Digital Commons Network^™

Generation Of A Retinoblastoma (Rb)1-Inducible Dominant-Negative (Dn) Mouse Model., Shikha Tarang, Songila M.S.R Doi, Channabasavaiah B. Gurumurthy, Donald W. Harms, Rolen M. Quadros, Sonia M. Rocha-Sanchez

Journal Articles: Genetics, Cell Biology & Anatomy

Retinoblastoma 1 (Rb1) is an essential gene regulating cellular proliferation, differentiation, and homeostasis. To exert these functions, Rb1 is recruited and physically interacts with a growing variety of signaling pathways. While Rb1 does not appear to be ubiquitously expressed, its expression has been confirmed in a variety of hematopoietic and neuronal-derived cells, including the inner ear hair cells (HCs). Studies in transgenic mice demonstrate that complete germline or conditional Rb1 deletion leads to abnormal cell proliferation, followed by massive apoptosis; making it difficult to fully address Rb1's biochemical activities. To overcome these limitations, we developed a tetracycline-inducible TetO-CB-myc6-Rb1 (CBRb) mouse …

8th Annual Research Week- Event Proceedings, Office Of Research Development

Excellence Summit (Research Week) Archived Proceedings

8th Annual Research Week

The Parthenon, February 23, 2015, Codi Mohr

The Parthenon

The Parthenon, Marshall University’s student newspaper, is published by students Monday through Friday during the regular semester and weekly Thursday during the summer. The editorial staff is responsible for the news and the editorial content.

My News

My News (2014-2020)

• Nicholas Kristof at the PAC Tonight
• Viral Video Competition Advinup Wins 3 Day Startup
• SGA President Azell Francis wins Regent Willis J. Potts Leadership Award
• Megan Johnson of Savannah Named Miss Georgia Southern 2015
• Georgia Southern Celebrates Arbor Day
• Speaker Invites You to 'Hug An Elephant, Kiss A Giraffe'

Research Express News, Georgia Southern University

Research & Economic Development

• The 2015 Research Symposium

Primary Mental Health Prevention Themes In Published Research And Academic Programs In Israel, Ora Nakash, Liat Razon, Itzhak Levav

School for Social Work: Faculty Publications

Background: The World Health Organization Comprehensive Mental Health Action Plan (CMHAP) 2013-2020 proposes the implementation of primary prevention strategies to reduce the mental health burden of disease. The extent to which Israeli academic programs and published research adhere to the principles spelled out by the CMHAP is unknown. Objective: To investigate the presence of mental health primary prevention themes in published research and academic programs in Israel. Methods: We searched for mental health primary prevention themes in: (1) three major journals of psychiatry and social sciences during the years 2001-2012; (2) university graduate programs in psychology, social work and medicine …

Reformed And Biblical Counseling, Mark Christians

Faculty Work Comprehensive List

"What is the difference between Biblical counseling and Christian counseling? In Reformed circles, is Biblical Counseling the norm or are people encouraged to seek professional counseling help?"

Posting about reformed and Biblical counseling from In All Things - an online hub committed to the claim that the life, death, and resurrection of Jesus Christ has implications for the entire world.

http://inallthings.org/answering-your-question-reformed-and-biblical-counseling/

Medical School Watercooler Newsletter - February 22, 2015, Lindsey Lyle

Watercooler Newsletter

This is the February 22, 2015 edition of the Frederick P. Whiddon College of Medicine's Newsletter - Watercooler.

Contents Include:

March Med School Café – ‘Surgical Treatment of Epilepsy'

USA Medical Students Recognized for Service to Student-Run Clinic at 15 Place

Dr. Lisa Moreno Walton Presents Internal Medicine Grand Rounds

Dr. Di Palma Recognized with ACG Master Award

Graduate Student Awarded Grant for Lung Research

The Influence Of Push-Off Timing In A Robotic Ankle-Foot Prosthesis On The Energetics And Mechanics Of Walking, Philippe Malcolm, Robert E. Quesada, Joshua M. Caputo, Steven H. Collins

Journal Articles

Background

Robotic ankle-foot prostheses that provide net positive push-off work can reduce the metabolic rate of walking for individuals with amputation, but benefits might be sensitive to push-off timing. Simple walking models suggest that preemptive push-off reduces center-of-mass work, possibly reducing metabolic rate. Studies with bilateral exoskeletons have found that push-off beginning before leading leg contact minimizes metabolic rate, but timing was not varied independently from push-off work, and the effects of push-off timing on biomechanics were not measured. Most lower-limb amputations are unilateral, which could also affect optimal timing. The goal of this study was to vary the timing …

Predicting Functional And Regulatory Divergence Of A Drug Resistance Transporter Gene In The Human Malaria Parasite, Geoffrey H. Siwo, Asako Tan, Katrina A. Button-Simons, Upeka Samarakoon, Lisa A. Checkley, Richard S. Pinapati, Michael T. Ferdig

Dartmouth Scholarship

Background:

The paradigm of resistance evolution to chemotherapeutic agents is that a key coding mutation in a specific gene drives resistance to a particular drug. In the case of resistance to the anti-malarial drug chloroquine (CQ), a specific mutation in the transporter pfcrt is associated with resistance. Here, we apply a series of analytical steps to gene expression data from our lab and leverage 3 independent datasets to identify pfcrt-interacting genes. Resulting networks provide insights into pfcrt’s biological functions and regulation, as well as the divergent phenotypic effects of its allelic variants in different genetic backgrounds.

Results:

To …

Inhibition Of Inos As A Novel Effective Targeted Therapy Against Triple-Negative Breast Cancer, Sergio Granados-Principal, Yi Liu, Maria L. Guevara, Elvin Blanco, Dong Soon Choi, Wei Qian, Tejal Patel, Angel A. Rodriguez, Joseph Cusimano, Heidi L. Weiss, Hong Zhao, Melissa D. Landis, Bhuvanesh Dave, Steven S. Gross, Jenny C. Chang

Markey Cancer Center Faculty Publications

INTRODUCTION: Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer with no effective targeted therapy. Inducible nitric oxide synthase (iNOS) is associated with poor survival in patients with breast cancer by increasing tumor aggressiveness. This work aimed to investigate the potential of iNOS inhibitors as a targeted therapy for TNBC. We hypothesized that inhibition of endogenous iNOS would decrease TNBC aggressiveness by reducing tumor initiation and metastasis through modulation of epithelial-mesenchymal transition (EMT)-inducing factors.

METHODS: iNOS protein levels were determined in 83 human TNBC tissues and correlated with clinical outcome. Proliferation, mammosphere-forming efficiency, migration, and EMT transcription factors …

It's Not Just A Leave, Genesis L. Montalvo

First-Gen Voices: Creative and Critical Narratives on the First-Generation College Experience

In this piece, the author sets out to explore the first-generation college identity through a gothic lens. In the early stages of this project, Montalvo had considered doing research on narratives from other first-gen college students as a way to trace the uncanny and the abject in their experiences. However, as she began reflecting on her own personal history, she realized that in a matter of only two years she had already experienced moments of distance, uncanniness, and confusion, which are recorded here. In presenting these installments in non-chronological order, Montalvo intends to insert a gothic element of disorder, which …

A Comparative Study On The Energy Cost Of Pushing The Hope Haven Kidchair And Free Wheelchair Mission Gen 2 Wheelchair, Elisa J. Hamm, Benjamin M. Jonah, Karen Rispin

International Journal of Exercise Science: Conference Proceedings

Introduction: Wheelchair skills tests can be used to assess the mobility provided by different types of wheelchairs [1]. A repeated measures study design in which participants complete skills in one type of wheelchair and then another minimizes individual variation [2]. Free Wheelchair Mission Generation 2 (FWM-2) and Hope Haven KidChair (H-KC) offer two pediatric-sized wheelchairs designed for use in low-resource settings. We hypothesize that four simple skills tests will be able to distinguish some strengths and weaknesses of the mobility provided by these two wheelchairs. Methods: This study was done in partnership with a host organization at a …

The Effects Of Metabolic Syndrome On The Increased Prevalence Of Cognitive Decline In Minority Groups., Omokeji T. Adeniji, Juan Navarro, Upender Cheeti, Matthew Barlow

International Journal of Exercise Science: Conference Proceedings

Alzheimer’s disease is one of the leading causes of dementia, affecting over five million people in the United States. It is clinically diagnosed by the presence of amyloid plaques and hyperphosphoryated tau. Alzheimer’s disease patients present with memory and cognitive decline. The cumulative effects of an increasing elderly population and the elevation in the number of persons with diseases such as hypertension, diabetes and obesity, which are risk factors for Alzheimer’s disease elevated the interest in understanding the interrelatedness between factors of metabolic syndrome and Alzheimer’s disease. The disparity between the incidences of Alzheimer’s disease among racial groups in the …

Analysis Of Cognitive Deficits Of Concussion Patients: Dual Task, Motor Cognition, And Memory, Jorge A. Quezada Jr, Matthew A. Barlow, Michael F. Shaughnessy, Robyn Rausch

International Journal of Exercise Science: Conference Proceedings

The severity of a concussion is determined by the magnitude of the force of impact and the symptoms expressed post-injury. The most current and widely used test to identify a concussion in college athletics is called the Immediate Post Concussion Assessment and Cognitive Testing (ImPACT). It is a computerized neurocognitive test battery that measures different cognitive abilities and compares baseline with post-injury results. In the current study we formulated a series of physical and psychological cognition tests that measure similar cognitive abilities as the ImPACT. The purpose of this study is to demonstrate that physical tests paired with neurocognitive tests …

Influence Of Tetrahydrobiopterin Supplementation On Rate Pressure Product, Upender Cheeti, Matthew Barlow Dr, David Proctor Dr

International Journal of Exercise Science: Conference Proceedings

Augmentation of tetrahydrobiopterin (BH₄) could potentially improve eNOS uncoupling by increasing Nitric oxide (NO) bioavailability to improve endothelial health in cardiovascular diseases. With age, the bioactivity of eNOS decreases resulting in a decrease in concentration and bioavailability of NO. Elevated levels of eNOS cofactor BH₄ helps in synthesizing NO, whereas limited concentrations of BH₄ production potentiallyleads to uncoupling of eNOS and the production of superoxides. A study conducted by Pierce et al., 2012 on young and old men showed that limited BH₄ bioavailability contributed to impaired arterial compliance, elasticity and other hemodynamics of vascular tissue. …

C.Elegans As A Diabetes & Ischemia Model: Identification Of Genetic And Cellular Changes That Modulate The Survival Of Hyperglycemia And Oxygen-Deprivation, Anastacia M. Garcia, Mary L. Ladage, Brian K. Mcfarlin, Rajeev K. Azad, Pamela A. Padilla

International Journal of Exercise Science: Conference Proceedings

Diet represents an exogenous influence that often yields colossal effects on an individual’s phenotype, physiology, long-term health and disease risk. The overconsumption of dietary sugars for example, has contributed to significant increases in obesity and type 2 diabetes, health issues that are costly both in terms of dollars and human life. Additionally, individuals with these conditions have compromised oxygen delivery and thus, an increased vulnerability to other oxygen-deprivation related disease states, including cardiovascular disease, ischemic strokes, vascular and coronary diseases and myocardial infarction. While human and other mammalian studies have shown that individuals with type 2 diabetes have a worse …

Consumption Of A High-Fat Meal Alters Post-Prandial Sirt Mrna Expression In Blood Leukocytes, Jill N. Sampson, Andrea L. Henning, Eric A. Prado, Adam Venable, Pamela Padilla, Brian K. Mcfarlin

International Journal of Exercise Science: Conference Proceedings

Introduction. Sirtuins (SIRT) are protein deacetylases, hypothesized to regulate the transcription of various genes involved in the prevention of atherogenesis and diet induced obesity. Previous research from our laboratory has demonstrated that consumption of a single, high-fat meal increases various CVD risk factors for up to 5-h post-prandial. Given the importance of SIRT to metabolic disorders, it is reasonable to speculate that a single, high-fat meal also disrupts SIRT. Methods. The purpose of this study was to determine the effect of a high-fat meal (75% of daily kcals & 80% of daily fat needs), on SIRT mRNA expression in blood …

Vectors Or Constellations? Curatorial Narratives Of Latin American Art, Camila Maroja, Abigail Winograd

Artl@s Bulletin

This paper examines the curatorial visions guiding the Mercosul Biennial (1997), curated by Frederico Morais, and Inverted Utopias (2004), co-curated by Mari Carmen Ramírez and Héctor Olea. Both strove to shift the association of Latin American art with the fantastic that had dominated the region’s historiography. The structural metaphors used to frame these shows demonstrated differing aims: Morais’s desire to create an autochthonous historiography versus Ramírez and Olea’s wish to revise constructions of global modernism. Nonetheless, both exhibitions showcased similar works and helped to consolidate a revised vision of Latin American art.

A Proposed Framework For Consensus-Based Lung Tumour Volume Auto-Segmentation In 4d Computed Tomography Imaging., Spencer Martin, Mark Brophy, David Palma, Alexander V Louie, Edward Yu, Brian Yaremko, Belal Ahmad, John L Barron, Steven S Beauchemin, George Rodrigues, Stewart Gaede

Medical Biophysics Publications

This work aims to propose and validate a framework for tumour volume auto-segmentation based on ground-truth estimates derived from multi-physician input contours to expedite 4D-CT based lung tumour volume delineation. 4D-CT datasets of ten non-small cell lung cancer (NSCLC) patients were manually segmented by 6 physicians. Multi-expert ground truth (GT) estimates were constructed using the STAPLE algorithm for the gross tumour volume (GTV) on all respiratory phases. Next, using a deformable model-based method, multi-expert GT on each individual phase of the 4D-CT dataset was propagated to all other phases providing auto-segmented GTVs and motion encompassing internal gross target volumes (IGTVs) …

Compost Carryover: Nitrogen Phosphorous And Ft-Ir Analysis Of Soil Organic Matter, Dave J. R. Olsen, Jeffrey B. Endelman, Astrid R. Jacobson, Jennifer R. Reeve

Plants, Soils, and Climate Faculty Publications

Compost plays a central role in organic soil fertility plans but is bulky and costly to apply. Determining compost carryover is therefore important for cost-effective soil fertility planning. This study investigated two aspects of nutritive carryover [nitrogen and phosphorus (P)], and an indicator of non-nutritive carryover [soil organic matter (SOM)] to determine the residual effect of a one-time compost application applied at four rates in a corn-squash rotation. Crop yield was measured as an integrated carryover indicator of nutritive and non-nutritive effects. Functional groups of compost and SOM were investigated using FT-IR spectroscopy and soil organic carbon (SOC). While year …

Exposing Sunstein's Naked Preferences, Stephen Matthew Feldman

Faculty Articles

In Naked Preferences and the Constitution and subsequent articles Professor Cass R Sunstein argues that the Constitution requires legislatures to pursue public values or common goods From this republican political theory Sunstein argues for a theory of judicial review when the Supreme Court reviews the constitutionality of a legislative act the Court should ensure that the act does not reflect a mere naked preference but rather reflects some public value or common good This essay questions the coherence of the concept of naked preferences by arguing that preferences are socially constructed not only through the political process as Sunstein suggests …

Robustness Of Target Dose Coverage To Motion Uncertainties For Scanned Carbon Ion Beam Tracking Therapy Of Moving Tumors, John Gordon Eley, Wayne David Newhauser, Daniel Richter, Robert Lüchtenborg, Nami Saito, Christoph Bert

Faculty Publications

Beam tracking with scanned carbon ion radiotherapy achieves highly conformal target dose by steering carbon pencil beams to follow moving tumors using real-time magnetic deflection and range modulation. The purpose of this study was to evaluate the robustness of target dose coverage from beam tracking in light of positional uncertainties of moving targets and beams. To accomplish this, we simulated beam tracking for moving targets in both water phantoms and a sample of lung cancer patients using a research treatment planning system. We modeled various deviations from perfect tracking that could arise due to uncertainty in organ motion and limited …

Sexuality Among Fathers Of Newborns In Jamaica, Peter B. Gray, Jody-Ann Reece, Charlene Coore-Desai, Twana Dinnall-Johnson, Sydonnie Pellington, Maureen Samms-Vaughan

Anthropology Faculty Research

Background While a growing body of research has addressed pregnancy and postpartum impacts on female sexuality, relatively little work has been focused upon men. A few studies suggest that a fraction of men report decreases in libido during a partner’s pregnancy and/or postpartum, with alterations in men’s sexual behavior also commonly aligning with those of a partner. Here, we investigate sexuality among fathers of newborn children in Jamaica. In Jamaica, as elsewhere in the Caribbean, relationship dynamics can be fluid, contributing to variable paternal roles and care, as well as a high fraction of children born into visiting relationships in …

Intramolecular Nitrogen Delivery For The Synthesis Of C-Glycosphingolipids. Application To The C-Glycoside Of The Immunostimulant Krn7000, Ahmad S. Altiti, David R. Mootoo

Publications and Research

The key reaction in this approach to C-glycosphingolipids is the stereoselective iodocyclization of a sugar-linked homoallylic carbonimidothioate. E and Z reaction substrates were assembled in a convergent fashion via an alkene metathesis strategy and exhibited the same alkene facial selectivity in the iodocyclization irrespective of alkene geometry, although the E alkene was found to be less reactive.

Developing A Comparative Marine Socio-Economic Framework For The European Atlantic Area, Naomi S. Foley, Rebecca Corless, Marta Escapa, Frances Fahy, Javier Fernandez-Macho, Susana Gabriel, Pilar Gonzalez, Stephen Hynes, Regis Kalaydjian, Susana Moreira, Kieran Moylan, Arantza Murillas, Michael O'Brien, Katherine Simpson, Dugald Tinch

Journal of Ocean and Coastal Economics

Availability and easy access to a wide range of natural and human-activity data on the oceans and coastal regions of Europe is the basis for strategic decision-making on coastal and marine policy. Strategies within Europe’s Integrated Maritime Policy, including the Maritime Strategy for the Atlantic Area, Blue Growth, Maritime Spatial Planning and Marine Data and Knowledge, require coherent and comparable socio-economic data across European countries. Similarly, the Marine Strategy Framework Directive requires member states to carry out economic and social analysis of their waters and the reformed Common Fisheries Policy includes a social dimension requiring socio-economic data. However, the availability …

What Have We Learned From The Deepwater Horizon Disaster? An Economist’S Perspective, Daniel R. Petrolia

Journal of Ocean and Coastal Economics

This paper outlines what we have learned about the impacts of the Deepwater Horizon (DWH) oil disaster from the economics discipline as well as what effect the DWH disaster has had on the economics discipline. It appears that what we know about the economic impact of the DWH spill today is limited, possibly because such analysis is tied up in the federal Natural Resource Damage Assessment (NRDA) process and other state-led efforts. There is evidence, however, that the NRDA process has changed over time to de-emphasize economic valuation of damages. There is also evidence that economists may be producing fewer …

Science Educators Will Be On Campus This Weekend Discussing Teaching Strategies, Winthrop University

Winthrop News 2015

• Called “Connecting Core Concepts and Best Teaching Practices in Biochemistry and Molecular Biology,” the workshop will help attendees develop new assessment tools for core concepts in biochemistry and molecular biology.
• Presenters are Ellis Bell of the University of Richmond, Malcolm Campbell of Davidson College and Cheryl Bailey of Mount Mary University.

The Murray Ledger And Times, February 20, 2015, The Murray Ledger And Times

The Murray Ledger & Times

No abstract provided.

Antibiotics For Cancer Therapy., Richard Pestell, Albert A Rizvanov

Department of Cancer Biology Faculty Papers

No abstract provided.