Digital Commons Network^™

Identification And Phylogeny Of The First T Cell Epitope Identified From A Human Gut Bacteroides Species, Maria Elisa Perez-Muñoz, Payal Joglekar, Yi-Ji Shen, Kuan Y. Chang, Daniel A. Peterson

Department of Food Science and Technology: Faculty Publications

Host T cell reactivity toward gut bacterial epitopes has been recognized as part of disease pathogenesis. However, the specificity of T cells that recognize this vast number of epitopes has not yet been well described. After colonizing a C57BL/6J germ-free mouse with the human gut symbiotic bacteria Bacteroides thetaiotaomicron, we isolated a T cell that recognized these bacteria in vitro. Using this T cell, we mapped the first known non-carbohydrate T cell epitope within the phylum Bacteroidetes. The T cell also reacted to two other additional Bacteroides species. We identified the peptide that stimulated the T cell by …

Distillation Time As Tool For Improved Antimalarial Activity And Differential Oil Composition Of Cumin Seed Oil, Valtcho D. Zheljazkov, Archana Gawde, Charles L. Cantrell, Tess Astatkie, Vicki Schlegel

Department of Food Science and Technology: Faculty Publications

A steam distillation extraction kinetics experiment was conducted to estimate essential oil yield, composition, antimalarial, and antioxidant capacity of cumin (Cuminum cyminum L.) seed (fruits). Furthermore, regression models were developed to predict essential oil yield and composition for a given duration of the steam distillation time (DT). Ten DT durations were tested in this study: 5, 7.5, 15, 30, 60, 120, 240, 360, 480, and 600 min. Oil yields increased with an increase in the DT. Maximum oil yield (content, 2.3 g/100 seed), was achieved at 480 min; longer DT did not increase oil yields. The concentrations of the …

The Human Gut Mycobiome: Pitfalls And Potentials — A Mycologist's Perspective, Mallory J. Suhr, Heather E. Hallen-Adams

Department of Food Science and Technology: Faculty Publications

We have entered the Age of the Microbiome, with new studies appearing constantly and whole journals devoted to the human microbiome. While bacteria outnumber other gut microbes by orders of magnitude, eukaryotes are consistently found in the human gut, and are represented primarily by the fungi. Compiling 36 studies spanning from 1917 to 2015, we found at least 267 distinct fungal taxa have been reported from the human gut, and seemingly every new study includes one or more fungi not previously described from this niche. This diversity, while impressive, is illusory. If we examine gut fungi, we will quickly observe …

Background Differences In Baseline And Stimulated Mmp Levels Influence Abdominal Aortic Aneurysm Susceptibility, Matthew A. Dale, Melissa K. Suh, Shijia Zhao, Trevor Meisinger, Linxia Gu, Vicki J. Swier, Devendra K. Agrawal, Timothy Greiner, Jeffrey S. Carson, B. Timothy Baxter, Wanfen Xiong

Department of Mechanical and Materials Engineering: Faculty Publications

Objective: Evidence has demonstrated profound influence of genetic background on cardiovascular phenotypes. Murine models in Marfan syndrome (MFS) have shown that genetic background-related variations affect thoracic aortic aneurysm formation, rupture, and lifespan of mice. MFS mice with C57Bl/6 genetic background are less susceptible to aneurysm formation compared to the 129/SvEv genetic background. In this study, we hypothesize that susceptibility to abdominal aortic aneurysm (AAA) will be increased in 129/SvEv mice versus C57Bl/6 mice. We tested this hypothesis by assessing differences in aneurysm size, tissue properties, immune response, and MMP expression.

Methods: Mice of C57Bl/6 or 129/SvEv background underwent AAA induction …

The Neurobiology Of Circadian Rhythms, Patricia J. Sollars, Gary E. Pickard

School of Veterinary and Biomedical Sciences: Faculty Publications

Daily rhythms in nature, such as the opening and closing of flowers or our patterns of sleep and wakefulness and their association with the perpetual alteration of night and day, were recognized in antiquity although their origins were not questioned until the eighteenth century. The French Astronomer Jean-Jacques d’Ortous de Mairan conducted an investigation into whether the leaves of the Mimosa plant opened in response to light.¹ While de Mairan’s experiments were the first to question the origin of such daily rhythms, Augustin Pyramus de Candolle is credited with the first suggestion that they arose through an internal timekeeping …

A Synthetic Porcine Reproductive And Respiratory Syndrome Virus Strain Confers Unprecedented Levels Of Heterologous Protection, Hiep Vu, Fangrui Ma, William W. Laegreid, Asit K. Pattnaik, David Steffen, Alan R. Doster, Fernando Osorio

School of Veterinary and Biomedical Sciences: Faculty Publications

Current vaccines do not provide sufficient levels of protection against divergent porcine reproductive and respiratory syndrome virus (PRRSV) strains circulating in the field, mainly due to the substantial variation of the viral genome. We describe here a novel approach to generate a PRRSV vaccine candidate that could confer unprecedented levels of heterologous protection against divergent PRRSV isolates. By using a set of 59 nonredundant, full-genome sequences of type 2 PRRSVs, a consensus genome (designated PRRSV-CON) was generated by aligning these 59 PRRSV full-genome sequences, followed by selecting the most common nucleotide found at each position of the alignment. Next, the …

The Association Between The Cc Chemokine Ligand 5 -28c>G Gene Polymorphism And Tuberculosis Susceptibility, Hongfang Lu, Jingang Wang, Baoan Gao, Shixiong Chen, Guangming Xiang, Shaojuan Yang, Yuan Gong, Li Guan

Saudi Medical Journal

Objectives: To assess the association between chemotactic chemokine (C-C motif) ligand 5 (CCL5) -28C>G polymorphism and tuberculosis (TB) risk. Methods: PubMed, Web of Science, and WanFang were searched up to April 2015 for eligible studies on CCL5 -28C>G polymorphism. Data was extracted, and pooled odd ratios (ORs) as well as 95% confidence intervals (95% CI) were calculated. Results: Eight case-control studies were extracted from 8 articles on the polymorphism involving 1852 TB cases and 2068 controls. The results of meta-analysis showed that significant reduced risks were found for the polymorphism with the risk of TB in Asians and …

Lack Of Association Between The Insulin Receptor Substrates-1 Gly972arg Polymorphism And Type-2 Diabetes Mellitus Among Saudis From Eastern Saudi Arabia, Hawra A. Alsalman, Yahia A. Kaabi

Saudi Medical Journal

Objectives: To investigate the association between the insulin receptor substrate-1 ( IRS1 ) Gly972Arg polymorphism and type-2 diabetes mellitus (T2DM) among Saudis from Eastern Saudi Arabia. Methods: This study was conducted between May and December 2014 at King Fahad Hospital of the University, Al-Khobar, Kingdom of Saudi Arabia. In a case-control study design, a total of 143 subjects (age range: 35-73 years) comprising 74 healthy controls and 69 patients with T2DM were examined. Blood samples were collected from subjects and subjected to genomic DNA extraction and chemical analysis. The IRS1 Gly972Arg polymorphism was then genotyped using the standard polymerase chain …

Does Social Support Affect Development Of Cognitive Dysfunction In Individuals With Diabetes Mellitus?, Feride T. Yilmaz, Selma Sabancıogullari, Kadriye Aldemir, Azime K. Kumsar

Saudi Medical Journal

Objectives: To determine cognitive functions and perceived social support (SS) among individuals with diabetes mellitus (DM), and the effects of SS on the development of cognitive dysfunction (CD). Methods: This cross-sectional study was conducted in 121 patients with DM presenting at the Endocrinology Clinic of Cumhuriyet University Health Services Application and Research Hospital, Sivas, Turkey between April and June 2014. Data were collected utilizing the “Patient Assessment Form”, “Standardized Mini Mental State Examination (SMMSE)”, and “Multidimensional Scale of Perceived Social Support (MSPSS)”. Results: The mean score obtained for DM patients from the SMMSE was 21.55±5.7, with 65.3% found to have …

Characteristics And Treatment Outcomes Of Patients With Multi-Drug Resistant Tuberculosis At A Tertiary Care Hospital In Peshawar, Pakistan, Mazhar A. Khan, Sumaira Mehreen, Anila Basit, Raza A. Khan, Faheem Jan, Irfan Ullah, Muhammad Ihtesham, Afsar Khan, Ubaid Ullah, Arshad Javaid

Saudi Medical Journal

Objectives: To determine characteristics and treatment outcomes of multidrugs resistant tuberculosis (MDR-TB) patients and risk factors for poor outcomes in MDR-TB patients in a tertiary care hospital in Peshawar, Pakistan. Methods: This retrospective study was conducted at the Programmatic Management of Drug Resistant TB Unit, Lady Reading Hospital Peshawar, Pakistan and included all MDR-TB patients registered between January 2012 and December 2012. A special proforma was used for data collection. Analysis was performed using SPSS version 16, after exporting data from the proforma. Differences in proportions were assessed using Pearson’s Chi square test whereas for predictors of poor outcomes, multivariate …

Shared Clinical Decision Making: A Saudi Arabian Perspective, Ali I. Alhaqwi, Turki M. Aldrees, Ahmad Alrumayyan, Ali I. Alfarhan, Sultan S. Alotaibi, Hesham I. Alkhashan, Motasim Badri

Saudi Medical Journal

Objectives: To determine preferences of patients regarding their involvement in the clinical decision making process and the related factors in Saudi Arabia. Methods: This cross-sectional study was conducted in a major family practice center in King Abdulaziz Medical City, Riyadh, Saudi Arabia, between March and May 2012. Multivariate multinomial regression models were fitted to identify factors associated with patients preferences. Results: The study included 236 participants. The most preferred decision-making style was shared decision-making (57%), followed by paternalistic (28%), and informed consumerism (14%). The preference for shared clinical decision making was significantly higher among male patients and those with higher …

Dental Knowledge Of Educators And Healthcare Providers Working With Children With Autism Spectrum Disorders, Ebtissam Z. Murshid

Saudi Medical Journal

Objectives: To evaluate dental knowledge and attitudes toward oral health care among healthcare providers and educators working with children with autism spectrum disorders (ASD) in central Saudi Arabia. Methods: There were 305 questionnaires distributed to 7 special-needs centers between September and November 2014. A total of 217 questionnaires were collected with a response rate of 71.1%. The study took place in the College of Dentistry, King Saud University, Riyadh, Kingdom of Saudi Arabia. Results: Approximately 50.2% of the participants did not offer any toothbrushing advice, and 73.3% never recommended dental checkup visits to parents, and 75.6% never performed dental examinations …

Contra-Lateral Shoulder Dislocation Caused By Seat Belts In Drivers And Front-Seat Passengers, Fikri M. Abu-Zidan, Mohamed I. Abusharia, Tomas A. Braunsteiner

Saudi Medical Journal

No abstract provided.

Who Calls On Countries To Protect Health From Climate Change

Saudi Medical Journal

No abstract provided.

Measles Vaccination Has Saved An Estimated 17.1 Million Lives Since 2000

Saudi Medical Journal

No abstract provided.

Borderplex Economic Outlook To 2017, Thomas M. Fullerton Jr.

Border Region Modeling Project

No abstract provided.

Tiers 1, 2 & 3 Intervention: Sleep And School, Katherine M. Kidwell, Maren Hankey, Donna M. Flores, Tori R. Van Dyk, Alyssa Lundahl, Timothy D. Nelson

Department of Special Education and Communication Disorders: Faculty Publications

Conclusion

Educators need to take a more active role in identifying and addressing sleep related issues in students in order to maximize their learning potential and to minimize the numerous negative outcomes of sub-optimal sleep and sleep disorders. Specifically, school personnel can educate parents on the importance of sleep and advocate for later school start times for middle and high school students. In addition, when symptoms persist, educators can make recommendations to parents as a part of the SAT and MDT. See Figure 4 for recommendations for schools.

A Cultural Consideration: Eliminating The Barriers In Order To Effectively Communicate Crises, Morgan H. Dunaway

Master's Theses

This study aimed at gaining a better understanding of the Hispanic American culture in an effort to evaluate how they view and receive messages sent from the government. The purpose of this study was to further the conversation that messages should be designed with careful thought in order to resonate with the target audience involved in the communication process. A previous study found that the majority of the Hispanic American population felt as if they are overlooked and would not be warned properly in a time of crisis (Heath, Lee, & Ni, 2009). Therefore, the present study focused on variables …

Examining The Association Between Psychotropic Medication And Suicidal Desire And Risk, Brittney L. Assavedo

Master's Theses

The primary aim of this study was to examine the relationship between components of suicidal desire and psychotropic medication. Specifically, the usage of psychotropic medication, the usage of specific classes of psychotropic medications and the amount of psychotropic medication utilized and differences in feelings of perceived burdensomeness, thwarted belongingness and overall suicide risk were examined. The present study utilized pre-collected data consisting of 225 patients with substance use disorder undergoing residential treatment for substance dependence. It was posited that individuals utilizing psychotropic medications would exhibit higher mean levels of thwarted belongingness, perceived burdensomeness, and suicide risk relative to individuals not …

A Statistical Model For The Prediction Of Dissolved Oxygen Dynamics And The Potential For Hypoxia In The Mississippi Sound And Bight, Andreas Moshogianis

Master's Theses

Hypoxia events occur when dissolved oxygen concentrations fall below the minimum threshold (dissolved oxygen concentrations < 2 mg O₂ L^-1) necessary to avoid respiratory distress among aquatic organisms. In the Mississippi Sound and Bight, hypoxia is most prevalent from late-spring through late summer. Since hypoxia events can have dramatic effects on coastal fisheries, the spatial and temporal magnitude of hypoxia presents a clear threat to the productive fisheries in the northern Gulf of Mexico. Long-term hydrographic data were collected from eight sampling stations on a monthly basis from January 2009 to December 2011 along a cross-shelf transect from the mouth of …

Encouraging Insurers To Regulate: The Role (If Any) For Tort Law, Kyle D. Logue

Articles

Insurance companies are financially responsible for a substantial portion of the losses associated with risky activities in the economy. The more insurers can lower the risks posed by their insureds, the more competitively they can price their policies, and the more customers they can attract. Thus, competition forces insurers to be private regulators of risk. To that end, insurers deploy a range of techniques to encourage their insureds to reduce the risks of their insured activities, from charging experience-rated premiums to discounting premium rates for insureds who make specific behavioral changes designed to reduce risk. Somewhat paradoxically, however, tort law …

The Neurochemistry Of Group Singing: Bonding And Oxytocin, Jason Keeler

Masters Theses

The purpose of this study was to examine the neurochemical correlates of group vocal improvisation and to determine the feasibility of the research methods. One group of four participants sang together in two conditions: pre-composed and improvised. Concentrations of plasma oxytocin and adrenocorticotropic hormone (ACTH) were measured before and after each singing condition to assess levels of hormones associated with social affiliation, engagement and arousal. Successful implementation of the methodology, including recruitment, data collection, and sample analysis, served as the primary outcome of this study. ACTH concentrations decreased in both conditions, and significantly so in the pre-composed singing condition. Mean …

The Taphonomic Factors On Human Remains Inside Chullpas: Marcajirca, Peru, Samantha Lauren Lininger

Masters Theses

This study explored the taphonomic factors that contributed to the preservation of human skeletal remains inside ancient above-ground tomb in Marcajirca, Peru. This study incorporated one hundred and eighteen bones from three chullpas. Five taphonomic factors were examined: bone type, plant activity, root presence, weathering, and cultural factors. Surface layers inside each chullpa were analyzed using Geographic Information System (GIS) software. Chi-square tests were employed to investigate preservation and taphonomic factors. The results from the statistical tests indicated that there was a significant difference in the taphonomic factors on different bone types. Chullpa 6 was significant because it was unique …

An Integrated Framework For Cardiac Sounds Diagnosis, Zichun Tong

Masters Theses

The Phonocardiogram (PCG) signal contains valuable information about the cardiac condition and is a useful tool in recognizing dysfunction and heart failure. By analyzing the PCG, early detection and diagnosis of heart diseases can be accomplished since many pathological conditions of the cardiovascular system cause murmurs or abnormal heart sounds. This thesis presents an algorithm to classify normal and abnormal heart sound signals using PCG. The proposed analysis is based on a framework composed of several statistical signal analysis techniques such as wavelet based de-noising, energy-based segmentation, Hilbert-Huang transform based feature extraction, and Support Vector Machine based classification. The MATLAB …

Are Large Dogs Smarter Than Small Dogs? Investigating Within Species Differences In Large And Small Dogs: Spatial Memory, Megan S. Broadway

Master's Theses

The study of canine cognition can be useful in understanding the ontology and selective pressures that affect the development of cognitive abilities. Dogs have undergone intensive artificial selection yielding distinctive breeds which differ both phenotypically and behaviorally. Breed based cognitive differences have not been found but some studies suggest there may be differences in broader categories such as working disposition and sex. The influence of size on canine cognition has not been thoroughly addressed despite the fact that large dogs are often perceived to be ‘smarter’ than small dogs. This preconception has only recently been addressed and supported in one …

Do Speed Humps Help Reduce Vehicular Speeds, Volumes, And Motorist Accidents?, Tanisha Werner

Master's Projects

California has adopted a Complete Streets policy, which requires local municipalities to design roadways that meet the needs of all users (pedestrians, bicyclists, and motorists). This policy, combined with complaints about motorists speeding in residential areas, has been a catalyst for jurisdictions to install traffic calming measures on residential streets. One popular traffic calming measure used in the City of Redwood City is the installation of speed humps. A speed hump is a raised pavement surface that provides a physical reminder for motorists to slow down while traveling over it. Although literature shows that the installation of speed humps can …

Are Bay Area Cities Inclusive? Evaluating How San Francisco Bay Area Cities Can Address Environmental Justice Challenges By Strengthening Their Engagement Practices With Low-Income And Minority Communities Through The California Environmental Quality Act Process, Kenneth Antonio Rosales

Master's Projects

No abstract provided.

The Problem Of Masculinity For Male Health, Kieran Geary, Maurice Murphy

Dept. of Management & Enterprise Publications

Men’s health has historically received little attention in terms of consultation, planning, strategy development or project implementation, but in recent years there has been an increased focus on gender in the context of men’s health. Whilst in the past the focus on gender and health in Ireland has tended to be synonymous with women’s health, the significance of gendered health practices (particularly gendered patterns of help-seeking) have more recently come to the forefront in the context of men. Men’s reluctance to seek help and use health services is a concern across most Western cultures. Some commentary has suggested that men …

Rethinking America's Grand Strategy: Insights From The Cold War, Hal Brands

The US Army War College Quarterly: Parameters

No abstract provided.

America's All Volunteer Force: A Success?, Louis G. Yuengert

The US Army War College Quarterly: Parameters

No abstract provided.