Digital Commons Network^™

Rational Design Of A Chalcogenopyrylium-Based Surface-Enhanced Resonance Raman Scattering-Nanoprobe With Attomolar Sensitivity, Stefan Harmsen, Matthew A. Bedics, Matthew A. Wall, Ruimin Huang, Michael R. Detty, Moritz F. Kircher

Publications and Research

High sensitivity and specificity are two desirable features in biomedical imaging. Raman imaging has surfaced as a promising optical modality that offers both. Here, we report the design and synthesis of a group of near infrared absorbing 2-thienyl-substituted chalcogenopyrylium dyes tailored to have high affinity for gold. When adsorbed onto gold nanoparticles, these dyes produce biocompatible SERRS-nanoprobes with attomolar limits of detection amenable to ultrasensitive in vivo multiplexed tumor and disease marker detection.

Oncostatin M Modulation Of Lipid Storage, Carrie M. Elks, Jacqueline M. Stephens, Jacqueline M. Stephens

Faculty Publications

© 2015 by the authors; licensee MDPI, Basel, Switzerland. Oncostatin M (OSM) is a cytokine belonging to the gp130 family, whose members serve pleiotropic functions. However, several actions of OSM are unique from those of other gp130 cytokines, and these actions may have critical roles in inflammatory mechanisms influencing several metabolic and biological functions of insulin-sensitive tissues. In this review, the actions of OSM in adipose tissue and liver are discussed, with an emphasis on lipid metabolism.

February 13-14, 2015, Vs. Denver, University Of North Dakota

UND Athletics Publications: Men's Hockey

Program for the February 13-14, 2015, weekend series against the Denver Pioneers.

Long-Term Forest Soil Warming Alters Microbial Communities In Temperate Forest Soils, Kristen M. Deangelis, Grace Pold, Begum D. Topcuoglu, Linda T. A. Van Diepen, Rebecca M. Varney, Jeffrey L. Blanchard, Jerry Melillo, Serita D. Frey

Faculty Publications

Soil microbes are major drivers of soil carbon cycling, yet we lack an understanding of how climate warming will affect microbial communities. Three ongoing field studies at the Harvard Forest Long-term Ecological Research (LTER) site (Petersham, MA) have warmed soils 5°C above ambient temperatures for 5, 8, and 20 years. We used this chronosequence to test the hypothesis that soil microbial communities have changed in response to chronic warming. Bacterial community composition was studied using Illumina sequencing of the 16S ribosomal RNA gene, and bacterial and fungal abundance were assessed using quantitative PCR. Only the 20-year warmed site exhibited significant …

Matural Exams In Kosovo: An Analysis On 2014 Test Results, Genta Agaj

Theses

The focus of this research project was to address some of the criticisms associated with Kosovo’s standardized tests - Matura Exams. The main goal of the project was to statistically analyze students’ test results using three statistical techniques. This problem was tackled by obtaining the 2014 results for the Municipality of Prishtina.

First, Prishtina’s Matura Exam test results were checked for normality. The results from this test suggested that even though Matura Exam is supposed to have normally-distributed results, it failed to do so. Its implications include students and universities not being able to compare individual results with the population …

Uab Team Sets Sail For Antarctica To Conduct Predatory Crab Research, Staff

Browse All News

No abstract provided.

Book Review: Nuclear Weapons And Law. Ed. Arthur Selwyn Miller And Martin Feinrider. Westport, Connecticut: Greenwood Press, 1984., Dorinda G. Dallmeyer

Georgia Journal of International & Comparative Law

No abstract provided.

The Fierce Green Fire: Vol 5 Issue 13, Wofford College Environmental Studies Program

The Fierce Green Fire

No abstract provided.

Cwu Curriculum Committee Minutes - 02/12/15, Janet Shields

All Faculty Committee Minutes

These are the official Central Washington University Curriculum Committee minutes for the 02/12/15 meeting.

Agenda: Seeds Of Change: Responding To Global Change In A Bottom-Up World, University Of Colorado Boulder. Getches-Wilkinson Center For Natural Resources, Energy, And The Environment, University Of Colorado Boulder. School Of Law, Posner Center For International Development, Resolve (Firm), Newmont Mining Corporation

Seeds of Change: Responding to Global Change in a Bottom-Up World (Martz Winter Symposium, February 12-13)

Sponsors: Posner Center for International Development, RESOLVE, Inc., Newmont Mining Corporation, and Getches-Wilkinson Center for Natural Resources, Energy, and the Environment.

Conference moderators, panelists and speakers included University of Colorado Law School professors Phil Weiser, Sarah Krakoff, Britt Banks, and Lakshman Guruswamy.

This conference is made possible through the generous support of donors who sponsored this year’s Martz Sustainability Symposium (including Newmont Mining Corporation) and those who have invested in our Clyde O. Martz Endowed Fund for Natural Resources Management (including Brian Dolan and Davis Graham and Stubbs LLP). The Martz Natural Resources Management Fund was established in the memory …

Preparing Students To Be Ethical Decision Makers, Sheila Strider, Lazo Alexandre

Faculty Articles

ethics, academia, corporate social responsibility, decision making, leadership, stakeholder interest, financial misconduct.

The Setonian, February 12, 2015, Seton Hall University

2015

No abstract provided.

The Pacifican February 12, 2015, University Of The Pacific

All Issues - Student Newspaper, The Pacifican, Pacific Weekly

No abstract provided.

Otter Realm, February 12, 2015, California State University, Monterey Bay

The Otter Realm

Black History Month: Clubs and Organizations Pay Tribute To Black History Month At CSUMB -- An Educator Outside The Classroom -- What You Otter Be Doing February 12 - February 25 -- Safety First In Transportation: Every Student Has The Right To Be Safe By Reminding Themselves Of Safety Guidelines For All Commuters on Campus -- Board Of Trustees Adopts New Opt-Out Fee Across CSU System: $2 Goes A Long Way, "Success Fees" Take A Step Back -- CSUMB, Seaside And African American History--Part 1 -- History In The Making: Clubs And Organizations Pay Tribute To Black History Month At …

February 12, 2015, James Madison University

The Breeze, 2010-2019

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

Flipping The Classroom And Student Performance In Advanced Statistics: Evidence From A Quasi-Experiment, Michael Touchton

Political Science Faculty Publications and Presentations

I administer a quasi-experiment using undergraduate political science majors in statistics classes to evaluate whether “flipping the classroom” (the treatment) alters students’ applied problem-solving performance and satisfaction relative to students in a traditional classroom environment (the control). I also assess whether general student characteristics such as when and where students took the prerequisite course, grade point average (GPA), and gender influence performance. I find flipping the classroom gives students statistically significant advantages in difficult, applied areas emphasized in class. Furthermore, students in the flipped classroom feel they learned more and enjoyed the course more than those in a traditional classroom. …

The Scarlet - Volume Xciv, No. 14 (February 12, 2015), Scarlet Staff

The Scarlet (Student Newspaper) (2011-present)

The February 12, 2015 edition of The Scarlet (est. 1939), Clark University's student-run newspaper. The Scarlet is intellectually and editorially independent of the University.

The Utah Statesman, February 12, 2015, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

New Country Records Of Scarabaeoidea (Coleoptera) From The Palaearctic Region, Stefano Ziani, Aleš Bezděk, Tristão Branco, Oliver Hillert, Stanislav Jákl, David Král, Marion Mantič, Eckehard Rößner, Richard Sehnal

Insecta Mundi

New country records for Coleoptera Scarabaeoidea are provided. For each species the distribution is given.

Born Naked By Farley Mowat, Ted Geier

The Goose

Farley Mowat's charming childhood memoir covers the usual Mowat terrain: riotous humour, humble reverence, and a meticulous accounting of the little things that make life--all life--dear to us. Mowat's work deserves regular attention in animal studies and environmental literary studies. His autobiographical techniques, as this review suggests, can be both assets and occasional impediments. But there is no replacing or replicating a Farley Mowat, and Born Naked deserves to be read immediately and repeatedly as one of the lasting legacies of a long life, well-lived.

Impaired Gamma Delta T Cell-Derived Il-17a And Inflammasome Activation During Early Respiratory Syncytial Virus Infection In Infants, Huaqiong Huang, Jordy Saravia, Dahui You, Aaron J. Shaw, Stephania A. Cormier

Faculty Publications

© 2015 Australasian Society for Immunology Inc. Respiratory syncytial virus (RSV) infection remains a significant global health burden disproportionately affecting infants and leading to long-term lung disease. Interleukin (IL)-17A has been shown to be involved in regulating viral and allergic lung inflammatory responses, which has led to a more recent interest in its role in RSV infection. Using a neonatal mouse model of RSV, we demonstrate that neonates fail to develop IL-17A responses compared with adult mice; the main immediate IL-17A contributor in adults were γδ T cells. Antibody neutralization of IL-17A in adult mice caused increased lung inflammation and …

Metagenomics Reveals Planktonic Bacterial Community Shifts Across A Natural Co2 Gradient In The Mediterranean Sea., Ashvini Chauhan, Ashish Pathak, Riccardo Rodolfo-Metalpa, Marco Milazzo, Stefan J. Green, Jason M. Hall-Spencer

School of Biological and Marine Sciences

Bacterial communities at a CO2 vent (pH 6.7) were compared with those at control (pH 8.0) and transition sites (pH 7.6) using 16S rRNA metagenomics. Firmicutes and unclassified bacteria dominated across all sites, Proteobacteria, especially Gammaproteobacteria, declined, and Epsilonproteobacteria increased in the vent with an increase in Bacteroidetes at both the vent and transition sites.

New Genetic Loci Link Adipose And Insulin Biology To Body Fat Distribution, D. Shungin, T. W. Winkler, D. C. Croteau-Chonka, T. Ferreira, A. E. Locke, R. Mägi, R. J. Strawbridge, T. H. Pers, K. Fischer, A. E. Justice, T. Workalemahu, J. M.W. Wu, M. L. Buchkovich, N. L. Heard-Costa, T. S. Roman, A. W. Drong, C. Song, S. Gustafsson, F. R. Day, T. Esko, T. Fall, Z. Kutalik, J. Luan, J. C. Randall, A. Scherag, S. Vedantam, A. R. Wood, J. Chen, R. Fehrmann, J. Karjalainen, B. Kahali, C. T. Liu, E. M. Schmidt

Faculty Publications

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, we conducted genome-wide association meta-analyses of waist and hip circumference-related traits in up to 224,459 individuals. We identified 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (WHRadjBMI) and an additional 19 loci newly associated with related waist and hip circumference measures (P<5×10-8). Twenty of the 49 WHRadjBMI loci showed significant sexual dimorphism, 19 of which displayed a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation, and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.

Genetic Studies Of Body Mass Index Yield New Insights For Obesity Biology, A. E. Locke, B. Kahali, S. I. Berndt, A. E. Justice, T. H. Pers, F. R. Day, C. Powell, S. Vedantam, M. L. Buchkovich, J. Yang, D. C. Croteau-Chonka, T. Esko, T. Fall, T. Ferreira, S. Gustafsson, Z. Kutalik, J. Luan, R. Mägi, J. C. Randall, T. W. Winkler, A. R. Wood, T. Workalemahu, J. D. Faul, J. A. Smith, J. H. Zhao, W. Zhao, J. Chen, R. Fehrmann, K. Hedman, J. Karjalainen, E. M. Schmidt, D. Absher, N. Amin

Faculty Publications

Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10-8), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20 % of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.

The Weekly Challenger, February 12, 2015, The Weekly Challenger, Et Al

Weekly Challenger Newspaper Collection

The February 12, 2015, issue of The Weekly Challenger.

Panther - February 2015 - Vol. Xcv No. 2, Prairie View A&M University

PV Panther Newspapers

No abstract provided.

Abnormal Myofiber Morphology And Limb Dysfunction In Claudication, Panagiotis Koutakis, Sara A. Myers, Kim Cluff, Duy M. Ha, Gleb Haynatzki, Rodney D. Mccomb, Koji Uchida, Dimitrios Miserlis, Evlampia Papoutsi, Jason M. Johanning, George P. Casale, Iraklis Pipinos

Journal Articles

Background

Methods

Wsu Board Of Trustees Meeting Minutes, February 12-13, 2015

Board of Trustees Minutes

Minutes from the Wright State University Board of Trustees Meeting held on February 12-13, 2015.

Radiative Energy And Momentum Transfer For Various Spherical Shapes: A Single Sphere, A Bubble, A Spherical Shell And A Coated Sphere, Yi Zheng, Alok Ghanekar

Mechanical, Industrial & Systems Engineering Faculty Publications

We use fluctuational electrodynamics to determine spectral emissivity and van der Waals contribution to surface energy for various spherical shapes, such as a sphere, a bubble, a spherical shell, and a coated sphere, in a homogeneous and isotropic medium. The dyadic Green's function formalism of radiative energy and fluctuation-induced van der Waals stress for different spherical configurations has been developed. We show (1) emission spectra of micro- and nano-sized single and coated spheres display several emissivity sharp peaks as the size of object reduces and (2) surface energy becomes size dependent due to van der Waals phenomena when size of …

Elimination Of Hydrogenase Active Site Assembly Blocks H2 Production And Increases Ethanol Yield In Clostridium Thermocellum, Ranjita Biswas, Tianyong Zheng, Daniel G. Olson, Lee R. Lynd, Adam M. Guss

Dartmouth Scholarship

Background: The native ability of Clostridium thermocellum to rapidly consume cellulose and produce ethanol makes it a leading candidate for a consolidated bioprocessing (CBP) biofuel production strategy. C. thermocellum also synthesizes lactate, formate, acetate, H₂ , and amino acids that compete with ethanol production for carbon and electrons. Elimination of H₂ production could redirect carbon flux towards ethanol production by making more electrons available for acetyl coenzyme A reduction to ethanol. Results: H₂ production in C. thermocellum is encoded by four hydrogenases. Rather than delete each individually, we targeted hydrogenase maturase gene hydG, involved in converting the …