Digital Commons Network^™

Computer Simulation, Bioinformatics, And Statistical Analysis Of Cancer Data And Processes, Kellie J. Archer, Kevin Dobbin, Swati Biswas, Roger S. Day, David C. Wheeler, Hao Wu

Biostatistics Publications

No abstract provided.

Pdgfrα Signaling Drives Adipose Tissue Fibrosis By Targeting Progenitor Cell Plasticity, Tomoaki Iwayama, Cameron Steele, Longbiao Yao, Mikhail G. Dozmorov, Dimitris Karamichos, Jonathan D. Wren, Lorin E. Olson

Biostatistics Publications

Fibrosis is a common disease process in which profibrotic cells disturb organ function by secreting disorganized extracellular matrix (ECM). Adipose tissue fibrosis occurs during obesity and is associated with metabolic dysfunction, but how profibrotic cells originate is still being elucidated. Here, we use a developmental model to investigate perivascular cells in white adipose tissue (WAT) and their potential to cause organ fibrosis. We show that a Nestin-Cre transgene targets perivascular cells (adventitial cells and pericyte-like cells) in WAT, and Nestin-GFP specifically labels pericyte-like cells. Activation of PDGFRα signaling in perivascular cells causes them to transition into ECM-synthesizing profibrotic cells. Before …

Analysis Of Environmental Chemical Mixtures And Non-Hodgkin Lymphoma Risk In The Nci-Seer Nhl Study, Jenna Czarnota, Chris Gennings, Joanne S. Colt, Anneclaire J. De Roos, James R. Cerhan, Richard K. Severson, Patricia Hartge, Mary H. Ward, David C. Wheeler

Biostatistics Publications

Background: There are several suspected environmental risk factors for non-Hodgkin lymphoma (NHL). The associations between NHL and environmental chemical exposures have typically been evaluated for individual chemicals (i.e., one-by-one).

Objectives: We determined the association between a mixture of 27 correlated chemicals measured in house dust and NHL risk.

Methods: We conducted a population-based case–control study of NHL in four National Cancer Institute–Surveillance, Epidemiology, and End Results centers—Detroit, Michigan; Iowa; Los Angeles County, California; and Seattle, Washington—from 1998 to 2000. We used weighted quantile sum (WQS) regression to model the association of a mixture of chemicals and risk of NHL. The …

B-Cell And Monocyte Contribution To Systemic Lupus Erythematosus Identified By Cell-Type-Specific Differential Expression Analysis In Rna-Seq Data, Mikhail G. Dozmorov, Nicolas Dominguez, Krista Bean, Susan R. Macwana, Virginia Roberts, Edmund Glass, Judith A. James, Joel M. Guthridge

Biostatistics Publications

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by complex interplay among immune cell types. SLE activity is experimentally assessed by several blood tests, including gene expression profiling of heterogeneous populations of cells in peripheral blood. To better understand the contribution of different cell types in SLE pathogenesis, we applied the two methods in cell-type-specific differential expression analysis, csSAM and DSection, to identify cell-type-specific gene expression differences in heterogeneous gene expression measures obtained using RNA-seq technology. We identified B-cell-, monocyte-, and neutrophil-specific gene expression differences. Immunoglobulin-coding gene expression was altered in B-cells, while a ribosomal signature was prominent in …

Diabetes Management Before And After Cancer Diagnosis: Missed Opportunity, Nengliang Yao, Fabian T. Camacho, Askar S. Chukmaitov, Steven T. Fleming, Roger T. Anderson

Health Policy Publications

Background

Few studies have examined the management of comorbidities in cancer patients. This study used population-based data to estimate the guideline concordance rates for diabetes management before and after cancer diagnosis and examined if diabetes management services among cancer patients was associated with characteristics of the hospital where the patient was treated.

Methods

We linked 2005-2009 Medicare claims data to information on 2,707 breast and colorectal cancers patients in state cancer registry files. Multivariate logistic regression models examined hospital characteristics associated with receipt of diabetes management care after cancer diagnosis.

Results

The rates of HbAlc testing, LDL-C testing, and retinal …

The Relationship Between Terrorism, Oil Prices, And Airline Profitability, Ubirathan Miranda

2010-2016 Archived Posters

Increase in the price of petroleum and terrorism negatively affect airline profitability. This quantitative study was an exploration of the relationship between terrorism, fuel price, and airline profitability. Airline financial and security archives were the data for this study. Results indicate that terrorism and fuel cost significantly predict profitability.

Biological Invasion Hotspots: A Trait-Based Perspective Reveals New Sub-Continental Patterns, Basil V. Iannone Iii, Kevin M. Potter, Qinfeng Guo, Andrew M. Liebhold, Bryan C. Pijanowski, Christopher M. Oswalt, Songlin Fei

United States Department of Agriculture, Forest Service / University of Nebraska-Lincoln: Faculty Publications

Invader traits (including plant growth form) may play an important, and perhaps overlooked, role in determining macroscale patterns of biological invasions and therefore warrant greater consideration in future investigations aimed at understanding these patterns. To assess this need, we used empirical data from a national-level survey of forest in the contiguous 48 states of the USA to identify geographic hotspots of forest plant invasion for three distinct invasion characteristics: invasive species richness, trait richness (defined as the number of the five following plant growth forms represented by the invasive plants present at a given location: forbs, grasses, shrubs, trees, and …

Photogenerated O-Azaxylylenes: Mechanistic Studies And Synthetic Applications, William Cole Cronk

Electronic Theses and Dissertations

This research sets out to build upon excited state o-azaxylylene cycloaddition. The mechanism behind the excitation and cycloaddition process of photogenerated o-azaxylylenes was determined experimentally. Time-correlated single-photon counting, steady-state spectroscopy, triplet quenching experiments, and quantum yield studies provided evidence suggesting that excited state intramolecular proton transfer is followed by intersystem crossing and stepwise addition to the tethered unsaturated pendant.

In keeping with the principles of diversity oriented synthesis, a modular approach was taken to gain access to a diverse array of N,O,S-Polyheterocycles which were modified postphotochemically via Suzuki coupling to yield fused biaryls. Cycloaddition products, outfitted with halogens …

Climate Trends In The Casco Bay Region, Marina Schauffler Phd

Publications

The Casco Bay region is vulnerable to all seven of the climate stressors identified by the U.S. Environmental Protection Agency (US EPA): warmer summers; warmer winters; warmer waters; increased drought; increased storminess (evident in higher total precipitation, frequency and intensity); sea-level rise; and ocean acidification (US EPA 2014). These climate stressors do not operate in isolation. Compounding their impacts are factors such as population growth, habitat fragmentation and destruction, and resource depletion that can further tax ecosystems and species. This document summarizes current scientific evidence of these trends within Maine and, where possible, within the Casco Bay watershed (which coincides …

A Changing Casco Bay, The Bay Where You Work And Play Is At Risk, Learn How You Can Help Protect The Health Of Casco Bay, Friends Of Casco Bay

Publications

No abstract provided.

Can A Right To Reproduce Justify The Status Quo On Parental Licensing?, Andrew Botterell, Carolyn Mcleod

Philosophy Publications

Most Western jurisdictions require parental licensing in the case of adoption but not in the case of assisted or unassisted biological reproduction. In an earlier paper, we set out to show that no arguments in favour of such a system of parental licensing succeed. One argument that we failed to consider, however, is one that appeals to the notion of a right to reproduce. According to this argument, prospective biological parents are protected from parental licensing because they exercise a right to reproduce when attempting to have children, while the same cannot be said about prospective adoptive parents. This paper …

Dye Distance Mapping Using Waveguide Evanescent Field Fluorescence Microscopy And Its Application To Cell Biology, Frederik Fleissner, Michael Morawitz, S. Jeffrey Dixon, Uwe Langbein, Silvia Mittler

Physics and Astronomy Publications

Previous studies have measured the distance between cells and the substratum at sites of adhesion via the emission of a fluorescent dye and waveguide methods. Here, we demonstrate a novel approach to measure the position of fluorescent dyes above a waveguide surface in the 10-200 nm distance range throughout an entire area, yielding a 2D dye distance map or a 3D contour plot. The dye is located in a multilayered Langmuir Blodgett (LB) film or in the plasma membrane of a cell. Waveguide evanescent field fluorescence (WEFF) images obtained using two different waveguide modes are employed allowing, with a simple …

Cd4+ And Cd8+ T Cells Have Opposing Roles In Breast Cancer Progression And Outcome, Yi Huang, Chunling Ma, Qunyuan Zhang, Jian Ye, Fang Wang, Yanping Zhang, Pamela Hunborg, Mark A. Varvares, Daniel F. Hoft, Eddy C. Hsueh, Guangyong Peng

Open Access Publications

No abstract provided.

De Novo Design Of Heat-Repressible Rna Thermosensors In E-Coli, Allison Hoynes-O'Connor, Kristina Hinman, Lukas Kirchner, Tae Seok Moon

Open Access Publications

No abstract provided.

Does Diacylglycerol Accumulation In Fatty Liver Disease Cause Hepatic Insulin Resistance?, Brian N. Finck, Angela M. Hall

Open Access Publications

No abstract provided.

Imidazolium Salts As Small-Molecule Urinary Bladder Exfoliants In A Murine Model, Patrick O. Wagers, Kristin M. Tiemann, Kerri L. Shelton, William G. Kofron, Matthew J. Panzner, Karen L. Wooley, Wiley J. Youngs, David A. Hunstad

Open Access Publications

No abstract provided.

The Role Of The Lymphatic System In Cholesterol Transport, Li-Hao Huang, Andrew Elvington, Gwendalyn J. Randolph

Open Access Publications

No abstract provided.

Trans-Mitochondrial Coordination Of Cristae At Regulated Membrane Junctions, Martin Picard, Meagan J. Mcmanus, György Csordás, Péter Várnai, Gerald W. Dorn Ii, Dewight Williams, György Hajnóczky, Douglas C. Wallace

Open Access Publications

No abstract provided.

Global Analyses Revealed Age-Related Alterations In Innate Immune Responses After Stimulation Of Pathogen Recognition Receptors, Talibah U. Metcalf, Rafael A. Cubas, Khader Ghneim, Michael J. Cartwright, Julien Van Grevenynghe, Justin M. Richner, David P. Olagnier, Peter A. Wilkinson, Mark J. Cameron, Byung S. Park, John B. Hiscott, Michael S. Diamond, Anne M. Wertheimer, Janko Nikolich-Zugich, Elias K. Haddad

Open Access Publications

No abstract provided.

Selective Cognitive And Psychiatric Manifestations In Wolfram Syndrome, Allison N. Bischoff, Angela M. Reiersen, Anna Buttlaire, Amal Al-Lozi, Tasha Doty, Bess A. Marshall, Tamara Hershey, Washington University Wolfram Syndrome Research Group

Open Access Publications

No abstract provided.

How Resort Owners And Customers Perceive Ecosystems To Be Affected By Changes In Water Level Regulation In Voyageurs National Park, Lauren M. Meckle

Honors Capstones

Capstone submitted as a graduation requirement for the BSU Honors Program.

Validating A Method For Measuring Protein Domain And Lipid Binding Interactions Using Luciferase Fusion Proteins, Dezaray E. Thoen

Honors Capstones

Capstone submitted as a graduation requirement for the BSU Honors Program.

Tyk2 Protein-Coding Variants Protect Against Rheumatoid Arthritis And Autoimmunity, With No Evidence Of Major Pleiotropic Effects On Non-Autoimmune Complex Traits, Robert S. Fulton, David E. Larson, Tracie L. Deluca, Michelle O'Laughlin, Catrina C. Fronick, Lucinda L. Fulton, Elaine R. Mardis, Et Al

Open Access Publications

No abstract provided.

Sugarcoated Isolation: Evidence That Social Avoidance Is Linked To Higher Basal Glucose Levels And Higher Consumption Of Glucose, Tsachi Ein-Dor, James A. Coan, Abira Reizer, Elizabeth B. Gross, Dana Dahan, Meredyth A. Wegener, Rafael Carel, Claude R. Cloninger, Ada H. Zohar

Open Access Publications

No abstract provided.

Visual Learning Induces Changes In Resting-State Fmri Multivariate Pattern Of Information, Roberto Guidotti, Cosimo Del Gratta, Antonello Baldassarre, Gian Luca Romani, Maurizio Corbetta

Open Access Publications

No abstract provided.

The Dek Oncoprotein Is A Critical Component Of The Eklf/Klf1 Enhancer In Erythroid Cells, Felix Lohmann, Mohan Dangeti, Shefali Soni, Xiaoyong Chen, Antanas Planutis, Margaret H. Baron, Kyunghee Choi, James J. Bieker

Open Access Publications

No abstract provided.

Physical Mapping And Refinement Of The Painted Turtle Genome (Chrysemys Picta) Inform Amniote Genome Evolution And Challenge Turtle-Bird Chromosomal Conservation, Daleen Badenhorst, Ladeana W. Hillier, Robert Literman, Eugenia Elisabet Montiel, Srihari Radhakrishnan, Yingjia Shen, Patrick Minx, Daniel E. Janes, Wesley C. Warren, Scott V. Edwards, Nicole Valenzuela

Open Access Publications

No abstract provided.

Detailed Phenotypic And Molecular Analyses Of Genetically Modified Mice Generated By Crispr-Cas9-Mediated Editing, Bijal A. Parikh, Diana L. Beckman, Swapneel J. Patel, J. Michael White, Wayne M. Yokoyama

Open Access Publications

No abstract provided.

Small Sized Egfr1 And Her2 Specific Bifunctional Antibody For Targeted Cancer Therapy, Li Ding, Caiping Tian, Song Feng, Guissi Fida, Congying Zhang, Yuxiang Ma, Guanhua Ai, Samuel Achilefu, Yueqing Gu

Open Access Publications

No abstract provided.

Malaria Parasites Produce Volatile Mosquito Attractants, Megan Kelly, Chih-Ying Su, Chad Schaber, Jan R. Crowley, Fong-Fu Hsu, John R. Carlson, Audrey R. Odom

Open Access Publications

No abstract provided.