Digital Commons Network^™

B Lymphocytes Are Required During The Early Priming Of Cd4+ T Cells For Clearance Of Pneumocystis Infection In Mice, Michael M. Opata, Melissa L. Hollifield, Frances E. Lund, Troy D. Randall, Robert Dunn, Beth A. Garvy, David J. Feola

Microbiology, Immunology, and Molecular Genetics Faculty Publications

B cells play a critical role in the clearance of Pneumocystis. In addition to production of Pneumocystis-specific Abs, B cells are required during the priming phase for CD4⁺ T cells to expand normally and generate memory. Clearance of Pneumocystis was found to be dependent on Ag specific B cells and on the ability of B cells to secrete Pneumocystis-specific Ab, as mice with B cells defective in these functions or with a restricted BCR were unable to control Pneumocystis infection. Because Pneumocystis-specific antiserum was only able to partially protect B cell–deficient mice from infection, we …

Meteorological Conditions, Climate Change, New Emerging Factors, And Asthma And Related Allergic Disorders. A Statement Of The World Allergy Organization., Gennaro D'Amato, Stephen T. Holgate, Ruby Pawankar, Dennis K. Ledford, Lorenzo Cecchi, Mona Al-Ahmad, Fatma Al-Enezi, Saleh Al-Muhsen, Ignacio Ansotegui, Carlos E. Baena-Cagnani, David J. Baker, Hasan Bayram, Karl Christian Bergmann, Louis-Philippe Boulet, Jeroen T M Buters, Maria D'Amato, Sofia Dorsano, Jeroen Douwes, Sarah Elise Finlay, Donata Garrasi, Maximiliano Gómez, Tari Haahtela, Rabih Halwani, Youssouf Hassani, Basam Mahboub, Guy Marks, Paola Michelozzi, Marcello Montagni, Carlos Nunes, Jay Jae-Won Oh, Todor A. Popov, Jay M. Portnoy, Erminia Ridolo, Nelson Rosário, Menachem Rottem, Mario Sánchez-Borges, Elopy Sibanda, Juan José Sienra-Monge, Carolina Vitale, Isabella Annesi-Maesano

Manuscripts, Articles, Book Chapters and Other Papers

The prevalence of allergic airway diseases such as asthma and rhinitis has increased dramatically to epidemic proportions worldwide. Besides air pollution from industry derived emissions and motor vehicles, the rising trend can only be explained by gross changes in the environments where we live. The world economy has been transformed over the last 25 years with developing countries being at the core of these changes. Around the planet, in both developed and developing countries, environments are undergoing profound changes. Many of these changes are considered to have negative effects on respiratory health and to enhance the frequency and severity of …

Bjc Today

BJC Today

No abstract provided.

The Role Of Philornis Downsi In Avian Disease Transmission In The Galápagos Islands, Courtney Lauren Pike

Theses

Philornis downsi is a dipteran fly species known to parasitize passerine birds in the Neotropics. P. downsi is speculated to be a recently introduced species in Galápagos Islands, so it is important to understand its effects on the archipelago’s native and endemic avian species. Avian parasites and pathogens have been previously reported in the Galápagos, leading the Galápagos National Park and the Charles Darwin Foundation to focus efforts on the study and management of potential avian disease vectors. The main goal of this study was to determine whether P. downsi is a host for avian parasites and pathogens found in …

Aspirin Triggered Resolution Phase Interaction Product D1: A Novel Treatment For Hyperoxic Acute Lung Injury, Ruan Rollin Cox, Jr.

USF Tampa Graduate Theses and Dissertations

Acute Lung injury (ALI) and the more severe acute respiratory distress syndrome (ARDS) are respiratory maladies that present immense clinical challenges. ALI affects 200,000 individuals annually and features a 40% mortality rate. ALI can be initiated by both pathogenic and sterile insults originating locally in the lungs or systemically. While immense research has been poured into this disease in an effort to find a therapeutic strategy, the heterogeneously diffuse nature of the disease has not yielded a cure for the disease. Death from this disease is strongly attributed to reduced gas exchange from a severely compromised alveolar-capillary barrier. The only …

Bibliometric Study Of Literature On Leptospirosis For The Period 2006-2013, Kotti Thavamani

Library Philosophy and Practice (e-journal)

This paper attempts to assess the literary output in the field of Leptospirosis productivity for the period 2006-2013. Statistical analysis has been carried out using SPSS and other relevant measures. It shows that the year wise distributions of Leptospirosis records are increasing year after year except the years 2008, 2009 and 2011. It shows that 88.76% articles are of English language and followed by Spanish and French languages. It is observed that USA has contributed the highest number of records in the study period. Next major contribution belongs to England, Netherlands and India. India has the 4th position among the …

Download Entire Issue Of The Medicine Forum, Volume 15, 2013-2014

The Medicine Forum

Download entire issue of The Medicine Forum, Volume 15, 2013-2014

Tb, Or Not Tb?, Michael A. Valentino, Md, Phd

The Medicine Forum

The patient is a 43-year-old African American male with a past medical history of hypertension, hyperlipidemia, and chronic low back pain who presented to the ER for worsening dyspnea and a 30-lb weight loss over the past 3 months. He also reported a nonproductive cough over this period of time as well as an eruption of small ~1cm flesh-colored nodules on his extremities and trunk. He denied any fevers, chills, or night sweats. In the ER, he had a chest x-ray performed (Figure 1) which showed diffuse centrilobular nodules visualized throughout the lung fields in a miliary pattern. He subsequently …

A Case Of Fanconi’S Syndrome In A Patient With Hiv, Mariam Kabir, Md, Phd, Christopher Miller, Md, Rakesh Gulati, Md, Mrcp, William R. Short, Md, Mph

The Medicine Forum

Introduction

Tenofovir disoproxil fumarate (TDF) is a nucleotide analogue reverse transcriptase inhibitor (NtRTI), which blocks reverse transcriptase, an enzyme found in HIV. Since its approval for use in HIV by the FDA in 2001, it has contributed to effective treatment in numerous patients. The most common side effects include nausea, vomiting, diarrhea, asthenia, abdominal pain and hepatotoxicity. A less common side effect is nephrotoxicity leading to Fanconi’s syndrome. Here is an interesting case of Fanconi’s Syndrome caused by Tenofovir.

Case

A 50-year-old Caucasian female with a past medical history of HIV and Hepatitis C presented to the Emergency Department with …

A Case Of Septic Portal Vein Thrombosis (Pylephlebitis), Erin Carnish, Md, Andrew Garrett, Md, Mary Slome, Ms1

The Medicine Forum

INTRODUCTION

Pylephlebitis, defined as suppurative thrombosis of the portal vein often associated with bacteremia, is a rare and serious complication of intra-abdominal infections. Prior to antibiotics, the mortality rate of this disease approached 100%.1 The veins adjacent to the infection are the first to be involved, with later spread to the portal vein and possibly the mesenteric and splenic veins.2-3 Extension into the mesenteric veins can lead to bowel necrosis and increased morbidity and mortality.2-4

CASE PRESENTATION

A 63-year old male with a history of hypertension presented to the emergency department with one week of progressively worsening malaise, chills, severe …

A Case Of Complete Heart Block Secondary To Anca-Associated Vasculitis, Krista Lim-Hing, Md

The Medicine Forum

INTRODUCTION

Anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitides are systemic autoimmune diseases that often present as non-specific prodromal symptoms such as fever, fatigue, headache, and weight loss.1 With modern treatment, the disease has changed from being universally fatal to being treatable. It can have a chronic relapsing and remitting course. Therefore, early diagnosis is necessary.2,3

CASE PRESENTATION

A 53-year-old male with a past medical history of chronic sinusitis and some epistaxis needing multiple courses of antibiotics and steroids, was admitted after being diagnosed with high-grade heart block at another institution. He was found to have a heart rate of 26 and …

An Unusual Atrial Mass: A Case Study, David F. Reilly, Bs, Christina Lindenmeyer, Md

The Medicine Forum

BACKGROUND

This case highlights the evolution of a broad differential diagnosis when presented with a rare and diagnostically enigmatic clinical finding.

Hiv Screening: A Review Of Nationally Recommended Guidelines And Specific Instances In Which Hiv Screening Is Often Overlooked, Anusha Ganesh, Md

The Medicine Forum

INTRODUCTION

According to the Centers for Disease Control and Prevention (CDC), one in five human immunodeficiency virus (HIV)-infected individuals are currently living without knowledge of their diagnosis.1 In 2006, the cost of a rapid HIV test with pre/post-test HIV counseling was anywhere between 48-64 US dollars (USD). The majority of the cost incurred was for HIV counseling, with the cost of the rapid HIV test being between 8-25 USD.2 Research looking at the cost-effectiveness of HIV screening shows that it is more cost-effective than routine screening for breast cancer with mammography yearly or even routine screening for diabetes mellitus with …

A Case Of Fibrosing Mediastinitis, Esther Molnar, Md

The Medicine Forum

Introduction

Fibrosing mediastinitis (FM) is a rare disease of slowly progressive fibrosis that encases major mediastinal structures. Complications include obstruction of mediastinal vasculature, including main pulmonary arteries, which may lead to life-threatening hemodynamic compromise. In North America, the disease is usually a sequela of histoplasmosis. Because Histoplasma capsulatum (H. capsulatum) is found in the Ohio River Valley, physicians in Pennsylvania must be able to recognize and diagnose the disease.

Case Presentation

The patient is a 59 year-old female who was seen for follow-up in April 2013. She originally presented to the outpatient office in 2008 with chronic chest pain and …

A Speedy Recovery With Medical Management In A Patient With Emphysematous Gastritis, Tanvi Khurana, Md

The Medicine Forum

INTRODUCTION

Emphysematous gastritis is a rare and serious condition characterized by evidence of intramural air and inflammation of the gastric wall as well as systemic toxicity. It is generally caused by local infection by gas-forming organisms through a mucosal defect or via hematogenous spread from a distant focus.1 Since emphysematous gastritis has a fulminant course with a mortality rate of 60%, prompt recognition as well as early treatment are crucial.2 Here, we present a case of a 65 year-old male who presented with abdominal pain and had CT findings consistent with emphysematous gastritis. He was treated with antibiotics and had …

Recurrent Cryptococcosis In A Human Immunodeficiency Virus-Negative Patient, Lillian C. Man, Md

The Medicine Forum

Introduction

Idiopathic CD4+ lymphocytopenia (ICL) is a rare disorder that can predispose otherwise immunocompetent individuals to life-threatening opportunistic infections. We present a case of a human immunodeficiency virus (HIV)-negative patient with ICL who presented with recurrent cryptococcosis.

Case Presentation

A 39-year-old Caucasian, HIV-negative male with a past medical history of stroke 13 years prior to admission and an episode of cryptococcal meningitis 18 months prior to admission presented to the hospital with generalized weakness for 7 days. The patient had a 10 pack-year smoking history and no significant environmental or occupational exposures. On admission, vital signs were significant for a …

Sustained Achromobacter Xylosoxidans Bacteremia In A Patient With Adenocarcinoma Of The Colon, Matt Enriquez, Ms4, Andi Favini, Ms4, Kevin Curl, Md

The Medicine Forum

Introduction

Achromobacter xylosoxidans is a rare cause of bacteremia; however patients with underlying illness, especially malignancies, are at increased risk of infection. Antibiotic therapy against this pathogen can be difficult owing to its inherent resistance to multiple common antibiotics.

Case Presentation

A 69-year-old male with adenocarcinoma of the colon status post right hemicolectomy and chemotherapy presented with fever and fatigue 10 days following endoscopic retrograde cholangiopancreatography (ERCP) with biliary stent placement for new liver metastases. The patient had undergone partial hemicolectomy and had completed 12 cycles of adjuvant FOLFOX (leucovorin, 5-fluorouracil, and oxaliplatin) at the time of initial diagnosis. Two …

Trust In Scientists On Climate Change And Vaccines, Lawrence C. Hamilton, Joel N. Hartter, Kei Saito

Sociology

On climate change and other topics, conservatives have taken positions at odds with a strong scientific consensus. Claims that this indicates a broad conservative distrust of science have been countered by assertions that while conservatives might oppose the scientific consensus on climate change or evolution, liberals oppose scientists on some other domains such as vaccines. Evidence for disproportionately liberal bias against science on vaccines has been largely anecdotal, however. Here, we test this proposition of opposite biases using 2014 survey data from Oregon and New Hampshire. Across vaccine as well as climate change questions on each of these two surveys, …

Common Cell Shape Evolution Of Two Nasopharyngeal Pathogens, Frédéric J. Veyrier, Nicolas Biais, Pablo Morales, Nouria Belkacem, Cyril Guilhen, Sylvia Ranjeva, Odile Sismeiro, Gérard Péhau-Arnaudet, Eduardo P. Rocha, Catherine Werts, Muhamed-Kheir Taha, Ivo G. Boneca

Publications and Research

Respiratory infectious diseases are the third cause of worldwide death. The nasopharynx is the portal of entry and the ecological niche of many microorganisms, of which some are pathogenic to humans, such as Neisseria meningitidis and Moraxella catarrhalis. These microbes possess several surface structures that interact with the actors of the innate immune system. In our attempt to understand the past evolution of these bacteria and their adaption to the nasopharynx, we first studied differences in cell wall structure, one of the strongest immune-modulators. We were able to show that a modification of peptidoglycan (PG) composition (increased proportion of pentapeptides) …

Characterization Of A Prefusion-Specific Antibody That Recognizes A Quaternary, Cleavage-Dependent Epitope On The Rsv Fusion Glycoprotein, Morgan S.A Gilman, Syed M. Moin, Vicente Mas, Man Chen, Nita K. Patel, Kari Kramer, Qing Zhu, Stephanie C. Kabeche, Azad Kumar, Concepción Palomo, Tim Beaumont, Ulrich Baxa, Nancy D. Ulbrandt, José A. Melero, Barney S. Graham, Jason S. Mclellan

Dartmouth Scholarship

Prevention efforts for respiratory syncytial virus (RSV) have been advanced due to the recent isolation and characterization of antibodies that specifically recognize the prefusion conformation of the RSV fusion (F) glycoprotein. These potently neutralizing antibodies are in clinical development for passive prophylaxis and have also aided the design of vaccine antigens that display prefusion-specific epitopes. To date, prefusion-specific antibodies have been shown to target two antigenic sites on RSV F, but both of these sites are also present on monomeric forms of F. Here we present a structural and functional characterization of human antibody AM14, which potently neutralized laboratory strains …

Sudden Vision Loss During Hemodialysis, Andrew W. Panakos, Md

The Medicine Forum

Introduction

Catheter-related blood stream infections (CRBSIs) are a common and unfortunate consequence of prolonged vascular access in hemodialysis patients. Metastatic infections are feared sequelae of bacteremia, and include endocarditis, osteomyelitis, septic arthritis, epidural abscess, and endophthalmitis.1 The following is a case of Serratia endophthalmitis originating from a tunneled-dialysis catheter.

Case Presentation

A 47 year-old Caucasian female with a history of end stage renal disease on hemodialysis, Type 2 diabetes mellitus, and hypertension was undergoing her routinely scheduled hemodialysis session when she experienced “flashes of hot pink” in her left eye. The hemodialysis session was terminated, and the patient returned home. …

Pulmonary Mucormycosis In A Patient With Acute Myeloid Leukemia, Jonathan Pan, Md, Margaret Kasner, Md, Sheel Patel, Md, Gretchen Diemer, Md

The Medicine Forum

Introduction

Mucormycosis is a rare fungal infection that is common amongst uncontrolled diabetics and immunocompromised patients. The most common clinical presentation is rhino-orbital-cerebral infection, which typically affects diabetics with ketoacidosis.1 Less commonly, pulmonary mucormycosis can occur in patients with hematologic malignancy, solid organ transplant and patients taking steroids or deferoxamine.1 The following report describes a 25-year-old male with Acute Myeloid Leukemia (AML) who developed a pulmonary mucormycosis infection. With a mortality rate of about 87%, this case represents a favorable outcome for a rare and often lethal diagnosis.

Case Description

A 25-year-old male with no past medical history presented to …

Acute Respiratory Distress Syndrome From Tick-Borne Human Granulocytic Anaplasmosis Infection, Vedang Patel, Md

The Medicine Forum

Introduction

Tick-borne infections were first formally recognized over a century ago, but it was only in 1990 that the first case of human granulocytic anaplasmosis (HGA), a tick-borne infection caused by Anaplasma phagocytophilum, was identified.1,2 Like other tick-borne infections, HGA presents as a nonspecific febrile illness. The most common clinical features are fever, headache, myalgia and malaise.2 This case report presents a rare but serious complication of HGA – acute respiratory distress syndrome (ARDS).

CASE PRESENTATION

A 49-year-old female with no past medical history presented to her local emergency department with complaints of fevers, headache, neck pain, myalgia, and malaise. …

Hoesley Named Senior Associate Dean For Medical Education, Kendra Carter

Browse All News

No abstract provided.

St. Luke's Medical Staff Update, 1996 Sep, Advocate Aurora Health

Aurora St. Luke’s Medical Center Books, Documents, and Pamphlets

St. Luke's Medical Center: Medical staff update welcoming new physicians.

Medical Staff Pictorial, 1992 March, Advocate Aurora Health

Aurora St. Luke’s Medical Center Books, Documents, and Pamphlets

St. Luke's Medical Center: Pictorial roster of St. Luke's Medical Center Medical Staff.

St. Luke's Hospital Medical - Dental Staff Photo Identification, 1981, Advocate Aurora Health

Aurora St. Luke’s Medical Center Books, Documents, and Pamphlets

St. Luke's Hospital: Photographs for St. Luke's Medical Center medical and dental staff.

Burn Injury Alters The Intestinal Microbiome And Increases Gut Permeability And Bacterial Translocation, Zachary M. Earley, Suhail Akhtar, Stefan J. Green, Ankur Naqib, Omair Khan '15, Abigail R. Cannon, Adam M. Hammer, Niya L. Morris, Xiaoling Li, Joshua M. Eberhardt, Richard L. Gamelli, Richard H. Kennedy, Mashkoor A. Choudhry

Student Publications & Research

Sepsis remains one of the leading causes of death in burn patients who survive the initial insult of injury. Disruption of the intestinal epithelial barrier has been shown after burn injury; this can lead to the translocation of bacteria or their products (e.g., endotoxin) from the intestinal lumen to the circulation, thereby increasing the risk for sepsis in immunocompromised individuals. Since the maintenance of the epithelial barrier is largely dependent on the intestinal microbiota, we examined the diversity of the intestinal microbiome of severely burned patients and a controlled mouse model of burn injury. We show that burn injury induces …

Convalescent Serum Therapy As Rapid Advance Treatment For Ebola In West Africa, J Bankole Thompson Md, Phd, Patricia F. Mejabi Msc., Olugbenga O. Mejabi Phd, S Ahmed Tejan-Sie Md

International Journal of African Development

The 2014 public health crisis in Guinea, Liberia, and Sierra Leone has brought Ebola Viral Disease (EVD) to everyone’s attention. Discovered in 1976, this deadly disease infrequently struck in remote areas of Africa. This article will critically review the literature and describe the pathobiology, transmission, signs and symptoms, diagnosis, treatment, and prevention of EVDwhich, was predicted by the Centers for Disease Control to potentially infect 1.4 million persons in Liberia and Sierra Leone by January 2015 (“Questions and Answers”, 2014). Thankfully this worst case scenario did not occur and we may be experiencing natural burn out of the outbreak along …

Guide To Ms259 Hotel Dieu School Of Nursing Records, Carrie-Ann Chavez

Finding Aids

The Hotel Dieu School of Nursing opened in El Paso in 1898 as a training school for nurses. The Hotel Dieu School of Nursing records date from 1944 to 1987, bulk 1980 to 1981. Types of records include photographs, by-laws and section rules, yearbooks and directories, library plans, receipts, journal and magazine subscriptions, furniture specifications and catalogs, requisitions, bibliographies, lists of holdings, book orders, reports, handbooks, guides, minutes, newsletters and bulletins, general correspondence, forms, training information, publications, and medical information and correspondence from local doctors and hospitals.