Digital Commons Network^™

Amikacin Concentrations Predictive Of Ototoxicity In Multidrug-Resistant Tuberculosis Patients, Chawangwa Modongo, Jotam G. Pasipanodya, Nicola M. Zetola, Scott M. Williams

Dartmouth Scholarship

Aminoglycosides, such as amikacin, are used to treat multidrug-resistant tuberculosis. However, ototoxicity is a common problem and is monitored using peak and trough amikacin concentrations based on World Health Organization recommendations. Our objective was to identify clinical factors predictive of ototoxicity using an agnostic machine learning method. We used classification and regression tree (CART) analyses to identify clinical factors, including amikacin concentration t

hresholds that pre- dicted audiometry-confirmed ototoxicity among 28 multidrug-resistant pulmonary tuberculosis patients in Botswana. Amika- cin concentrations were measured for all patients. The quantitative relationship between predictive factors and the probability of ototoxicity were then identified using …

Week Of July 27, 2015, New York Medical College

InTouch

• Public Health Program Passes the Test... with Flying Colors
• School of Medicine Class of 2017 Transitions to the Clinical Years
• NYMC Hosts 16th Pediatric Cancer Research Foundation Memorial Lectureship
• NYMC Reaches Out to Nepal
• NYMC Hosts Open Door Family Medical Centers Summer Students
• Lawrence Shapiro, M.D., Is Named Professor Emeritus of Pediatrics

Cryptic Speciation In The Acari: A Function Of Species Lifestyles Or Our Ability To Separate Species?, Anna Skoracka, Sara Magalhães, Brian G. Rector, Lechosław Kuczyński

Harold W. Manter Laboratory of Parasitology: Library Materials

There are approximately 55,000 described Acari species, accounting for almost half of all known Arachnida species, but total estimated Acari diversity is reckoned to be far greater. One important source of currently hidden Acari diversity is cryptic speciation, which poses challenges to taxonomists documenting biodiversity assessment as well as to researchers in medicine and agriculture. In this review, we revisit the subject of biodiversity in the Acari and investigate what is currently known about cryptic species within this group. Based on a thorough literature search, we show that the probability of occurrence of cryptic species is mainly related to the …

Hazardous Biological Activities In Outer Space, Philip Mcgarrigle

Akron Law Review

The purpose of this article is to focus on space acts that may be classified as ultrahazardous (specifically microbiological research) and to discuss how these activities are or will be affected by current or future legal regulations. Legal standards from both a United States and an international perspective will be discussed.

Breach Of Medical Confidence In Ohio, Craig E. Johnston

Akron Law Review

Fortunately, the patchwork of state and federal statutory, administrative, and case law has greatly limited unrestricted disclosure of medical secrets through the threat of civil and criminal liability. While the law governing the disclosure of medical information sorely lacks a comprehensive approach, one overriding principle emerges from this patchwork: the concern for confidentiality represented in the Hippocratic Oath is alive in Ohio and should guide the release of any medical secrets in the state. There are several statutes that regulate the release of certain types of medical information. For example, information concerning patients suffering from alcohol or drug abuse is …

Recovery For The Wrongful Death Of A Viable Fetus: Werling V. Sandy, Janet I. Stich

Akron Law Review

In Werling v. Sandy, the Ohio Supreme Court held a viable fetus, negligently injured "en ventre sa mere" and subsequently stillborn, may be the basis for a wrongful death action pursuant to Ohio Rev. Code § 2125.01.1 The court's ruling represented Ohio's explicit acceptance of the trend allowing a wrongful death action for the death of a fetus. Although Werling was not a case of first impression in Ohio, it presented the Ohio Supreme Court with the first opportunity to expand the legal rights of the unborn.

Nonlinear Dynamics Of Some Ecological And Epidemiological Models, Jing Chen

Open Access Dissertations

In studying some biological problems, the descriptive features of biological systems are delivered by differential equations which can be studied quantitatively by both analytical and computational methods. The obtained results can be interpreted back to the biological level, then explain some phenomena and also provide some strategies. In this thesis, both of ecological and epidemiological problems have been studied. In the first chapter, I studied the nonlinear dynamics of some ecological models to understand how seasonal harvesting affects ecological systems. I proposed a predator- prey model with a non-monotone functional response and seasonal prey harvesting, which is described by a …

Biofilm Formation By Borrelia Burgdorferi Sensu Lato, Venkata Arun Timmaraju, Priyanka A.S. Theophilus, Kunthavai Balasubramanian, Shafiq Shakih, David F. Luecke, Eva Sapi

Biology and Environmental Science Faculty Publications

Bacterial biofilms are microbial communities held together by an extracellular polymeric substance matrix predominantly composed of polysaccharides, proteins and nucleic acids. We had previously shown that Borrelia burgdorferi sensu stricto, the causative organism of Lyme disease in the United States is capable of forming biofilms in vitro. Here, we investigated biofilm formation by B. afzelii and B. garinii, which cause Lyme disease in Europe. Using various histochemistry and microscopy techniques, we show that B. afzelii and B. garinii form biofilms, which resemble biofilms formed by B. burgdorferisensu stricto. High-resolution atomic force microscopy revealed similarities in the …

Gray To Lead Um Health Professions Advising Office, Michael Newsom

University of Mississippi News

No abstract provided.

Blood Donation: A Gift Of Life Or A Death Sentence?, Sharon L. Dieringer

Akron Law Review

Anyone who has AIDS is a victim. If AIDS produces a victim then who is the perpetrator? AIDS can be transmitted through intimate sexual contact, by sharing contaminated needles, via infected blood or blood products, and through passage of the virus from infected mothers to their newborns.

This comment will concentrate on transmission through infected blood or blood products, and the blood donor. The discussion will focus on the civil and criminal liabilities of a blood donor with the AIDS virus.

United States V. Moore: Aids And The Criminal Law: The Witch Hunt Begins, Robert Louis Stauter Md., J.D.

Akron Law Review

The United States v. Moore opinions written by Federal District Judge Diana E. Murphy and Circuit Judge Timbers reveal a fundamental misunderstanding of the disease process of AIDS. The purpose of this article is to help the reader critically analyze these court opinions. To facilitate this discussion the article will first provide the reader with some very basic, yet very technical, vocabulary used by medical specialists who care for and study patients with AIDS.

Welsh V. United States, The Sixth Circuit Gives A Physics Lesson - For Every Action There Is An Equal And Opposite Reaction, Daniel L. Bell

Akron Law Review

This casenote will review the facts of Welsh v. United States and present the current judicial approaches to spoliation of evidence in civil litigation. Second, the note will analyze the Welsh court's proposed solution to the spoliation problem. Finally, the note will discuss the use of the Welsh approach in litigation and management implications for health care facilities.

Chalk V. United States District Court Central District Of California: A Major Victory For Aids Employees Under The Federal Rehabilitation Act Of 1973, Janet A. Michael

Akron Law Review

This note will first review the facts of Chalk v. United States District Court Central District of California and will present a broad overview of AIDS, outlining current medical knowledge of the disease. Second, this note will analyze the Rehabilitation Act, examining regulations, legislative history, and case law interpreting the Act. Finally, this note will analyze the impact of Chalk on future employment cases.

Marijuana Use And Cardiometabolic Disease Risk Throughout Adulthood: An Analysis Of The National Health And Nutrition Examination Surveys, 2005-2010, Denise Christina Vidot

Open Access Dissertations

Background. Rates of marijuana use in the United States are the highest recorded over the past decade. Little is known about its relationship with Metabolic Syndrome. The aim of this study were to: Therefore, the aims of this study were to: AIM 1: Estimate the prevalence of cardiometabolic disease risk factors and metabolic syndrome among a nationally representative sample of marijuana users in early adulthood (20-to-30 years), adulthood (31-to-44 years), and middle-aged adulthood (45-to-59 years) using a nationally representative sample. AIM 2: Describe the relationship between marijuana use and metabolic syndrome at each stage of adulthood using a nationally representative …

National Security Implications Of Climate-Related Risks And A Changing Climate, Department Of Defense

State & Federal Reports and Publications

This report responds to the Congressional request to the Department of Defense to identify the most serious and likely climate-related security risks for each Combatant Command, the ways in which the Combatant Commands are integrating mitigation of these risks into their planning processes, and a description of the resources required for an effective response.

Submitted in response to a request contained in Senate Report 113-211, accompanying H.R. 4870, the Department of Defense Appropriations Bill, 2015.

Generated on 2015May27 RefID: 8-6475571

Macrolide-Resistant Mycoplasma Pneumoniae, United States, Xiaotian Zheng, Stella Lee, Rangaraj Selvarangan, Xuan Qin, Yi Wei Tang, Jeffrey Stiles, Tao Hong, Kathleen Todd, Amy E. Ratliff, Donna M. Crabb, Li Xiao, T. Prescott Atkinson, Ken B. Waites

Manuscripts, Articles, Book Chapters and Other Papers

© 2015, Centers for Disease Control and Prevention (CDC). All rights reserved.

Macrolide-resistant Mycoplasma pneumoniae (MRMP) is highly prevalent in Asia and is now being reported from Europe. Few data on MRMP are available in the United States. Using genotypic and phenotypic methods, we detected high-level MRMP in 13.2% of 91 M. pneumoniae–positive specimens from 6 US locations.

National Security Implications Of Climate-Related Risks And A Changing Climate, Department Of Defense

State & Federal Reports and Publications

This report responds to the Congressional request to the Department of Defense to identify the most serious and likely climate-related security risks for each Combatant Command, the ways in which the Combatant Commands are integrating mitigation of these risks into their planning processes, and a description of the resources required for an effective response.

Submitted in response to a request contained in Senate Report 113-211, accompanying H.R. 4870, the Department of Defense Appropriations Bill, 2015.

Generated on 2015May27 RefID: 8-6475571

Quantitative Study Of Nano To Submicron Scales Intracellular Structural Disorder Using Electron And Confocal Microscopies: Application To Cancer Detection, Hemendra Ghimire

Electronic Theses and Dissertations Archive

Cancer is one of the leading causes of death with over a million people being diagnosed every year. Many cancers eventually result in death because they go undetected in their early stages when they can be cured. The conventional techniques used for cancer diagnostics exhibit limitations in detecting early stage cancer, which has nano-scale structural changes. On the other hand, alcoholism is one of the biggest cause of health problems. This study examines the effect of alcohol in early stage carcinogenesis in the colon and healthy hippocampal cells of mice models by quantifying the structural changes in their nuclei via …

Increased Harbor Porpoise Mortality In The Pacific Northwest, Usa: Understanding When Higher Levels May Be Normal, Jessica L. Higgins, Stephen A. Raverty, Stephanie A. Norman, John Calambokidis, Joseph K. Gaydos, Deborah A. Duffield, Dyanna M. Lambourn, James M. Rice, Brad Hanson, Kristin Wilkinson, Steven J. Jeffries, Brent Norberg, Lynne Barre

Biology Faculty Publications and Presentations

In 2006, a marked increase in harbor porpoise Phocoena phocoena strandings were reported in the Pacific Northwest of the USA, resulting in the declaration of an unusual mortality event (UME) for Washington and Oregon to facilitate investigation into potential causes. The UME was in place during all of 2006 and 2007, and a total of 114 porpoises stranded during this period. Responders examined 95 porpoises; of these, detailed necropsies were conducted on 75 animals. Here we review the findings related to this event and how these compared to the years immediately before and after the UME. Relatively equal numbers among …

Steps Towards Deciphering The Post-Polyketide Synthase Tailoring Steps In The Phoslactomycin Biosynthesis Pathway, Patience Marimo

Dissertations and Theses

Phoslactomycins (PLMs) are a group of natural products belonging to a polyketides class. These polyketides are synthesized by sequential reaction catalyzed by a collection of enzymes activities called polyketide synthases. A polyketide is a large class of diverse compounds that are characterized by more than two carbonyl groups connected by single intervening carbon atoms. In other words, a polyketide is a polymer whose monomer is a ketide. The PLMs are also known as phosphazomycins or phospholines. These compounds were isolated based on antifungal and antitumor activities. This array of promising biological activities has stimulated research into the field of PLMs …

Safe From Subpoena? The Importance Of Certificates Of Confidentiality To The Viability And Ethics Of Research, Emily Haney-Caron, Naomi E. Goldstein, David Dematteo

Akron Law Review

This Article addresses legal issues related to Certificates, recognizes that Certificates face an uncertain future if challenged in court—based on the statutory history and limited relevant case law—and proposes that changes should be made to ensure Certificates actually offer the protection they promise. Part II reviews the background of Certificates of Confidentiality. Part III explores how Certificates fulfill vital functions by encouraging research participation, satisfying ethical obligations of researchers to protect participant data, and promoting the accuracy of data provided by participants in research studies. Part IV observes that the case law relevant to Certificates of Confidentiality, though limited, presents …

Volume 52, Number 49: July 22, 2015, University Of North Dakota

University Letter Archive

No abstract provided.

Sistrunk Triplets Finally Ready To Attend Um, Nathan Weber

University of Mississippi News

Dr. and Mrs. William Sistrunk met at UM and now see their children take the next step at their alma mater.

Improving The Image And Legal Status Of The Burial Services Industry, Marvin M. Moore

Akron Law Review

The purpose of this article is to examine the reasons advanced for excluding funeral parlors and graveyards from predominantly residential neighborhoods, the legal devices most commonly employed to accomplish such exclusion, and the propriety of using the police powers of the state to bar a land use that may not always threaten to thwart any of the recognized aims that the police powers are intended to promote. Finally, the article will recommend some practical steps that operators of mortuaries and cemeteries might take in order to gain more public acceptance. To the extent that the law merely reflects the values, …

Efficacy Of Visual Surveys For White-Nose Syndrome At Bat Hibernacula, A. F. Janicki, W. F. Frick, A. M. Kilpatrick

KIP Articles

White-Nose Syndrome (WNS) is an epizootic disease in hibernating bats caused by the fungus Pseudogymnoascus destructans. Surveillance for P. destructans at bat hibernacula consists primarily of visual surveys of bats, collection of potentially infected bats, and submission of these bats for laboratory testing. Cryptic infections (bats that are infected but display no visual signs of fungus) could lead to the mischaracterization of the infection status of a site and the inadvertent spread of P. destructans. We determined the efficacy of visual detection of P. destructans by examining visual signs and molecular detection of P. destructans on 928 bats of six …

Delineation Of Aeromonas Hydrophila Pathotypes By Dectection Of Putative Virulence Factors Using Polymerase Chain Reaction And Nematode Challenge Assay, John Metz

Master of Science in Integrative Biology Theses

Aeromonas hydrophila is a Gram-negative, bacterial pathogen of humans and other vertebrates. To delineate pathotypes, the genomes of twenty-eight Aeromonas isolates were screened by PCR to determine the presence of virulence factors including: aerolysin (aerA), cytotoxic enterotoxin (act), hemolysin (ahh1), elastase (ahyB), enolase (eno), S-layer protein (ahsA), serine protease (ser), Type IV Aeromonas pilus (tapA), lipase (lip), and Type Three Secretion System (T3SS) components (aopB, ascV). Genes for ahh1, lip, ser, and ahyB …

New Evidence Prompts Rethinking The Clinical Management Of Community Acquired Pneumonia In Patients Admitted To General Medical Services., J. Timothy Caldwell

Clinical Research in Practice: The Journal of Team Hippocrates

A critical appraisal and clinical application of Postma DF, van Werkhoven CH, van Elden LJR, et al. Antibiotic treatment strategies for community-acquired pneumonia in adults. N Engl J Med. 2015;372(14):1312-1323. doi:10.1056/NEJMoa1406330

Quantitative Reasoning: Interdisciplinary Stem 21st Century Reasoning Modality, Robert L. Mayes

Teaching & Learning: Faculty Presentations (2012-2017)

The Next Generation Science Standards (NGSS 2013) and the Common Core State Standards for Mathematics (NGA 2010) call for improving scientific, engineering, and mathematical practices. Among the practices called for are model-based reasoning which engages students in developing and using models, analyzing and interpreting data, and using mathematics and computational thinking. Fundamental to these processes is quantitative reasoning (QR), which for this project is defined as:

Quantitative reasoning is mathematics and statistics applied in real-life, authentic situations that impact an individual’s life as a constructive, concerned, and reflective citizen (Mayes et al. 2014b).

In the NSF project, Culturally Relevant Ecology, …

The Epidemic Of Antibiotic Resistance: A Legal Remedy To Eradicate The "Bugs" In The Treatment Of Infectious Diseases, Mike Misocky

Akron Law Review

Even though some hospitals have initiated programs aimed at curbing inappropriate antibiotic use, present day circumstances warrant a comprehensive approach to the pending epidemic. In an era where managed care organizations are prevalent and the crux of health care takes place in the community, the opportunity exists for a legal remedy to halt the progression of a possible "superbug" tyranny. This article sets forth the Antibiotic Resistance Epidemic in Part 11. Parts III and IV discuss the causative agents while emphasizing the need for a regulatory attack to the problem. The remainder of this article concentrates on a proposal to …

The Multifactorial Role Of The 3rs In Shifting The Harm-Benefit Analysis In Animal Models Of Disease, Melanie L. Graham, Mark J. Prescott

Biomedical Research and Alternative Methods Collection

Ethics on animal use in science in Western society is based on utilitarianism, weighing the harms and benefits to the animals involved against those of the intended human beneficiaries. The 3Rs concept (Replacement, Reduction, Refinement) is both a robust framework for minimizing animal use and suffering (addressing the harms to animals) and a means of supporting high quality science and translation (addressing the benefits). The ambiguity of basic research performed early in the research continuum can sometimes make harm-benefit analysis more difficult since anticipated benefit is often an incremental contribution to a field of knowledge. On the other hand, benefit …