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2015

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Campus Research Day Program: April 14, 2015, Southern Adventist University Apr 2015

Campus Research Day Program: April 14, 2015, Southern Adventist University

Campus Research Day Programs

Campus research day program for April 14, 2015.

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Phylogenomic Identification Of Regulatory Sequences In Bacteria: An Analysis Of Statistical Power And An Application To Borrelia Burgdorferi Sensu Lato, Che I. Martin, Tika Y. Sukarna, Saymon Akther, Girish Ramrattan, Pedro Pagan, Lia Di, Emmanuel F. Mongodin, Claire M. Fraser, Steven E. Schutzer, Benjamin J. Luft, Sherwood R. Casjens, Wei-Gang Qiu Apr 2015

Phylogenomic Identification Of Regulatory Sequences In Bacteria: An Analysis Of Statistical Power And An Application To Borrelia Burgdorferi Sensu Lato, Che I. Martin, Tika Y. Sukarna, Saymon Akther, Girish Ramrattan, Pedro Pagan, Lia Di, Emmanuel F. Mongodin, Claire M. Fraser, Steven E. Schutzer, Benjamin J. Luft, Sherwood R. Casjens, Wei-Gang Qiu

Publications and Research

Phylogenomic footprinting is an approach for ab initio identification of genome-wide regulatory elements in bacterial species based on sequence conservation. The statistical power of the phylogenomic approach depends on the degree of sequence conservation, the length of regulatory elements, and the level of phylogenetic divergence among genomes. Building on an earlier model, we propose a binomial model that uses synonymous tree lengths as neutral expectations for determining the statistical significance of conserved intergenic spacer (IGS) sequences. Simulations show that the binomial model is robust to variations in the value of evolutionary parameters, including base frequencies and the transition-to-transversion ratio. We …

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Vaccination Hesitation: Investigation Why Parents Decline Pediatric Influenza Vaccines In Juneau, Alaska, Lindsey Leder Apr 2015

Vaccination Hesitation: Investigation Why Parents Decline Pediatric Influenza Vaccines In Juneau, Alaska, Lindsey Leder

Student Projects for Graduate Degrees

The influenza virus is responsible for hundreds of childhood deaths and costs the health care system millions of dollars each year (Hassan, Lewis, Davis, Gebremariam, and Dombkowski, 2009). The influenza vaccine is the most effective intervention for prevention of pediatric influenza, yet many parents decline this vaccine for their children. Studies completed in various geographic locations cite different factors influencing parents who decline pediatric vaccinations. Alaska has the second lowest rate of influenza vaccination in the country (Center for Disease Control [CDC], 2012). The purpose of this project was to understand the factors that influence parental decision to refuse influenza …

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Subacute Bacterial Endocarditis Secondary To Lactobacillus Species, Shreemayee De Do Apr 2015

Subacute Bacterial Endocarditis Secondary To Lactobacillus Species, Shreemayee De Do

Department of Medicine

No abstract provided.

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Program Review: Unk Science/Math Education M.S.Ed. Program, Christopher L. Exstrom Apr 2015

Program Review: Unk Science/Math Education M.S.Ed. Program, Christopher L. Exstrom

Academic Program Reviews

No abstract provided.

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Machine Learning Methods Enable Predictive Modeling Of Antibody Feature:Function Relationships In Rv144 Vaccinees, Ickwon Choi, Amy W. Chung, Todd J. Suscovich, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sorachai Nitayapha, Jaranit Kaewkungwal, Robert J. O'Connell, Donald Francis, Merlin L. Robb, Nelson L. Michael, Jerome H. Kim, Galit Alter, Margaret E. Ackerman, Chris Bailey-Kellogg Apr 2015

Machine Learning Methods Enable Predictive Modeling Of Antibody Feature:Function Relationships In Rv144 Vaccinees, Ickwon Choi, Amy W. Chung, Todd J. Suscovich, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sorachai Nitayapha, Jaranit Kaewkungwal, Robert J. O'Connell, Donald Francis, Merlin L. Robb, Nelson L. Michael, Jerome H. Kim, Galit Alter, Margaret E. Ackerman, Chris Bailey-Kellogg

Dartmouth Scholarship

The adaptive immune response to vaccination or infection can lead to the production of specific antibodies to neutralize the pathogen or recruit innate immune effector cells for help. The non-neutralizing role of antibodies in stimulating effector cell responses may have been a key mechanism of the protection observed in the RV144 HIV vaccine trial. In an extensive investigation of a rich set of data collected from RV144 vaccine recipients, we here employ machine learning methods to identify and model associations between antibody features (IgG subclass and antigen specificity) and effector function activities (antibody dependent cellular phagocytosis, cellular cytotoxicity, and cytokine …

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Wood County Reentry Coalition: Needs Assessment Survey Results, Melissa W. Burek, Judith A. Leary, Brittany Johnson, Mamta Ojha Apr 2015

Wood County Reentry Coalition: Needs Assessment Survey Results, Melissa W. Burek, Judith A. Leary, Brittany Johnson, Mamta Ojha

Criminal Justice Faculty Publications

The purpose of this research was to assess the services needed by offenders who are soon going to be released. As a result, we recruited all incarcerated persons in jails, prisons and community-based correctional facilities (CBCFs) in Ohio who would be returning to the Wood County area upon release (i.e., we recruited incarcerated individuals who had a Wood County, OH address as their last place of residence prior to their most recent incarceration, or were arrested in and processed through Wood County courts). We designed a survey for individuals in Ohio Department of Rehabilitation and Correction (ODRC) custody containing questions …

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A Novel Assay To Screen Drugs That Target Bacterial Type Iii Secretion Systems, Poorandai Sanicharran, Joanna Theodorou Apr 2015

A Novel Assay To Screen Drugs That Target Bacterial Type Iii Secretion Systems, Poorandai Sanicharran, Joanna Theodorou

Undergraduate Student Symposium

In recent years antibiotic resistant strains of bacteria have increasingly become a problem and pose a global threat. Several problematic bacteria utilize a type III secretion system (T3SS) to infect their host. T3SSs are needle-like appendages on the bacteria used to inject the host cell with toxins which disrupts the cell's defense. Hence, the T3SS would be agood target for a novel antibiotic drug. The goal of this study is to develop an assay to screen for compounds that inhibit bacterial T3SSs. Y. enterocolitica uses a T3SS to cause gastroenteritis and will be utilized as the test organism. A disc …

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Agricom: A Soil Nutrient Additive And Its Effect On Soil Microbial Growth And Tomato Plants, Lisa Marie Pace Apr 2015

Agricom: A Soil Nutrient Additive And Its Effect On Soil Microbial Growth And Tomato Plants, Lisa Marie Pace

Undergraduate Student Symposium

The purpose of these experiments was to assess the efficacy of a novel nutrient stimulant in enhancing the growth of plants in the absence of fertilizer. Agricom is a natural mixture that works to increase the nitrogen fixation capabilities of the bacteria in the soil, thus aiding in the growth of the plants. Prior to working with the plants, the growth of the soil bacteria, in the presence of Agricom, was tested using respirometry. Agricom produced a significant positive effect on the overall growth rate of the soil bacteria that had been treated. Next, a series of four different groups …

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An Algebro-Geometric Approach To Reverse Engineering The Lac Operon In E. Coli, Priscila Reyes, Ly Nguyen Apr 2015

An Algebro-Geometric Approach To Reverse Engineering The Lac Operon In E. Coli, Priscila Reyes, Ly Nguyen

Undergraduate Student Symposium

Discrete modeling of biological mechanisms such as the lac operon is crucial in giving us a thorough understanding of their function and the related control mechanisms. This, in turn, provides us with a deeper insight into the organisms that employ these biological mechanisms as a whole. In this work, we utilize certain techniques from algebraic geometry, such as Gröbner basis, to attain a polynomial representation of the lac operon in E. coli based on its required catalysts and environmental conditions. First, we construct a Boolean network and wiring diagram of the lac operon system in order to predict the status …

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An Unusual Meeting, Alessandra Sironi Apr 2015

An Unusual Meeting, Alessandra Sironi

Undergraduate Student Symposium

“An Unusual Meeting” is a short film about two strangers who happen to be living the same lifestyle. These two characters have a similar routine every morning; they wake up, stretch, brush their teeth, make coffee, read magazines, navigate the internet, and drink the same brand of coffee, “Café Bustelo.” The two characters live near each other, and they meet while shopping for coffee at the grocery store. The universe and the coincidence of being coffee-holics leads them to fall in love at first sight. The film is directed by Alessandra Sironi. Andres Martinez Paz serves as the principal actor …

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Antibacterial Of Natural Plant Extracts And Synthetic Compounds, Joanna Theodorou, Poorandai Sanicharran Apr 2015

Antibacterial Of Natural Plant Extracts And Synthetic Compounds, Joanna Theodorou, Poorandai Sanicharran

Undergraduate Student Symposium

Due to the growing problem of antibiotic resistant pathogens, development of new antimicrobials is a necessity. Biologically active plant extracts have the potential to combat the detrimental effects of pathogens without the risks sometimes associated with synthetic drugs. However, synthetic drugs have the benefit of having antibacterial activity and being well characterized. Mixing a natural plant extract with a synthetic compound could be an extremely beneficial and potent antibiotic. The purpose of the present study is to evaluate the antimicrobial efficacy of various classes of plants and synthetic compounds (2-Oxindole derivatives) against gram-negative and gram-positive bacteria. The antibacterial activity of …

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Attitudes Of Rural Ecuadorians Toward Conservation Of Species And Environmental Education, Amanda Craig Apr 2015

Attitudes Of Rural Ecuadorians Toward Conservation Of Species And Environmental Education, Amanda Craig

Undergraduate Student Symposium

The exploration of people's attitudes in regard to other animal species with whom they co-exist in a shared ecosystem is a key element necessary for the improvement of local and regional conservation initiatives. In Ecuador, species such as the jaguar (Panthera Onca) require vast ranges of tropical rain forest and stretches of riverbank in order to survive in the wild. Increasing numbers of people share the forest with jaguars and other species. Habitat destruction and conversion, hunting and the potential lack of knowledge regarding the species’ ecological role continue to influence the conservation efforts of these threatened large …

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Can Affordable Housing Stimulate The Fort Lauderdale Economy?, Andrew Socarras Apr 2015

Can Affordable Housing Stimulate The Fort Lauderdale Economy?, Andrew Socarras

Undergraduate Student Symposium

The purpose of this research is to determine whether or not affordable housing can have a positive impact on the Fort Lauderdale economy and, if possible, to identify the methods on how to extract the most profitable outcomes for society. Many times, affordable housing is managed improperly and after only a matter of years is regarded by locals as the “projects” or “ghetto.” As a result, the neighborhoods that encompass these developments depreciate in value, impairing the local economy.

Fort Lauderdale has experienced a grown spurt within the past 5 years and is continuing to grow at a steady pace …

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D.A.R.K., Lauren Mcgarrett Apr 2015

D.A.R.K., Lauren Mcgarrett

Undergraduate Student Symposium

“D.A.R.K.” is a silent, avant-garde short film that highlights the very possible, and commonly unseen, repercussions of our day-to-day positive interactions with others, or lack thereof. The smallest act of kindness often makes the largest difference. The film is directed by Lauren McGarrett.

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Determining The Binding Of Phycocyanin To The Lncap Prostate Cancer Cells By Fluorescence Microscopy, Shona Joseph, Syed Hussain Apr 2015

Determining The Binding Of Phycocyanin To The Lncap Prostate Cancer Cells By Fluorescence Microscopy, Shona Joseph, Syed Hussain

Undergraduate Student Symposium

Phycocyanin (C-PC) is a natural pigment found in blue-green algae known as Spirulina. Since it has antiinflammatory properties, it was speculated that it might also be effective in treating cancers. Therefore, the main purpose of this study was to see whether C-PC would bind to the receptors on the cell membrane of cancer cells or penetrate the cell. Furthermore, the study was conducted to see whether the C-PC was able to bind to the membrane receptors with high or low affinity. For our binding and uptake experiments, LNCaP cells were used. After incubating with C-PC, the cells underwent multiple …

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Don't Think It, Don't Do It: Controlling Executive Control, Karissa Delorme, Hannah Dean Apr 2015

Don't Think It, Don't Do It: Controlling Executive Control, Karissa Delorme, Hannah Dean

Undergraduate Student Symposium

Self-control involves the ability to control immediate impulses and desires. According to the ego depletion model, self-control is a limited resource. Many studies have found that participants who perform a selfcontrol task show impaired performance on subsequent executive control tasks, such as those measuring working memory and attention. In this study, we hypothesized that individuals who perform a self-control task would subsequently demonstrate poorer inhibitory control as measured in a Stroop and stop signal task. Participants were first given instructions to list their daily activities for five minutes as they either attempted to not think about a white bear (self-control …

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Dsc And Tga Analysis On 3-Flowable Dental-Light Cured Restorative Composite, Samon Nazemian Apr 2015

Dsc And Tga Analysis On 3-Flowable Dental-Light Cured Restorative Composite, Samon Nazemian

Undergraduate Student Symposium

Since their introduction in 1996, dental-light cured flowable composites have been used as restorative materials for filling and repairing minimally invasive cavities. They are commonly used because they are insoluble, aesthetic, insensitive to dehydration, easy to manipulate, and reasonably inexpensive. Various brands advertise multiple advantages and are comprised differently. One property prior flowable composites exhibited was a significant polymerization shrinkage, which makes it unsuitable for occlusal wear. In this project, we analyzed the marginal shrinkage and stability of three different types of composites: CLEARFIL MAJESTY ES Flow, Genesis Flowable Light Cure Composite, and GrandioSO Heavy Flow. The composites were cured …

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Dynamic Regulation Of Toxic Engineered Bacteria Prevents Learning In The Model Nematode Caenorhabditis Elegans, Olena Bracho, Cyril Manchery Apr 2015

Dynamic Regulation Of Toxic Engineered Bacteria Prevents Learning In The Model Nematode Caenorhabditis Elegans, Olena Bracho, Cyril Manchery

Undergraduate Student Symposium

Infections due to parasitic nematodes result in nearly 125,000 deaths annually. Strikingly, this rate remains nearly unchanged in the past 50 years likely owing to the fact that treatment options are either inefficient or inaccessible. Prior to infecting humans, most parasitic nematodes begin as larvae where they feed nearly exclusively on bacteria. This unique property may offer an opportunity to develop new biological control agents with the use of synthetic biology. Recently, we have engineered a bacterium, consisting of an attraction module and toxin module that lures in and kills nematodes, respectively, using the principles of synthetic biology to act …

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Effects Of Functional Pattern Training On Hip And Knee Kinematics In Healthy Runners, Justin Romanes Apr 2015

Effects Of Functional Pattern Training On Hip And Knee Kinematics In Healthy Runners, Justin Romanes

Undergraduate Student Symposium

Faulty running biomechanics such as excessive hip internal rotation and knee valgus have been linked to overuse injuries in runners. Therapy interventions such as hip strengthening and mirrored gait retraining produce inconsistent results. The role of movement pattern training, predicated on Functional Movement Screen™ (FMS) performance has yet to be investigated. The objective of this study was to examine the effects of 6 weeks of functional pattern training on hip and knee kinematics in healthy, competitive runners with low FMS scores. 9 healthy adults [(males, n=6; age, 24.3±8.1 yrs; height, 1.78±0.09m; mass, 68.4±9.3kg)(females, n=3; age, 31±15.6 yrs; height, 1.70±0.06m; mass, …

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Hangings And Body Snatchings: The Exploitation Of Humans In 18th Century London In The Name Of Medicine, Chanice Allen Apr 2015

Hangings And Body Snatchings: The Exploitation Of Humans In 18th Century London In The Name Of Medicine, Chanice Allen

Undergraduate Student Symposium

This project is an exploration into the cultural and sociological intricacies of 18th century London that allowed for and even necessitated the practice of the procurement of human bodies via public execution, grave robbing, and murder in the name of medicine. This uncommon glance at medicine examines aspects such as economic benefits of the black market activities of body purchasing and grave robbing by the medical profession, how the social hierarchy (and, inherently, religion) of pre-modern London played into corpse selection, and the juxtaposition of the attainment of corpses by medical professionals to the regulation of social order. This …

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Hawaiian Monk Seals: Record Of Environmental Influence In An Endangered Species, Courtney Cenkner, Krista Colburn, Samantha Mcnear Apr 2015

Hawaiian Monk Seals: Record Of Environmental Influence In An Endangered Species, Courtney Cenkner, Krista Colburn, Samantha Mcnear

Undergraduate Student Symposium

The Hawaiian monk seal (Monachus schaundslani) is one of the most endangered species on the planet, largely due to environmental and anthropogenic influences. Analysis of the animals' tooth and bone complexes allows us to ascertain critical information regarding changes to their habitats and the effects on the animals. Tooth and bone samples from 240 naturally deceased Hawaiian monk seals were collected from the Northwest Hawaiian Island chain (NWHI) and Main Hawaiian Islands (MHI). Stable carbon, nitrogen and oxygen isotope rations (δ13C, δ15N, δ18O, respectively) provide a record of dietary and environmental change, …

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Hypoxia Inducible Factor Mediated Human Angiotensinogen Gene Regulation, Nida Rizvi Apr 2015

Hypoxia Inducible Factor Mediated Human Angiotensinogen Gene Regulation, Nida Rizvi

Undergraduate Student Symposium

Alcohol usage is linked to increased blood pressure and fibrotic transformation of the liver. Angiotensinogen (AGT) is the source of Ang II which regulates blood pressure and participates in fibrotic transformation of the liver after the hepatocyte death. Ang II is produced from AGT by sequential action of renin followed by angiotensin converting enzyme. The levels of AGT are less than the MichaelisMenten constant of renin. Therefore, an increase in blood AGT levels would result into corresponding increase in Ang II levels that might affect blood pressure regulation and liver fibrogenic processes.

Alcohol metabolism by the liver produces oxidative stress …

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Invegstigating The Causes Of Antibiotic Resistance In A Periodic Environment, Haley Mckissack, Uzair Mohammed, Kyle Cahill, Steven Thomas Apr 2015

Invegstigating The Causes Of Antibiotic Resistance In A Periodic Environment, Haley Mckissack, Uzair Mohammed, Kyle Cahill, Steven Thomas

Undergraduate Student Symposium

Misuse of antibiotics, coupled with a lack of new antibiotics being discovered, has threatened our ability to treat bacterial infections. Confounding our ability to effectively combat antibiotic resistance is the myriad of ways in which bacteria can resist antibiotic treatment. One mechanism is the inoculum effect, a phenomenon in which the inhibitory concentration of an antibiotic increases with initial cell density. Previously acquired data has indicated a mutation exclusive mechanism by which resistance arises. However, it is currently unknown as to whether or not the generation of antibiotic resistant bacteria due to spontaneous mutation plays a role in the inoculum …

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Induction Of Apoptosis By Jfd-Ws In Human Breast Adenocarcinoma Xenograft Implanted Athymic Nude Mice, Janelle Alvarez, Meera Bhalani, Thanigaivelan Kanagasabai Ph.D., Sivanesan Dhandayuthapani Ph.D., Appu Rathinavelu Ph.D. Apr 2015

Induction Of Apoptosis By Jfd-Ws In Human Breast Adenocarcinoma Xenograft Implanted Athymic Nude Mice, Janelle Alvarez, Meera Bhalani, Thanigaivelan Kanagasabai Ph.D., Sivanesan Dhandayuthapani Ph.D., Appu Rathinavelu Ph.D.

Undergraduate Student Symposium

Apoptosis (programmed cell death) can be stimulated when a cell has reached its pre-determined lifespan. The intrinsic pathway is typically activated for cell cycle regulation, thus preventing tumor formation. Bcl-2 family proteins can play a pro or anti-apoptotic role by regulating the expression levels and modes of action of other proteins such as caspases, which cleave cell parts until the cell is no longer functional. Many studies are focusing on proteins that regulate the apoptotic pathway, as anomalies may lead to tumor formation. The purpose of this study was to assess effects of a novel water-soluble cancer drug, known as …

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Nova Southeastern University's Participation In Many Labs 3: Evaluating Participant Pool Characteristics Across The Semester Via Replication, Guy Merus, Andrea Moran, Boglarka Varga, Stephanie Ponce, Idania Elizabeth Cater, Alexis Murphy Apr 2015

Nova Southeastern University's Participation In Many Labs 3: Evaluating Participant Pool Characteristics Across The Semester Via Replication, Guy Merus, Andrea Moran, Boglarka Varga, Stephanie Ponce, Idania Elizabeth Cater, Alexis Murphy

Undergraduate Student Symposium

A crowdsourced project from 23 university participant pools, including NSU (total N = 2,696; NSU N = 131), examined variation in 10 well known psychological findings and 8 individual difference measures over the course of the academic semester. Undergraduate psychology participant pools serve as a major resource for behavioral research studies. Many researchers have hypothesized that the traits and attentiveness of student research participants vary across an academic term (e.g., students who participate later in the semester may be lower in conscientiousness and higher in openness to experience). However, there is very little systematic evidence regarding the magnitude of such …

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Osteogenic Differentiation Of Human Umbilical Cord Derived Stem Cells In A 3-Dimensional (3-D) Hydrogel, Anastasia Talalenko, Kevin Petersen Apr 2015

Osteogenic Differentiation Of Human Umbilical Cord Derived Stem Cells In A 3-Dimensional (3-D) Hydrogel, Anastasia Talalenko, Kevin Petersen

Undergraduate Student Symposium

Introduction: Bone Regeneration in craniofacial region due to traumatic injuries and congenital defects is a major clinical problem. Cleft palate is the second most common congenital defect. Our long-term goal is to regenerate bone in the palatal region using tissue-engineering approaches. Bone tissue engineering utilizes osteogenic cells, osteoconductive scaffolds and osteoinductive signals. Mesenchymal stem cells derived from human umbilical cord (HUMSCs) are highly proliferative with the ability to differentiate into osteogenic precursor cells. Objective: The primary objective of the study was to encapsulate HUMSCs in PuraMatrix™ (PM), a peptide hydrogel, and investigate their survival and osteogenic differentiation. PM is an …

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Post-Exercise Ice Bath (10 Degrees Celsius) And Athlete Recovery, Sierra Lelii Apr 2015

Post-Exercise Ice Bath (10 Degrees Celsius) And Athlete Recovery, Sierra Lelii

Undergraduate Student Symposium

Coaching professionals implement post-workout ice baths with athletes; however, minimal research exists demonstrating the effectiveness of these practices on athletic performance and recovery. Purpose: To assess the effects of a post-workout ice bath on recovery. Methods: Ten athletic subjects (18-24 yrs; 171.5±11.2 cm.; 68.1±14.9 kg; 23.0±3.5 BMI) were tested for flexibility (sit-and-reach), power (vertical jump), strength (squat), agility (5-10-5), speed (10-m) and pain perception (scale). Following performance measures, each athlete completed a damaging eccentric plyometric protocol. Athletes were randomly assigned into a post-workout ice bath group (ICE), which took a 15 minute ice bath (10° C) following exercise protocol; or …

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Posture And Cognition, Jana Mrkaja Apr 2015

Posture And Cognition, Jana Mrkaja

Undergraduate Student Symposium

This experiment examined how priming and posture influence attention. Previous experiments have shown that different body postures can influence cognitive focus and task performance. For instance, participants adopting an unfocused posture were slower at performing a visual search task (Chisholm, Risko, Evan, & Kingstone, 2013). However, this could be due to the effects of priming on attention (Bargn, Chen, & Burrows, 1996). In the current experiment, participants adopted either a focused leaning, forward upright or an unfocused, back slouched posture. Furthermore, participants were either primed or not primed by indicting that the posture will either increase or decrease their attentional …

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Spiritual And Supernatural Elements Of English Theatre (1550-1612), Mariah Busk Apr 2015

Spiritual And Supernatural Elements Of English Theatre (1550-1612), Mariah Busk

Undergraduate Student Symposium

In “Spiritual and Supernatural Elements of English Theatre (1550-1612)”, I use four plays to examine the secularization of supernatural elements of English theatre during the High Middle Ages and the Early Modern Period. My research shows that in Everyman (c.1500) by Anonymous, The Tragical History of Dr. Faustus (c. 1588) by Christopher Marlowe, Hamlet (c. 1600) by William Shakespeare, and The White Devil (c.1612) by John Webster good and evil characters digress from being religious, spiritual figures to being humanized representations of these figures. Corresponding to this secularization is the loss of a God-like figure and a more common use …

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