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2015

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Nrg Oncology/Rtog 0921: A Phase 2 Study Of Postoperative Intensity-Modulated Radiotherapy With Concurrent Cisplatin And Bevacizumab Followed By Carboplatin And Paclitaxel For Patients With Endometrial Cancer., Akila N. Viswanathan, Jennifer Moughan, Brigitte E. Miller, Ying Xiao, Anuja Jhingran, Lorraine Portelance, Walter R. Bosch, Ursula A. Matulonis, Neil S. Horowitz, Robert S S. Mannel, Luis Souhami, Beth A. Erickson, Kathryn A. Winter, William Small, David K. Gaffney Jul 2015

Nrg Oncology/Rtog 0921: A Phase 2 Study Of Postoperative Intensity-Modulated Radiotherapy With Concurrent Cisplatin And Bevacizumab Followed By Carboplatin And Paclitaxel For Patients With Endometrial Cancer., Akila N. Viswanathan, Jennifer Moughan, Brigitte E. Miller, Ying Xiao, Anuja Jhingran, Lorraine Portelance, Walter R. Bosch, Ursula A. Matulonis, Neil S. Horowitz, Robert S S. Mannel, Luis Souhami, Beth A. Erickson, Kathryn A. Winter, William Small, David K. Gaffney

Department of Radiation Oncology Faculty Papers

BACKGROUND: The current study was conducted to assess acute and late adverse events (AEs), overall survival (OS), pelvic failure, regional failure, distant failure, and disease-free survival in a prospective phase 2 clinical trial of bevacizumab and pelvic intensity-modulated radiotherapy (IMRT) with chemotherapy in patients with high-risk endometrial cancer.

METHODS: Patients underwent a hysterectomy and lymph node removal, and had ≥1 of the following high-risk factors: grade 3 carcinoma with >50% myometrial invasion, grade 2 or 3 disease with any cervical stromal invasion, or known extrauterine extension confined to the pelvis. Treatment included pelvic IMRT and concurrent cisplatin on days 1 …


2015/2016 University Of The Pacific Arthur A. Dugoni School Of Dentistry Catalog, University Of The Pacific Jul 2015

2015/2016 University Of The Pacific Arthur A. Dugoni School Of Dentistry Catalog, University Of The Pacific

Catalogue, Bulletin, Catalog

No abstract provided.


Shiga Toxin-Producing Escherichia Coli (Stec) Detection Strategies With Formalin-Fixed Stec Cells, Christopher Adam Baker Jul 2015

Shiga Toxin-Producing Escherichia Coli (Stec) Detection Strategies With Formalin-Fixed Stec Cells, Christopher Adam Baker

Graduate Theses and Dissertations

Certain pathogenic Escherichia coli known as Shiga toxin (Stx)-producing Escherichia coli (STEC) are commensals in cattle, and typically cause bloody diarrhea in humans once the Stx toxin is secreted in invaded intestinal epithelial cells. Infections with STEC cells can lead to hemolytic uremic syndrome, which is commonly associated with kidney failure. Several STEC serogroups have been declared adulterants in raw, non-intact ground meat, and future regulations could potentially lead to a higher number of STEC serogroup detection strategies for these pathogenic microorganisms. Microbiological research laboratories may benefit from formalin-fixed STEC cells for periodic (daily, weekly, monthly, among others) instrument validation/calibration …


Clinical Characteristics And Risk Factors Of Candidemia In Tertiary Care Hospital, Iffat Khanum, Syed Faisal Mahmood, Farheen Ali, Hafsa Waqar, Safia Awan Jul 2015

Clinical Characteristics And Risk Factors Of Candidemia In Tertiary Care Hospital, Iffat Khanum, Syed Faisal Mahmood, Farheen Ali, Hafsa Waqar, Safia Awan

Department of Medicine

Introduction: During the past two decades, the incidence of candidemia has doubled and Candida spp. currently ranks in top blood stream pathogen in developed countries. Given the need to ensure appropriate and timely antifungal therapy, there is need to identify these patients as early as possible and therefore a risk stratification for candidemia is imperative. We aim to identify the risk factors of candidemia in patients admitted at our tertiary care center.

Methods: A retrospective case control study were conducted on adult patients (15 years. or more) admitted to Aga Khan University Hospital between 2009 and 2013 who developed candidemia …


Evaluation Of Control Strategies For The Spread Of Citrus Greening, Vicente Valle Martinez Jul 2015

Evaluation Of Control Strategies For The Spread Of Citrus Greening, Vicente Valle Martinez

Theses and Dissertations - UTB/UTPA

Huanglongbing, also known as citrus greening, is a vector-based disease in citrus (with no cure known to date) that has drastically affected the citrus production in Florida in less than a decade and has been recently detected in Texas and California. In this paper, an epidemic model of the spatial spread of the disease is implemented among commercial and residential groves by taking into consideration the diffusion patterns of the psyllid vectors. A system of differential equations resembling one for malaria infection in humans is derived to evaluate different control methods such as quarantine, treatment, removal, foliar treatment, and pest …


Assessing Coral Assemblages Inhabiting Relic Coral Banks Off The South Texas Coast, Rebekah E. Rodriguez Jul 2015

Assessing Coral Assemblages Inhabiting Relic Coral Banks Off The South Texas Coast, Rebekah E. Rodriguez

Theses and Dissertations - UTB/UTPA

Community composition and distribution of coral species in the mesophotic zone off the South Texas Coast were cataloged from five relict mid-shelf coral algal banks referred to as the South Texas Banks including, from north to south, Baker, Aransas, Dream, Blackfish Ridge, and a previously undescribed reef thereto referred as Harte Bank. Hermatypic corals flourished at these sites, approximately 21,000 to 12,000 years BP in the late Pleistocene to early Holocene epochs. Today these reefs are located 97 km offshore and protrude to heights ranging 58 to 83 m below the sea surface with portions extending 20 to 30 m …


Exploring The Effect A Speaker Series Has On Students Level Of Multicultural Sensitivity And Cultural Competence Awareness, Christine Karpinski, Scott Heinerichs Jul 2015

Exploring The Effect A Speaker Series Has On Students Level Of Multicultural Sensitivity And Cultural Competence Awareness, Christine Karpinski, Scott Heinerichs

Internet Journal of Allied Health Sciences and Practice

Purpose: The population of the United States continues to become more diverse each day, and this changing demographic impacts our healthcare system, demanding that healthcare providers begin to provide culturally competent services. In order to have culturally competent practitioners, it would be prudent to incorporate the concepts of cultural competence effectively into respective health professions curricula. The purpose of this study was to assess the effectiveness of a three-part, semester-long cultural competency speaker series on students’ level of multicultural sensitivity and their attitudes toward cultural competence and its effect on healthcare. Methods: A convenience sample of 118 athletic training and …


Health Implications Of Adults’ Eating At And Living Near Fast Food Or Quick Service Restaurants, Junfeng Jiao, A. V. Moudon, S. Y. Kim, P. M. Hurvitz, A. Drewnowski Jul 2015

Health Implications Of Adults’ Eating At And Living Near Fast Food Or Quick Service Restaurants, Junfeng Jiao, A. V. Moudon, S. Y. Kim, P. M. Hurvitz, A. Drewnowski

Research Collection College of Integrative Studies

BACKGROUND: This paper examined whether the reported health impacts of frequent eating at a fast food or quick service restaurant on health were related to having such a restaurant near home. METHODS: Logistic regressions estimated associations between frequent fast food or quick service restaurant use and health status, being overweight or obese, having a cardiovascular disease or diabetes, as binary health outcomes. In all, 2001 participants in the 2008–2009 Seattle Obesity Study survey were included in the analyses. RESULTS: Results showed eating ⩾ 2 times a week at a fast food or quick service restaurant was associated with perceived poor …


Association Mapping For Elemental Concentration Resulting From Vegetative Stage Soil Waterlogging Stress In Wheat (Triticum Aestivum L.), Maria Nelly Arguello-Blanco Jul 2015

Association Mapping For Elemental Concentration Resulting From Vegetative Stage Soil Waterlogging Stress In Wheat (Triticum Aestivum L.), Maria Nelly Arguello-Blanco

Graduate Theses and Dissertations

Soil waterlogging (WL) affects wheat production worldwide, including the southern of the U.S. Little is known about the genetics of tolerance mechanisms to WL, particularly of potentially toxic elements such as aluminum, iron and sodium. The objectives of this study were to use association mapping (AM) to identify SNP associated with the EC in the vegetative tissue of a set of 240 diverse soft winter wheat genotypes (AM panel) grown under field WL and to determine the impact of WL on wheat yield (GY) and yield components in a set 28 adapted cultivars (YT)

YT study showed reductions in GY …


Phenology And Diversity Of Arthropod Communities In Leaf Litter, Fredericka Hamilton Jul 2015

Phenology And Diversity Of Arthropod Communities In Leaf Litter, Fredericka Hamilton

Graduate Theses and Dissertations

Temperate deciduous forests produce a layer of leaf litter on the forest floor annually. This layer is dynamic, and both the composition and depth change throughout the year. The leaf litter layer is an important habitat to many arthropods since they utilize it for food, shelter from adverse environmental conditions, and protection from predators.

Two commonly encountered and diverse taxa found in the litter layer are the ground beetles (Coleoptera: Carabidae) and the ground spiders (Araneae: Gnaphosidae). Carabidae and Gnaphosidae were collected and identified on a monthly basis from April 2014 to March 2015 from the Ozark Mountains of Arkansas …


Asymmetric Synthesis And Transition Metal-Catalyzed Cross-Coupling Arylations Of Selected Organolithiums, Barry Kyle Sharp Jul 2015

Asymmetric Synthesis And Transition Metal-Catalyzed Cross-Coupling Arylations Of Selected Organolithiums, Barry Kyle Sharp

Graduate Theses and Dissertations

My former boss, Dr. Gawley, always loved to say, “The world is chiral” (à la Pasteur). From DNA and proteins to hands and feet, it is obviously true. Also, a wide variety of chemical products exist as single enantiomers. Advances in chemical technology have greatly accelerated asymmetric synthesis in the past quarter century, and namely, organolithiums, have been shown to provide a versatile route to chiral natural products and biologically active molecules. Versatility arises from the array of methods that produce a chiral organolithium. Dynamic thermodynamic resolution (DTR) is considered one of the most practical methods, but among the others …


Effect Of Feeding Regimen And Age On Lipid Metabolism In Broiler Breeder Hens And Progeny, Nirun Boonsinchai Jul 2015

Effect Of Feeding Regimen And Age On Lipid Metabolism In Broiler Breeder Hens And Progeny, Nirun Boonsinchai

Graduate Theses and Dissertations

Age of hens and feed allocation can affect egg yolk lipid compositions which in turn directly relate to chick quality. A series of experiments were conducted to determine the effects of age and feeding programs on lipid metabolism in breeder hens and progeny. In the first trial, the rate of yolk absorption and fatty acid profiles in the yolk were compared among 28, 35, and 49wk old hens. The results revealed that the rate of yolk absorption was higher, but the absolute amount of fatty acids absorbed was lower in young hens than in the old hens. The second trial …


A Comparison And Exploration Of Arkansas Professional School Counselor Activities Across Poverty, Angela Mccoy Harless Jul 2015

A Comparison And Exploration Of Arkansas Professional School Counselor Activities Across Poverty, Angela Mccoy Harless

Graduate Theses and Dissertations

This study is an exploration of the actual and preferred practices of Arkansas K-12 school counselors in low, mid, and high-poverty schools using the School Counselor Activity Rating Scale (Scarborough, 2005), follow-up questionnaires, and interviews. The qualitative component of this study brings to light the contextual factors that prevent school counselors from providing direct and indirect services to students outlined in the ASCA National Model. This research study examines the hidden dynamics of the counselor/principal relationship and how this relationship has a pivotal role in the realization of a fully comprehensive developmental school counseling program. This study contributes to the …


Grass Finishing Systems For Lambs, Erin Leigh Smyth Jul 2015

Grass Finishing Systems For Lambs, Erin Leigh Smyth

Graduate Theses and Dissertations

There is strong interest in sustainably produced meat. Grass-fed lamb could fulfill this market by reducing off-farm inputs. The objective was to examine the effect of grass-finishing or minimal supplementation on performance of lambs in the southeastern US. Katahdin lambs born in October 2013 and 2014 and February 2014 were weaned in January 2014/2015 and May 2014, respectively. Lambs were blocked by gender (fall; winter included only ram lambs) and randomly assigned to receive no (NON) or grain co-product supplement (SUP; 15% CP) at 0.5% of BW/d. Lambs were rotationally grazed on predominantly grass. Body weight, fecal egg counts (FEC), …


Food Waste At Retail, Erin G. Killeen Davis Jul 2015

Food Waste At Retail, Erin G. Killeen Davis

Graduate Theses and Dissertations

Food waste at retail represents forgone sales and embodies store management and disposal costs. Fresh produce is the largest contributing sector to food waste at retail and bulky, seasonal products are an added challenge when stores experience a high waste event. In order to improve, retailers need to better understand the costs of food waste, as well as how management strategies can impact these costs.

Using pumpkins as an example of bulky, seasonal products, a twofold research project was conducted to better understand contributors to, and costs of food waste at the retail level. In part one, using data from …


Temperature In The Cotton (Gossypium Hirsutum L.) Canopy And Effects On Cotton Leaf And Boll Growth, Maria Soledad Berlangieri Costa Jul 2015

Temperature In The Cotton (Gossypium Hirsutum L.) Canopy And Effects On Cotton Leaf And Boll Growth, Maria Soledad Berlangieri Costa

Graduate Theses and Dissertations

Cotton development and yield are negatively influenced by extremes temperatures, mainly during reproductive stage. Ambient air temperature is used to evaluate temperature stress effect on yield under field conditions; however, there is evidence that actual temperatures in the canopy where bolls develop are different. In terms of cotton responses, there is limited research about the effects of elevated day and night temperatures upon boll carbohydrate content, size, and boll respiration. Field and growth chamber experiments were performed during 2014-2015 using the cotton (Gossypium hirsutum L.) cultivar DP0912B2RF. Field studies for determining temperature gradients through the canopy consisted of two planting …


Perceived Discrimination And Markers Of Cardiovascular Risk Among Low-Income African American Youth, Bridget J. Goosby, Sarah Malone, Elizabeth A. Richardson, Jacob Cheadle, Deadric T. Williams Jul 2015

Perceived Discrimination And Markers Of Cardiovascular Risk Among Low-Income African American Youth, Bridget J. Goosby, Sarah Malone, Elizabeth A. Richardson, Jacob Cheadle, Deadric T. Williams

Department of Sociology: Faculty Publications

Objectives: Our study examines the relationship between perceived discrimination and levels of C-reactive protein and blood pressure in low-income youth ages 10215 years old.

Methods: Data were collected from 10 to 15 year old focal children and their mothers. Face-to-face interviews were implemented to collect data on stressors including experiences of everyday discrimination from youth. High sensitivity CRP in dried blood spot samples and diastolic and systolic blood pressure were also collected at the time of the interview.

Results: Perceived discrimination among youth was significantly associated with higher levels of CRP, systolic, and diastolic blood pressure. CRP, systolic, and diastolic …


The Association Of Racial Identity And Locus Of Control With Eating Attitudes And Obesity In African American College Women, Jamie Grisham Jul 2015

The Association Of Racial Identity And Locus Of Control With Eating Attitudes And Obesity In African American College Women, Jamie Grisham

Psychology Theses & Dissertations

African-American women have been disproportionately affected by the obesity epidemic in the United States, and studies have suggested that sociocultural factors may have a negative influence on weight and weight loss efforts. Relatedly, other studies have found that African-American women have reported feeling less motivated to lose weight than other ethnic groups. Previous research has also indicated that locus of control plays a role in some health outcomes for African America women. The current study aimed to examine the impact of Black identity, external locus of control, and exercise motivation on obesity in African-American college women. Uncontrolled eating and exercise …


The Effects Of Pre-Maximal Exertion Inhalation Of Ammonia And The Performance Effects During Deadlift Maximal Tests, Justin Nicholas Vigil Jul 2015

The Effects Of Pre-Maximal Exertion Inhalation Of Ammonia And The Performance Effects During Deadlift Maximal Tests, Justin Nicholas Vigil

Human Movement Studies & Special Education Theses & Dissertations

The purpose of this study was to investigate the effects of ammonia as a stimulant on athletic performance during a deadlift one maximal repetition (1-RM) absolute strength test. It was hypothesized that ammonia inhalation would result in a larger 1-RM, possibly due to immediate catecholamine release attributed to the fight-or-flight response. If proven effective, ammonia inhalation would present an option to increase power and strength performance during training and competition based on an acute manipulation of natural occurring hormones, eliminating the side effects attributed to other supplementation methods. Subjects (n = 10 males, X±SD age = 21±1 years, mass = …


Science And Charity: Rival Catholic Visions For Humanitarian Practice At The End Of French Rule In Cameroon, Charlotte Walker-Said Jul 2015

Science And Charity: Rival Catholic Visions For Humanitarian Practice At The End Of French Rule In Cameroon, Charlotte Walker-Said

Publications and Research

This paper explores the conflict between local expressions of Christian charity and new theories of scientific humanitarianism in the final years of French rule in Africa. Compassionate phenomena inspired by Catholic social organizing had transformed everyday life throughout French Cameroon’s cities and villages in the interwar and postwar years, and yet, in 1950, poverty, crime, poor public health, and social tensions remained prevalent. Seeking a more deeply transformative approach to social rehabilitation, ecclesiastical leaders in the Catholic Church in Europe and French foreign missionary societies in Africa partnered with international medical and scientific organizations in order to invigorate charity with …


A Phenomenological Investigation Of Wellness And Wellness Promotion In Counselor Education Programs, Brett Kyle Gleason Jul 2015

A Phenomenological Investigation Of Wellness And Wellness Promotion In Counselor Education Programs, Brett Kyle Gleason

Counseling & Human Services Theses & Dissertations

This phenomenological investigation explored the lived wellness experiences and perceptions of wellness promotion of doctoral level counseling trainees enrolled in CACREP-accredited programs. Participants included a national heterogeneous sample of 12 doctoral level counselor trainees currently enrolled in CACREP-accredited counseling programs. Semi-structured individual interviews were conducted to provide a textural-structural description of doctoral students' lived wellness experiences and perceptions of wellness promotion while enrolled in a CACREP-accredited counseling program. Three structural codes includingcomponents of wellness, program culture, and recommendations were identified along with 13 textural codes throughout participant interviews. The findings of this study provide insight into wellness …


The Flame, 2014-2015, Mennonite College Of Nursing Jul 2015

The Flame, 2014-2015, Mennonite College Of Nursing

The Flame (1985-present)

The Flame is a newsletter of Illinois State University's Mennonite College of Nursing


Iron-Mediated Stabilization Of Soil Carbon Amplifies The Benefits Of Ecological Restoration In Degraded Lands, Lucas C. R. Silva, Timothy A. Doane, Rodrigo S. Correa, Vinicius Valverde, Engil Isadora Pujol Pereira, William R. Horwath Jul 2015

Iron-Mediated Stabilization Of Soil Carbon Amplifies The Benefits Of Ecological Restoration In Degraded Lands, Lucas C. R. Silva, Timothy A. Doane, Rodrigo S. Correa, Vinicius Valverde, Engil Isadora Pujol Pereira, William R. Horwath

School of Earth, Environmental, & Marine Sciences Faculty Publications

Recent observations across a 14‐year restoration chronosequence have shown an unexpected accumulation of soil organic carbon in strip‐mined areas of central Brazil. This was attributed to the rapid plant colonization that followed the incorporation of biosolids into exposed regoliths, but the specific mechanisms involved in the stabilization of carbon inputs from the vegetation remained unclear. Using isotopic and elemental analyses, we tested the hypothesis that plant‐derived carbon accumulation was triggered by the formation of iron‐coordinated complexes, stabilized into physically protected (occluded) soil fractions. Confirming this hypothesis, we identified a fast formation of microaggregates shortly after the application of iron‐rich biosolids, …


Safety Guide For The Adventurous Outdoor Hiker, Lori Bailey, Cindy Nelson Jul 2015

Safety Guide For The Adventurous Outdoor Hiker, Lori Bailey, Cindy Nelson

All Current Publications

This tri-fold brochure gives safety tips for hikers, especially 4-H youth.


Brand Comparison For Electric Programmable Pressure Cookers, Susan Haws, Teresa Hunsaker, Debra Proctor, Ellen Serfustini, Karin Allen Jul 2015

Brand Comparison For Electric Programmable Pressure Cookers, Susan Haws, Teresa Hunsaker, Debra Proctor, Ellen Serfustini, Karin Allen

All Current Publications

This fact sheet shows results of a brand comparisons for four different electric programmable pressure cookers. Cuisinart, Deni, Fagor, and Nesco were tested using five different foods, at four different altitudes.


Gastrostomy In Patients With Amyotrophic Lateral Sclerosis (Progas): A Prospective Cohort Study, Progas Study Group, Christopher J. Mcdermott, Oliver Hanemann Jul 2015

Gastrostomy In Patients With Amyotrophic Lateral Sclerosis (Progas): A Prospective Cohort Study, Progas Study Group, Christopher J. Mcdermott, Oliver Hanemann

Peninsula Medical School

Background: Gastrostomy feeding is commonly used to support patients with amyotrophic lateral sclerosis who develop severe dysphagia. Although recommended by both the American Academy of Neurology and the European Federation of Neurological Societies, currently little evidence indicates the optimum method and timing for gastrostomy insertion. We aimed to compare gastrostomy insertion approaches in terms of safety and clinical outcomes. Methods: In this large, longitudinal, prospective cohort study (ProGas), we enrolled patients with a diagnosis of definite, probable, laboratory supported, or possible amyotrophic lateral sclerosis who had agreed with their treating clinicians to undergo gastrostomy at 24 motor neuron disease care …


Seasonal Variation In Chronic Stress And Energetic Condition In Three Species Of Migratory Birds, Meghan Oberkircher Jul 2015

Seasonal Variation In Chronic Stress And Energetic Condition In Three Species Of Migratory Birds, Meghan Oberkircher

Theses

Neotropical migrants face multiple challenges throughout their annual cycle. During migration, birds must avoid predation, face adverse weather, and find stopover sites with food adequate to support their needs. Upon return to the breeding grounds following migration, males must find and defend territory from other males. Females incubate eggs and both males and females may participate in feeding young leaving less time to feed themselves. After the breeding season birds undergo the energy intensive process of molt. Declines in populations of Neotropical migrants have been reported over the past several decades. In order to prevent further population declines of Neotropical …


The Correlation Between Nutrition And Academic Achievement In Georgia Middle Schools, Lesia Griffin Jul 2015

The Correlation Between Nutrition And Academic Achievement In Georgia Middle Schools, Lesia Griffin

Doctoral Dissertations and Projects

Breakfast is the most important meal of the day and it is an important part of the academic achievement of students. Several hours after breakfast, the body requires more fuel. The fuel is used to energize the body and help feel refreshed. The wrong fuel may have the opposite effect. The primary objective of this correlation study was to determine if there was a relationship between the academic achievement, as measured by reading and math scores on the Georgia Criterion Referenced Competency Test (CRCT) of 8th grade students and their nutritional intake. The qualifications of the selected participants were that …


Obesity Early In Adulthood Increases Risk But Does Not Affect Outcomes Of Hepatocellular Carcinoma, Manal M. Hassan, Reham Abdel-Wahab, Ahmed Kaseb, Ahmed Shalaby, Alexandria Phan, Hashem El-Serag, Ernest Hawk, Jeff Morris, Kanwal Pratap Singh Raghav, Ju-Seog Lee, Jean-Nicolas Vauthey, Gehan Bortus, Harrys Torres, Christopher Amos, Robert Wolff, Donghui Li Jul 2015

Obesity Early In Adulthood Increases Risk But Does Not Affect Outcomes Of Hepatocellular Carcinoma, Manal M. Hassan, Reham Abdel-Wahab, Ahmed Kaseb, Ahmed Shalaby, Alexandria Phan, Hashem El-Serag, Ernest Hawk, Jeff Morris, Kanwal Pratap Singh Raghav, Ju-Seog Lee, Jean-Nicolas Vauthey, Gehan Bortus, Harrys Torres, Christopher Amos, Robert Wolff, Donghui Li

Dartmouth Scholarship

Despite the significant association between obesity and several cancers, it has been difficult to establish an association between obesity and hepatocellular carcinoma (HCC). Patients with HCC often have ascites, making it a challenge to accurately determine body mass index (BMI), and many factors contribute to the development of HCC. We performed a case–control study to investigate whether obesity early in adulthood affects risk, age of onset, or outcomes of patients with HCC.


Focal Point, Volume 29, Portland State University. Regional Research Institute Jul 2015

Focal Point, Volume 29, Portland State University. Regional Research Institute

Research and Training Center - Focal Point

This issue of Focal Point focuses on trauma–informed care and its growing relevance in research, official policy, practice methods, and organizational structure.