Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

2015

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 20461 - 20490 of 27541

Full-Text Articles in Entire DC Network

Epigenetic Instability Of Imprinted Genes In Human Cancers, Joomyeong Kim, Corey L. Bretz, Suman Lee Jan 2015

Epigenetic Instability Of Imprinted Genes In Human Cancers, Joomyeong Kim, Corey L. Bretz, Suman Lee

Faculty Publications

© The Author(s) 2015. Many imprinted genes are often epigenetically affected in human cancers due to their functional linkage to insulin and insulin-like growth factor signaling pathways. Thus, the current study systematically characterized the epigenetic instability of imprinted genes in multiple human cancers. First, the survey results from TCGA (The Cancer Genome Atlas) revealed that the expression levels of the majority of imprinted genes are downregulated in primary tumors compared to normal cells. These changes are also accompanied by DNA methylation level changes in several imprinted domains, such as the PEG3, MEST and GNAS domains. Second, these DNA methylation level …

Go to article

Aebp2 As A Transcriptional Activator And Its Role In Cell Migration, Hana Kim, Muhammad B. Ekram, Arundhati Bakshi, Joomyeong Kim Jan 2015

Aebp2 As A Transcriptional Activator And Its Role In Cell Migration, Hana Kim, Muhammad B. Ekram, Arundhati Bakshi, Joomyeong Kim

Faculty Publications

© 2014 Elsevier Inc. Aebp2 encodes an evolutionarily conserved zinc finger protein that has not been well studied so far, yet recent studies indicated that this gene is closely associated with the Polycomb Repressive Complex 2 (PRC2). Thus, the current study characterized the basic aspects of this gene, including alternative promoters and protein isoforms. According to the results, Aebp2 is controlled through three alternative promoters, deriving three different transcripts encoding the embryonic (32. kDa) and somatic (52. kDa) forms. Chromatin Immuno-Precipitation (ChIP) experiments revealed that AEBP2 binds to its own promoter as well as the promoters of Jarid2 and Snai2. …

Go to article

Positive Priming Of Terrestrially Derived Dissolved Organic Matter In A Freshwater Microcosm System, Thomas S. Bianchi, Daniel C.O. Thornton, Shari A. Yvon-Lewis, Gary M. King, Timothy I. Eglinton, Michael R. Shields, Nicholas D. Ward, Jason Curtis Jan 2015

Positive Priming Of Terrestrially Derived Dissolved Organic Matter In A Freshwater Microcosm System, Thomas S. Bianchi, Daniel C.O. Thornton, Shari A. Yvon-Lewis, Gary M. King, Timothy I. Eglinton, Michael R. Shields, Nicholas D. Ward, Jason Curtis

Faculty Publications

© 2015. American Geophysical Union. All Rights Reserved. The role of priming processes in the remineralization of terrestrially derived dissolved organic carbon (TDOC) in aquatic systems has been overlooked. We provide evidence for TDOC priming using a lab-based microcosm experiment in which TDOC was primed by the addition of 13C-labeled algal dissolved organic carbon (ADOC) or a 13C-labeled disaccharide (trehalose). The rate of TDOC remineralization to carbon dioxide (CO2) occurred 4.1±0.9 and 1.5±0.3 times more rapidly with the addition of trehalose and ADOC, respectively, relative to experiments with TDOC as the sole carbon source over the course of …

Go to article

Physiological Strategies During Animal Diapause: Lessons From Brine Shrimp And Annual Killifish, Jason E. Podrabsky, Steven C. Hand Jan 2015

Physiological Strategies During Animal Diapause: Lessons From Brine Shrimp And Annual Killifish, Jason E. Podrabsky, Steven C. Hand

Faculty Publications

© 2015. Published by The Company of Biologists Ltd. Diapause is a programmed state of developmental arrest that typically occurs as part of the natural developmental progression of organisms that inhabit seasonal environments. The brine shrimp Artemia franciscana and annual killifish Austrofundulus limnaeus share strikingly similar life histories that include embryonic diapause as a means to synchronize the growth and reproduction phases of their life history to favorable environmental conditions. In both species, respiration rate is severely depressed during diapause and thus alterations in mitochondrial physiology are a key component of the suite of characters associated with cessation of development. …

Go to article

Divergent Evolution Of Two Corticotropin-Releasing Hormone (Crh) Genes In Teleost Fishes, Brian P. Grone, Karen P. Maruska Jan 2015

Divergent Evolution Of Two Corticotropin-Releasing Hormone (Crh) Genes In Teleost Fishes, Brian P. Grone, Karen P. Maruska

Faculty Publications

© 2015 Grone and Maruska. Genome duplication, thought to have happened twice early in vertebrate evolution and a third time in teleost fishes, gives rise to gene paralogs that can evolve subfunctions or neofunctions via sequence and regulatory changes. To explore the evolution and functions of corticotropin-releasing hormone (CRH), we searched sequenced teleost genomes for CRH paralogs. Our phylogenetic and synteny analyses indicate that two CRH genes, crha and crhb, evolved via duplication of crh1 early in the teleost lineage. We examined the expression of crha and crhb in two teleost species from different orders: an African cichlid, Burton's mouthbrooder, …

Go to article

Increased Phosphate Transport Of Arabidopsis Thalianapht1;1 By Site-Directed Mutagenesis Of Tyrosine 312 May Be Attributed To The Disruption Of Homomeric Interactions, Elena B. Fontenot, Sandra Feuer Ditusa, Naohiro Kato, Danielle M. Olivier, Renee Dale, Wei Yi Lin, Tzyy Jen Chiou, Megan A. Macnaughtan, Aaron P. Smith Jan 2015

Increased Phosphate Transport Of Arabidopsis Thalianapht1;1 By Site-Directed Mutagenesis Of Tyrosine 312 May Be Attributed To The Disruption Of Homomeric Interactions, Elena B. Fontenot, Sandra Feuer Ditusa, Naohiro Kato, Danielle M. Olivier, Renee Dale, Wei Yi Lin, Tzyy Jen Chiou, Megan A. Macnaughtan, Aaron P. Smith

Faculty Publications

& Sons Ltd. Members of the Pht1 family of plant phosphate (Pi) transporters play vital roles in Pi acquisition from soil and in plantaPi translocation to maintain optimal growth and development. The study of the specificities and biochemical properties of Pht1 transporters will contribute to improving the current understanding of plant phosphorus homeostasis and use-efficiency. In this study, we show through split in vivo interaction methods and in vitro analysis of microsomal root tissues that Arabidopsis thalianaPht1;1 and Pht1;4 form homomeric and heteromeric complexes. Transient and heterologous expression of the Pht1;1 variants, Pht1;1Y312D, Pht1;1Y312A and Pht1;1Y312F …

Go to article

Differentially Expressed Genes Match Bill Morphology And Plumage Despite Largely Undifferentiated Genomes In A Holarctic Songbird, Nicholas A. Mason, Scott A. Taylor Jan 2015

Differentially Expressed Genes Match Bill Morphology And Plumage Despite Largely Undifferentiated Genomes In A Holarctic Songbird, Nicholas A. Mason, Scott A. Taylor

Faculty Publications

© 2015 John Wiley & Sons Ltd. Understanding the patterns and processes that contribute to phenotypic diversity and speciation is a central goal of evolutionary biology. Recently, high-throughput sequencing has provided unprecedented phylogenetic resolution in many lineages that have experienced rapid diversification. The Holarctic redpoll finches (Genus: Acanthis) provide an intriguing example of a recent, phenotypically diverse lineage; traditional sequencing and genotyping methods have failed to detect any genetic differences between currently recognized species, despite marked variation in plumage and morphology within the genus. We examined variation among 20 712 anonymous single nucleotide polymorphisms (SNPs) distributed throughout the redpoll genome …

Go to article

The Effect Of Habitat And Body Size On The Evolution Of Vocal Displays In Thraupidae (Tanagers), The Largest Family Of Songbirds, Nicholas A. Mason, Kevin J. Burns Jan 2015

The Effect Of Habitat And Body Size On The Evolution Of Vocal Displays In Thraupidae (Tanagers), The Largest Family Of Songbirds, Nicholas A. Mason, Kevin J. Burns

Faculty Publications

© 2015 The Linnean Society of London. Animals rely on auditory cues to relay important information between individuals regarding territoriality, mating status, and individual condition. The efficacy of acoustic signals can depend on many factors, including the transmitter, the receiver, and the signalling environment. In the present study, we evaluate the effect of body size and habitat on the evolution of learned vocal displays across the tanagers (Aves: Thraupidae), a group that comprises nearly 10% of all songbird species. We find that body size affects tanager vocalizations, such that nine out of ten song characters and scores from two principal …

Go to article

How Global Biodiversity Hotspots May Go Unrecognized: Lessons From The North American Coastal Plain, Reed F. Noss, William J. Platt, Bruce A. Sorrie, Alan S. Weakley, D. Bruce Means, Jennifer Costanza, Robert K. Peet Jan 2015

How Global Biodiversity Hotspots May Go Unrecognized: Lessons From The North American Coastal Plain, Reed F. Noss, William J. Platt, Bruce A. Sorrie, Alan S. Weakley, D. Bruce Means, Jennifer Costanza, Robert K. Peet

Faculty Publications

© 2014 John Wiley & Sons Ltd. Biodiversity hotspots are conservation priorities. We identify the North American Coastal Plain (NACP) as a global hotspot based on the classic definition, a region with > 1500 endemic plant species and > 70% habitat loss. This region has been bypassed in prior designations due to misconceptions and myths about its ecology and history. These fallacies include: (1) young age of the NACP, climatic instability over time and submergence during high sea-level stands; (2) climatic and environmental homogeneity; (3) closed forest as the climax vegetation; and (4) fire regimes that are mostly anthropogenic. We show that …

Go to article

Hurricane Wrack Generates Landscape-Level Heterogeneity In Coastal Pine Savanna, William J. Platt, Dwayne Joseph, Darin P. Ellair Jan 2015

Hurricane Wrack Generates Landscape-Level Heterogeneity In Coastal Pine Savanna, William J. Platt, Dwayne Joseph, Darin P. Ellair

Faculty Publications

© 2014 The Authors. Wrack (vegetation debris) deposited by storm surges of major hurricanes along the northern Gulf of Mexico produces depressant effects that vary from partial to complete mortality of groundcover vegetation in coastal savannas. As wrack decomposes or is relocated by a subsequent hurricane, patches are opened to colonization. We postulated that patterns of wrack deposition and removal, coupled with differential responses by savanna plant species should produce alternate states of groundcover vegetation. We explored extreme effects of wrack deposited by Hurricane Katrina (2005) in savannas dominated by slash pine Pinus elliottii and cordgrass Spartina patens and located …

Go to article

Military Genomic Testing: Proportionality, Expected Benefits, And The Connection Between Genotypes And Phenotypes, Charles H. Pence Jan 2015

Military Genomic Testing: Proportionality, Expected Benefits, And The Connection Between Genotypes And Phenotypes, Charles H. Pence

Faculty Publications

Mehlman and Li offer a framework for approaching the bioethical issues raised by the military use of genomics that is compellingly grounded in both the contemporary civilian and military ethics of medical research, arguing that military commanders must be bound by the two principles of paternalism and proportionality. I agree fully. But I argue here that this is a much higher bar than we may fully realize. Just as the principle of proportionality relies upon a thorough assessment of harms caused and military advantage gained, the use of genomic research, on Mehlman and Li's view, will require an accurate understanding …

Go to article

Effect Of 12 Weeks Of Periodized Resistance Training Upon Total Plasma Adiponectin Concentration In Healthy Young Men, Greggory R. Davis, Jacqueline M. Stephens, Arnold G. Nelson Jan 2015

Effect Of 12 Weeks Of Periodized Resistance Training Upon Total Plasma Adiponectin Concentration In Healthy Young Men, Greggory R. Davis, Jacqueline M. Stephens, Arnold G. Nelson

Faculty Publications

© 2015 National Strength and Conditioning Association. The effects of resistance training on adiponectin have thus far yielded equivocal results. However, the effect of periodized resistance training on plasma adiponectin in offspring of type 2 diabetic and nondiabetic (ND) parents (first-degree family history) has yet to be determined. Untrained healthy young men with and without a first-degree family history of type 2 diabetes were assigned to an exercise intervention group (E) or an active control group (C). The E group performed a 12-week periodized resistance training program, whereas the C group did not participate in any structured exercise program. Fasting …

Go to article

Freedom From Thought, Jane Bambauer Jan 2015

Freedom From Thought, Jane Bambauer

Emory Law Journal

This short Essay explores when ignorance can be supported or even coerced by law, and when it cannot. In the end, although freedom from thought has much to offer to the development of privacy and dignitary rights, interests in self-ignorance are better handled through norms than through law. Like other forms of privacy, First Amendment commitments are likely to frustrate legal efforts to support or coerce self-ignorance. If a speaker wishes to disclose information, the government is unlikely to be able to interfere with that disclosure unless the speaker¿s interests are demonstrably weak. However, when both the speaker and the …

Go to article

Experiential Education As A Framework For Student Affairs' Educator Role, Aaron D. Clevenger Jan 2015

Experiential Education As A Framework For Student Affairs' Educator Role, Aaron D. Clevenger

Publications

"The purpose of this article is to provide student affairs practitioner-scholars with an applied framework/action plan for incorporating experiential education techniques into their daily practice of hosting and/or advising events, and other planned experiences. Utilizing the National Society of Experiential Education’s eight principles of good practice as a praxis, student affairs educators may achieve many of the following benefits: 1) a consistent language and definitions, which will promote a common understanding and common values; 2) a learning community helping to develop skills, known to be effective in ensuring learning and creating an engaged environment; 3) a plethora of research and …

Go to article

Research Matters Spring 2015, Louisiana State University And Agricultural & Mechanical College Jan 2015

Research Matters Spring 2015, Louisiana State University And Agricultural & Mechanical College

Research Matters & RNR Newsletters

Research Matters is a publication which highlights ongoing research, international travel experiences, classroom happenings and degree program developments of and for the School of Renewable Natural Resources' students and faculty.

Go to article

Sixteenth-Century Soil Carbon Sequestration Rates Based On Mexican Land-Grant Documents, Andrew Sluyter, Richard Hunter Jan 2015

Sixteenth-Century Soil Carbon Sequestration Rates Based On Mexican Land-Grant Documents, Andrew Sluyter, Richard Hunter

Faculty Publications

A significant gap in our understanding of global change involves the linkages between historical land-use and land-cover change (LULCC), Holocene terrestrial carbon (C) pool fluxes, and climate change. To address that research problem, this method uses land grants for sheep ranches awarded in early colonial (1521–1620 CE) Mexico to quantify the amount of land converted from cropland to pastureland. Soil is the largest terrestrial C pool, and converting cropland to pastureland significantly increases soil C sequestration rates, thereby reducing atmospheric C. The land grants and associated archival documents contain location-specific information about soils, vegetation, hydrology, and other variables that make …

Go to article

African Fire Cultures, Cattle Ranching, And Colonial Landscape Transformations In The Neotropics, Andrew Sluyter, Chris Duvall Jan 2015

African Fire Cultures, Cattle Ranching, And Colonial Landscape Transformations In The Neotropics, Andrew Sluyter, Chris Duvall

Faculty Publications

Fire regimes emerge partly from human activities that reflect cultural-ecological knowledge of the relationships among fire, vegetation, grazing, climate, and other variables, as well as social relations. More knowledge of such “fire cultures,” past and present, therefore remains necessary to better understand the causes and persistent consequences of landscape burning. In the neotropics, people have used fire for centuries to manage livestock pastures. Conventional wisdom has long posited that such practices derived solely from antecedent European and indigenous, Native American fire cultures. Analysis of accounts of rangeland burning from throughout the neotropics during colonial times, however, demonstrates that ranchers incorporated …

Go to article

Comparison Of The Effects Of Neonicotinoids And Pyrethroids Against Oebalus Pugnax (Hemiptera: Pentatomidae) In Rice, Bryce Blackman, Srinivas Lanka, Natalie Hummel, Mo Way, Michael Stout Jan 2015

Comparison Of The Effects Of Neonicotinoids And Pyrethroids Against Oebalus Pugnax (Hemiptera: Pentatomidae) In Rice, Bryce Blackman, Srinivas Lanka, Natalie Hummel, Mo Way, Michael Stout

Faculty Publications

The rice stink bug, Oebalus pugnax (F.) (Hemiptera: Pentatomidae), is an economically important late-season pest of rice in the southern United States. Stink bug feeding results in yield reduction and discounted purchase price due to broken or discolored ("pecky") rice grains. The primary tactic for O. pugnax management is the application of insecticides once adults reach an action threshold. Recent surveys show that pyrethroids are preferred by southern U.S. rice farmers over all other insecticides to reduce O. pugnax densities. However, preliminary tests in 2009 suggested resistance to pyrethroids may be developing in an O. pugnax population in Texas, where …

Go to article

Induced Jasmonate Signaling Leads To Contrasting Effects On Root Damage And Herbivore Performance, Jing Lu, Christelle Aurélie Maud Robert, Michael Riemann, Marco Cosme, Laurent Mène-Saffrané, Josep Massana, Michael Joseph Stout, Yonggen Lou, Jonathan Gershenzon, Matthias Erb Jan 2015

Induced Jasmonate Signaling Leads To Contrasting Effects On Root Damage And Herbivore Performance, Jing Lu, Christelle Aurélie Maud Robert, Michael Riemann, Marco Cosme, Laurent Mène-Saffrané, Josep Massana, Michael Joseph Stout, Yonggen Lou, Jonathan Gershenzon, Matthias Erb

Faculty Publications

© 2015 American Society of Plant Biologists. All rights reserved. Induced defenses play a key role in plant resistance against leaf feeders. However, very little is known about the signals that are involved in defending plants against root feeders and how they are influenced by abiotic factors. We investigated these aspects for the interaction between rice (Oryza sativa) and two root-feeding insects: the generalist cucumber beetle (Diabrotica balteata) and the more specialized rice water weevil (Lissorhoptrus oryzophilus). Rice plants responded to root attack by increasing the production of jasmonic acid (JA) and abscisic acid, whereas in contrast to in herbivore-attacked …

Go to article

Factors Influencing Expression Of Antixenosis In Soybean To Anticarsia Gemmatalis And Spodoptera Frugiperda (Lepidoptera: Noctuidae), Arlindo Leal Boiça Júnior, Bruno Henrique Sardinha De Souza, Eduardo Neves Costa, Zulene Antonio Ribeiro, Michael Joseph Stout Jan 2015

Factors Influencing Expression Of Antixenosis In Soybean To Anticarsia Gemmatalis And Spodoptera Frugiperda (Lepidoptera: Noctuidae), Arlindo Leal Boiça Júnior, Bruno Henrique Sardinha De Souza, Eduardo Neves Costa, Zulene Antonio Ribeiro, Michael Joseph Stout

Faculty Publications

© The Authors 2015. Published by Oxford University Press on behalf of Entomological Society of America. This study aimed to evaluate some factors that influence the expression of antixenosis in soybean genotypes against Anticarsia gemmatalis Hübner and Spodoptera frugiperda (J. E. Smith) (Lepidoptera: Noctuidae). Free-choice and no-choice feeding assays were performed with the resistant soybean genotype IAC 100 and the susceptible genotype BRSGO 8360 using A. gemmatalis and S. frugiperda larvae. The following factors that may affect expression of resistance were evaluated: one larva versus two larvae per leaf disc; use of larvae without prior feeding suspension versus larvae starved …

Go to article

Leptin Deficient Ob/Ob Mice And Diet-Induced Obese Mice Responded Differently To Roux-En-Y Bypass Surgery, Z. Hao, H. Münzberg, K. Rezai-Zadeh, M. Keenan, D. Coulon, H. Lu, H. R. Berthoud, J. Ye Jan 2015

Leptin Deficient Ob/Ob Mice And Diet-Induced Obese Mice Responded Differently To Roux-En-Y Bypass Surgery, Z. Hao, H. Münzberg, K. Rezai-Zadeh, M. Keenan, D. Coulon, H. Lu, H. R. Berthoud, J. Ye

Faculty Publications

© 2015 Macmillan Publishers Limited. Weight regain contributes to the therapeutic failure in 15-20% of type 2 diabetic patients after Roux-en-Y gastric bypass surgery (RYGB), and the mechanism remains largely unknown. This study was conducted to explore the mechanism of weight regain.Research design:Wild-type (WT) diet-induced obese (DIO) mice were used to mimic human obesity, and ob/ob mice were used for leptin deficiency-induced obesity. Two groups of mice were compared in weight regain for 10 months after RYGB. Weight loss, food intake, fecal energy loss and energy expenditure were monitored in the study of weight regain. Fasting insulin, insulin tolerance and …

Go to article

Role Of Resistant Starch In Improving Gut Health, Adiposity, And Insulin Resistance, Michael J. Keenan, June Zhou, Maren Hegsted, Christine Pelkman, Holiday A. Durham, Diana B. Coulon, Roy J. Martin Jan 2015

Role Of Resistant Starch In Improving Gut Health, Adiposity, And Insulin Resistance, Michael J. Keenan, June Zhou, Maren Hegsted, Christine Pelkman, Holiday A. Durham, Diana B. Coulon, Roy J. Martin

Faculty Publications

© 2015 American Society for Nutrition. The realization that low-glycemic index diets were formulated using resistant starch led to more than a decade of research on the health effects of resistant starch. Determination of the metabolizable energy of the resistant starch product allowed for the performance of isocaloric studies. Fermentation of resistant starch in rodent studies results in what appears to be a healthier gut, demonstrated by increased amounts of short-chain fatty acids, an apparent positive change in the microbiota, and increased gene expression for gene products involved in normal healthy proliferation and apoptosis of potential cancer cells. Additionally, consumption …

Go to article

Photoactivated Mir-148b-Nanoparticle Conjugates Improve Closure Of Critical Size Mouse Calvarial Defects, Ammar T. Qureshi, Andrew Doyle, Cong Chen, Diana Coulon, Vinod Dasa, Fabio Delpiero, Benjamin Levi, W. Todd Monroe, Jeffrey M. Gimble, Daniel J. Hayes Jan 2015

Photoactivated Mir-148b-Nanoparticle Conjugates Improve Closure Of Critical Size Mouse Calvarial Defects, Ammar T. Qureshi, Andrew Doyle, Cong Chen, Diana Coulon, Vinod Dasa, Fabio Delpiero, Benjamin Levi, W. Todd Monroe, Jeffrey M. Gimble, Daniel J. Hayes

Faculty Publications

© 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. Inducible systems providing temporal control of differentiation have the potential to improve outcomes in surgical reconstruction and regenerative medicine by precise modulation of wound healing and tissue repair processes. The aim of this study was to demonstrate that nanoformulated microRNA (miRNA) conjugates activated via photo exposure can lead to the induced osteogenic differentiation of human adipose-derived stromal/stem cells (hASCs) in vivo. The conjugate PC-miR-148b-SNP, a mimic of miRNA-148b tethered to silver nanoparticles (SNPs) via a photolabile linker, was used to modulate gene expression for improved closure of a …

Go to article

Leptin Deficient Ob/Ob Mice And Diet-Induced Obese Mice Responded Differently To Roux-En-Y Bypass Surgery, Z. Hao, H. Münzberg, K. Rezai-Zadeh, M. Keenan, D. Coulon, H. Lu, H. R. Berthoud, J. Ye Jan 2015

Leptin Deficient Ob/Ob Mice And Diet-Induced Obese Mice Responded Differently To Roux-En-Y Bypass Surgery, Z. Hao, H. Münzberg, K. Rezai-Zadeh, M. Keenan, D. Coulon, H. Lu, H. R. Berthoud, J. Ye

Faculty Publications

© 2015 Macmillan Publishers Limited. Weight regain contributes to the therapeutic failure in 15-20% of type 2 diabetic patients after Roux-en-Y gastric bypass surgery (RYGB), and the mechanism remains largely unknown. This study was conducted to explore the mechanism of weight regain.Research design:Wild-type (WT) diet-induced obese (DIO) mice were used to mimic human obesity, and ob/ob mice were used for leptin deficiency-induced obesity. Two groups of mice were compared in weight regain for 10 months after RYGB. Weight loss, food intake, fecal energy loss and energy expenditure were monitored in the study of weight regain. Fasting insulin, insulin tolerance and …

Go to article

Role Of Resistant Starch In Improving Gut Health, Adiposity, And Insulin Resistance, Michael J. Keenan, June Zhou, Maren Hegsted, Christine Pelkman, Holiday A. Durham, Diana B. Coulon, Roy J. Martin Jan 2015

Role Of Resistant Starch In Improving Gut Health, Adiposity, And Insulin Resistance, Michael J. Keenan, June Zhou, Maren Hegsted, Christine Pelkman, Holiday A. Durham, Diana B. Coulon, Roy J. Martin

Faculty Publications

© 2015 American Society for Nutrition. The realization that low-glycemic index diets were formulated using resistant starch led to more than a decade of research on the health effects of resistant starch. Determination of the metabolizable energy of the resistant starch product allowed for the performance of isocaloric studies. Fermentation of resistant starch in rodent studies results in what appears to be a healthier gut, demonstrated by increased amounts of short-chain fatty acids, an apparent positive change in the microbiota, and increased gene expression for gene products involved in normal healthy proliferation and apoptosis of potential cancer cells. Additionally, consumption …

Go to article

Photoactivated Mir-148b-Nanoparticle Conjugates Improve Closure Of Critical Size Mouse Calvarial Defects, Ammar T. Qureshi, Andrew Doyle, Cong Chen, Diana Coulon, Vinod Dasa, Fabio Delpiero, Benjamin Levi, W. Todd Monroe, Jeffrey M. Gimble, Daniel J. Hayes Jan 2015

Photoactivated Mir-148b-Nanoparticle Conjugates Improve Closure Of Critical Size Mouse Calvarial Defects, Ammar T. Qureshi, Andrew Doyle, Cong Chen, Diana Coulon, Vinod Dasa, Fabio Delpiero, Benjamin Levi, W. Todd Monroe, Jeffrey M. Gimble, Daniel J. Hayes

Faculty Publications

© 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. Inducible systems providing temporal control of differentiation have the potential to improve outcomes in surgical reconstruction and regenerative medicine by precise modulation of wound healing and tissue repair processes. The aim of this study was to demonstrate that nanoformulated microRNA (miRNA) conjugates activated via photo exposure can lead to the induced osteogenic differentiation of human adipose-derived stromal/stem cells (hASCs) in vivo. The conjugate PC-miR-148b-SNP, a mimic of miRNA-148b tethered to silver nanoparticles (SNPs) via a photolabile linker, was used to modulate gene expression for improved closure of a …

Go to article

Prowashonupana Barley Dietary Fibre Reduces Body Fat And Increases Insulin Sensitivity In Caenorhabditis Elegans Model, Chenfei Gao, Michael L. King, Zachary L. Fitzpatrick, Wenqian Wei, Jason F. King, Mingming Wang, Frank L. Greenway, John W. Finley, Jeffrey H. Burton, William D. Johnson, Michael J. Keenan, Frederick M. Enright, Roy J. Martin, Jolene Zheng Jan 2015

Prowashonupana Barley Dietary Fibre Reduces Body Fat And Increases Insulin Sensitivity In Caenorhabditis Elegans Model, Chenfei Gao, Michael L. King, Zachary L. Fitzpatrick, Wenqian Wei, Jason F. King, Mingming Wang, Frank L. Greenway, John W. Finley, Jeffrey H. Burton, William D. Johnson, Michael J. Keenan, Frederick M. Enright, Roy J. Martin, Jolene Zheng

Faculty Publications

© 2015 Elsevier Ltd. Prowashonupana barley (PWB) is high in β-glucan with moderate content of resistant starch. PWB reduced intestinal fat deposition (IFD) in wild type Caenorhabditis elegans (C. elegans, N2), and in sir-2.1 or daf-16 null mutants, and sustained a surrogate marker of lifespan, pharyngeal pumping rate (PPR), in N2, sir-2.1, daf-16, or daf-16/daf-2 mutants. Hyperglycaemia (2% glucose) reversed or reduced the PWB effect on IFD in N2 or daf-16/daf-2 mutants with a sustained PPR. mRNA expression of cpt-1, cpt-2, ckr-1, and gcy-8 were dose-dependently reduced in N2 or daf-16 mutants, elevated in daf-16/daf-2 mutants with reduction in cpt-1, …

Go to article

The F-Bar Cdc15 Promotes Contractile Ring Formation Through The Direct Recruitment Of The Formin Cdc12, Alaina H. Willet, Nathan A. Mcdonald, K. Adam Bohnert, Michelle A. Baird, John R. Allen, Michael W. Davidson, Kathleen L. Gould Jan 2015

The F-Bar Cdc15 Promotes Contractile Ring Formation Through The Direct Recruitment Of The Formin Cdc12, Alaina H. Willet, Nathan A. Mcdonald, K. Adam Bohnert, Michelle A. Baird, John R. Allen, Michael W. Davidson, Kathleen L. Gould

Faculty Publications

© 2015 Willet et al. In Schizosaccharomyces pombe, cytokinesis requires the assembly and constriction of an actomyosin-based contractile ring (CR). Nucleation of F-actin for the CR requires a single formin, Cdc12, that localizes to the cell middle at mitotic onset. Although genetic requirements for formin Cdc12 recruitment have been determined, the molecular mechanisms dictating its targeting to the medial cortex during cytokinesis are unknown. In this paper, we define a short motif within the N terminus of Cdc12 that binds directly to the F-BAR domain of the scaffolding protein Cdc15. Mutations preventing the Cdc12-Cdc15 interaction resulted in reduced Cdc12, F-actin, …

Go to article

Chandlerea And Nunnea (Coleoptera: Staphylinidae: Pselaphinae), Two New Genera From New Zealand With Descriptions Of Three New Species, Jong Seok Park, Christopher E. Carlton Jan 2015

Chandlerea And Nunnea (Coleoptera: Staphylinidae: Pselaphinae), Two New Genera From New Zealand With Descriptions Of Three New Species, Jong Seok Park, Christopher E. Carlton

Faculty Publications

Two new genera and three new species of New Zealand endemic pselaphine staphylinid beetles belonging to the supertribe Faronitae are described as follows: Chandlerea Park & Carlton, gen. nov., including C. donaldi Park & Carlton, sp. nov.; and Nunnea Park & Carlton, gen. nov., including N. johni Park & Carlton, sp. nov., and N. kuscheli Park & Carlton, sp. nov. A key to species, habitus photographs, line drawings of diagnostic characters and distribution maps for all species are provided.

Go to article

Errata: Chandlerea And Nunnea (Coleoptera: Staphylinidae: Pselaphinae), Two New Genera From New Zealand With Descriptions Of Three New Species (Florida Entomologist 98, 2 (588-592)), Jong Seok Park, Christopher E. Carlton Jan 2015

Errata: Chandlerea And Nunnea (Coleoptera: Staphylinidae: Pselaphinae), Two New Genera From New Zealand With Descriptions Of Three New Species (Florida Entomologist 98, 2 (588-592)), Jong Seok Park, Christopher E. Carlton

Faculty Publications

No abstract provided.

Go to article

First Prev Next Last