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Uab Research Probes Molecular Basis Of Rare Genetic Disorder, Jeff Hansen

Browse All News

No abstract provided.

Repressive Mutations Restore Function-Loss Caused By The Disruption Of Trimerization In Escherichia Coli Multidrug Transporter Acrb, Zhaoshuai Wang, Meng Zhong, Wei Lu, Qian Chai, Yinan Wei

Chemistry Faculty Publications

AcrAB-TolC and their homologs are major multidrug efflux systems in Gram-negative bacteria. The inner membrane component AcrB functions as a trimer. Replacement of Pro223 by Gly in AcrB decreases the trimer stability and drastically reduces the drug efflux activity. The goal of this study is to identify suppressor mutations that restore function to mutant AcrB_P223G and explore the mechanism of function recovery. Two methods were used to introduce random mutations into the plasmid of AcrB_P223G. Mutants with elevated drug efflux activity were identified, purified, and characterized to examine their expression level, trimer stability, interaction with AcrA, and …

Pact/Rax Regulates The Migration Of Cerebellar Granule Neurons In The Developing Cerebellum, Yue Yong, Ya Meng, Hanqing Ding, Zhiqin Fan, Yifen Tang, Chenghua Zhou, Jia Luo, Zun-Ji Ke

Pharmacology and Nutritional Sciences Faculty Publications

PACT and its murine ortholog RAX were originally identified as a protein activator for the dsRNA-dependent, interferon-inducible protein kinase PKR. Recent studies indicated that RAX played a role in embryogenesis and neuronal development. In this study, we investigated the expression of RAX during the postnatal development of the mouse cerebellum and its role in the migration of cerebellar granule neurons (CGNs). High expression of RAX was observed in the cerebellum from postnatal day (PD) 4 to PD9, a period when the CGNs migrate from the external granule layer (EGL) to the internal granule layer (IGL). The migration of the EGL …

Structural Mechanism Of Laforin Function In Glycogen Dephosphorylation And Lafora Disease, Madushi Raththagala, M. Kathryn Brewer, Matthew W. Parker, Amanda R. Sherwood, Brian K. Wong, Simon Hsu, Travis M. Bridges, Bradley C. Paasch, Lance M. Hellman, Satrio Husodo, David A. Meekins, Adam O. Taylor, Benjamin D. Turner, Kyle D. Auger, Vikas V. Dukhande, Srinivas Chakravarthy, Pascual Sanz, Virgil L. Woods Jr., Sheng Li, Craig Vander Kooi, Matthew S. Gentry

Molecular and Cellular Biochemistry Faculty Publications

Glycogen is the major mammalian glucose storage cache and is critical for energy homeostasis. Glycogen synthesis in neurons must be tightly controlled due to neuronal sensitivity to perturbations in glycogen metabolism. Lafora disease (LD) is a fatal, congenital, neurodegenerative epilepsy. Mutations in the gene encoding the glycogen phosphatase laforin result in hyperphosphorylated glycogen that forms water-insoluble inclusions called Lafora bodies (LBs). LBs induce neuronal apoptosis and are the causative agent of LD. The mechanism of glycogen dephosphorylation by laforin and dysfunction in LD is unknown. We report the crystal structure of laforin bound to phosphoglucan product, revealing its unique integrated …

Hidden Formaldehyde In E-Cigarette Aerosols, R. Paul Jensen, Wentai Luo, James F. Pankow, Robert M. Strongin, David H. Peyton

Chemistry Faculty Publications and Presentations

This letter reports a chemical analysis of vapor from electronic cigarettes that shows high levels of formaldehyde, a known carcinogen. The authors project that the associated incremental lifetime risk of cancer could be higher than that from long-term smoking.

Freshman Year Experience: A Comprehensive Review, Portland State University. University Studies Council

University Studies Assessment Research

Report that conceptualizes the challenges faced by future freshmen, and recommend strategies, alignments, and any changes needed for developing a unique first -year experience that address these challenges.

The Leishmania Years At Unl (Or, My Life As A Cell Biologist, 1966-1981), John J. Janovy Jr.

Harold W. Manter Laboratory of Parasitology: Faculty Publications

Slides for a talk during which Professor Janovy discussed the methods he used in researching Leishmania during the years 1966-1981. Includes lists of references.

The George-Anne, Georgia Southern University

The George-Anne

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Developmental Telomere Attrition Predicts Impulsive Decision-Making In Adult Starlings, M Bateson, Bo Brilot, R Gillespie, P Monaghan, D Nettle

School of Biological and Marine Sciences

Animals in a poor biological state face reduced life expectancy, and as a consequence should make decisions that prioritize immediate survival and reproduction over long-term benefits. We tested the prediction that if, as has been suggested, developmental telomere attrition is a biomarker of state and future life expectancy, then individuals who have undergone greater developmental telomere attrition should display greater choice impulsivity as adults. We measured impulsive decision-making in a cohort of European starlings (Sturnus vulgaris) in which we had previously manipulated developmental telomere attrition by cross-fostering sibling chicks into broods of different sizes. We show that as predicted by …

Assign: Context-Specific Genomic Profiling Of Multiple Heterogeneous Biological Pathways, Ying Shen, Mumtahena Rahman, Stephen R. Piccolo, Daniel Gusenleitner, Nader N. El-Chaar, Luis Cheng, Stefano Monti, Andrea H. Bild, W. Evan Johnson

Faculty Publications

Motivation: Although gene-expression signature-based biomarkers are often developed for clinical diagnosis, many promising signatures fail to replicate during validation. One major challenge is that biological samples used to generate and validate the signature are often from heterogeneous biological contexts—controlled or in vitro samples may be used to generate the signature, but patient samples may be used for validation. In addition, systematic technical biases from multiple genome-profiling platforms often mask true biological variation. Addressing such challenges will enable us to better elucidate disease mechanisms and provide improved guidance for personalized therapeutics.

Results: Here, we present a pathway profiling toolkit, Adaptive Signature …

Ethics In The Field: Contemporary Challenges, Lisa C. Depaoli

Journal of Ecological Anthropology

No abstract provided.

Liar, Liar, Jury's The Trier? The Future Of Neuroscience-Based Credibility Assessment In The Court, John B. Meixner

Northwestern University Law Review

No abstract provided.

Reining In Patent Term Extensions For Related Pharmaceutical Products Post-Photocure And Ortho-Mcneil, Ann Kotze

Northwestern University Law Review

No abstract provided.

Uptake And Accumulation Of Bulk And Nanosized Cerium Oxide Particles And Ionic Cerium By Radish (Raphanus Sativus L.)., Weilan Zhang, Stephen D. Ebbs, Craig Musante, Jason C. White, Cunmei Gao, Xingmao Ma

Publications

The potential toxicity and accumulation of engineered nanomaterials (ENMs) in agricultural crops has become an area of great concern and intense investigation. Interestingly, although below-ground vegetables are most likely to accumulate the highest concentrations of ENMs, little work has been done investigating the potential uptake and accumulation of ENMs for this plant group. The overall objective of this study was to evaluate how different forms of cerium (bulk cerium oxide, cerium oxide nanoparticles, and the cerium ion) affected the growth of radish (Raphanus sativus L.) and accumulation of cerium in radish tissues. Ionic cerium (Ce(3+)) had a negative effect on …

Weekly News Digest 01/21/2015, Jenna Ray

Weekly Bulletin Archive

In This Issue:

● Performing Arts Series Presents Ragamala Dance

● Morris Receives NSF Funding for STEM Education

● Work by Ng Published in Discrete Mathematics

● Niche Names Morris One of the 10 Best Colleges in Minnesota

January 21, 2015 Cal Poly Report, Public Affairs Office

Cal Poly Report

No abstract provided.

Science Cafe: Brune On ‘Cosmic Cooking: Origin Of Elements,’ Jan. 21, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

January Agenda, Wku Graduate Council

Graduate School

Meeting agenda.

The Lumberjack, January 21, 2015, The Lumberjack Staff

2015

The student newspaper of Humboldt State University

The Intended And Unintended Effects Of Fishing On Deep Sea Fish, David M. Bailey, Rosanna Milligan

Marine & Environmental Sciences Faculty Proceedings, Presentations, Speeches, Lectures

No abstract provided.

Observations And Analysis Of Organic Aerosol Evolution In Some Prescribed Fire Smoke Plumes, A. A. May, T. Lee, G. R. Mcmeeking, Sheryl Kashi Akagi, A. P. Sullivan, S. P. Urbanski, Robert Yokelson, S. M. Kreidenweis

Chemistry and Biochemistry Faculty Publications

Open biomass burning is a significant source of primary air pollutants such as particulate matter and non-methane organic gases. However, the physical and chemical atmospheric processing of these emissions during transport is poorly understood. Atmospheric 5 transformations of biomass burning emissions have been investigated in environmental chambers, but there have been limited opportunities to investigate these transformations in the atmosphere. In this study, we deployed a suite of real-time instrumentation on a Twin Otter aircraft to sample smoke from prescribed fires in South Carolina, conducting measurements at both the source and downwind to character10 ize smoke evolution with atmospheric aging. …

Skeletal Muscle Fibrosis In The Mdx/Utrn Plus /- Mouse Validates Its Suitability As A Murine Model Of Duchenne Muscular Dystrophy, Kelly M. Gutpell, William T. Hrinivich, Lisa M. Hoffman

Anatomy and Cell Biology Publications

Various therapeutic approaches have been studied for the treatment of Duchenne muscular dystrophy (DMD), but none of these approaches have led to significant long-term effects in patients. One reason for this observed inefficacy may be the use of inappropriate animal models for the testing of therapeutic agents. The mdx mouse is the most widely used murine model of DMD, yet it does not model the fibrotic progression observed in patients. Other murine models of DMD are available that lack one or both alleles of utrophin, a functional analog of dystrophin. The aim of this study was to compare fibrosis and …

Vesicle Biomechanics In A Time-Varying Magnetic Field, Hui Ye, Austen Curcuru

Biology: Faculty Publications and Other Works

Background Cells exhibit distortion when exposed to a strong electric field, suggesting that the field imposes control over cellular biomechanics. Closed pure lipid bilayer membranes (vesicles) have been widely used for the experimental and theoretical studies of cellular biomechanics under this electrodeformation. An alternative method used to generate an electric field is by electromagnetic induction with a time-varying magnetic field. References reporting the magnetic control of cellular mechanics have recently emerged. However, theoretical analysis of the cellular mechanics under a time-varying magnetic field is inadequate. We developed an analytical theory to investigate the biomechanics of a modeled vesicle under a …

Mathematical Biology Seminar Features Xue Gong, Jan 21, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Outside, Inside By Michael Penny, Mark Byers

The Goose

Review of Michael Penny's Outside, Inside.

Volume 52, Number 23: January 21, 2015, University Of North Dakota

University Letter Archive

No abstract provided.

Rift Valley Fever Virus Infection In Golden Syrian Hamsters, Dionna Scharton, Arnaud J. Van Wettere, Kevin W. Bailey, Zachary Vest, Jonna B. Westover, Venkatraman Siddharthan, Brian B. Gowen

Animal, Dairy, and Veterinary Science Faculty Publications

Rift Valley fever virus (RVFV) is a formidable pathogen that causes severe disease and abortion in a variety of livestock species and a range of disease in humans that includes hemorrhagic fever, fulminant hepatitis, encephalitis and blindness. The natural transmission cycle involves mosquito vectors, but exposure can also occur through contact with infected fluids and tissues. The lack of approved antiviral therapies and vaccines for human use underlies the importance of small animal models for proof-of-concept efficacy studies. Several mouse and rat models of RVFV infection have been well characterized and provide useful systems for the study of certain aspects …

Daily Eastern News: January 21, 2015, Eastern Illinois University

January

No abstract provided.

Minutes, University Of South Florida St. Petersburg Undergraduate Council Meeting, January 21, 2015, University Of South Florida St. Petersburg. Faculty Senate. Undergraduate Council

USF St. Petersburg Undergraduate Council

Minutes from the January 21, 2015, meeting of the University of South Florida St. Petersburg's Undergraduate Council.

Postnatal Growth Rates Covary Weakly With Embryonic Development Rates And Do Not Explain Adult Mortality Probability Among Songbirds On Four Continents, Thomas E. Martin, Oteyza C. Oteyza, Adam E. Mitchell, Ahva L. Potticary, Penn Lloyd

Wildlife Biology Faculty Publications

Growth and development rates may result from genetic programming of intrinsic processes that yield correlated rates between life stages. These intrinsic rates are thought to affect adult mortality probability and longevity. However, if proximate extrinsic factors (e.g., temperature, food) influence development rates differently between stages and yield low covariance between stages, then development rates may not explain adult morality probability. We examined these issues based on study of 90 songbird species on four continents to capture the diverse life-history strategies observed across geographic space. The length of the embryonic period explained little variation (ca. 13%) in nestling periods and growth …