Digital Commons Network^™

Current, November 30, 2015, University Of Missouri-St. Louis

Current (2010s)

No abstract provided.

Penemuan Kasus Infeksi Kusta Subklinis Pada Anak Melalui Deteksi Kadar Antibodi (Igm) Anti Pgl-1, Arif Sujagat, Fardhiasih Dwi Astuti, Eva Muslimawati Saputri, Annisa Sani, Agil Dwi Prasetya

Kesmas

]Kusta merupakan penyakit menular kronis yang disebabkan Mycobacterium leprae. Indonesia menempati peringkat ketiga penyumbang kasus kusta terbanyak di dunia pada tahun 2012 – 2014. Kota Surabaya merupakan daerah endemis kusta. Penelitian ini bertujuan untuk deteksi dini kusta subklinis berdasarkan pengukuran kadar antibodi (IgM) anti PGL-1 dan mengetahui faktor-faktor yang berhubungan dengan kusta subklinis pada anak di Kota Surabaya. Penelitian analitik menggunakan desain potong lintang pada bulan April - Mei 2015. Populasi dilakukan penelitian adalah keluarga yang memiliki anggota penderita kusta. Sampel dipilih dengan teknik simple random sampling dan sebanyak 30 kepala keluarga terpilih melalui rapid school and village survey pada …

Development Of A Novel Photocatalyst For The Advanced Antibiotic Oxidation Of Wastewater, Dickson Yuk Shing Yan, Frank Leung Yuk Lam

Practical Social and Industrial Research Symposium

No abstract provided.

The Population History Of The Philippines: A Genetic Overview, Frederick C. Delfin

Philippine Studies: Historical and Ethnographic Viewpoints

This professorial address synthesizes the findings of several studies on the genetics of Philippine population groups and presents them in a manner accessible to nonspecialists. These studies examined different types of DNA (Y-chromosome, mitochondrial, and autosomal) samples contributed by participants in twelve regional centers and nineteen ethnolinguistic groups. The data reveal (a) genetic affinities with different groups in the Asia-Pacific region, (b) genetic signals of ancient demographic events, (c) an ancient genetic history of about 5,000–50,000 years ago, and (d) a complex population genetic structure. This genetic overview has implications for the study of human history, forensics, and medicine.Keywords: DNA …

Methods And Compositions For Inducing An Immune Response To Egfrviii, Peter M. Lauer, Ketih Bahjat

Technology Transfer - Patents

The present invention relates to methods of inducing a T-cell response against a EGFRvIII in a subject. These method comprise administering to a subject a composition which expresses at least one immunogenic polypeptide, the amino acid sequence of which comprise a plurality of EGFRvIII polypeptide sequences, the sequence of which each comprise EEKKGNYV (SEQ ID NO: 3), and/or administering the polypeptide itself.

Prevalence Of Blood Parasites In Damselfishes And Blennies Of The Eastern Caribbean And Their Detection Using Molecular Techniques, Lance Pierre Renoux

Student Theses and Dissertations

This study built on the recent discovery of Apicomplexan blood parasites in damsel and blennioid fishes in the Caribbean (Cook et al. 2015), by elucidating their geographical distribution, species and life history stages of damselfishes they infect, and developing specific molecular primers to identify them. From 2013-2015, eight damselfish species from three genera were sampled from 11 localities (n = 807), and eight blenny species from two genera (n = 114) were sampled from 7 of these sites. Damselfish parasites appeared only in Stegastes species and at all localities, except Curacao (n = only 6), but were rare in the …

Study Finds Genetic Risk Factor Can Lead To Hyperinflammatory Disorder, Death After Viral Infection, Staff

Browse All News

No abstract provided.

Estudios En Biodiversidad, Volumen I, Griselda Pulido-Flores, Scott Monks, Maritza López-Herrera

Zea E-Books Collection

Este libro es el producto del trabajo colegiado que han desarrollado los profesores, investigadores, y estudiantes que conforman la Red Temática de Calidad Ambiental y Desarrollo Sustentable, a través del macroproyecto “Evaluación del impacto ambiental por actividades antropogénicas: Alternativas de mitigación”. El cual fue apoyado con recursos financieros por parte del Programa para el Desarrollo Profesional Docente (PRODEP), de la Secretaria de Educación Pública (SEP) en México. Las instituciones de educación superior y cuerpos participantes en la red temática son la Universidad Autónoma del Estado de Hidalgo (Uso, Manejo y Conservación de la Biodiversidad UAEHCA- 10; Ciencias Ambientales UAEH-CA-59); Universidad …

Compositions Including Triciribine And Bortezomib And Derivatives Thereof And Methods Of Use Thereof, Jin Q. Cheng, Said M. Sebti

USF Patents

This application relates to combination therapies including triciribine and related compounds and bortezomib and derivatives thereof analogs and compositions with reduced toxicity for the treatment and prevention of tumors, cancer, and other disorders associated with abnormal cell proliferation.

Synthesis And Application Of Silica Based Mesoporous Materials For Removal Of Endocrine Disrupting Compounds In Aqueous Solution / Shanmuga Suntharam Kittappa, Kittappa Shanmuga Suntharam

Student Works (2010-2019)

The economical synthesis route of silica based mesoporous materials using eco-friendly and cheaper chemicals and material was studied. Three mesoporous silica-based materials were successfully synthesized and applied for the removal of endocrine disrupting compounds (EDCs): mesoporous silica materials (MSMs) synthesized by reacting pore templating agent Pluronic P123® with silica (SiO2) powder instead of organometallic precursors [i.e. tetraethyl orthosilicate (TEOS)]; magnetised nanocomposite silica material (MNCM) synthesized by incorporating MSMs with nano magnetite; and N1-(3-Trimethoxysilylpropyl) diethylenetriamine (Tris) coated magnetised nanocomposite silica materials (MNCMT) synthesized by incorporating MNCM with Tris. The synthesized materials were characterized by X-ray diffraction (XRD), Brunauer–Emmett–Teller (BET)/Barrett-Joyner-Halenda (BJH) surface …

2015-11-23-New Employees, University Marketing And Communications, East Tennessee State University

Accent [newsletter]

No abstract provided.

Hãwäg And B’Atìb: The Balance Between Health And Disease Among The Hupd’ÄH In The Upper Rio Negro Region, Brazil, Renato Athias

Tipití: Journal of the Society for the Anthropology of Lowland South America

No abstract provided.

Direct And Indirect Effects Of The Caribbean Cymothoid Parasite Anilocra Haemuli On Host Energetics, Behavior, And Trophic Interactions, Rachel Lynn Welicky

Student Theses and Dissertations

The majority of coral reef research focuses on organisms that are familiar to humans, yet 80% of coral reef animals are parasites. Research on the direct effects of parasitism has suggested that hosts may undergo both behavioral and physiological changes. These changes may manifest at the ecosystem level, yet evidence of such changes are scarce. The objectives of this study were to investigate the direct and indirect effects of the Caribbean cymothoid parasite Anilocra haemuli on Haemulon flavolineatum (French grunt) energetics, behavior and trophic interactions. I conducted field surveys to measure A. haemuli prevalence of infection and determine its association …

Serum Zinc Concentrations In Children With Acute Bloody And Watery Diarrhoea, Abolfazl Mahyar, Parviz Ayazi, Victoria Sahmani, Mehdi, Sonia Oveisi, Shiva Esmaeily

Sultan Qaboos University Medical Journal

Objectives: The role of zinc in the pathogenesis of diarrhoea is controversial. This study was conducted to compare serum zinc levels in children with acute diarrhoea to those found in healthy children. Methods: This case-control study was carried out at the Qazvin Children’s Hospital in Qazvin, Iran, between July 2012 and January 2013. A total of 60 children with acute diarrhoea (12 children with bloody diarrhoea and 48 children with watery diarrhoea) and 60 healthy children were included. Zinc levels for all subjects were measured using a flame atomic absorption spectrophotometer and data were analysed and compared between groups. Results: …

Temporomandibular Joint Ankylosis As A Complication Of Neonatal Septic Arthritis : Report Of Two Cases, Noor J. Al-Saadi, Abdulaziz A. Bakathir, Ahmed K. Al-Ismaili, Mohammad I.

Sultan Qaboos University Medical Journal

Temporomandibular joint (TMJ) ankylosis as a complication of neonatal septic arthritis is rarely reported in the literature. We report two clinical cases of unilateral TMJ ankylosis occurring in paediatric patients subsequent to neonatal septic arthritis. The first case was a 15-month-old male infant who presented to the Sultan Qaboos University Hospital, Muscat, Oman, in May 2010. According to the published English scientific literature, he is the youngest person yet to be diagnosed with this condition. The second case was a five-year-old female who presented to the Al-Nahda Hospital, Muscat, Oman, in October 2011. Both cases presented with facial asymmetry and …

The Changing Pattern Of Hospital Admission To Medical Wards : Burden Of Non-Communicable Diseases At A Hospital In A Developing Country, Sufian K. Noor, Wadie M. Elmadhoun, Sarra O. Ahmed, Mohamed H.

Sultan Qaboos University Medical Journal

Objectives: This study aimed to determine the pattern of hospital admissions and patient outcomes in medical wards at Atbara Teaching Hospital in River Nile State, Sudan. Methods: This retrospective cross-sectional study was conducted from August 2013 to July 2014 and included all patients admitted to medical wards at the Atbara Teaching Hospital during the study period. Morbidity and mortality data was obtained from medical records. Diseases were categorised using the World Health Organization’s International Classification of Diseases (ICD) coding system. Results: A total of 2,614 patient records were analysed. The age group with the highest admissions was the 56‒65-year-old age …

Engaging Young Fathers In Research Through Photo-Interviewing, Nicolette Sopcak, Maria Mayan, Berna J. Skrypnek

The Qualitative Report

Although conducting interviews is the most popular research strategy in qualitative research, we question whether it is the best strategy to use with young fathers and other populations who may be less willing to share personal experiences and thoughts with an unknown researcher. The reluctance of young fathers to engage in research leads to the omission of important perspectives and inadvertently results in young fathers' being understudied and unwittingly excluded from support programming and services. In this paper, we describe our experiences of using two different research strategies with young fathers: conventional in-depth interviews (i.e., interviews that rely on words …

Self-Experimenting Physicians : Mavericks Or Martyrs?, Ritu Lakhtakia, Ikram Burney

Sultan Qaboos University Medical Journal

No abstract provided.

Synthesis Of Agents For The Treatment And Analysis Of Tropical Diseases, Jeanine Yacoub

USF Tampa Graduate Theses and Dissertations

Toxoplasmosis is an opportunistic disease caused by the protozoan parasite Toxoplasma gondii. The parasite is usually staved off by a healthy immune system and remains dormant in the body. In immunocompromised patients, the parasite can become active and spread throughout the body causing symptoms such as encephalitis, cognitive disorders, seizures, and death. Combination drug therapy is the usual treatment for toxoplasmosis; however, patients suffer from problems of intolerance, allergic reactions, and cytotoxicity. In an effort to identify new drug targets for toxoplasmosis, a series of compounds have been synthesized that can be used as tools to probe the unique …

The International Health Regulations 10 Years On: The Governing Framework For Global Health Security, Lawrence O. Gostin, Mary C. Debartolo, Eric A. Friedman

Georgetown Law Faculty Publications and Other Works

The World Health Organization (WHO) and its global health security treaty, the International Health Regulations (2005) (IHR) have lost the world's confidence after the West African Ebola epidemic. The epidemic led to several high-level reviews of the IHR and global health security more broadly. Here, we propose a series of recommendations for operational and legal reforms to enhance the functioning of the FCGH. It is critical that WHO act on them quickly, before the window of opportunity for fundamental reform closes.

WHO should ensure that all states fulfill their obligations to develop national core surveillance and response capacities, including through …

Antibiotic Resistance And The White House Forum On Antibiotic Stewardship, Mary Lou Manning Phd, Crnp, Cic, Faan

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Β-Thujaplicin: A Soil Antifungal, Dennis J. Baumgardner

Journal of Patient-Centered Research and Reviews

Background: β-thujaplicin (β-Th), also known as hinokitiol, naturally occurs in cedar mulch, is found in personal care products and has in vitro antitumor activities. It is antibacterial and antifungal, but has not been tested on soil. Scedosporium apiospermum (Sce) is an emerging “extremophile” fungal pathogen found in built outdoor environments.

Purpose: Pilot β-Th as “natural” soil antimicrobial or for isolation of extremophiles, and to explore β-Th resistance as selective advantage to Sce in mulched landscape.

Methods: A variety of outdoor and indoor environments were used for 2 sets of 24 paired soil samples. Soil/H20 slurry (0.1 ml) was spread on …

Eosinophils From Murine Lamina Propria Induce Differentiation Of Naïve T Cells Into Regulatory T Cells Via Tgf-Β1 And Retinoic Acid, Hong-Hu Chen, Ai-Hua Sun, David M. Ojcius, Wei-Lin Hu, Yu-Mei Ge, Xu'ai Lin, Lan-Juan Li, Jian-Ping Pan, Jie Yan

All Dugoni School of Dentistry Faculty Articles

Treg cells play a crucial role in immune tolerance, but mechanisms that induce Treg cells are poorly understood. We here have described eosinophils in lamina propria (LP) that displayed high aldehyde dehydrogenase (ALDH) activity, a rate-limiting step during all-trans retinoic acid (ATRA) synthesis, and expressed TGF-β1 mRNA and high levels of ATRA. Co-incubation assay confirmed that LP eosinophils induced the differentiation of naïve T cells into Treg cells. Differentiation promoted by LP eosinophils were inhibited by blocked either TGF-β1 or ATRA. Peripheral blood (PB) eosinophils did not produce ATRA and could not induce Treg differentiation. These data identifies LP eosinophils …

The Relationship Of Childhood Stress To Adult Health And Mortality Among Individuals From Two U.S. Documented Skeletal Collections, Late 19Th To Early 20Th Centuries, Rhonda Coolidge

USF Tampa Graduate Theses and Dissertations

Although the association between social inequality and poor adult health is well established, the mechanisms by which inequality is translated into poor adult health are less clear. Increasingly, evidence suggests that many adult health problems and health disparities have their origins in early life; the developmental origins of health and disease (DOHaD) hypothesis provides an explanatory mechanism linking adverse early life conditions with permanent structural or functional changes that increase the risk for disease. This hypothesis is consistent with bioarchaeological research noting reduced lifespan among individuals exhibiting signs of childhood stress.

The principal aim of this dissertation is to contribute …

Indorsing Infant Immunity: An Argument For Criminalizing Parents' Refusal To Immunize Their Children, Megan Elyse Waterman

Tulsa Law Review

No abstract provided.

Targeting Autopalmitoylation To Modulate Protein S-Palmitoylation, Laura Dawn Hamel

USF Tampa Graduate Theses and Dissertations

Palmitoylation refers to the covalent attachment of fatty acids, such as palmitate, onto the cysteine residues of proteins. This process may subsequently alter their localization and function. Nearly all of the enzymes that catalyze palmitoylation, zDHHC protein acyl transferases (PATs), are implicated in neurological disorders, infectious diseases, and cancer in humans. Of particular interest to those who study palmitoylation are Ras family GTPas and zDHHC9-GCP16, the zDHHC PAT that palmitoylates Ras proteins. Erf2-Erf4 is the zDHHC PAT that palmitoylates Ras proteins in Saccharomyces cerevisiae. Currently, there are no methods to therapeutically target palmitoylation for the treatment of disease. One …

Compositions Including Triciribine And Trastuzumab And Methods Of Use Thereof, Jin Q. Cheng, Said M. Sebti

USF Patents

This application relates to combination therapies including triciribine and related compounds and trastuzumab or a salt thereof and compositions with reduced toxicity for the treatment and prevention of tumors, cancer, and other disorders associated with abnormal cell proliferation.

Molecular And Phenotypic Studies Validating The Role Of The Ecdysone Receptor In The Human Parasite Brugia Malayi, Amruta Mhashilkar

USF Tampa Graduate Theses and Dissertations

Filariasis and onchocerciasis are debilitating diseases affecting 120 million people globally. The massive socio-economic impact of these diseases energized the international community to declare a goal of eliminating filariasis 2020. This resulted in a dramatic increase in the efforts to eliminate filariasis and onchocerciasis, employing a strategy of mass drug administration (MDA). However, these programs rely upon the small arsenal of drugs. This leaves these programs vulnerable to failure in the face of developing resistance and local intolerance to the current drug regimens. Thus, new drugs against these infections are critically needed. A homologue of the ecdysone receptor (EcR), a …

Cross-Sector Partnerships And Public Health: Challenges And Opportunities With The Private Sector, Lee Johnston, Diane Finegood

Frontiers in Public Health Services and Systems Research

Over the past few decades, cross-sector partnerships that include the private sector have become an increasingly accepted practice in public health, particularly in efforts to address infectious disease in low and middle income countries. Now they are becoming a popular tool in efforts to reduce and prevent obesity and the epidemic of non-communicable disease. Partnering with business presents a means of acquiring resources, as well as opportunities to influence the private sector toward more healthful practices. Collaboration is a core principle of public health practice; however public-private or non-profit-private partnerships present risks and challenges that warrant specific consideration. In this …

Cost Effectiveness Analysis Of Year 2 Of An Elementary School-Located Influenza Vaccination Program-Results From A Randomized Controlled Trial., Byung-Kwang Yoo, Sharon Humiston, Peter G. Szilagyi, Stanley J. Schaffer, Christine Long, Maureen Kolasa

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: School-located vaccination against influenza (SLV-I) has the potential to improve current suboptimal influenza immunization coverage for U.S. school-aged children. However, little is known about SLV-I's cost-effectiveness. The objective of this study is to establish the cost-effectiveness of SLV-I based on a two-year community-based randomized controlled trial (Year 1: 2009-2010 vaccination season, an unusual H1N1 pandemic influenza season, and Year 2: 2010-2011, a more typical influenza season).

METHODS: We performed a cost-effectiveness analysis on a two-year randomized controlled trial of a Western New York SLV-I program. SLV-I clinics were offered in 21 intervention elementary schools (Year 1 n = 9,027; …