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Effects Of Resistance Training And Creatine Monohydrate On Doxorubicin-Induced Muscle Dysfunction, Eric Christopher Bredahl

Dissertations

Doxorubicin (DOX) is a powerful chemotherapy agent that is associated with a number of deleterious side effects, including skeletal muscle dysfunction. The exact mechanisms behind the observed skeletal muscle dysfunction have yet to be fully understood. Nonetheless, the observed myotoxicity is believed to be the result of an increased oxidative stress. Resistance training (RT) has been shown to preserve skeletal muscle function in DOX treated muscles. Conversely, creatine (Cr) has been shown to improve skeletal muscle function. Yet, there has been no investigation into the effect of combined RT and Cr on DOX-induced muscle dysfunction. Thus, the possibility exists that …

Exploring Male Counselors’ Experiences With Vulnerability In The Counseling Relationship, Hannah Edith Davis Kreider

Dissertations

While existing literature clearly indicates that the relationship between counselor and client is important and crucial for therapeutic progress (e.g., Norcross & Wampold, 2011), little research has been done on the experiences of counselors within the therapeutic relationship. Vulnerability has been noted as an important component of growth-fostering relationships (e.g., Jordan, 2008), however research is lacking on how counselors experience vulnerability with their clients. Within the field of counseling, men are underrepresented (Michel, Hall, Hays, & Runyan, 2013) and little research exists exploring their unique experiences as counselors. Additionally, due to gender role socialization, men are likely to struggle with …

Physical Education Teacher Education Teacher Candidates’ Perceptions About And Implementation Of Caring, Tanjian Liang

Dissertations

The purpose of this study was to examine physical education teacher education (PETE) teacher candidates’ perceptions about and implementation of caring during eight-week student teaching experiences. The specific research questions were: (a) How do caring teacher candidates perceive and define caring? and (b) How do caring teacher candidates implement caring behaviors throughout their eight-week student teaching assignments? In line with the research questions, a qualitative case study approach was used. Participants were two PETE caring physical education teacher candidates from the same program. Data sources included semi-structured interviews, informational conversational interviews, field notes, documents, and research journals. Data were analyzed …

The Effectiveness, Usability, And Motivational Characteristics Of Using Animated Role- Playing Situational Simulation Programs For Air War College Distance Learning Curriculum, Dennis Michael Armstrong

Dissertations

This study examined perceived effectiveness, usability, and motivational characteristics of using animated role playing situational simulations for Air War College distance learning (AWC/DL). The AWC/DL curriculum provides education to senior military officers who are geographically dispersed around the world with varying degrees of internet connectivity, creating specific limitations as to what methods of instruction are viable. An additional challenge is the very high student-to-teacher ratio (620:1). Traditionally, the AWC/DL program relied on text-based readings and tests to teach and evaluate students. Simulations might provide a realistic and valuable augmentation to the curriculum. The key potential advantages of adding simulations are …

Biomechanical Assessment Of Ertl And Burgess Transtibial Amputation Techniques, Abbie Elthea Ferris

Dissertations

In this dissertation, a model was developed to predict the inertial properties of the shank and foot of persons with TTA and functional differences between Ertl and Burgess amputees during curb negotiation and the sit-to-stand tasks were evaluated. The developed inertial model was able to predict the shank and foot segment mass, COM location, and MOI more accurately than using the intact limb inertial properties. Used as inputs into inverse dynamics equations, the general model predictions produced joint moments which were also similar to the subject-specific measures. Thus, this model is a better predictor than the current method of using …

School Policy And Practice To Tackle A Public Health Problem: Sudden Cardiac Arrest, Leigh Lynn Mcgown-Kauffman

Dissertations

Sudden cardiac arrest (SCA) is a leading cause of death in the United States. While the medical research has exhaustively documented that immediate response directly impacts survival rates in SCA and that schools could be the best catalyst for creating change by bystanders, there is little to no educational research addressing school policy or practices in regards to cardiac emergencies in schools. The purpose of this dissertation was to identify and describe characteristics of the Colorado schools that offer cardiopulmonary resuscitation (CPR) training and onsite automated external defibrillators (AED). Two research questions were answered, Of respondents, what are the characteristics …

Predicting Coaching Efficacy In National Collegiate Athletic Association Assistant Coaches: A Social Psychological Analysis Of Coaching Goals, Commitment, And Values, Brett Allen Nichols

Dissertations

Coaching is a complex undertaking and understanding what it takes to be an effective coach is important for coaches and researchers in the field of sport and exercise science. Horn’s (2008) heuristic model of coaching effectiveness organizes and summarizes the previously established relationships among predictors and outcomes of effective coaching. The purpose of this study was to examine the heart of Horn’s model, specifically examining coaching goals, coaching commitment, and coaching values with the five dimensions of coaching efficacy (Feltz et al., 1999; Myers et al., 2008). Using intercollegiate assistant coaches (N=740) this study demonstrated initial reliability and factorial validity …

The Meaning Of Physical Activity From The Perspective Of Indonesian Immigrant Youth, Caly Setiawan

Dissertations

The purpose of this phenomenological study was to examine what constitutes the experience of physical activity for Indonesian immigrant youth. Fifteen Indonesian young people aged 13 to 18 participated in the study. Data were collected through two sets of interviews. During the first set of interviews, data were gathered about physical activity experiences and the meanings that the youth ascribed to their participation. A second set of interviews were conducted to collect information about the participants’ strategies for engaging Indonesian immigrants in physical activity. Seven purposefully selected participants were the respondents in these interviews. Data were analyzed using a three …

All Families Are Unique: Experiences Of Lesbian-Parented Families, Rachel Tova Gall

Dissertations

This study explored the experiences of families with lesbian mothers and elementary school-aged children residing in metropolitan areas of the United States. This phenomenology aimed to transcend comparative and binary research to include the voices of sexual minorities and children. Eight whole-family interviews were conducted in alignment with the study’s systemic-constructivist approach. A number of themes emerged from the data that were generally consistent with prior research. Mothers were intentional about the communities in which they surrounded themselves, the process of having children, and having discussions with children about potential discrimination. Participants saw themselves as advocates and were typically out …

Eliciting Bootstrapping: The Development Of Introductory Statistics Students’ Informal Inferential Reasoning Via Resampling, Jeffrey Allen Mclean

Dissertations - ALL

Bootstrapping has become an important tool for statisticians, who assert that it is intuitive to novice statistics students. The process of collecting bootstrap resamples was once time demanding, but technology now allows data collection to be performed nearly instantaneously. This study focuses on the construction and development of secondary and tertiary introductory statistics students' (n=68) reasoning about bootstrapping and informal inference. Students engaged in a four-week instructional unit designed as two model development sequences. Through the use of hands-on manipulatives and technology, students constructed and developed reasoning of sampling, the resampling process of bootstrapping, and inference. The focus of my …

Trying Times: Disability, Activism, And Education In Samoa, 1970-1980, Juliann Anesi

Dissertations - ALL

In the 1970s and 1980s, Samoan women organizers established Aoga Fiamalamalama and Loto Taumafai, which were educational institutions in Samoa, an island in the Pacific. Establishing these schools for students with intellectual and physical disabilities, excluded from attending formal schools based on the misconception that they were "uneducable". In this project, I seek to understand how parent advocates, allies, teachers, women organizers, women with disabilities, and former students of these schools understood disability, illness, inclusive education, and community organizing. Through interviews and analysis of archival documents, stories, cultural myths, legends related to people with disabilities, pamphlets, and newspaper media, I …

Preventing Thymus Involution In K5.Cyclin D1 Transgenic Mice Sustains The Naïve T Cell Compartment With Age, Michelle L. Bolner

Dissertations and Theses (Open Access)

The thymus maintains T cell receptor (TCR) repertoire diversity through perpetual release of self-MHC restricted naive T cells. However, thymus involution during the aging process reduces naïve T cell output, leading to defective immune responsiveness to newly encountered antigens. We have found that early thymus involution precipitates the age-associated shift favoring memory T cell dominancy in young control mice. Furthermore, we have shown that age-related thymus involution is prevented in mice expressing a keratin 5 promoter-driven Cyclin D1 (K5.D1) transgene in thymic epithelial cells (TECs). Thymopoiesis occurs normally in K5.D1 transgenic thymi and sustains T cell output to prevent the …

Investigation Of Quatitative Image Features From Pretreatment Ct And Fdg-Pet Scans In Stage Iii Nsclc Patients Undergoing Defintive Radiation Therapy, David Fried

Dissertations and Theses (Open Access)

The purpose of this work was to determine if quantitative image features (QIFs) extracted from computed tomography (CT) and flourodeoxyglucose (FDG) positron emission tomography (PET) could provide prognostic information to improve outcome models. Our goal for this work was to determine if it may one day be feasible to incorporate QIFs into personalized cancer care. QIFs were used to quantitatively characterize patient disease as seen on imaging. A leave-one-out cross-validation procedure was used to assess the prognostic ability of QIFs extracted from CT and PET in addition to conventional prognostic factors (CPFs). QIFs were found to improve model fit for …

Reforming U.S. Export Controls Reforms: Advancing U.S. Army Interests, Richard Weitz Dr.

Books, Monographs & Collaborative Studies

The U.S. defense export system needs further major reforms to reduce inefficiencies and weaknesses. Although the International Traffic in Arms Regulations (ITAR) do help prevent potential foreign adversaries from using U.S. arms against the United States and its allies, the Regulations, as enforced, can weaken U.S. national security in other important ways. For example, by excessively impeding defense exports, the ITAR makes it more difficult for U.S. firms to sustain core U.S. defense technological and industrial advantages, decreases U.S. military interoperability with allies that purchase ITAR-free weapons from other sources, and generates other undesirable effects for the U.S. Army and …

Validating Side Scan Sonar As A Fish Survey Tool, Michael A. Bollinger

Theses and Dissertations

Hydroacoustic methods can be used to answer a variety of questions regarding fish populations and behavior. In this study, side scan sonar methodology was developed to quantify abundance and biomass and compared to established visual observation methods on SCUBA over artificial reef structures in the western Gulf of Mexico. Side scan sonar methods were equivalent to SCUBA surveys for measuring fish abundance over the same reef areas, however, abundances were significantly higher when the larger area sampled by side scan was utilized. Side scan sonar methods were also more time efficient than SCUBA, ROV and long line fishing methods (66.7%, …

Molecular Modeling And Mutational Mapping Of The Gpr119 Binding Site, Shane M. Askar

Theses and Dissertations

GPR119 receptor’s biological role in regulating glucose homeostasis has been studied extensively. Results in the scientific literature indicate that, when activated, GPR119 releases insulin in a glucose dependent manner. Currently the 3D structure of GPR119 has not been resolved.

The goal of this research is to use a combination of homology modeling and ligand docking studies to predict the binding mode of GPR119 ligands. Amino acids implicated to have direct interactions with docked ligands will further be assessed experimentally for their roll in binding and activation of GPR119. Our results indicate that residues W2656.48 and R813.28 are likely to be …

Examination Of The Chagas Disease Vector, Triatoma Gerstackeri, In The Lower Rio Grande Valley, Alfredo Flores

Theses and Dissertations

Chagas disease is caused by the protozoan parasite Trypanosoma cruzi, which is carried by an insect vector of the family Reduviidae, and of the subfamily Triatomina. The species Triatoma gerstaeckeri is identified as the primary vector of T. cruzi within the Rio Grande Valley. Species of Triatoma gerstaeckeri were trapped in La Sal del Rey National Refuge in 2012 and 2013.

Data indicates a seasonal dispersal pattern of activity for T. gerstaeckeri. Optimal time of capture was between 1-2 hours after sunset. Different methods were utilized to determine the best combination of lures. Results indicate that the UV-light alone is …

Decomposition And Nitrogen Dynamics Of Turtle Grass (Thalassia Testudinum) In A Subtropical Estuarine System, Monica Delgado

Theses and Dissertations

Seagrass beds are pivotal in the functioning of coastal ecosystems in terms of productivity, organic matter turnover and nutrient cycling. Aiming to document decay and nitrogen (N) dynamics of turtle grass (Thalassia testudinum) in a subtropical estuarine system, decomposition patterns of leaves and rhizomes were characterized and compared. Nitrogen usage during decomposition of tissues, and of live tissues and epiphytes growing on live leaves, was also quantified and compared. Stable isotope ratios allowed tracing N within the seagrass bed, following N incorporation into seagrass tissues from the surrounding media (water, sediment). Leaves had a higher N content and decomposed at …

Activation Of Microglia In The Rotenone Lymnaea Stagnalis Model Of Parkinson's Disease, Xiomara Galvan

Theses and Dissertations

Parkinson’s disease (PD) is the most common irreversible neurodegenerative movement disorder affecting approximately ten million people worldwide. In the central nervous system (CNS), PD is known by the selective loss of Dopamine (DA) cells of the substantia nigra pars compacta. Although the disease has been very widely studied, the underlying mechanisms are not yet understood. Several hypotheses have arisen as result of injury of the mitochondria, some experiments include microglia activation, microtubule damage, and reactive oxidative species, which all result in the death of DA cells. The theory of microglia activation upon inflammation was explored in this study. Using the …

A Handcrafted Multi-Branch Nerve Scaffold For In Vivo Peripheral Nerve Regeneration, Ridwan Fayaz Hossain

Theses and Dissertations

Arm and leg peripheral nerve injuries contribute largely to functional disability. These injuries seldom affect a single-line nerve; rather the injury goes beyond and disrupts the nerve tissue across multiple nerve paths. Here we investigate handcrafted PDMS based multi-branch nerve guidance conduit, which addresses this crucial branching from the sciatic nerve to aid with the regeneration to their appropriate distal targets. The design concept of the developed multiple branch nerve scaffolds is not specific for the sciatic nerve but can be modified for general use of all peripheral nerves and additional applications. Microchannels are also fabricated into a device in …

Balanus Eburneus (Crustacea: Cirripedia) As A Potential Indicator Of Estuarine System Recovery In South Texas: A Study Of Recruitment, Growth And Stable Isotopes, Crystal Martinez

Theses and Dissertations

Population characteristics of the barnacle Balanus eburneus were analyzed with the purpose of exploring its potential use as a discriminating indicator among sites exhibiting different disturbances or stages of recovery. The study was conducted from May 2012 to May 2013 at four estuaries in the Lower Laguna Madre, TX including a) Bahia Grande, currently under restoration and divided into Bahia Grande North and Bahia Grande South, b) San Martin Lake, which receives runoff water and c) South Bay, a relatively undisturbed reference estuary. In general, similar barnacle recruitment and growth trends in Bahia Grande South and South Bay were explained …

An Exploratory Investigation Of Tele-Counseling: Looking At The Power Of Therapeutic Alliance In Improving Wellness, Jorge Rostro

Theses and Dissertations

The present study explored the power of one tele-counseling session to elicit change within post wellness ratings scores and the relationship between clients’ perceptions of relationship, goals and topics, approach and method, and overall session with clients’ wellness ratings. Results indicated that the mean for post-session wellness was significantly greater than pre-test wellness ratings. The standardized effect size, d, was .43, indicative of a moderate effect size. No difference was found between client’s perceptions of predictor variables with post-wellness rating scores. This study adds support for the use of tele-counseling services as one session might have the power to elicit …

Influence Of Property School Wealth On Fifth Grade Student Achievement In Reading And Mathematics, Jesus R. Reyna

Theses and Dissertations

The purpose of this study was to investigate whether, or to what extent, property wealth of the upper and lower 5% districts, per pupil expenditure, limited English proficient students, economically disadvantaged students, membership, and teacher experience contribute to student achievement in 5th grade reading and mathematics. To do this, the fifth grade reading and math achievement scores, based on the TAKS Assessments, to represent student achievement were evaluated against district wealth, per pupil expenditure, economic disadvantage, limited English language proficiency, membership, and years of teaching experience of teachers for the years 2009, 2010, and 2011. A combination of descriptive statistics, …

Mack Thomas: The Total Beat, James B. Welton

Theses and Dissertations

Mack Thomas enjoyed both an audience seat and a role in the Beat Generation. He lives the life that fits one of his mottos, “if at first you don’t succeed, quit”. Thomas was the author of two autobiographical novels Gumbo and The Total Beast, a jazz and literature columnist for Grove Press in the 1950s and 1960s. Thomas was also a jazz musician worthy to share the stage with Miles Davis, inventor, and entrepreneur among numerous other interests. His friendship with William S. Burroughs was forged by their Texas ties while they were neighbors living in Paris, France and offered …

Higher Education Governance Structures And Operational Efficiency And Effectiveness Of 4 -Year Public Institutions, Angela H. Claxton-Freeman

Electronic Theses and Dissertations

This study benchmarks 4-year public institutions in the Southern Regional Education Board to determine if there are significant differences between the institutions based on efficiency and effectiveness scores within the types of governance structures in operation among the states. Efficiency and effectiveness scores are also used to determine if there are significant differences between institutions based on state appropriation levels. In this quantitative study, data envelopment analysis (DEA) was used to collapse selected institutional data reported to IPEDS into effectiveness and efficiency scores which were then used as the dependent variables. The variable returns to scale (VRS) model was used …

Radiography Clinical Instructors' Perceptions Of The Transition From Technologist To Educator, Christina G. Lee

Electronic Theses and Dissertations

Radiologic technologists who transition into the role of clinical instructor are usually expert practitioners but may lack knowledge of best practices regarding student instruction and evaluation. The purpose of this phenomenological qualitative study was to investigate how CIs experience the transition from practitioner to educator and what knowledge or education of best practices of instruction and evaluation they bring to the position. This study consisted of interviews with radiography CIs from one associate degree radiography program in the southeastern part of the United States. While some CIs felt prepared to transition into the CI role, none of them had previously …

Determining If Custodial Grandparents Of Pre-K - Third Grade Students Perceive Delivery Of Information And Services Offered As Effective In Decreasing Early Chronic Absence, Kimberly S. Cassidy

Electronic Theses and Dissertations

This study examined the delivery of information and services offered to grandparents who had become the primary caregivers of pre-k through third grade students to determine if the information and services were effective in decreasing chronic early absence as defined by Chang and Romero (2008). This mixed-method, multi-case study focused on the perceived needs of custodial grandparents and examined if the school system was meeting their needs through delivery of information and services. The researcher sought participation from 5 custodial grandparents who had grandchildren in pre-k, kindergarten, first, second, or third grades in a Northeast Tennessee school system and whose …

Influence Of Lactobacillus Rhamnosus Isolated From “Amabere Amaruranu” Cultured Milk On Adipogenesis, Justin E. Kotala

Electronic Theses and Dissertations

This study was performed to test the in vitro effects of a Lactobacillus rhamnosus isolate from “amabere amaruranu”, a traditional Kenyan cultured milk, on 3T3-L1 and Caco-2 cell lines. Cultures of fully mature 3T3-L1 adipocytes were treated with bacterial isolate cell extract (CE), filtered spent broth (FSB) from overnight bacterial culture, or with a PBS control. Expression levels of PPAR³1 and 2, C/EBP±, and ATGL proteins in 3T3-L1 cells were upregulated by FSB treatment. CE treatment did not affect protein expression levels. Expression of MTTP and SREBP-1c proteins in Caco-2 cells showed no change with either treatment. Optical density measurements …

The Lawrentian Woman: Monsters In The Margins Of 20th-Century British Literature, Dusty A. Brice

Electronic Theses and Dissertations

Despite his own conservative values, D.H. Lawrence writes sexually liberated female characters. The most subversive female characters in Lawrence’s oeuvre are the Brangwens of The Rainbow. The Brangwens are prototypical models of a form of femininity that connects women to Nature while distancing them from society; his women are cast as monsters, but are strengthened from their link with Nature. They represent what I am calling the Lawrentian-Woman.

The Lawrentian-Woman has proven influential for contemporary British authors. I examine the Lawrentian-Woman’s adoption by later writers and her evolution from modernist frame to postmodern appropriation. First, I look at the …

The Effects Of Transcutaneous Electrical Neurostimulation On Analgesia And Peripheral Perfusion, Leah I. Schafer

Master's Theses

Peripheral arterial occlusive disease (PAOD) affects 8 to 12 million Americans over the age of 50. As the disease progresses, arterial occlusions arising from atherosclerotic lesions inhibit normal metabolic vasodilation in the peripheries, resulting in limb ischemia and claudication. Pharmacological and surgical treatments currently used to treat both the hemodynamic and pain symptoms associated with PAOD can involve adverse and potentially life-threatening side effects. Thus, there is a need for additional innovative therapies for PAOD.

Neurostimulation has a known analgesic effect on both acute and chronic pain. Although the exact mechanisms remain under investigation, local vascular tone may be modulated …