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Parasitism Revealed: On The Absence Of Concession, Ann G. Winfield

Education Faculty Publications

An examination of the role of ideologies from the past in shaping educational thought, action, policy and practice in the present. Takes the position that inequality is an expression of a fundamentally parasitic relationship forged during the 17th century colonial push and cemented institutionally in the early 20th century by a progressive version of social Darwinist thought known as eugenic ideology. Considered are the roles of historical disciplinary limitations, memory, and the co-optation of the language of social justice in perpetuating a racist, classist, hierarchy in education that has been bearing fruit for nearly two centuries. Warns against uncritical use …

Identifying A Gene Expression Signature Of Frequent Copd Exacerbations In Peripheral Blood Using Network Methods, Jarrett D. Morrow, Weiliang Qiu, Divya Chhabra, Stephen I. Rennard, Paula Belloni, Anton Belousov, Sreekumar G. Pillai, Craig P. Hersh

Journal Articles: Pulmonary & Critical Care Med

BACKGROUND: Exacerbations of chronic obstructive pulmonary disease (COPD), characterized by acute deterioration in symptoms, may be due to bacterial or viral infections, environmental exposures, or unknown factors. Exacerbation frequency may be a stable trait in COPD patients, which could imply genetic susceptibility. Observing the genes, networks, and pathways that are up- and down-regulated in COPD patients with differing susceptibility to exacerbations will help to elucidate the molecular signature and pathogenesis of COPD exacerbations.

METHODS: Gene expression array and plasma biomarker data were obtained using whole-blood samples from subjects enrolled in the Treatment of Emphysema With a Gamma-Selective Retinoid Agonist (TESRA) …

Undernutrition And Associated Risk Factors Among School Age Children In Addis Ababa, Ethiopia, Dawit Degarege, Abraham Degarege, Abebe Animut

Journal Articles: Epidemiology

BACKGROUND: Causes of child undernutrition are diverse and change in space and time. Investigating current determinants of undernutrition remains vital to design an effective intervention strategy. The study assessed prevalence of undernutrition and its associated factors among children living in Addis Ababa, Ethiopia.

METHODS: A community based cross-sectional study was conducted in 459 school age children and their parents or caregivers living in Lideta sub-city, Addis Ababa, Ethiopia. Participants were selected using a multi-stage simple random sampling technique. Height and weight of children was measured and their parents or care givers were interviewed for factors associated with undernutrition.

RESULTS: About …

Lovers And Mothers In Antonio García Gutiérrez’S El Trovador, Christine Blackshaw-Naberhaus

Decimonónica

Since the emergence of feminist literary criticism over four decades ago, scholars have been posing “new questions about old texts” (Tuttle 184), and in the field of Nineteenth- Century Spanish studies, questions Bridget Aldaraca, Lou Charnon-Deutsch, Catherine Jagoe, Susan Kirkpatrick, Jo Labanyi, Linda Materna and Karen Rauch have advanced continue to inform our understanding of gender discourse in nineteenth-century Spain. More specifically, Labanyi, Kirkpatrick, and Materna have elucidated how Spanish Romantic plays “dramatize the contradictions inherent in liberal individualism” (Labanyi 8). In their assessment, the progressive ideological project of the early nineteenth century, while endeavoring to expand forms of self-expression …

Volume 68 Issue 2 (Fall/Winter 2014)

Utah Science

4 Help Non-Thirsty Natives Feel at Home

Cultivating native plants that have evolved to thrive in dry conditions could reduce the amount of water landscapes require. But natives can’t simply be uprooted from the foothills and deserts and plopped in the suburbs. Scientists are exploring which native plants have potential and working to bring them to a nursery near you (provided that “near you“ means in the arid West).

12 Exploring the Water We Can’t See

Managing water supplies well begins with knowing how much water you have. That’s more complex than measuring precipitation and runoff. It means considering water …

Eduarda Mansilla’S Mestizo Argentina: Orphanhood, Transnationalism, And Race In Lucía Miranda (1860), Sarah Moody

Decimonónica

The first known writing of the Lucía Miranda legend, a story of Argentine national origins, dates to 1612 with a work by Spanish soldier Ruy Díaz de Guzmán. Though apparently fictional, the episode appears as a chapter in an otherwise fact-based account of early European activity in the River Plate region known as La Argentina manuscrita.¹ Later writers reworked the legend in their own ways, adapting it to the circumstances of their own historical moment, but the consistent points of the storyline focus on irremediable interethnic conflict: Lucía was a young, virtuous Spanish woman who accompanied her husband …

Molecular Overlap In The Regulation Of Sk Channels By Small Molecules And Phosphoinositides, Miao Zhang, Xuan-Yu Meng, Ji-Fang Zhang, Meng Cui, Diomedes E. Logothetis

Physiology and Biophysics Publications and Presentations

Phosphatidylinositol 4,5-bisphosphate (PIP2) directly interacts with the small-conductance Ca2+-activated K+2-a (SK2-a) channel/calmodulin complex, serving as a critical element in the regulation of channel activity. We report that changes of protein conformation in close proximity to the PIP2 binding site induced by a small-molecule SK channel modulator, NS309, can effectively enhance the interaction between the protein and PIP2 to potentiate channel activity. This novel modulation of PIP2 sensitivity by small-molecule drugs is likely not to be limited in its application to SK channels, representing an intriguing strategy to develop drugs controlling the activity of the large number of PIP2-dependent proteins.

Impact Of V-Ets Erythroblastosis Virus E26 Oncogene Homolog 1 Gene Polymorphisms Upon Susceptibility To Autoimmune Diseases, Ye Zhou, Miao Liu, Jun Li, Fiza Hashmi, Zhi Mao, Ning Zhang, Liang Zhou, Weiran Lv, Jingwei Zheng, Xiaoli Nie, Changzheng Li

Physiology and Biophysics Publications and Presentations

V-ets erythroblastosis virus E26 oncogene homolog 1 (ETS1) is recognized as a gene of risk to autoimmune diseases (ADs). Two single nucleotide polymorphisms (SNPs) in ETS1 (rs1128334 G>A and rs10893872 T>C) were considered associated with ADs risk. However, the results remain conflicting.

We performed a meta-analysis to evaluate more precise estimations of any relationship. We searched PubMed, OvidSP, and Chinese National Knowledge Infrastructure databases (papers published prior to September 12, 2014) and extracted data from eligible studies. Meta-analysis was performed using the STATA 12.0 software. Random effect model or fixed effect model were chosen according to …

Editorial: Phosphoinositides And Their Phosphatases: Linking Electrical And Chemical Signals In Biological Processes, Susy C. Kohout, Carlos A. Villalba-Galea

Physiology and Biophysics Publications and Presentations

The voltage-sensing phosphatase (VSP) has changed the way we think about both cellular electrical activity and PIPs (phosphatidylinositol phosphates). Originally discovered in 1999 (Chen et al., 1999), these proteins were not recognized as electrically-controlled enzymes until 2005 (Murata et al., 2005). They constitute the first, and so far the only, example of an enzyme linking electrical signals at the plasma membrane to the catalysis of PIPs (Murata et al., 2005), a ubiquitous family of intracellular signaling molecules (Di Paolo and De Camilli, 2006; Balla, 2013). Before the discovery of VSP, there were no known direct links between the two. Textbook …

A Rapid In Vivo Screen For Pancreatic Ductal Adenocarcinoma Therapeutics, Ozhan Ocal, Victor Pashkov, Rahul K. Kollipara, Yalda Zolghadri, Victoria H. Cruz, Michael A. Hale, Blake R. Heath, Alex B. Artyukhin, Alana L. Christie, Pantelis Tsoulfas, James B. Lorens, Galvin H. Swift, Rolf A. Brekken, Thomas M. Wilkie

Physiology and Biophysics Publications and Presentations

Pancreatic ductal adenocarcinoma (PDA) is the fourth leading cause of cancer-related deaths in the United States, and is projected to be second by 2025. It has the worst survival rate among all major cancers. Two pressing needs for extending life expectancy of affected individuals are the development of new approaches to identify improved therapeutics, addressed herein, and the identification of early markers. PDA advances through a complex series of intercellular and physiological interactions that drive cancer progression in response to organ stress, organ failure, malnutrition, and infiltrating immune and stromal cells. Candidate drugs identified in organ culture or cell-based screens …

Starvation-Induced Collective Behavior In C. Elegans, Alexander B. Artyukhin, Virginia Commonwealth University J. Yim, Mi Cheong Cheong, Leon Avery

Physiology and Biophysics Publications and Presentations

We describe a new type of collective behavior in C. elegans nematodes, aggregation of starved L1 larvae. Shortly after hatching in the absence of food, L1 larvae arrest their development and disperse in search for food. In contrast, after two or more days without food, the worms change their behavior—they start to aggregate. The aggregation requires a small amount of ethanol or acetate in the environment. In the case of ethanol, it has to be metabolized, which requires functional alcohol dehydrogenase sodh-1. The resulting acetate is used in de novo fatty acid synthesis, and some of the newly made fatty …

A Multilaboratory Comparison Of Calibration Accuracy And The Performance Of External References In Analytical Ultracentrifugation, Huaying Zhao, Rodolfo Ghirlando, Carlos Alfonso, Fumio Arisaka, Ilan Attali, David L. Bain, Marina M. Bakhtina, Donald F. Becker, Gregory J. Bedwell, Ahmet Bekdemir, Tabot M. D. Besong, Catherine Birck, Chad A. Brautigam, William Brennerman, Olwyn Byron, Agnieszka Bzowska, Jonathan B. Chaires, Catherine T. Chaton, Helmut Cölfen, Keith D. Connaghan, Kimberly A. Crowley, Ute Curth, Tina Daviter, William L. Dean, Ana I. Díez, Christine Ebel, Debra M. Eckert, Leslie E. Eisele, Edward Eisenstein, Patrick England, Carlos Escalante, Jeffrey A. Fagan, Robert Fairman, Ron M. Finn, Wolfgang Fischle, José García De La Torre, Jayesh Gor, Henning Gustafsson, Damien Hall, Stephen E. Harding, José G. Hernández Cifre, Andrew B. Herr, Elizabeth E. Howell, Richard S. Isaac, Shu-Chuan Jao, Davis Jose, Soon-Jong Kim, Bashkim Kokona, Jack A. Kornblatt, Dalibor Kosek, Elena Krayukhina, Daniel Krzizike, Eric A. Kusznir, Hyewon Kwon, Adam Larson, Thomas M. Laue, Aline Le Roy, Andrew P. Leech, Hauke Lilie, Karolin Lugar, Juan R. Luque-Ortega, Jia Ma, Carrie A. May, Ernest L. Maynard, Anna Modrak-Wojcik, Yee-Foong Mok, Norbert Mücke, Luitgard Nagel-Steger, Geeta J. Narlikar, Masanori Noda, Amanda Nourse, Tomas Obsil, Chad K. Park, Jin-Ku Park, Peter D. Pawelek, Erby E. Perdue, Stephen J. Perkins, Matthew A. Perugini, Craig L. Peterson, Martin G. Peverelli, Grzegorz Piszczek, Gali Prag, Peter E. Prevelige, Bertrand D. E. Raynal, Lenka Rezabkova, Klaus Richter, Alison E. Ringel, Rose Rosenberg, Arthur J. Rowe, Arne C. Rufer, David J. Scott, Javier G. Seravalli, Alexandra S. Solovyova, Renjie Song, David Staunton, Catlin Stoddard, Katherine Stott, Holger M. Strauss, Werner W. Streicher, John P. Sumida, Sarah G. Swygert, Roman H. Szczepanowski, Ingrid Tessmer, Ronald T. Toth Iv., Ashutosh Tripathy, Susumu Uchiyama, Stephen F. W. Uebel, Satoru Unzai, Anna Vitlin Gruber, Peter H. Von Hippel, Christine Wandrey, Szu-Huan Wang, Steven E. Weitzel, Beata Wielgus-Kutrowska, Cynthia Wolberger, Martin Wolff, Edward Wright, Yu-Sung Wu, Jacinta M. Wubben, Peter Schuck

Physiology and Biophysics Publications and Presentations

Analytical ultracentrifugation (AUC) is a first principles based method to determine absolute sedimentation coefficients and buoyant molar masses of macromolecules and their complexes, reporting on their size and shape in free solution. The purpose of this multi-laboratory study was to establish the precision and accuracy of basic data dimensions in AUC and validate previously proposed calibration techniques. Three kits of AUC cell assemblies containing radial and temperature calibration tools and a bovine serum albumin (BSA) reference sample were shared among 67 laboratories, generating 129 comprehensive data sets. These allowed for an assessment of many parameters of instrument performance, including accuracy …

An Opioid-Like System Regulating Feeding Behavior In C. Elegans, Mi Cheong Cheong, Alexander B. Artyukhin, Yong-Jai You, Leon Avery

Physiology and Biophysics Publications and Presentations

Neuropeptides are essential for the regulation of appetite. Here we show that neuropeptides could regulate feeding in mutants that lack neurotransmission from the motor neurons that stimulate feeding muscles. We identified nlp-24 by an RNAi screen of 115 neuropeptide genes, testing whether they affected growth. NLP-24 peptides have a conserved YGGXX sequence, similar to mammalian opioid neuropeptides. In addition, morphine and naloxone respectively stimulated and inhibited feeding in starved worms, but not in worms lacking NPR-17, which encodes a protein with sequence similarity to opioid receptors. Opioid agonists activated heterologously expressed NPR-17, as did at least one NLP-24 peptide. Worms …

A Primer: Air And Water Environmental Quality Standards In The United State, Jason J. Czarnezki, Siu Tip Lam, Nadia B. Ahmad

Faculty Scholarship

No abstract provided.

Adopting An International Convention On Surrogacy—A Lesson From Intercountry Adoption, Seema Mohapatra

Faculty Scholarship

No abstract provided.

Growth, Injury, And Population Dynamics In The Extant Cyrtocrinid Holopus Mikihe (Crinoidea, Echinodermata) Near Roatan, Honduras, V. J. Syverson, Charles G. Messing, Karl Stanley, Tomasz K. Baumiller

Marine & Environmental Sciences Faculty Articles

The crinoid order Cyrtocrinida is known mainly from Mesozoic fossils; its few surviving members, all from bathyal environments, are among the most peculiar living crinoids. Cyrtocrinids attributed to Holopus mikihe Donovan and Pawson, 2008, have been observed in large numbers via submersible off the western coast of Roatán, Honduras, on vertical and overhanging walls at depths between 430 and 640 m. Observations in 2012, 2013, and 2014 have permitted the first estimates of population structure, growth, and regeneration. Two size modes were observed; the flat barnacle-like “juvenile” stage resembles confamilial and co-occurring Cyathidium pourtalesiAméziane, 1999, whereas the larger “adults” …

You Don’T Need A Metaphor To Know Which Way The Case Goes: The Senate Reference And Constitutional Metaphors, Richard Haigh

The Supreme Court Law Review: Osgoode’s Annual Constitutional Cases Conference

This article uses the Supreme Court of Canada’s Reference re Senate Reform as a basis for arguing that metaphors are not always appropriate in constitutional adjudication. In that decision, the Court relies on the metaphor of “constitutional architecture” ten times (11 if a subheading is counted). Despite the multiple references, the Court leaves unanswered questions about what the architecture metaphor is doing. Does it help to clarify? Is it the same or different from the text itself? Is it the same or different from “structure”? Is not the metaphor itself capable of multiple meanings? Relying too heavily on metaphors allows …

Switchable Release Of Entrapped Nanoparticles From Alginate Hydrogels, Cathal J. Kearney, Hadas Skaat, Stephen M. Kennedy, Jennifer Hu, Max Darnell, Theresa M. Raimondo, David J. Mooney

Chemical, Biomolecular, and Materials Engineering Faculty Publications

Natural biological processes are intricately controlled by the timing and spatial distribution of various cues. To mimic this precise level of control, the physical sizes of gold nanoparticles are utilized to sterically entrap them in hydrogel materials, where they are subsequently released only in response to ultrasound. These nanoparticles can transport bioactive factors to cells and direct cell behavior on‐demand.

The Willingness-To-Pay For Caplanian Irrationality, Ryan Murphy

Bridwell Institute for Economic Freedom Research

Bryan Caplan’s The Myth of the Rational Voter popularizes the “near-neoclassical” demand curve for irrationality. This article attempts to show that there is a demand for irrationality at prices higher than zero. This may change policy implications. Many instances of consumer behavior, such as paying a premium for locally produced and “fair trade” goods, the use of local currencies, and the failure to vaccinate children, are other instances of the means-ends irrationality that Caplan observes in political markets.

Buddhism, Uncertainty And Modernity In A Hometown In Heart, Ronald S. Green, Chanju Mun

Philosophy and Religious Studies

A Hometown in Heart (Maeumui gohyang, 1949), written by Ham Sedeok (1915-1950) and directed by Yun Yonggyu (b.1913), is said to be the first Korean Buddhist film. It depicts Buddhism in a remote mountain region without even electricity. The main character of the film, an orphaned child monk, must decide what to do with his life. This paper argues that the central aspect of the Buddhism-related symbols represent Korean tradition and that the supporting characters represent socio-political forces in post-liberation Korean society just after liberation, pulling the young generation of Koreans in various directions. In particular, the film centers on …

Medicine@Yale June 2015 Volume 11, Issue 1, Yale School Of Medicine Office Of Communications

Medicine@Yale - development newsletter

Medicine@Yale : advancing biomedical science, education and health care was a print and online newsletter which published news about academics, research and philanthropy for alumni, donors, faculty, students and the general public. It was initially published 6 times a year and then changed to a quarterly schedule. The first issue came out June/Jul. 2005. The final issue was published in May/June 2022, vol. 17, issue 1. Published by Yale School of Medicine, Office of Communications.

Predictive Time Series Analysis Linking Bengal Cholera With Terrestrial Water Storage Measured From Gravity Recovery And Climate Experiment Sensors, Antarpreet Jutla, Ali Akanda, Avinash Unnikrishnan, Anwar Huq, Rita Colwell

Civil & Environmental Engineering Faculty Publications

Outbreaks of diarrheal diseases, including cholera, are related to floods and droughts in regions where water and sanitation infrastructure are inadequate or insufficient. However, availability of data on water scarcity and abundance in transnational basins, are a prerequisite for developing cholera forecasting systems. With more than a decade of terrestrial water storage (TWS) data from the Gravity Recovery and Climate Experiment, conditions favorable for predicting cholera occurrence may now be determined. We explored lead–lag relationships between TWS in the Ganges–Brahmaputra–Meghna basin and endemic cholera in Bangladesh. Since bimodal seasonal peaks in cholera in Bangladesh occur during spring and autumn seasons, …

Unm Hsc Annual Education Day Agenda 2015, Office For Medical Educator Development

HSC Education Days

No abstract provided.

"We're All Jock Tamson's Bairns": Scottish Ethnic Identity And Nationalism In America, Avalon Harder

Scripps Senior Theses

This paper explores how Scottish-Americans have contributed to Scottish national dialogues by laying roots for future generations in the form of early ethnic organizations as well as religious and social practices, engaging in discussion about what it means to be both white and ethnic, sustaining forms of traditional culture through Scottish Highland Games, and interpreting their personal experiences with ethnic and national identity as a way of negotiating their relationships with Scottish nationalism. The 2014 referendum on Scottish independence offered historical circumstances that were both relevant and exhilarating to explore these topics under. This exploration incorporates both interview and survey …

Trans People And Legal Recognition: What The U.S. Federal Government Can Learn From Foreign Nations, Amy Rappole

Maryland Journal of International Law

No abstract provided.

Effect Of The Acute Stress Response On Foraging Behavior In Mountain White-Crowned Sparrows, Zonotrichia Leucophrys, Sarah C. Osborne

Scripps Senior Theses

Free-living vertebrates likely encounter many stressors throughout their lifetime, from fighting off a predator to coping with unpredictable weather. As a result, vertebrates will mount an acute response to the stressors. Here, we outline previous research conducted in behavioral endocrinology and stress physiology as it relates to our research. We then discuss our study with white-crowned sparrows (Zonotrichia leucophrys) in Tioga Pass Meadow, in which we examined how the acute stress response affects foraging behavior 24 hours after a stressor. In birds that underwent a stress series, we found there to be a significant 57% decrease in foraging …

Amphibian And Small Mammal Assemblages In A Northern Virginia Forest Before And After Defoliation By Gypsy Moths (Lymantria Dispar), Joseph C. Mitchell

Virginia Journal of Science

The introduced European gypsy moth (Lymantria dispar) caused substantial defoliation and mortality of oak trees along the North Fork of Quantico Creek in Prince William Forest Park, Prince William County, Virginia, U.S.A., in 1989 and the early 1990s. Results of a drift fence/pitfall study conducted in 1988 were compared to those obtained from the same technique in the same areas in 1993 to elucidate whether the amphibian and small mammal assemblages had changed over time. Number of Lithobates sylvaticus increased significantly in 1993, but the numbers of Lithobates clamitans and Plethodon cinereus were significantly higher in 1988. Total …

International Investment And Development, Uche Ewelukwa, Qingqing Miao, Irina Feofanova, Amala Nath, Melissa Boudreau, Anne Marie Carson

The International Lawyer

No abstract provided.

Triplet Excitons In Natural Photosynthetic And Artificial Light Harvesting Systems: Measurement And Modeling., Daniel Allen Hartzler

Open Access Dissertations

Under full sunlight, unprotected (Bacterio)Chlorophyll ((B)Chl) molecules photodegrade in a matter of minutes. This is the result of the generation of highly reactive singlet oxygen (1O2) by energy transfer from the (B)Chl triplet state (3(B)Chl) to the oxygen ground state. Natural photosynthetic systems must protect themselves from 1O2, typically done by positioning carotenoids within a few angstroms of each (B)Chl molecule to quench 3(B)Chl states. Using phosphorescence spectroscopy and computational modeling, we investigated alternative, carotenoid independent, mechanisms which nature may employ to prevent 1O2 sensitization by lowering the energy of 3(B)Chl below that of 1O2. The two proposed triplet lowering …

Advanced Modeling And Efficient Optimization Methods For Real-Time Response In Water Networks, Arpan Seth

Open Access Dissertations

In response to a contamination incident in water distribution networks, effective mitigation procedures must be planned. Disinfectant booster stations can be used to neutralize a variety of contaminant and protect the public. In this thesis, two methods are proposed for the optimal placement of booster stations. Since the contaminant species is unknown a priori, these two methods differ in how they model the unknown reaction between the contaminant and the disinfectant. Both methods employ Mixed-Integer Linear Programming to minimize the expected impact over a large set of potential contamination scenarios that consider the uncertainty in the location and time of …