Digital Commons Network^™

Megan Polzin Plans For Graduate School, Brittney Johnson

GWU-Today

As graduation approaches for Megan Polzin, it seems that she is far ahead of the game. The Raleigh, N.C., native and Biology major, Polzin already has her eyes set on her next journey to graduate school.

It's A Bird! It's A Plane! It's...Cultural Anxiety? Using Detective Comics' Three Biggest Heroes To Identify And Explore Cultural Anxieties As Depicted Through Television, Jonathan Vander Lugt

Media and Communication Studies Honors Papers

This collection of essays uses the mythic nature of superheroes to examine and discuss specific cultural anxieties as they’re navigated and alleviated in superhero television texts. First, I examine the way that anxiety over feminism and the women’s rights movement manifested itself in Wonder Woman, the 70s television series starring Lynda Carter. Next, I use Smallville and its depictions of a teenaged Superman to explore its handling of anxieties over the September 11, 2001 terrorist attacks. Finally, I performed a content analysis of six different series of Batman cartoons to examine the way they respond to national concerns over …

The Regulation Of Cathepsin L Activity By Estrogen And Bisphenols A & S: Relationship To Systemic Lupus Erythematosus, Dylan T. Cuva

Biology Honors Papers

Systemic Lupus Erythematosus (SLE) is an autoimmune disease that is linked to increased levels of estrogen. Bisphenol A (BPA) is an environmental estrogen that may also play a role in SLE. BPA is used in the production of polycarbonate plastics and epoxy resins, including use in the creation of cans and plastic bottles. This study investigated the role of BPA and other bisphenols on enzyme activity in a murine model for SLE.

Comparing Antibiotic Self-Medication In Two Socio-Economic Groups In Guatemala City: A Descriptive Cross-Sectional Study, Brooke M. Ramay, Paola Lambour, Alejandro Cerón

Anthropology: Faculty Scholarship

Background

Self-medication with antibiotics may result in antimicrobial resistance and its high prevalence is of particular concern in Low to Middle Income Countries (LMIC) like Guatemala. A better understanding of self-medication with antibiotics may represent an opportunity to develop interventions guiding the rational use of antibiotics. We aimed to compare the magnitude of antibiotic self-medication and the characteristics of those who self-medicate in two pharmacies serving disparate socio-economic communities in Guatemala City.

Methods

We conducted a descriptive, cross-sectional study in one Suburban pharmacy and one City Center pharmacy in Guatemala City. We used a questionnaire to gather information about frequency …

Coculture Of Staphylococcus Aureus With Pseudomonas Aeruginosa Drives S. Aureus Towards Fermentative Metabolism And Reduced Viability In A Cystic Fibrosis Model, Laura M. Filkins, Jyoti A. Graber, Daniel G. Olson, Emily L. Dolben, Lee Lynd, Sabin Bhuju, George A. O'Toole

Dartmouth Scholarship

The airways of patients with cystic fibrosis are colonized with diverse bacterial communities that change dynamically during pediatric years and early adulthood. Staphylococcus aureus is the most prevalent pathogen during early childhood, but during late teens and early adulthood, a shift in microbial composition occurs leading to Pseudomonas aeruginosa community predominance in ∼50% of adults. We developed a robust dual-bacterial in vitro coculture system of P. aeruginosa and S. aureus on monolayers of human bronchial epithelial cells homozygous for the ΔF508 cystic fibrosis transmembrane conductance regulator (CFTR) mutation to better model the mechanisms of this interaction. We show that P. …

Antiviral Activity Of The Human Cathelicidin, Ll-37, And Derived Peptides On Seasonal And Pandemic Influenza A Viruses., Shweta Tripathi, Guangshun Wang, Mitchell White, Li Qi, Jeffery Taubenberger, Kevan L. Hartshorn

Journal Articles: Pathology and Microbiology

Human LL-37, a cationic antimicrobial peptide, was recently shown to have antiviral activity against influenza A virus (IAV) strains in vitro and in vivo. In this study we compared the anti-influenza activity of LL-37 with that of several fragments derived from LL-37. We first tested the peptides against a seasonal H3N2 strain and the mouse adapted H1N1 strain, PR-8. The N-terminal fragment, LL-23, had slight neutralizing activity against these strains. In LL-23V9 serine 9 is substituted by valine creating a continuous hydrophobic surface. LL-23V9 has been shown to have increased anti-bacterial activity compared to LL-23 and we now show slightly …

The Girl With The Peanut Necklace: Experiences Of Infertility And In Vitro Fertilization In China, Ruoxi Yu

Student Work

A 2014-2015 William Prize for best essay in East Asian Studies was awarded to Ruoxi Yu (Berkeley College '15) for her essay submitted to the Department of Anthropology, “The Girl with the Peanut Necklace: Experiences of Infertility and in vitro Fertilization in China.” (Marcia Inhorn, William K. Lanman Jr. Professor of Anthropology, advisor; Susan Brownell, Professor of Anthropology at USML, secondary reader.)

Ruoxi Yu’s essay, “The Girl with the Peanut Necklace: Experiences of Infertility and in vitro Fertilization in China,” situates original research within the history of the one-child birth control policy and the tension between the …

A Microrna Profile Associated With Opisthorchis Viverrini-Induced Cholangiocarcinoma In Tissue And Plasma., Jordan Plieskatt, Gabriel Rinaldi, Yanjun Feng, Jin Peng, Samantha Easley, Xinying Jia, Jeremy Potriquet, Chawalit Pairojkul, Vajarabhongsa Bhudhisawasdi, Banchob Sripa, Paul J Brindley, Jeffrey Bethony, Jason Mulvenna

Microbiology, Immunology, and Tropical Medicine Faculty Publications

Background

Intrahepatic cholangiocarcinoma (ICC) is a highly aggressive tumor of the bile duct, and a significant public health problem in East Asia, where it is associated with infection by the parasiteOpisthorchis viverrini. ICC is often detected at an advanced stage and with a poor prognosis, making a biomarker for early detection a priority.

Methods

We have comprehensively profiled miRNA expression levels in ICC tumor tissue using small RNA-Seq and validated these profiles using quantitative PCR on matched plasma samples.

Results

Distinct miRNA profiles were associated with increasing histological differentiation of ICC tumor tissue. We also observed that histologically …

Ua12/2/1 College Heights Herald, Vol. 90, No. 49, Wku Student Affairs

WKU Administration Documents

WKU campus newspaper reporting campus, athletic and Bowling Green, Kentucky news.

• Rogers, Shelby. Parking, Tuition to be Key Topics at WKU Regents’ Friday Meeting
• Henderson, Andrew. GIScience Club Celebrates Earth Day – Geography & Geology, Geographic Information Science
• Rogers, Shelby. New Temporary Lot Coming to Russellville Road – Parking & Transportation Services
• Crumbie, Trey. WKU Hosting Gubernatorial Debate Next Week – Politicians
• Henderson, Andrew. Student Voice Program Concludes First Semester at WKU – Voices of Discovery
• Profumo, Morgan. Sneezing Season – Allergies
• Sproles, Katherine. Old Conditions for Animals in Logan County Human Society Unacceptable
• Dahmer, Jody. Corruption Starting in Student …

An Analysis Of Bacterial Contamination Of Chicken Eggs And Antimicrobial Resistance, Holly Spitzer

Celebrating Scholarship & Creativity Day (2011-2017)

Chicken eggs are a major component of American diets, with an average yearly consumption of approximately 250 eggs per person (according to estimates made by the American Humane Society). While highly nutritious, eggs are also one of the leading causes of food poisoning and food borne illness in the United States. Eggs may become contaminated by a number of different types of bacteria during production, including Salmonella, a group of bacteria that, according to the CDC, causes more than 1.2 million cases of food borne illness in the United States every year. In an effort to decrease the frequency …

The Liberal Arts And The Wealth Of Nations, Louis D. Johnston

Phi Beta Kappa Lectures

Sixty-eight students from the College of Saint Benedict and Saint John's University have been invited into the Theta of Minnesota Chapter of Phi Beta Kappa at CSB and SJU.

The students will be formally inducted into the chapter during a ceremony at 5 p.m. Wednesday, April 22, in Alumnae Hall, Haehn Campus Center, CSB. The public is welcome to attend the induction ceremony, which will be followed by an invitation-only dinner for the Phi Beta Kappa members and guests.

Louis Johnston, associate professor of economics at CSB and SJU, delivered the keynote address, "The Liberal Arts and the Wealth of …

The Bg News April 22, 2015, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. April 22, 2015. Volume 94-Issue 91.

Drug-Drug Interactions Among Hepatitis C Virus (Hcv) And Human Immunodeficiency Virus (Hiv) Medications, Kirpal Kaur, Mona A. Gandhi, Judianne Slish

Doctoral External Publications

One-fourth of individuals diagnosed with the human immunodeficiency virus concomitantly have the hepatitis C virus infection. Since the discovery of highly active antiretroviral therapy, liver complications have become the leading cause of morbidity and mortality in HIV-HCV coinfected individuals. Optimal treatment in this patient population is critical, as coinfection has been linked to deterioration of both disease states. The objective of this review article is to highlight the current literature on drug-drug interactions between HIV and HCV treatments. The management of the treatment of coinfection patients has been covered extensively in numerous other publications.

Summer Courses Tier Ii Applied Sciences 2as Online On Campus, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

T-Reqs | Where Are The Dinosaurs This Summer?, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

The Plight Of The Lucluc: Examining The Deadly Mystery Of Nodding Syndrome, Ethan K. Mcgann

Senior Honors Theses

Nodding syndrome (NS) is an emerging epidemic neurological disease that is shrouded in mystery. It is currently only found in the post-conflict regions of South Sudan, northern Uganda, and Tanzania. NS occurs in children from the ages of five to fifteen and is characterized by a loss of motor control in the neck muscles. Seizure episodes can range in intensity from atonic to tonic-clonic, and the onset of the first episode generally marks the beginning of a decline in the child’s physical and mental health. NS is a progressive disease that generally results in physical wasting, stunted growth, behavioral difficulties, …

Identification Guide To Larval Stages Of Ticks Of Medical Importance In The Usa, Kymbreana Coley

Honors College Theses

Scanning Electron Micrographs were prepared of four morphologically diagnostic regions (dorsal capitulum, ventral capitulum, scutum, leg coxae) for the larval stage of the 16 species of ixodid (hard) ticks known to parasitize humans in the USA. These species are: Amblyomma americanum, A. maculatum, A. mixtum, A. tuberculatum, Dermacentor albipictus, D. andersoni, D. occidentalis, D. variabilis, Haemaphysalis leporispalustris, Ixodes angustus, I. cookei, I. pacificus, I. scapularis, I. spinipalpis, I. texanus, and Rhipicephalus sanguineus. Based on the morphological characters observed, a dichotomous identification key to ixodid larvae that parasitize humans in the USA was prepared. Common names, hosts and geographical distributions are …

The Effects Of Digestion On Innate Immunity, Rachel L. Luoma

Honors College Theses

Following a meal, an animal can exhibit dramatic shifts in its physiology that can result in rapid growth of the gut and heart, as well as a massive (>40-fold) increase in metabolic rate associated with the energetic costs of processing the meal. However, little is known about the effects of digestion on an important physiological trait: immune function. Thus, I tested the following competing hypotheses. First, digesting animals may upregulate their immune systems due to increased microbial exposure from ingested food. This hypothesis predicts that animals will exhibit greater immune function during digestion. Second, digesting animals may downregulate their …

Analyzing The Presence Of Bacterial Colonies Within A Neonatal Suctioning Device: The Blue-Bulb Syringe, Norman Edward Damron

Honors Capstone Projects and Theses

No abstract provided.

Prevalence Of Disorders Recorded In Cavalier King Charles Spaniels Attending Primary-Care Veterinary Practices In England, Jennifer F. Summers, Dan G. O'Neill, David B. Church, Peter C. Thomson, Paul D. Mcgreevy, David C. Brodbelt

Epidemiology Collection

Background: Concerns have been raised over breed-related health issues in purebred dogs, but reliable prevalence estimates for disorders within specific breeds are sparse. Electronically stored patient health records from primary-care practice are emerging as a useful source of epidemiological data in companion animals. This study used large volumes of health data from UK primary-care practices participating in the VetCompass animal health surveillance project to evaluate in detail the disorders diagnosed in a random selection of over 50% of dogs recorded as Cavalier King Charles Spaniels (CKCSs). Confirmation of breed using available microchip and Kennel Club (KC) registration data was attempted. …

Saag Tapped To Lead Global Health Initiatives In Medicine, Kendra Carter

Browse All News

No abstract provided.

Clinical Implications Of Vancomycin Heteroresistant And Intermediately Susceptible Staphylococcus Aureus, Diane M. Gomes, Kristina E. Ward, Kerry L. Laplante

Pharmacy Practice and Clinical Research Faculty Publications

Staphylococcus aureus (S. aureus) has proven to be a major pathogen with the emergence of methicillin-resistant S. aureus (MRSA) infections and recently with heteroresistant vancomycin-intermediate S. aureus (hVISA) and vancomycin-intermediate S. aureus (VISA) infections. Although vancomycin is traditionally a first-line and relatively effective antibiotic, its continued use is under question because reports of heteroresistance in S. aureus isolates are increasing. Both hVISA and VISA infections are associated with complicated clinical courses and treatment failures. The prevalence, mechanism of resistance, clinical significance, and laboratory detection of hVISA and VISA infections are not conclusive, making it difficult to apply research …

Occupational Health Risk Factors For Schistosomiasis: Systematic Review And Analysis, Sarah Grace Sawyer, Amira Roess, Gisela Butera

GW Research Days 2015

Schistosomiasis is a neglected tropical disease caused by a parasitic flatworm which afflicts over 200 million people in the poorest regions of Africa. Carried by snails living in fresh, stagnant water, the parasite penetrates human skin upon contact, causing the victim to suffer a range of symptoms including diarrhea, blood in the urine, and eventual death. Despite its prevalence, schistosomiasis is preventable, treatable, and curable once a control program is implemented. Substantial reduction of schistosomiasis would relieve suffering and produce many socio-economic benefits, including higher productivity and higher school attendance rates. Disease transmission is directly tied to the environment, and …

April 16, 2015, James Madison University

The Breeze, 2010-2019

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

Hiv Pioneer: Use Lessons From The Epidemic To Improve Health-Care System, Jim Bakken

Browse All News

No abstract provided.

The Gut Microbiota Of Rural Papua New Guineans: Composition, Diversity Patterns, And Ecological Processes, Ines Martinez, James C. Stegen, Maria X. Maldonado-Gomez, A. Murat Eren, Peter M. Siba, Andrew R. Greenhill, Jens Walter

Department of Food Science and Technology: Faculty Publications

Although recent research revealed an impact of westernization on diversity and composition of the human gut microbiota, the exact consequences on metacommunity characteristics are insufficiently understood, and the underlying ecological mechanisms have not been elucidated. Here, we have compared the fecal microbiota of adults from two non-industrialized regions in Papua New Guinea (PNG) with that of United States (US) residents. Papua New Guineans harbor communities with greater bacterial diversity, lower inter-individual variation, vastly different abundance profiles, and bacterial lineages undetectable in US residents. A quantification of the ecological processes that govern community assembly identified bacterial dispersal as the dominant process …

Implementing A Coordinated Care Model For Sex Trafficked Minors In Smaller Cities, Mary Burke, Heather L. Mccauley, Anne Rackow, Bradley Orsini, Bridget Simunovic, Elizabeth Miller

Journal of Applied Research on Children: Informing Policy for Children at Risk

Background

Addressing the social and clinical service needs of minors who have been sexually exploited remains a challenge across the United States. While larger metropolitan centers have established shelters and service provision specific for trafficked persons, in smaller cities and more rural settings, survivors of trafficking (especially minors) are usually served by multiple, disparate social service and health providers working across different systems. Sexually exploited minors present an even greater challenge due to intersections with child welfare and juvenile justice systems, histories of abuse by family that limit placement options, and limited services that address the complex medical, mental health, …

Cationic Phenylene Ethynylene Polymers And Oligomers Induce Conformational Changes To Proteins, Gregory Soliz

Biomedical Engineering ETDs

Infectious diseases have been a growing health care concern resulting in added expenses and health care resources to the community. Due to this rising issues research groups have devoted time to resolve this growing issue through the development of various compounds to treat or prevent disease. Research at the University of New Mexico began with trying to kill various strains of bacteria with a novel class of synthetic phenylene ethynylene (PPE)-based conjugated polyelectrolytes (CPEs) has helped in providing a new antimicrobial compound. Results proved successful and lead to experimentation to use the new class of compounds as an antiviral answer …

Antimicrobial Activity Of Thymoquinone, Alya A. Almatrafi

MSMLS Capstone Projects

Abstract

With the increase in resistance to traditional antibiotics displayed by microbial agents, efforts have been devoted to the explorations of naturally derived antimicrobial compounds.

One such compound is thymoquinone (TQ), derived from Nigella Sativa (black seeds). This compound has been known for its anti-inflammatory and antioxidant properties (Ahmad et al., 2013); however, other healing properties may also be attributed to this compound. Nigella Sativa (NS), an herb, is a member of the Ranunculaceae family. Nigella Sativa has been used to treat different diseases since the ancient era. Extracts from the seeds have been used to treat bacterial infections such …

An Outcome Analysis Of The Achievement Of The Five Objectives By The Housing 1000 Care Coordination Project: Ending Homelessness In Santa Clara County Through Affordable Housing, Darren K. Bader

Master's Projects

No abstract provided.