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2015

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La Medida De Un Hombre: Las Representaciones De La Masculinidad En Las Novelas De Benito Pã©Rez Galdã³S | La Medida De Un Hombre: Las Representaciones De La Masculinidad En Las Novelas De Benito Pérez Galdós, Jose Ismael Souto Rumbo Dec 2015

La Medida De Un Hombre: Las Representaciones De La Masculinidad En Las Novelas De Benito Pã©Rez Galdã³S | La Medida De Un Hombre: Las Representaciones De La Masculinidad En Las Novelas De Benito Pérez Galdós, Jose Ismael Souto Rumbo

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

This dissertation contributes to the analysis of the representation of masculinity in the Nineteenth Century Spanish novel, an area still somewhat underdeveloped in Spanish Peninsular literature. Most studies have focused almost exclusively on the analysis of male characters that, in one way or another, challenged culturally produced sexual and gender norms and served as examples of alternative constructions to a normative male role. The proliferation of these types of characters has been explained by the perception that fin-de-siècle society as a whole was moving towards gender slippage and indifferentiation motivated by the changing roles of women, the collapse of the …

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The Role And Regulation Of Sphingosine Kinases In Cancer Biology, Mohamad Adada Dec 2015

The Role And Regulation Of Sphingosine Kinases In Cancer Biology, Mohamad Adada

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Sphingolipids have emerged as bioactive constituents of eukaryotic cells. The bioactive sphingolipid ceramide mediates cellular senescence, apoptosis and cell cycle arrest. Acted upon by ceramidase, it is transformed to sphingosine that in turn gets phosphorylated by sphingosine kinases (SK1 and SK2) to generate sphingosine-1-phosphate (S1P). This lipid, on the contrary, mediates cellular proliferation, mitogenesis, inflammation, angiogenesis, and cancer metastasis through its actions on specific G-protein coupled receptors (S1PR1-5). ERM (ezrin, radixin, and moesin) proteins are a group of adaptor molecules linking the cortical actin cytoskeleton to the plasma membrane, and are emerging as critical regulators of cancer metastasis and progression …

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Study Of Stat3 Protein Interactions Using An In Vitro Binding Assay, Julie Armstrong Dec 2015

Study Of Stat3 Protein Interactions Using An In Vitro Binding Assay, Julie Armstrong

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Transcription factors function as regulators of gene expression by controlling the activation of target genes. As a member of the STAT (Signal Transducer and Activators of Transcription) family, STAT3 regulates gene expression responsible for controlling differentiation, cell survival, proliferation, migration, and apoptosis. Activation of STAT3 conventionally occurs through tyrosine phosphorylation by JAK kinases stimulated following cytokine binding receptors. Cytokines like IL-6 bind to cell surface receptors, leading to the activation of associated JAK kinases. JAKs phosphorylate the cytoplasmic domains of the receptors, and STAT3 is recruited through its SH2 domain resulting in its phosphorylation by JAKs. It has been determined …

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Primary Cilia Modulate Functionality Of Dentate Granule Cells In The Adult Brain, Soyoung Rhee Dec 2015

Primary Cilia Modulate Functionality Of Dentate Granule Cells In The Adult Brain, Soyoung Rhee

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Adult born neurons in the hippocampal dentate gyrus start to assemble primary cilia at 14 days after their birth. At 21 days, all newborn neurons show a typical primary cilium. Although this small microtubule-based structure has been shown to be important for early neuronal development, its physiological/behavioral roles remain elusive. Therefore, I set out to investigate both behavioral and physiological functions of primary cilia in immature and mature dentate granule cells (DGCs) of the adult brain. After selectively knocking out IFT20 to ablate primary cilia from mature DGCs, I found defects of hippocampal spatial and cognitive memory, suggesting a crucial …

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Cancer-Associated Mutations In The Non-Receptor Tyrosine Kinases Brk And Hck Differentially Affect Enzyme Activity And Substrate Recognition, Tiffany Tsui Dec 2015

Cancer-Associated Mutations In The Non-Receptor Tyrosine Kinases Brk And Hck Differentially Affect Enzyme Activity And Substrate Recognition, Tiffany Tsui

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Tyrosine kinases play a vital role in proper cell growth and function. Aberrantly activated kinases often lead to diseases and have been recognized as important drivers of cancer. Aberrant kinase activity can occur by various mechanisms, such as by kinase overexpression or by activating mutations. This dissertation examines the effect of cancer associated mutations on two non-receptor tyrosine kinases. The first part of the dissertation will focus on breast tumor kinase (Brk, also known as PTK6), first identified in breast tumor samples. The second part of the dissertation focuses on hematopoietic cell kinase (Hck), which is implicated in drug resistance …

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Recoding Of Vesicular Stomatitis Virus Genes By Computer-Aided Design Provides A Live Attenuated Vaccine Candidate, Bingyin Wang Dec 2015

Recoding Of Vesicular Stomatitis Virus Genes By Computer-Aided Design Provides A Live Attenuated Vaccine Candidate, Bingyin Wang

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Codon pair bias (CPB), which has been observed in all organisms, is a neglected genomic phenomenon that substantially affects gene expression. CPB results from synonymous codons that are paired more or less frequently in ORFeomes regardless of codon bias. The effect of an individual codon pair change is usually small, but when amplified by large-scale genome recoding (simultaneously generating hundreds of synonymous mutations without altering codon usage or amino acid sequence), strikingly altered biological phenotypes are observed. Although the molecular mechanism underlying codon pair bias still remains enigmatic, the utility of codon pair bias in the development of live attenuated …

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A Role For Hmgb2 In Mammalian Neurogenesis And Stroke, Robert Bronstein Dec 2015

A Role For Hmgb2 In Mammalian Neurogenesis And Stroke, Robert Bronstein

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Stroke results in areas of neuronal cell death with concomitant inflammation and edema in the surrounding tissues. Ischemia in the thalamus can present as an accumulation of many smaller lacunar infarcts leading to potential cognitive deficits and central post-stroke pain syndromes, for which curative therapies are lacking. The capacity of the brain to repair itself rests upon the robust response of adult neurogenesis, and gliogenesis, to formidable ischemic conditions. In this study I assess the role chromatin modulator HMGB2 plays in both neurogenesis/gliogenesis and adult thalamic ischemia. Firstly, we demonstrate that this protein can affect the transition between the creation …

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An In Vivo Assessment Of The Effects Of Using Different Implant Abutment Occluding Materials On Implant Microleakage And The Peri-Implant Microbiome, Caroline Rubino Dec 2015

An In Vivo Assessment Of The Effects Of Using Different Implant Abutment Occluding Materials On Implant Microleakage And The Peri-Implant Microbiome, Caroline Rubino

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Microleakage may be a factor in the progression of peri-implant pathology. Microleakage in implant dentistry refers to the passage of bacteria, fluids, molecules or ions between the abutment-implant interface to and from the surrounding periodontal tissues. This creates a zone of inflammation and reservoir of bacteria at the implant-abutment interface. Bone loss typically occurs within the first year of abutment connection and then stabilizes. It has not yet been definitively proven that the occurrence of microleakage cannot contribute to future bone loss or impede the treatment of peri-implant disease. Therefore, strategies to reduce or eliminate microleakage are sought out. Recent …

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Dynamics Of Atomic Matter Waves In Optical Lattices, Jeremy Brian Reeves Dec 2015

Dynamics Of Atomic Matter Waves In Optical Lattices, Jeremy Brian Reeves

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Quantum gases in optical lattices allow for fundamental studies in atomic and condensed-matter physics and the exploration of novel effects. After a brief introduction to the fundamentals of quantum gas experiments in optical lattices, we discuss two recent experiments focusing on driven matter waves in a one-dimensional optical lattice. The first experiment uses a tilted bichromatic optical lattice to investigate the interplay of disorder and collisional interactions in the accelerated transport of a Bose-Einstein condensate. Here, a screening effect is observed, in which the interactions effectively cancel the damping of Bloch oscillations induced by a (quasi-)disordered potential. This effect can …

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Racialized Partisan Identity: The Role Of Pan-Ethnic Identity In Partisan Movement Among Asian Americans, Richard Cho Dec 2015

Racialized Partisan Identity: The Role Of Pan-Ethnic Identity In Partisan Movement Among Asian Americans, Richard Cho

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

I conduct empirical and experimental tests to highlight the impact of perceived commonality with racial-minority groups and its effects on subsequent political behavior among Asian Americans. This includes an exploration into how a shared identity interacts with Asian Americans’ racial identity to shape their subsequent political behavior. Using experimental treatments adopted from real-world messages in the news media, I show how exposure to the political derogation of both illegal and legal immigrant groups in the United States activates Asian Americans’ own racial identification and that the extent to which this identity affects political attitudes related to this derogation are largely …

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€Œpost-Truth†Politics? Media Causes And Potential Effects Of Perceptions Of Candidate Honesty, Matthew Harris Dec 2015

€Œpost-Truth†Politics? Media Causes And Potential Effects Of Perceptions Of Candidate Honesty, Matthew Harris

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Honesty has long been a trait voters seek in candidates for political office, yet the past few decades of American politics are strewn with examples of blatant dishonesty by political figures, sometimes with seemingly few electoral consequences. This dissertation examines how perceptions of candidate honesty are formed, as well as potential consequences of dishonest behavior for candidates as well as parties. The first empirical chapter uses ANES data to look at how media usage by citizens can shape perceived honesty. The second empirical chapter uses ARFIMA-MLM framework to look at usage while adding content in the form of news media …

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Understanding Social Mobility, Economic Environment, And Their Effects On Social Policy Attitudes, Patrick Lown Dec 2015

Understanding Social Mobility, Economic Environment, And Their Effects On Social Policy Attitudes, Patrick Lown

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Economic opportunity has long been a topic of interest among students of society and politics, and has made its way back to the forefront of inquiry with the resurgence of levels of inequality beyond those observed during the Gilded Age in the 1920s. Recent studies conducted by The Pew Charitable Trust Mobility Project, as well as others, have revealed that despite Americans’ beliefs in a land of opportunity, the chances to get ahead in life have dwindled for many. However, there is a dearth of information about what members of the public think about their own economic mobility and the …

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Folk Couture: A Fashion Exhibition At The American Folk Art Museum, Alexis Carreno Dec 2015

Folk Couture: A Fashion Exhibition At The American Folk Art Museum, Alexis Carreno

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

This dissertation describes the conceptual framework and the materialization of the exhibition I guest-curated at the American Folk Art Museum, Folk Couture: Fashion and Folk Art. Based on the tradition of artists using fashion to produce artworks, (for instance, Sylvie Fleury’s installation Poison, which commented upon issues of consumerism); couturiers appropriating images from art to create garments (such as Yves Saint Laurent’s Mondrian Dress, in which the designer replicated a painting made by the Russian constructivist artist), and collaborations between fashion designers and artists (for example, designer Marc Jacobs’s and artist Yayoi Kusama’s collaboration for Louis Vuitton), thirteen New York …

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Lost And Found: Transgender Elders’ Journey Toward Authenticity. A Constructionist Grounded Theory Study | Lost And Found: Transgender Elders’ Journey Toward Authenticity. A Constructionist Grounded Theory Study, Donna Barbara Riley Dec 2015

Lost And Found: Transgender Elders’ Journey Toward Authenticity. A Constructionist Grounded Theory Study | Lost And Found: Transgender Elders’ Journey Toward Authenticity. A Constructionist Grounded Theory Study, Donna Barbara Riley

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

While theoretical models of transgender identity development exist, theoretical models of post-transition social identity development are limited, and theoretical models of transgender individuals transitioning in later life are absent. As such, the purpose of this study is to explore the experience of transgender individuals coming out later in life, often after decades of hiding. Their experiences give voice to the trans community to define self-fulfillment as a transgender person post-transition. Additionally, this study explores the obstacles transgender elders navigate in middle and later life. Using a semi-structured interview guide with 42 transgender elders 55 years and older, respondents constructed chronological …

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Misconceptional Views About Epilepsy Exist Across Social Class System Of Society, Shoaib Rao, Bakhtyar Ali Shah, Nimra Altaf, Fazal M. Arain Dec 2015

Misconceptional Views About Epilepsy Exist Across Social Class System Of Society, Shoaib Rao, Bakhtyar Ali Shah, Nimra Altaf, Fazal M. Arain

Pakistan Journal of Neurological Sciences (PJNS)

Epilepsy affects over 1% of population worldwide. Studies have shown that although our understanding about epilepsy has come a long way, misconceptions about its etiology and treatment exist in rural slums. However, no study has been conducted to see whether such misconceptions exist in middle and upper socio-economic class. This study aims to explore the existence of misconceptions and social stigma in the middle and upper socio-economic class. Materials and Methods: We conducted a survey-based study about epilepsy on 227 participants, belonging to middle and upper socio-economic class. Results: The symptoms of generalized tonic-clonic seizures were correctly described by participants. …

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The Effects Of Ketorolac And Its Enantiomers On Breast Cancer Proliferation And Metastasis, Amanda Sheree Peretti Dec 2015

The Effects Of Ketorolac And Its Enantiomers On Breast Cancer Proliferation And Metastasis, Amanda Sheree Peretti

Biomedical Sciences ETDs

Breast cancer is the second leading cause of cancer related deaths in women. Advanced breast cancer can metastasize to the lungs, liver, bones and brain becoming fatal conditions for many patients. There is a dire need for metastasis preventing medications, however the process required for a medication to become FDA approved for clinical use is long and arduous. Studies have found promising benefits for breast cancer patients given ToradolTM, or racemic ketorolac, as an NSAID during resection surgery. However, long-term use of racemic ketorolac is not recommended. Currently FDA-approved for use in the racemic form, ketorolac has the potential to …

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Hilltopics: Volume 12, Issue 3, Hilltopics Staff Dec 2015

Hilltopics: Volume 12, Issue 3, Hilltopics Staff

Hilltopics

No abstract provided.

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University Of Dayton Magazine, Winter 2015-16, University Of Dayton Magazine Dec 2015

University Of Dayton Magazine, Winter 2015-16, University Of Dayton Magazine

University of Dayton Alumni Publications

This issue includes articles "Still Crazy After All These Years"; "What the Pope Says (And Why We Care)"; and "Seeking to be Safe".

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Mohamed Alduhbani Honors Portfolio, Mohamed Khaled Alduhbani Dec 2015

Mohamed Alduhbani Honors Portfolio, Mohamed Khaled Alduhbani

Honors Capstone Portfolios

Mohamed AlDuhbani's honors portfolio captured in December 2015.

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The Current Volume 26 : Issue 14, Nova Southeastern University Dec 2015

The Current Volume 26 : Issue 14, Nova Southeastern University

Student Newspapers

No abstract provided.

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October To December 2015 Dec 2015

October To December 2015

All Summaries

No abstract provided.

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Commencement Program 2015 December: College Of Science, The University Of Texas At Arlington Dec 2015

Commencement Program 2015 December: College Of Science, The University Of Texas At Arlington

Commencement Programs, Photos, and Video

No abstract provided.

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Number 19, 2015, Palara Editors Dec 2015

Number 19, 2015, Palara Editors

PALARA: Publication of the Afro-Latin/American Research Association

Complete Issue

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Thermal Transgenerational Plasticity And Its Effect On Competitive Ability And Consumer-Resource Dynamics In A Population Of Daphnia Ambigua, Holmes Julian Dec 2015

Thermal Transgenerational Plasticity And Its Effect On Competitive Ability And Consumer-Resource Dynamics In A Population Of Daphnia Ambigua, Holmes Julian

Biology Theses - Archive

Global temperature increases are predicted to quicken in pace this century, and with them so will the likely impact on natural populations. The extent to which organisms will be able to keep pace with and adapt to these environmental changes is an unanswered question. It has been demonstrated that changing environments can induce changes in phenotypes that persist across generations. TGP may be an important means for populations to cope with climate change stress, but our understanding of these interactions is incomplete. Prior work showed that Daphnia program their offspring for faster development when reared under cooler temperatures. Here I …

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Installments, University Of Texas At Arlington Library Dec 2015

Installments, University Of Texas At Arlington Library

Installments

A marketing periodical installed on the back of bathroom stall doors.

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Two Phase Flow Cfd Analysis Of Refrigerants In A Condenser Pipe For Prediction Of Pressure Drop And Pumping Power, Aniket Ramchandra Kalambe Dec 2015

Two Phase Flow Cfd Analysis Of Refrigerants In A Condenser Pipe For Prediction Of Pressure Drop And Pumping Power, Aniket Ramchandra Kalambe

Mechanical and Aerospace Engineering Theses - Archive

With the ever growing need of achieving optimum cooling at chip level at the expense of low input pumping power and keeping in check the Global Warming Potential (GWP) & Ozone Depletion Potential (ODP) has given rise to “two-phase on chip cooling” with nature friendly refrigerants. Currently, “air-cooling” and “single-phase water on-chip cooling” using copper micro-channel coolers are being used but “two-phase on chip cooling” with refrigerants have a very large scale & long lasting advantages over the prior. However, due to the perceived complexity of modelling two-phase flow, this solution is not yet well understood. Modelling of two phase …

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Developing And Validating Thermodynamic Models For Evaporative Cooling Employed In Data Centers, Niravkumar Prabhatsinh Dodia Dec 2015

Developing And Validating Thermodynamic Models For Evaporative Cooling Employed In Data Centers, Niravkumar Prabhatsinh Dodia

Mechanical and Aerospace Engineering Theses - Archive

Cooling of Data centers is of paramount importance for continuous and reliable operation of Servers housed by them. Considerable amount of total power is used to drive the cooling activity. Various different types of cooling methods have been implemented and are currently operating in various data centers. Evaporative (Indirect/Direct) Cooling is trending these days because of its ability to provide cooling at minimal cost. Previous studies have presented various cooling plants in data centers and studied them. A dedicated model for Evaporative cooling is developed and validated. The data is computed assuming the developed cooling model operating at a particular …

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A Model Analysis Of Sand Insertion In Hydraulic Fractures, Ya Hao Dec 2015

A Model Analysis Of Sand Insertion In Hydraulic Fractures, Ya Hao

Mechanical and Aerospace Engineering Theses - Archive

Hydraulic fracturing (fracking) is a well-stimulation technology to create large volume of fracture formation in rocks for gas and/or oil extraction. This technology has been applied to commercially exploit natural gas in unconventional shale reservoirs that contain immense quantity but low density of hydrocarbon sources. The productivity can be largely dependent on the connectivity of fractures that must stay open. However, upon initial hydraulic fracturing, the fractures would be closed due to high hydrostatic pressure deep inside the crust. Sand must be pumped into the fractures to keep them open. An in-depth understanding of the sand distribution and its dependence …

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Influencing Donor Decision-Making: An Examination Of Situational Determinants That Impact Donation, Floyd Kristopher Dec 2015

Influencing Donor Decision-Making: An Examination Of Situational Determinants That Impact Donation, Floyd Kristopher

Marketing Dissertations - Archive

Research around donor decision-making has shown the importance of understanding why donors make decisions. However, much less research exists explaining how donors make decisions. Set against the backdrop of online websites and in the context of donation, this dissertation examines how web characteristics, as situational determinants, influence donor decisions. Situational determinants are influences that arise because of a specific situation where a consumer is using the product or brand; these are instances that extend beyond the basic tendencies or traits of the consumer (Belk 1974). This could be a behavioral setting, a space, or a time (Belk 1974); other situational …

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Nanoparticle-Bridge Assay For Amplification-Free Electrical Detection Of Oligonucleotides, Manouchehr Teimouri Dec 2015

Nanoparticle-Bridge Assay For Amplification-Free Electrical Detection Of Oligonucleotides, Manouchehr Teimouri

Material Science and Engineering Dissertations - Archive

The aim of this research is to investigate a highly sensitive, fast, inexpensive, and field-applicable amplification-free nanoparticle-based oligonucleotide detection method which does not rely on any enzymatic or signal amplification process. In this approach, target oligonucleotide strands are detected through the formation of nanoparticle satellites which make an electrical path between two electrodes. This method enables an extremely sensitive oligonucleotide detection because even a few oligonucleotide strands can form a single nanoparticle satellite which can solely generates an electrical output signal. Results showed that this oligonucleotide detection method can detect oligonucleotide single strands at concentrations as low as 50 femtomolar …

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