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November 16, 2015 Armstrong Faculty Senate Agenda, Armstrong State University

Armstrong Faculty Senate: Armstrong Faculty Senate Agenda (Archived)

November 16, 2015 Armstrong Faculty Senate Agenda

Faculty Senate Bill Fsb-2015-11-16-01: University Curriculum Committee, Armstrong State University

Armstrong Faculty Senate: Bills, Motions & Resolutions (Archived)

Faculty Senate Bill FSB-2015-11-16-01: University Curriculum Committee

A Pilot Study Of The Impact Of A Pulmonary Clinical Decision Unit On Outcomes In Patients With Chronic Obstructive Pulmonary Disease, Shirl D. Johnson

Graduate Theses, Dissertations, and Capstones

The Affordable Care Act has transformed our nation’s healthcare system and reimbursement structure. The paradigm shift to improve efficiency, quality and to lower has created evolving models to rapidly diagnose and treat patients presenting to the emergency department with chronic disease. Clinical decision units (CDU) have become a leading strategy for treating patients at an appropriate level of care. CDU use evidence-based protocol driven care according to different disease status. Patients assigned to these areas, are provided with rapid and safe evaluations for patients identified at low-risk. Reducingthe number ofpatients who arereadmitted to thehospital with COPD is a prioritywithin NHC. …

The State Of Oral Health On The African Continent, Megan E. Josefczyk

Senior Honors Theses

The African continent has continuously suffered from poverty, poor sanitation, and malnutrition, leaving it an open feeding ground for infectious disease and premature death. Along with poor oral hygiene and an unavailability of dental clinics, oral disease is allowed to thrive and cause great harm. In the last two decades, the World Health Organization and others have tried to implement better systems of oral health care for the African people and have advocated for more well-trained dentists, dental clinics, equipment, and affordable dental care. Progress has been made in some African countries, but the continent is still in serious need …

Week Of November 16, 2015, New York Medical College

InTouch

• Amy S. Kahn Named Vice President for Development and Alumni Affairs
• BioInc@NYMC Welcomes Two New Clients
• Three High School Students Named Siemens Competition Semi-Finalists

Administration Of Panobinostat Is Associated With Increased Il-17a Mrna In The Intestinal Epithelium Of Hiv-1 Patients, Ane Bjerg Christensen, Anders Dige, Johan Vad-Nielsen, Christel R. Brinkmann, Mia Bendix, Lars Østergaard, Martin Tolstrup, Ole S. Søgaard, Thomas A. Rasmussen, Jens Randel Nyengaard, Jørgen Agnholt, Paul W. Denton

Biology Faculty Publications

Intestinal CD4+ T cell depletion is rapid and profound during early HIV-1 infection.This leads to a compromised mucosal barrier that prompts chronic systemic inflammation.The preferential loss of intestinal T helper 17 (Th17) cells in HIV-1 disease is a driver of the damage within the mucosal barrier and of disease progression.Thus, understanding the effects of new therapeutic strategies in the intestines has high priority. Histone deacetylase (HDAC) inhibitors (e.g., panobinostat) are actively under investigation as potential latency reversing agents in HIV eradication studies. These drugs have broad effects that go beyond reactivating virus, including modulation of immune pathways. We examined colonic …

2015-November-13-Research Team Studying Link Between Genetics, Drug Side Effects, University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.

A Forward Genetic Screen Reveals Novel Independent Regulators Of Ulbp1, An Activating Ligand For Natural Killer Cells, Benjamin G Gowen, Bryan Chim, Caleb D. Marceau, Trever T Greene, Patrick Burr, Jeanmarie R. Gonzalez, Charles Hesser, Peter A. Dietzen, Teal Russell, Alexandre Iannello, Laurent Coscoy, Charles L. Sentman

Dartmouth Scholarship

Recognition and elimination of tumor cells by the immune system is crucial for limiting tumor growth. Natural killer (NK) cells become activated when the receptor NKG2D is engaged by ligands that are frequently upregulated in primary tumors and on cancer cell lines. However, the molecular mechanisms driving NKG2D ligand expression on tumor cells are not well defined. Using a forward genetic screen in a tumor-derived human cell line, we identified several novel factors supporting expression of the NKG2D ligand ULBP1. Our results show stepwise contributions of independent pathways working at multiple stages of ULBP1 biogenesis. Deeper investigation of selected hits …

Should I Stay Or Should I Go? Patient Understandings Of And Responses To Source-Isolation Practices, Mary Wyer, Rick Iedema, Christine Jorm, Gary Armstrong, Su-Yin Hor, Claire Hooker, Debra Jackson, Clarissa Hughes, Matthew V.N. O'Sullivan, Gwendolyn L. Gilbert

Patient Experience Journal

Isolation of patients, who are colonised or infected with a multidrug-resistant organism (source-isolation), is a common practice in most acute health-care settings, to prevent transmission to other patients. Efforts to improve the efficacy of source-isolation in hospitals focus on healthcare staff compliance with isolation precautions. In this article we examine patients’ awareness, understandings and observance of source-isolation practices and directives with a view to understanding better the roles patients play or could play in transmitting, or limiting transmission, of multidrug-resistant organisms (MRO). Seventeen source-isolated adult surgical patients and two relatives participated in video-reflexive ethnography and interviews. We learned that, although …

Effectiveness Of Stevia Rebaudiana Whole Leaf Extract Against The Various Morphological Forms Of Borrelia Burgdorferi In Vitro, Priyanka Annabel Sugantham Theophilus, Maria J. Victoria, Kayla Socarras, Katherine R. Filush, Khusali Gupta, David F. Luecke, Eva Sapi

Biology and Environmental Science Faculty Publications

Lyme disease is a tick-borne multisystemic disease caused by Borrelia burgdorferi. Administering antibiotics is the primary treat-ment for this disease; however, relapse often occurs when antibiotic treatment is discontinued. The reason for relapse remains un-known, but recent studies suggested the possibilities of the presence of antibiotic resistant Borreliapersister cells and biofilms.In this study, we evaluated the effectiveness of whole leaf Stevia extract against B. burgdorferispirochetes, persisters, and bio-film forms in vitro. The susceptibility of the different forms was evaluated by various quantitative techniques in addition to differ-ent microscopy methods. The effectiveness of Stevia was compared to doxycycline, cefoperazone, daptomycin, and …

Sidestream Smoke Exposure Increases The Susceptibility Of Airway Epithelia To Adenoviral Infection, Priyanka Sharma, Abimbola O. Kolawole, Susan B. Core, Adriana E. Kajon, Katherine J.D.A. Excoffon

Biological Sciences Faculty Publications

Background: Although significant epidemiological evidence indicates that cigarette smoke exposure increases the incidence and severity of viral infection, the molecular mechanisms behind the increased susceptibility of the respiratory tract to viral pathogens are unclear. Adenoviruses are non-enveloped DNA viruses and important causative agents of acute respiratory disease. The Coxsackievirus and adenovirus receptor (CAR) is the primary receptor for many adenoviruses. We hypothesized that cigarette smoke exposure increases epithelial susceptibility to adenovirus infection by increasing the abundance of apical CAR. Methodology and Findings: Cultured human airway epithelial cells (CaLu-3) were used as a model to investigate the effect of sidestream cigarette …

The Pros And Cons Of Sick Pay Schemes: Testing For Contagious Presenteeism And Shirking Behavior, Stefan Pichler, Nicolas R. Ziebarth

Upjohn Institute Working Papers

This paper proposes a test for the existence and degree of contagious presenteeism and negative externalities in sickness insurance schemes. First, we theoretically decompose moral hazard into shirking and contagious presenteeism behavior and derive testable conditions. Then, we implement the test exploiting German sick pay reforms and administrative industry-level data on certified sick leave by diagnoses. The labor supply adjustment for contagious diseases is significantly smaller than for noncontagious diseases. Lastly, using Google Flu data and the staggered implementation of U.S. sick leave reforms, we show that flu rates decrease after employees gain access to paid sick leave.

The Pacifican November 12, 2015, University Of The Pacific

All Issues - Student Newspaper, The Pacifican, Pacific Weekly

No abstract provided.

Volume 53, Number 13: November 11, 2015, University Of North Dakota

University Letter Archive

No abstract provided.

The Diamond, November 11, 2015 [Spoof Issue], Dordt College

Dordt Diamond

No abstract provided.

Clinical Experience At Pasteur Clinic Đà Lạt, Vietnam, Emma Howard-Young, Jordan Howard-Young, Ma

CwiC Posters

History of the Pasteur Clinic Đà Lạt

The Pasteur Clinic is associated with the Institut Pasteur, part of the international network of research institutes dedicated to the prevention and treatment of infectious diseases. The Đà Lạt branch of Vietnam’s Institut Pasteur was built between 1930 and 1936 under the direction of Dr. Alexandre Yersin, a physician remembered for identifying Yersinia pestis as the causative agent of Plague and a student of the eponymous French chemist and microbiologist Louis Pasteur. While many overt references to the French colonial tradition have been supplanted in Vietnam by nationalist sentiments, the Institut Pasteur …

Self-Assembly Directs Enamel Formation And Regeneration, Malcolm Snead

Composites at Lake Louise (CALL 2015)

Enamel is a unique bioceramic tissue covering our teeth, which by improving feeding and nutrition fueled an explosion in vertebrate evolution. Enamel is also the tissue affected by the most prevalent infectious disease of humankind, caries. While enamel is the hardest tissue in the vertebrate body it develops as a soft extracellular protein matrix precursor synthesized by ameloblast cells that is composed mainly of the proteins amelogenin and ameloblastin. Amelogenins are small-, hydrophobic-, inherently disordered proteins that self-assembly to form nanospheres through the interaction of two domains located at opposite molecular ends, whereas, ameloblastin self-assembles through but a single N’-terminal …

Exclusive Breastfeeding Promotion Among Hiv-Infected Women: A Theory-Based Approach, Emily L. Tuthill

Doctoral Dissertations

In resource-limited settings, exclusive breastfeeding among HIV-infected mothers reduces infant morbidity and mortality from all causes, including HIV. Although breastfeeding by HIV- infected mothers carries a risk of HIV transmission from mother-to-child, that risk decreases from 45% to less than 5% with the practice of exclusive breastfeeding and appropriate antiretroviral therapy. The World Health Organization recommends women living with HIV exclusively breastfeed for the first 6 months of their infants life in recourse-limited settings. However, exclusive breastfeeding rates remain low. This dissertation highlights infant feeding experiences among HIV-infected women in recourse-limited settings and investigates a pilot intervention promoting exclusive breastfeeding …

The Impact Of Municipal Waste Water In Neredime River, Kosovo, Bekim Selimi

UBT International Conference

Today, environmental protection is of great concern in Kosovo. Almost all waste water effluents from the localities are discharging in surface water and groundwater without being significantly treated deterioning water quality in Kosovo’s rivers. The aim of this paper is to analyze the level of pollution in the Neredime river created from municipal wastewater as well as to identify pollutants and their impact on the river. An attempt has been made to present the situation of the waters defining physicochemical water qualities of Neredime river from the source to the outskirts of town in the south-west of Ferizaj; this includes …

Chimpanzee Use In Invasive Biomedical Research: The One-Percent Difference That Affects One-Hundred-Percent Of The Studies, Samantha Fox

Journal of Civil Rights and Economic Development

No abstract provided.

Nested Partially-Latent, Class Models For Dependent Binary Data, Estimating Disease Etiology, Zhenke Wu, Maria Deloria-Knoll, Scott L. Zeger

Johns Hopkins University, Dept. of Biostatistics Working Papers

The Pneumonia Etiology Research for Child Health (PERCH) study seeks to use modern measurement technology to infer the causes of pneumonia for which gold-standard evidence is unavailable. The paper describes a latent variable model designed to infer from case-control data the etiology distribution for the population of cases, and for an individual case given his or her measurements. We assume each observation is drawn from a mixture model for which each component represents one cause or disease class. The model addresses a major limitation of the traditional latent class approach by taking account of residual dependence among multivariate binary outcome …

“Imagine A World In Which”: Using Scenarios In Political Science, Naazneen H. Barma, Brent Durbin, Eric Lorber, Rachel E. Whitlark

Government: Faculty Publications

A crucial dimension of bridging the gap between international affairs scholarship and policymaking is the generation of substantive, policy-relevant research programs. We describe the use of scenario analysis as a valuable experiential and problem-based technique for developing innovative research ideas in political science. We focus especially on the scholarly and pedagogical potential of scenarios for doctoral students by describing the structured use of scenarios at the annual New Era Foreign Policy Conference. The features of scenario analysis that commend its use to policymakers also make it well suited to helping political scientists generate policy-relevant research programs. Scenarios are plausible and …

Complete Genome Sequences Of Four Escherichia Coli St95 Isolates From Bloodstream Infections, Craig M. Stephens, Jeffrey M. Skerker, Manraj S. Sekhon, Adam P. Arkin, Lee W. Riley

Biology

Finished genome sequences are presented for four Escherichia coli strains isolated from bloodstream infections at San Francisco General Hospital. These strains provide reference sequences for four major fimH-identified sublineages within the multilocus sequence type (MLST) ST95 group, and provide insights into pathogenicity and differential antimicrobial susceptibility within this group.

Gender Perspectives On Torture And Other Cruel, Inhuman, Or Degrading Treatment Or Punishment: Expert Consultation, Brenda V. Smith

Research Reports & White Papers

The aim of this consultation with experts is to ensure that the Special Rapporteur receives the necessary exposure to the different practices, international standards and jurisprudence, and expert opinions that will help him draft his forthcoming thematic report for the United Nations Human Rights Council. The report will focus on assessing the unique experiences of women, girl children and LGBTI persons from the perspective of torture and other cruel, inhuman or degrading treatment and punishment (“CIDTP”) in international law. The consultation will focus on specific practices where the mistreatment rises to the level of torture or CIDTP to identify gaps …

York Beaches Nexus Of Sustainability Research, Evelyn Jones

UNH Today Archive

No abstract provided.

Pleiotropic Effects Of Immune Responses Explain Variation In The Prevalence Of Fibroproliferative Diseases, Shirley B. Russell, Joan C. Smith, Minjun Huang, Joel S. Trupin, Scott M. Williams

Dartmouth Scholarship

Many diseases are differentially distributed among human populations. Differential selection on genetic variants in ancestral environments that coincidentally predispose to disease can be an underlying cause of these unequal prevalence patterns. Selected genes may be pleiotropic, affecting multiple phenotypes and resulting in more than one disease or trait. Patterns of pleiotropy may be helpful in understanding the underlying causes of an array of conditions in a population. For example, several fibroproliferative diseases are more prevalent and severe in populations of sub-Saharan ancestry. We propose that this disparity is due to selection for an enhanced Th2 response that confers resistance to …

Risk-Taking Behavior And Its Impact On Treatment, Vaccination And Diagnosing, Daniel Maxin

Journal of Mind and Medical Sciences

We present results from two recent mathematical biology studies that address the effect of risk-taking behavior on epidemic models. We show that when risk-taking prevails over riskavoidance, it is possible to show a detrimental and counterintuitive effect from increasing vaccination and treatment rates over certain critical time intervals. In addition, when risk-taking has a cumulative effect within the population, a lower transmission rate from diagnosed infected individuals may prevent the intended effect of vaccination.

2015-November-03-Etsu To Live-Stream 24 Hours Of Reality For Climate Change Roundtable, University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.

A Virtual Clinic Improves Pneumococcal Vaccination For Asplenic Veterans At High Risk For Pneumococcal Disease, Robin L.P. Jump, Brigid Wilson, Rebecca Carter, Susan Phillips, Federico Perez

Faculty Scholarship

We developed a "virtual clinic" to improve pneumococcal vaccination among asplenic adults. Using an electronic medical record, we identified patients, assessed their vaccination status, entered orders, and notified patients and providers. Within 180 days, 38 of 76 patients (50%) received a pneumococcal vaccination. Avirtual clinic may optimize vaccinations among high-risk patients.

Viral Infection Causes A Shift In The Self Peptide Repertoire Presented By Human Mhc Class I Molecules, Charles T. Spencer, Jelena S. Bezbradica, Mireya G. Ramos, Chenoa D. Arico, Stephanie B. Conant, Pavlo Gilchuk, Jennifer J. Gray, Mu Zheng, Xinnan Niu, William Hildebrand, Andrew J. Link, Sebastian Joyce

Chemistry Faculty Research

Purpose

MHC class I presentation of peptides allows T cells to survey the cytoplasmic protein milieu of host cells. During infection, presentation of self peptides is, in part, replaced by presentation of microbial peptides. However, little is known about the self peptides presented during infection, despite the fact that microbial infections alter host cell gene expression patterns and protein metabolism.

Experimental design

The self peptide repertoire presented by HLA-A*01;01, HLA-A*02;01, HLA-B*07;02, HLA-B*35;01, and HLA-B*45;01 (where HLA is human leukocyte antigen) was determined by tandem MS before and after vaccinia virus infection.

Results

We observed a profound alteration in the self …