory vacuoles and cytoplasmic projections …


Suspension Of Arthroderma And Trichophyton Species In Rpmi-1640medium Provided Long-Term Viability At Room Temperature, Çağri Ergi̇n, Mehmet Maci̇t İlki̇t Jan 2015

Suspension Of Arthroderma And Trichophyton Species In Rpmi-1640medium Provided Long-Term Viability At Room Temperature, Çağri Ergi̇n, Mehmet Maci̇t İlki̇t

Turkish Journal of Medical Sciences

No abstract provided.


Effects Of Turkish Propolis On Expression Of Hogg-1 And Neil-1, İbrahi̇m Turan, Orhan Değer, Yüksel Ali̇yazicioğlu, Seli̇m Demi̇r, Kağan Kilinç, Ayşegül Sümer Jan 2015

Effects Of Turkish Propolis On Expression Of Hogg-1 And Neil-1, İbrahi̇m Turan, Orhan Değer, Yüksel Ali̇yazicioğlu, Seli̇m Demi̇r, Kağan Kilinç, Ayşegül Sümer

Turkish Journal of Medical Sciences

Background/aim: Propolis is a bee product with antioxidative, antimutagenic, and other beneficial properties, and it is used as a natural drug. It is rich in polyphenolic compounds. Its composition varies depending on the particular geographical region. Oxidative stress is caused by an imbalanced free radical production and antioxidant system. The effects of flavonoids on the expression of DNA repair enzymes have been examined previously; however, no study has investigated the effects of propolis. This study investigated the effects of ethanolic extracts of Turkish propolis (EEP) on the expression of DNA repair enzymes. Materials and methods: The effects of EEP and …


Evaluation Of Gcf Mmp-1, Mmp-8, Tgf-Ss1, Pdgf-Ab, And Vegf Levels In Periodontally Healthy Smokers, Gülni̇hal Eren, Hati̇ce Oya Türkoğlu, Hari̇ka Atmaca, Fatma Gül Ati̇lla Jan 2015

Evaluation Of Gcf Mmp-1, Mmp-8, Tgf-Ss1, Pdgf-Ab, And Vegf Levels In Periodontally Healthy Smokers, Gülni̇hal Eren, Hati̇ce Oya Türkoğlu, Hari̇ka Atmaca, Fatma Gül Ati̇lla

Turkish Journal of Medical Sciences

Background/aim: The effect of smoking on inflammatory biomarkers in gingival crevicular fluid (GCF) is well established in the presence of periodontal inflammation. However, it is not clear if smoking has an influence on matrix metalloproteinase (MMP) and growth factor levels in the GCF of periodontally healthy subjects. The aim of this study was to investigate GCF levels of MMP-1, MMP-8, transforming growth factor (TGF)-ß1, platelet-derived growth factor (PDGF)-AB, and vascular endothelial growth factor (VEGF) in smoking versus nonsmoking periodontally healthy subjects. Materials and methods: Thirty-two periodontally healthy subjects were included in this study. Probing depths, bleeding on probing, and plaque …


A Study Of The Effect Of Bacillus Thuringiensis Serotype H14 (Subspecies Israelensis)Delta Endotoxin On Musca Larva, Mohammad Reza Mehrabi, Laya Zoghimofrad, Mahboubeh Mazinani, Azim Akbarzadeh, Amirabbas Rahimi Jan 2015

A Study Of The Effect Of Bacillus Thuringiensis Serotype H14 (Subspecies Israelensis)Delta Endotoxin On Musca Larva, Mohammad Reza Mehrabi, Laya Zoghimofrad, Mahboubeh Mazinani, Azim Akbarzadeh, Amirabbas Rahimi

Turkish Journal of Medical Sciences

Background/aim: House flies (Musca domestica) are of major public health concern in areas with poor sanitation and hygiene conditions. Biological control through the use of parasitoids and pathogens is one of the alternatives to the use of chemical pesticides for control of insects of public health importance. Materials and methods: The effects of the delta endotoxin of Bacillus thuringiensis on house fly larval mortality were studied. Gel filtration and SDS-PAGE methods were used for separation and purification of proteins. Delta endotoxin was incubated with larvae in concentrations of 0.43 mg/mL and 0.27 mg/mL in bioassay tests. Results: The results of …


Effects Of Melatonin And Theanine Administration On Pentylenetetrazole-Inducedseizures And Brain Tissue Oxidative Damage In Ovariectomized Rats, Shadi Choopankareh, Farzaneh Vafaee, Mohammad Naser Shafei, Hamid Reza Sadeghnia, Reza Salarinia, Leila Zarepoor, Mahmoud Hosseini Jan 2015

Effects Of Melatonin And Theanine Administration On Pentylenetetrazole-Inducedseizures And Brain Tissue Oxidative Damage In Ovariectomized Rats, Shadi Choopankareh, Farzaneh Vafaee, Mohammad Naser Shafei, Hamid Reza Sadeghnia, Reza Salarinia, Leila Zarepoor, Mahmoud Hosseini

Turkish Journal of Medical Sciences

Background/aim: The effects of coadministration of melatonin and theanine (Mel/Thea) on pentylenetetrazole (PTZ)-induced seizures and brain tissue oxidative damage were investigated in ovariectomized (OVX) and sham-operated rats. Materials and methods: The rats were divided into the following groups: 1) sham, 2) ovariectomized (OVX), 3) sham-PTZ, 4) OVX-PTZ, 5) sham-Mel/Thea-PTZ, and 6) OVX-Mel/Thea-PTZ. Groups 1-4 received saline, while groups 5 and 6 received a combination of Mel/Thea for 6 weeks. All animals except for those in groups 1 and 2 received a single injection of PTZ. Results: The OVX-PTZ group had higher generalized tonic-clonic seizure (GTCS) latency compared to the sham-PTZ …


Hepatoprotective And Antioxidant Effects Of Lycopene In Acute Cholestasis, Mehmet Tokaç, Sevtap Aydin, Gökçe Taner, Alper Bi̇lal Özkardeş, Mi̇ne Yavuz Taşlipinar, Mehmet Doğan, Hali̇t Zi̇ya Dündar, Mehmet Kiliç, Ari̇f Ahmet Başaran, Ayşe Nurşen Başaran Jan 2015

Hepatoprotective And Antioxidant Effects Of Lycopene In Acute Cholestasis, Mehmet Tokaç, Sevtap Aydin, Gökçe Taner, Alper Bi̇lal Özkardeş, Mi̇ne Yavuz Taşlipinar, Mehmet Doğan, Hali̇t Zi̇ya Dündar, Mehmet Kiliç, Ari̇f Ahmet Başaran, Ayşe Nurşen Başaran

Turkish Journal of Medical Sciences

Background/aim: Lycopene, which is suggested to be a potent antioxidant, may play a protective role in diseases related to oxidative stress. In order to understand the effects of lycopene in the pathogenesis of cholestasis, we investigated the effects of lycopene on oxidative stress parameters and DNA damage induced by experimental biliary obstruction in the liver tissues and the lymphocytes of Wistar albino rats. Materials and methods: The animals were randomized into 3 groups. The sham group was subjected to a sham operation, the BDL group was subjected to bile duct ligation (BDL), and the BDL+L group was subjected to BDL …


Antibiofilm Activity Of Trans-Cinnamaldehyde, P-Coumaric, And Ferulic Acids On Uropathogenic Escherichia Coli, Barbara Kot, Jolanta Wicha, Malgorzata Piechota, Katarzyna Wolska, Agata Gruzewska Jan 2015

Antibiofilm Activity Of Trans-Cinnamaldehyde, P-Coumaric, And Ferulic Acids On Uropathogenic Escherichia Coli, Barbara Kot, Jolanta Wicha, Malgorzata Piechota, Katarzyna Wolska, Agata Gruzewska

Turkish Journal of Medical Sciences

Background/aim: Biofilm on urinary catheters results in persistent infections that are resistant to antibiotics. In this study, phytochemicals were assessed as alternative antimicrobials in preventing and inactivating E. coli biofilm on urinary catheters. Materials and methods: Biofilm prevention was tested using catheter fragments inoculated with E. coli and treated with trans-cinnamaldehyde, p-coumaric, and ferulic acids (0%, 0.1%, 0.25%, and 0.5%) for 0, 1, 3, and 5 days. Inactivation of E. coli biofilm with the same agents at concentrations of 0%, 1%, 1.25%, or 1.5% used for 0, 1, 3, or 5 days was also evaluated. Results: All used concentrations of …


Periocular Changes In Topical Bimatoprost And Latanoprost Use, Meli̇sa Zi̇şan Karslioğlu, Melek Banu Hoşal, Oya Tekeli̇ Jan 2015

Periocular Changes In Topical Bimatoprost And Latanoprost Use, Meli̇sa Zi̇şan Karslioğlu, Melek Banu Hoşal, Oya Tekeli̇

Turkish Journal of Medical Sciences

Background/aim: To evaluate the periocular changes due to topical bimatoprost and latanoprost use and to investigate their effects on the lacrimal drainage system. Materials and methods: All participants (69 eyes of 43 patients, 52 eyes of 26 controls) were classified into three groups: bimatoprost (0.03%) users, latanoprost (0.005%) users, and healthy controls. Each patient was examined before prostaglandin therapy, and then at the first, third, sixth, and twelfth month of therapy. Palpebral fissure height, upper eyelid crease, and levator function were measured, and lacrimal system drainage irrigation was performed. Periocular hyperpigmentation and upper eyelid sulcus were also examined. Results: No …


Potential Genetic Biomarkers In The Early Diagnosisof Alzheimer Disease: Apoe And Bin1, Gülhan Kaya, Esra Gündüz, Muradi̇ye Acar, Ömer Faruk Hati̇poğlu, Burcu Acar, Ati̇lla İlhan, Mehmet Gündüz Jan 2015

Potential Genetic Biomarkers In The Early Diagnosisof Alzheimer Disease: Apoe And Bin1, Gülhan Kaya, Esra Gündüz, Muradi̇ye Acar, Ömer Faruk Hati̇poğlu, Burcu Acar, Ati̇lla İlhan, Mehmet Gündüz

Turkish Journal of Medical Sciences

Background/aim: Alzheimer disease (AD) is triggered by interactions of multiple genetic and environmental factors. The APOE gene E4 allele is the best-known risk factor for AD, yet it represents a small ratio of genetic factors. According to genome-wide association studies, the BIN1 gene is the second important risk factor for AD, following the APOE gene. We aimed to identify a novel biomarker indicating susceptibility to AD by investigating APOE alleles and BIN1 gene polymorphisms in a Turkish population. Materials and methods: Fifty-three AD patients and 56 controls were included to examine polymorphism and allele frequency of the APOE and BIN1 …


Nerve Growth Factor Receptors In Dementia, Manoochehr Messripour, Abolfazl Nazarian, Azadeh Mesripour, Iman Mohammadi Jan 2015

Nerve Growth Factor Receptors In Dementia, Manoochehr Messripour, Abolfazl Nazarian, Azadeh Mesripour, Iman Mohammadi

Turkish Journal of Medical Sciences

Background/aim: Nerve growth factor (NGF) promotes the survival and differentiation of sensory and sympathetic neurons. Several studies have found that certain neuropathological factors stimulate NGF receptor expression and release the truncated nerve growth factor receptor (TNGFR) to biological fluids. The aim of this pilot study was to determine urine TNGFR levels in patients with dementia and to verify whether TNGFR can be used as a biomarker of dementia. Materials and methods: Twelve patients with dementia and 12 healthy individuals were asked to voluntarily participate in this study. Ages, sexes, and weights were matched. The first morning urine samples were collected …


A Turkish 3-Center Study Evaluation Of Serum Folic Acid And Vitamin B12 Levels In Alzheimer Disease, Nuri̇ye Nuray Ulusu, Gökhan Yilmaz, Zübeyde Erbayraktar, Ahmet Turan Evli̇ce, Sevgi̇ Aras, Görsev Yener, Aslihan Avci Jan 2015

A Turkish 3-Center Study Evaluation Of Serum Folic Acid And Vitamin B12 Levels In Alzheimer Disease, Nuri̇ye Nuray Ulusu, Gökhan Yilmaz, Zübeyde Erbayraktar, Ahmet Turan Evli̇ce, Sevgi̇ Aras, Görsev Yener, Aslihan Avci

Turkish Journal of Medical Sciences

Background/aim: Alzheimer disease, a common proteopathy of advanced age, is characterized by cortical atrophy, neuron degeneration, neuronal loss, and accumulation of extracellular amyloid β plaques. We aimed to investigate serum vitamin B12 and folic acid levels in Alzheimer disease and other dementia patients, as a potential screening test to detect presymptomatic Alzheimer disease in Turkish patients. Materials and methods: We evaluated folic acid and vitamin B12 levels in Alzheimer disease patients as well as in other dementia and geriatric patients from Ankara, Dokuz Eylül, and Çukurova university hospitals; 290 female and male geriatric subjects were enrolled. Vitamin B12 and folic …


Parp Inhibition Prevents Acetaminophen-Induced Liver Injury And Increases Survival Rate In Rats, Melahat Dönmez, Bülent Uysal, Yavuz Poyrazoğlu, Yeşi̇m Er Öztaş, Türker Türker, Ümi̇t Kaldirim, Ahmet Korkmaz Jan 2015

Parp Inhibition Prevents Acetaminophen-Induced Liver Injury And Increases Survival Rate In Rats, Melahat Dönmez, Bülent Uysal, Yavuz Poyrazoğlu, Yeşi̇m Er Öztaş, Türker Türker, Ümi̇t Kaldirim, Ahmet Korkmaz

Turkish Journal of Medical Sciences

Acetaminophen (APAP) overdose results in severe liver damage that may develop into acute liver failure. Recent studies have demonstrated that inhibition of poly(ADP-ribose) polymerase (PARP) decreases tissue necrosis and inflammation. We evaluated the efficacy of 3-aminobenzamide (3-AB), a PARP inhibitor, in a rodent model of APAP-induced hepatotoxicity. Materials and methods: Twenty-four Sprague-Dawley rats were divided equally into 3 experimental groups: sham group, APAP group, and APAP + 3-AB group. In the experimental treatment groups APAP was administered orally at 1 g/kg and, in the APAP + 3-AB group, 3-AB was administered intraperitoneally at a dose of 20 mg/kg exactly 1 …


Polymorphism Characteristics Of Hiv-1 Gp120 And 5 Hypervariable Regions, Neng Yao, Chunxia Zhang, Qi Liu, Jun Liu, Chiyu Zhang Jan 2015

Polymorphism Characteristics Of Hiv-1 Gp120 And 5 Hypervariable Regions, Neng Yao, Chunxia Zhang, Qi Liu, Jun Liu, Chiyu Zhang

Turkish Journal of Medical Sciences

To investigate polymorphism characteristics of HIV-1 gp120 and its 5 hypervariable regions. Materials and methods: Length polymorphism, potential number of N-linked glycosylation sites (PNGSs), and sequence characteristics of nearly all available global gp120 and its 5 hypervariable regions from HIV-1 subtypes A, B, C, D, G, and H were analyzed. Results: We found that the majority of HIV-1 gp120s have 496-515 amino acids and 21-30 PNGSs, suggesting that a gp120 with this length might be a good virus candidate for vaccine development. Among 5 hypervariable regions, the V3 regions had the lowest levels of length polymorphism and heterogeneity and less …


Protective Effects Of Royal Jelly Against Testicular Damage In Streptozotocin-Induced Diabetic Rats, Turan Karaca, Seli̇m Demi̇rtaş, İhsan Karaboğa, Süleyman Ayvaz Jan 2015

Protective Effects Of Royal Jelly Against Testicular Damage In Streptozotocin-Induced Diabetic Rats, Turan Karaca, Seli̇m Demi̇rtaş, İhsan Karaboğa, Süleyman Ayvaz

Turkish Journal of Medical Sciences

To examine the effects of royal jelly (RJ) on testicular damage in streptozotocin (STZ)-induced diabetic rats. Materials and methods: Eighteen adult Wistar albino rats were used, 6 in each of the 3 treatment groups: Group A: control, Group B: STZ-induced diabetes (untreated), Group C: STZ-induced diabetes plus RJ (400 mg/kg daily for 4 weeks). Diabetes was induced by a single intraperitoneal injection of STZ (60 mg/kg). Four weeks after the onset of diabetes, testicular apoptotic cell death was examined using immunohistochemical staining for caspase-3 and Ki67 staining for localization of proliferative cells. Results: Compared with the control, the body and …


An In Vitro And In Vivo Investigation Of The Cytotoxic Effects Of Caffeic Acid (3,4-Dihydroxycinnamic Acid) Phenethyl Ester And Bortezomib In Multiple Myeloma Cells, Ertan Altayli, Özgür Koru, Önder Öngürü, Tayfun İde, Cengi̇zhan Açikel, Meral Sarper, Mualla Pinar Elçi̇, Rahşan Ilikçi Sağkan, Erhan Astarci, Duran Tok, Sali̇m Özenç, Ali̇ Uğur Ural, Feri̇t Avcu Jan 2015

An In Vitro And In Vivo Investigation Of The Cytotoxic Effects Of Caffeic Acid (3,4-Dihydroxycinnamic Acid) Phenethyl Ester And Bortezomib In Multiple Myeloma Cells, Ertan Altayli, Özgür Koru, Önder Öngürü, Tayfun İde, Cengi̇zhan Açikel, Meral Sarper, Mualla Pinar Elçi̇, Rahşan Ilikçi Sağkan, Erhan Astarci, Duran Tok, Sali̇m Özenç, Ali̇ Uğur Ural, Feri̇t Avcu

Turkish Journal of Medical Sciences

In this study, the in vitro and in vivo effectiveness of caffeic acid (3,4-dihydroxycinnamic acid) phenethyl ester (CAPE) in combination with bortezomib, a proteasome inhibitor, was explored in multiple myeloma (MM) cells. Materials and methods: The cytotoxic effects of CAPE and bortezomib were determined by XTT cell proliferation assay. Apoptosis levels were analyzed with annexin V-fluorescein isothiocyanate, nuclear factor kappa beta (NF-\kappaB) was analyzed with electrophoretic mobility-shift assay, and interleukin (IL)-6 levels were analyzed with enzyme-linked immunosorbent assay to evaluate CAPE's mechanism of action. To investigate the in vivo effectiveness of CAPE and bortezomib, an experimental plasmacytoma model was induced …


Comparative Study Of Virulence Factors Among Esβl-Producing And Nonproducing Pseudomonas Aeruginosa Clinical Isolates, Maha Abd El Fattah Khalil, Fatma Ibrahim Sonbol, Abdelfattah Badr, Samh Samir Ali Jan 2015

Comparative Study Of Virulence Factors Among Esβl-Producing And Nonproducing Pseudomonas Aeruginosa Clinical Isolates, Maha Abd El Fattah Khalil, Fatma Ibrahim Sonbol, Abdelfattah Badr, Samh Samir Ali

Turkish Journal of Medical Sciences

\beta-Lactamase production is considered one of the most important resistance mechanisms among virulent Pseudomonas aeruginosa isolates. The aim of this study was to compare the production and antimicrobial resistance patterns of some virulence factors in extended spectrum \beta-lactamase (ES\betaL)-producing and nonproducing P. aeruginosa clinical isolates. Materials and methods: Out of 183 different clinical specimens, 104 Pseudomonas aeruginosa isolates were recovered. The isolates were screened for ESbL production using the double disk diffusion test and phenotypic confirmatory disk diffusion test. All isolates were tested for susceptibility to 25 antimicrobials, as well as for expression of various virulence factors including pigment, hemolysin, …


Serum Vegf Levels In Gastric Cancer Patients: Correlation With Clinicopathological Parameters, Celal İsmai̇l Bi̇lgi̇ç, Mesut Tez Jan 2015

Serum Vegf Levels In Gastric Cancer Patients: Correlation With Clinicopathological Parameters, Celal İsmai̇l Bi̇lgi̇ç, Mesut Tez

Turkish Journal of Medical Sciences

To evaluate the predictive role of the circulating levels of vascular endothelial growth factor (VEGF) in gastric cancer patients. Materials and methods: This study is a case-control study. We measured serum VEGF levels of 30 patients aged between 34 and 83 years with gastric cancer and 30 patients without malignant pathology, operated on for benign pathologies, with ages ranging from 18 to 69. Results: Serum levels of VEGF were correlated with the tumor type classification (signet cell adenocarcinoma) and the presence of adjacent tissue invasion. There was also a positive correlation between serum VEGF and carcinoembryonic antigen levels. Conclusion: In …


Is There Any Impact Of Pet/Ct On Radiotherapy Planning In Rectal Cancer Patients Undergoing Preoperative Imrt?, Di̇clehan Kiliç, Serap Çatli, Şükran Ülger, Lütfi̇ye Özlem Kapucu Jan 2015

Is There Any Impact Of Pet/Ct On Radiotherapy Planning In Rectal Cancer Patients Undergoing Preoperative Imrt?, Di̇clehan Kiliç, Serap Çatli, Şükran Ülger, Lütfi̇ye Özlem Kapucu

Turkish Journal of Medical Sciences

To investigate the effect of positron emission tomography-computed tomography (PET/CT)-based contouring on dosimetric parameters in rectal cancer patients undergoing preoperative intensity-modulated radiation therapy (IMRT). Materials and methods: Preoperative radiation therapy plans with conformal radiotherapy (CRT) or IMRT were created and examined according to the CT- and PET/CT-based contouring of 20 rectal cancer patients, retrospectively. Results: The target volumes delineated with PET/CT were significantly larger than the volumes created by CT (P = 0.043). Dose delivered to 98% of the planning target volume was high in IMRT planning contouring with CT and PET/CT compared with CRT planning, but the difference was …


Investigation Of Tnf-Alpha Gene (G308a) And Gstp1 Gene (Ile105val) Polymorphisms In Turkish Patients With Retinopathy Of Prematurity, Mehmet Türe, Meral Yildiz, Mutlu Karkucak, Emi̇ne Tuna Gülten, Deni̇z Siğirli, Ahmet Tuncer Özmen, Tahsi̇n Yakut Jan 2015

Investigation Of Tnf-Alpha Gene (G308a) And Gstp1 Gene (Ile105val) Polymorphisms In Turkish Patients With Retinopathy Of Prematurity, Mehmet Türe, Meral Yildiz, Mutlu Karkucak, Emi̇ne Tuna Gülten, Deni̇z Siğirli, Ahmet Tuncer Özmen, Tahsi̇n Yakut

Turkish Journal of Medical Sciences

Retinopathy of prematurity (ROP) is one of the most frequent causes of blindness in newborn babies. Currently, its etiology is not fully understood. In this study we aimed to investigate the correlation between a patient group with ROP and a control group in terms of the tumor necrosis factor-alpha (TNF-alpha) (G308A) gene and glutathione-S-transferase P1 (GSTP1) (Ile105Val) gene polymorphism. Materials and methods: Sixty-two patients diagnosed with ROP and 58 control subjects were included in this study. For TNF-alpha (G308A) gene and GSTP1 (Ile105Val) gene polymorphisms, the polymerase chain reaction-restriction fragment length polymorphism method was used. In statistical analysis the significance …


Usage Of Attenuation Coefficients Of Some Tissue-Equivalent Materials, Ayşe Güneş Tanir, Fatma Serap Ketenci̇, Mustafa Hi̇cabi̇ Bölükdemi̇r Jan 2015

Usage Of Attenuation Coefficients Of Some Tissue-Equivalent Materials, Ayşe Güneş Tanir, Fatma Serap Ketenci̇, Mustafa Hi̇cabi̇ Bölükdemi̇r

Turkish Journal of Physics

The total attenuation coefficients of 11 biological targets against photon energies were plotted within the energy range 1-10 MeV. From these plots a possible equation describing the relationship between photon energy and the total attenuation coefficient was derived. The suggested equation is mu/ rho = 0.0696/ surd E. To test the validity of the equation and to compare the results of the total attenuation coefficients of 3 tissue-equivalent materials (bolus, rice grains, and boiled rice) that could not be determined before, they were determined experimentally by using X-rays produced at 6 MV and 18 MV. The results of the experiment …


Studies On Mass Attenuation Coefficient, Mass Energy Absorption Coefficient, And Kerma For Fe Alloys At Photon Energies Of 17.44 To 51.70 Kev, Demet Yilmaz, Yusuf Şahi̇n, Lütfü Demi̇r Jan 2015

Studies On Mass Attenuation Coefficient, Mass Energy Absorption Coefficient, And Kerma For Fe Alloys At Photon Energies Of 17.44 To 51.70 Kev, Demet Yilmaz, Yusuf Şahi̇n, Lütfü Demi̇r

Turkish Journal of Physics

The mass attenuation coefficient (mu_m), the mass energy absorption coefficient (mu_{en}/ rho), and kerma relative to air were determined for some alloys, namely Fe_{0.5}Cr_{0.5}, Fe_{0.7}Cr_{0.3}, Fe_{0.8}Cr_{0.2}, Fe_{0.9}Cr_{0.1}, Fe_{0.2}Ni_{0.8}, Fe_{0.3}Ni_{0.7}, Fe_{0.5}Ni_{0.5}, Fe_{0.6}Ni_{0.4}, Fe_{0.7}Ni_{0.3}, and Fe_{0.8}Ni_{0.2}, at 17.44, 19.63, 22.10, 24.90, 32.06, 36.39, 37.26, 43.74, 44.48, 50.38, and 51.70 photon energies by using an HPGe detector with a resolution of 182 eV at 5.9 keV. The experimental results of mu_m were compared with the theoretical results. The theoretical values of mu_{en}/ rho were compared with the semiempirical values. It was observed that kerma values relative to air values were different in Fe-Ce …


Symmetry And The Order Of Events In Time: The Thermodynamics Of Blackbodies Composed Of Positive Or Negative Masssymmetry And The Order Of Events In Time: The Thermodynamics Of Blackbodies Composed Of Positive Or Negative Mass, Randy Wayne Jan 2015

Symmetry And The Order Of Events In Time: The Thermodynamics Of Blackbodies Composed Of Positive Or Negative Masssymmetry And The Order Of Events In Time: The Thermodynamics Of Blackbodies Composed Of Positive Or Negative Mass, Randy Wayne

Turkish Journal of Physics

I have previously proposed a discrete symmetry called CPM (charge-parity-mass) symmetry that defines matter as having positive mass and antimatter as having negative mass-both being involved in processes that proceed forward in time. I have generalized the second law of thermodynamics to describe and predict the order of events in time that take place in reversible thermodynamic systems composed of positive or negative mass. Here I extend the CPM symmetry to irreversible thermo-optical radiation systems characterized by the Stefan-Boltzmann law, Planck's blackbody radiation law, and Einstein's law of specific heat. The laws of radiation analyzed in terms of CPM symmetry …


Effect Of Additives On Mineral Trioxide Aggregate Setting Reaction Product Formation, Angela M. Zapf, Sharath C.V. Chedella, David W. Berzins Jan 2015

Effect Of Additives On Mineral Trioxide Aggregate Setting Reaction Product Formation, Angela M. Zapf, Sharath C.V. Chedella, David W. Berzins

School of Dentistry Faculty Research and Publications

Introduction

Mineral trioxide aggregate (MTA) sets via hydration of calcium silicates to yield calcium silicate hydrates and calcium hydroxide (Ca[OH]2). However, a drawback of MTA is its long setting time. Therefore, many additives have been suggested to reduce the setting time. The effect those additives have on setting reaction product formation has been ignored. The objective was to examine the effect additives have on MTA's setting time and setting reaction using differential scanning calorimetry (DSC).

Methods

MTA powder was prepared with distilled water (control), phosphate buffered saline, 5% calcium chloride (CaCl2), 3% sodium hypochlorite (NaOCl), or …


Soil Bacteria Conferred A Positive Relationship And Improved Salt Stress Tolerance In Transgenic Pea (Pisum Sativum L.) Harboring Na+/H+ Antiporter, Zahid Ali, Nasr Ullah, Saadia Naseem, Muhammad Inam Ul Haq, Hans Joerg Jacobsen Jan 2015

Soil Bacteria Conferred A Positive Relationship And Improved Salt Stress Tolerance In Transgenic Pea (Pisum Sativum L.) Harboring Na+/H+ Antiporter, Zahid Ali, Nasr Ullah, Saadia Naseem, Muhammad Inam Ul Haq, Hans Joerg Jacobsen

Turkish Journal of Botany

Among grain legumes, peas (Pisum sativum L.) are highly sensitive to salt stress. Acclimatization of plants to such conditions is mandatory. We provide improved salt stress tolerance response of transgenic pea plants overexpressing the Na+/H+ gene from Arabidopsis thaliana and a positive association with salt-tolerant plant growth-promoting rhizobacteria (PGPR). In addition to salt stress tolerance and phosphate solubilization, the selected rhizobacterial isolates were identified for indole acetic acid and proline production ability. Seed germination percentage in transgenic pea plants was significantly higher under NaCl challenge. The wild-type (WT) pea plants inoculated with known numbers of viable cells of salt-tolerant PGPR …


Kinetics And Performance Studies Of A Switchable Solvent Tmg (1,1,3,3-Tetramethylguanidine)/1-Propanol/Carbon Dioxide System, Özge Yüksel, Mustafa Çağdaş Öztürk, Ayça Şeker, Erdoğan Alper Jan 2015

Kinetics And Performance Studies Of A Switchable Solvent Tmg (1,1,3,3-Tetramethylguanidine)/1-Propanol/Carbon Dioxide System, Özge Yüksel, Mustafa Çağdaş Öztürk, Ayça Şeker, Erdoğan Alper

Turkish Journal of Chemistry

The rate constants and the activation energies of the reaction between carbon dioxide and 1,1,3,3-tetramethylguanidine (TMG) in 1-propanol solution were measured by a stopped-flow technique at a temperature range of 288--308 K and at a TMG concentration range of 2.5--10.0 wt %. Based on the pseudo-first-order reaction for CO_2, the reaction was modeled by a termolecular reaction mechanism, which resulted in a rate constant of 199.30 m^3 kmol^{-1} s^{-1} at 298 K. The activation energies were 5.19 kJ/mol and 5.26 kJ/mol at 2.5 and 5.0 wt % TMG, respectively. In addition, carbon dioxide absorption capacity was investigated using a gas--liquid …