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Recoding Of Vesicular Stomatitis Virus Genes By Computer-Aided Design Provides A Live Attenuated Vaccine Candidate, Bingyin Wang

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Codon pair bias (CPB), which has been observed in all organisms, is a neglected genomic phenomenon that substantially affects gene expression. CPB results from synonymous codons that are paired more or less frequently in ORFeomes regardless of codon bias. The effect of an individual codon pair change is usually small, but when amplified by large-scale genome recoding (simultaneously generating hundreds of synonymous mutations without altering codon usage or amino acid sequence), strikingly altered biological phenotypes are observed. Although the molecular mechanism underlying codon pair bias still remains enigmatic, the utility of codon pair bias in the development of live attenuated …

A Role For Hmgb2 In Mammalian Neurogenesis And Stroke, Robert Bronstein

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Stroke results in areas of neuronal cell death with concomitant inflammation and edema in the surrounding tissues. Ischemia in the thalamus can present as an accumulation of many smaller lacunar infarcts leading to potential cognitive deficits and central post-stroke pain syndromes, for which curative therapies are lacking. The capacity of the brain to repair itself rests upon the robust response of adult neurogenesis, and gliogenesis, to formidable ischemic conditions. In this study I assess the role chromatin modulator HMGB2 plays in both neurogenesis/gliogenesis and adult thalamic ischemia. Firstly, we demonstrate that this protein can affect the transition between the creation …

An In Vivo Assessment Of The Effects Of Using Different Implant Abutment Occluding Materials On Implant Microleakage And The Peri-Implant Microbiome, Caroline Rubino

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Microleakage may be a factor in the progression of peri-implant pathology. Microleakage in implant dentistry refers to the passage of bacteria, fluids, molecules or ions between the abutment-implant interface to and from the surrounding periodontal tissues. This creates a zone of inflammation and reservoir of bacteria at the implant-abutment interface. Bone loss typically occurs within the first year of abutment connection and then stabilizes. It has not yet been definitively proven that the occurrence of microleakage cannot contribute to future bone loss or impede the treatment of peri-implant disease. Therefore, strategies to reduce or eliminate microleakage are sought out. Recent …

Secularization As Pastoral Power: Governmentality And Christianity, Maria Angeles Prado Ballarin

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

I focus on Foucault's Lectures at the Collège de France in order to show how his genealogy of the modern normalizing society leads him to trace the historical beginnings and the condition of possibility of bio-disciplinary practices of individual and collective government- together with the discourse of the hermeneutics of the subject that serves to justify them- to the organization and development of the Christian pastorate from the fourth century onwards. Taking up Nietzsche's critique of Western Christianity, Foucault analyses the emergence and deployment of the procedures or modalities of modern governmentality as effects of the extension or generalization of …

Folk Couture: A Fashion Exhibition At The American Folk Art Museum, Alexis Carreno

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

This dissertation describes the conceptual framework and the materialization of the exhibition I guest-curated at the American Folk Art Museum, Folk Couture: Fashion and Folk Art. Based on the tradition of artists using fashion to produce artworks, (for instance, Sylvie Fleury’s installation Poison, which commented upon issues of consumerism); couturiers appropriating images from art to create garments (such as Yves Saint Laurent’s Mondrian Dress, in which the designer replicated a painting made by the Russian constructivist artist), and collaborations between fashion designers and artists (for example, designer Marc Jacobs’s and artist Yayoi Kusama’s collaboration for Louis Vuitton), thirteen New York …

Formal Verification Of Nonlinear Biological Systems, Md Ariful Islam

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Abstraction and composition have proved to be particularly useful in extending the reach of formal verification. Abstraction reduces the size of the system under investigation by neglecting details irrelevant to the properties of interest. Compositionality allows us to decompose large-scale system into smaller components and verify each component individually and reason about the verification of entire system from verified components. Together, these two techniques permit us to substitute a component with its equivalent abstraction such that the overall system retains the property of interest. In this thesis, we first show that in the context of the Iyer et al. (IMW) …

The Effects Of Ketorolac And Its Enantiomers On Breast Cancer Proliferation And Metastasis, Amanda Sheree Peretti

Biomedical Sciences ETDs

Breast cancer is the second leading cause of cancer related deaths in women. Advanced breast cancer can metastasize to the lungs, liver, bones and brain becoming fatal conditions for many patients. There is a dire need for metastasis preventing medications, however the process required for a medication to become FDA approved for clinical use is long and arduous. Studies have found promising benefits for breast cancer patients given ToradolTM, or racemic ketorolac, as an NSAID during resection surgery. However, long-term use of racemic ketorolac is not recommended. Currently FDA-approved for use in the racemic form, ketorolac has the potential to …

Implementation Of Broad Band Ambient Light Activated Opsins To Treat Neurodegenerative Diseases In Retinal Cells, Gregory Cervenka

2015 Fall Honors Capstone Projects - Archive

Retinitis Pigmentosa is a degenerative eye disease that can eventually lead to blindness. This disease is caused by light desensitization of retinal cells resulting in a lack of neural impulses from the eye to the brain to form an image. Scientists are attempting to treat this condition by bringing light sensitivity back to retinal cells. They are accomplishing this by transfecting the cell with light activated channel proteins called opsins. However, researchers are facing a difficulty using these opsins as the proteins can only be activated by intense narrow band light that can damage cells further. Our objective was to …

Heat Dissipation During Hovering And Forward Flight In Hummingbirds, Don Powers, Bret W. Tobalske, J. Keaton Wilson, Keeley R. Corder

Faculty Publications - Department of Biological & Molecular Science

Flying animals generate large amounts of heat, which must be dissipated to avoid overheating. In birds, heat dissipation is complicated by feathers, which cover most body surfaces and retard heat loss. To understand how birds manage heat budgets during flight, it is critical to know how heat moves from the skin to the external environment. Hummingbirds are instructive because they fly at speeds from 0 to more than 12ms−1, during which they transit from radiative to convective heat loss. We used infrared thermography and particle image velocimetry to test the effects of flight speed on heat loss from specific body …

Bumetanide Demonstrates Amelioration Of Learning And Memory Deficits Induced By Ketamine Administration In A Neonatal Rat Model, Ryan Stevens

McNair Scholars Research Journal

No abstract provided.

Thermal Transgenerational Plasticity And Its Effect On Competitive Ability And Consumer-Resource Dynamics In A Population Of Daphnia Ambigua, Holmes Julian

Biology Theses - Archive

Global temperature increases are predicted to quicken in pace this century, and with them so will the likely impact on natural populations. The extent to which organisms will be able to keep pace with and adapt to these environmental changes is an unanswered question. It has been demonstrated that changing environments can induce changes in phenotypes that persist across generations. TGP may be an important means for populations to cope with climate change stress, but our understanding of these interactions is incomplete. Prior work showed that Daphnia program their offspring for faster development when reared under cooler temperatures. Here I …

Determination Of Total And D-Amino Acid Content In Mice Brain Tissue By Achiral-Chiral Heart-Cutting Two-Dimensional Liquid Chromatography: Diagnostic And Clinical Relevance And A Comparison Between Non-Perfused And Perfused Tissue, Curran Parpia

Chemistry & Biochemistry Theses - Archive

A heart-cutting two dimensional liquid chromatographic method for the quantification of free amino acid enantiomers from mouse brain tissue is demonstrated. Evidence to support the occurrence of D-amino acids in significant concentrations in physiological samples has spurred studies toward the elucidation of their importance and function. In this work, the level and regional distribution of select amino acids were determined by achiral-chiral LC/LC. Additionally, the effect of tissue perfusion on these levels was investigated. The free amino acid extracts were analyzed as their 9-fluorenylmethyloxycarbonyl derivatives and separated in the reverse phase mode on superficially porous C18. In the second dimension, …

Intoxication And Empire: Distilled Spirits And The Creation Of Addiction In The Early Modern British Atlantic, Kristen D. Burton

History Dissertations - Archive

This dissertation exams how the spread of imperialism in the British Atlantic led to the mass production and consumption of distilled spirits during the seventeenth and eighteenth centuries. Through transatlantic colonization, distilled liquors, once produced as medicinal remedies, developed into a thriving industry by the beginning of the eighteenth century. This change in the purpose and use of distilled spirits prompted political, religious, and medical leaders to ask new questions about the effects and possible threats of consuming such spirits. This dissertation is a study of perceptions; it examines how spirits became the means through which people evaluated the place …

Material Changes Of Bone Following Ishcemia Of The Immature Femoral Head, Olumide O. Aruwajoye

Material Science and Engineering Dissertations - Archive

Legg-Calvé-Perthes disease (LCPD) is a childhood hip disorder resulting from the loss of blood flow to the femoral head. In severe cases of the disease, the femoral head can develop a flattening deformity; additionally, if the disease is diagnosed at a later stage, it leaves most patients to develop early osteoarthritis of the hip. Due to a lack of pathological specimen from patients, an experimental piglet model of femoral head ischemia was developed. The model closely follows the radiographic changes seen in LCPD patients, where there is subchondral fracture, resorption, and a flattening deformity of the femoral head. After ischemia, …

Becomes A Woman Best: Female Prophetic Figures In Shakespeare's Plays, Alan Morris Cochrum

English Theses - Archive

This dissertation argues that female characters in Shakespeare’s The Winter’s Tale, Henry VIII, Richard III, Macbeth, and 1 Henry VI function as prophets in the style of the Old Testament. In a culture that venerates Holy Writ but also devalues women, a dramatic exemplar wrapped in the mantle of a biblical prophet becomes a potential model for playgoers as well as an embodied critique. Paulina, Katherine of Aragon, and Margaret of Anjou condemn injustice, uphold the cause of the vulnerable, challenge the abuse of royal and spiritual authority, and frequently echo aspects of biblical figures such as Moses, Isaiah, and …

Co-Treatment With Conjugated Linoleic Acid And Nitrite Modulates Mitochondrial Respiration And Electron Transport Chain Activity In Vivo And Attenuates Mitochondrial Dysfunction During Cardiac Injury., Patrick Van Hoose

Electronic Theses and Dissertations

Cardiovascular disease and subsequent complications, such as myocardial infarction (MI), is the leading cause of death within the United States. Clinical intervention to reduce cardiac damage following myocardial ischemia is limited. Polyunsaturated fatty acids have been linked to an overall beneficial effect on cardiovascular health and function. Conjugated linoleic acid (cLA) is an 18:2 unsaturated fatty acid found within the diet in ruminant meat and dairy products. The cis-9 trans-11 isomer of cLA is the most prominent isomer within the diet and cLA has been linked to favorable outcomes in numerous disease states. The mechanism mediating the effects of cLA …

Spreading Speeds And Traveling Waves In Some Population Models., Quancheng Meng

Electronic Theses and Dissertations

Virtually every ecosystem has been invaded by exotic organisms with potentially drastic consequences for the native fauna or flora. Studying the forms and rates of invading species has been an important topic in spatial ecology. We investigate two two-species competition models with Allee effects in the forms of reaction-diffusion equations and integro-difference equations. We discuss the spatial transitions from a mono-culture equilibrium to a coexistence equilibrium or a different mono-culture equilibrium in these models. We provide formulas for the spreading speeds based on the linear determinacy and show the results on the existence of traveling waves. We also study a …

Plant Community Responses To Invasive Shrub And Vine Removal In An Urban Park Woodland., Eric Richard Moore

Electronic Theses and Dissertations

Counter to what some people think, urban areas can be biodiversity hotspots. Maintaining this biodiversity can be challenging, since exotic shrubs and vines block sunlight and threaten native plant regeneration. Since 2007, the Louisville Olmsted Parks Conservancy (LOPC) has spent $2 million on invasive plant management in Cherokee Park. Before the project began, long-term transects were established by the LOPC to collect baseline presence/absence data on 11 invasive plant species. In 2014, I revisited these transects and documented presence/absence data on the entire plant community. I found that four species (garlic mustard, winter creeper, Japanese honeysuckle, and English ivy) have …

Cardiovascular Regulation And Effects Of Respiratory Motor Training In Patients With Chronic Spinal Cord Injury., Bonnie Legg Ditterline

Electronic Theses and Dissertations

This dissertation attempts to discover the mechanisms between cardiovascular and respiratory motor control post spinal cord injury (SCI): in normal, non-injured (NI) persons, cardiovascular regulation is dependent upon respiration, but there is nothing that suggests the mechanism for this relationship post-SCI. Thus we hoped to evaluate various aspects of cardiovascular regulation to further illustrate how this relationship is changed or unchanged by SCI. Chapter I describes the anatomy and physiology of the spine, respiratory system, and cardiovascular system in a NI person, and then describes how the function of these systems is changed by SCI. In addition, we describe therapies …

Educational Excellence Through Dual Degrees : Using Symbolic Convergence Theory To Make It Happen Here., Stephanie Ann French

Electronic Theses and Dissertations

Interdisciplinary studies is a goal for the University of Louisville as it pertains to the Vision 2020 Plan. Implementing interdisciplinary studies is a part of Educational Excellence, goal number one of five strategic goals in the Vision 2020. Each of the colleges at the university has devised a strategic plan to determine how each will contribute to that goal. This specific research provides an overview of various issues pertaining to implementing programs in interdisciplinary studies. It then explores a specific instance of interdisciplinary possibilities by focusing on a single instance of what might become an exemplar of interdisciplinary studies. Specifically, …

Pregnancy And Performance : Rights To The Unveiling., Takayla Justina Williams

Electronic Theses and Dissertations

Imagine you are an actress auditioning for a role, and the director asks, “If cast”, would you have conflicts?” You know you’re pregnant, but the director does not.You are also aware of the theatre’s production calendar; the production will be over before you start showing, or a couple of months before your due date. What do you do? Should you reveal the pregnancy, even though you know there is a possibility you may be discriminated against? Or do you hide it? What are the benefits and risks involved when the pregnant performer decides to conceal her pregnancy? This thesis serves …

Writing Trauma In Iraq: Literary Representations Of War And Oppression In The Fiction Of Sinan Antoon, Zahraa Qasim Habeeb

Graduate Theses/Dissertations

The Iraqi war narrative reflects the traumatizing situation that omnipresence of war and three decades of oppression have caused to Iraqis' views of life. Writing about their traumatic experience is an essential way of giving voice to their wounds. The Iraqi American novelist Sinan Antoon is a "wounded storyteller" who is able to give words to the wounds of his homeland. His two novels, I'jaam: An Iraqi Rhapsody and The Corpse Washer, address the physical and psychological trauma of wars and prolonged years of oppression in Iraq. Academic research and literary production about the effect of trauma presented in the …

Book Review: Body Banking From The Bench To The Bedside, Natalie Ram

All Faculty Scholarship

How much is a kidney worth? An ounce of breast milk? Genetic material from an individual facing a Parkinson's diagnosis? In today's America, it depends on who is selling. One might think that such body products are beyond value or that their value depends on the individual characteristics of the supplier. But under existing American law and practices, what matters more is whether the seller is also the supplier of that body product, or whether the seller is another entity, such as a pharmaceutical company, hospital, or biobanker.

Sponge Logics | Rethinking Thresholds Through A Porous Mass, Tanvi Sanghvi

Architecture Senior Theses

This thesis contends that the separation and distinction between the envelope and the mass in contemporary architecture is to be resisted. Architect and theorist, Greg Lynn, argues that mass “is not only the outward shape of a building; it’s also the projection of shape, plan organization, spatial and sectional type, and façade”1.This critical reevaluation of the mass, and its relationship to the interior spaces and the building’s face, is particularly pertinent to the modern construction in Jaipur, Rajasthan, India. The character of the historicist and postmodern buildings that make up Jaipur is made solely based on the applied façade. This …

Releasing The Unconsciousness | Visualizing The City, Taihui Li

Architecture Senior Theses

This thesis explores how subway stations lost their identity as strategic node of connectivity which constructed the prevailing image of New York City. In Civilization and Its Discontents (1930), Sigmund Freud famously compared the human mind to the city of Rome. He argues that both contain strata of memory and history which have accumulated over the years through a messy and ad-hoc process. Like Rome, New York City also has a layered history, albeit not as deep.

This thesis contends that the subway entrance serves as an experiential entre into the unconscious experience of the unknown elements of the past. …

Efficiency Of Energy Utilization And Fecal Mineral Excretion In Holstein And Jersey Dairy Cows, Gabriel Garcia Gomez

Department of Animal Science: Dissertations, Theses, and Student Research

Eight multiparous Holstein and 8 Jersey dairy cows were used to complete energy balance trials designed to determine the effect of breed on the production and energy efficiency of milk, and energy partitioning. A repeated switchback design was used to compare the effect of cow breed. Diets consisted of 24.5% corn silage, 18.4% alfalfa hay, 6.9% grass hay, with either 22.9% rolled corn and 14.8% soybean meal (CON) or 8.95% rolled corn and 28.8% reduced fat distillers grains (RFDDGS) DM-basis. Diets were offered ad libitum for a 28 d adaptation period and 95% ad libitum for a 4 d collection …

Outsourcing The Law: History And The Disciplinary Limits Of Constitutional Reasoning, Helen Irving

Fordham Law Review

    Debates about the use of history in constitutional interpretation find their primary nourishment in the originalism debate. This has generated a vast amount of literature, but also narrowed the terms of the debate. Originalism is a normative commitment wrapped in a questionable methodological confidence. Regardless of the multiple forms originalism takes, originalists are confident that the meaning (in the sense of intention) that animated the framing of the Constitution can be ascertained and, indeed, that they can ascertain it. The debate has largely focused, then, on whether modern-day scholars and jurists can ascertain original historical meaning or, alternatively, whether they …

Christian Chicken Vs. Mainstream Media: A Case Study Analysis Of Chick-Fil-A’S Stance On Traditional Marriage Using Situational Crisis Communication Theory, Christiannn Mcnew

Masters Theses

A crisis can strike an organization at any moment and it is the responsibility of the organization to be prepared with a plan of action. This thesis will explore crisis management, using Timothy Coombs’ crisis management strategies, of Chick-fil-A and then COO Dan Cathy to see if those two parties implemented crisis strategies in a way that benefited the organization following Cathy’s statements in support of the biblical definition of family. Since many interpreted these comments as anti-gay sentiments from Chick-fil-A itself, crisis struck the organization Cathy represented. This thesis will also look at the idea of social activism in …

The Taphonomic Factors On Human Remains Inside Chullpas: Marcajirca, Peru, Samantha Lauren Lininger

Masters Theses

This study explored the taphonomic factors that contributed to the preservation of human skeletal remains inside ancient above-ground tomb in Marcajirca, Peru. This study incorporated one hundred and eighteen bones from three chullpas. Five taphonomic factors were examined: bone type, plant activity, root presence, weathering, and cultural factors. Surface layers inside each chullpa were analyzed using Geographic Information System (GIS) software. Chi-square tests were employed to investigate preservation and taphonomic factors. The results from the statistical tests indicated that there was a significant difference in the taphonomic factors on different bone types. Chullpa 6 was significant because it was unique …

An Integrated Framework For Cardiac Sounds Diagnosis, Zichun Tong

Masters Theses

The Phonocardiogram (PCG) signal contains valuable information about the cardiac condition and is a useful tool in recognizing dysfunction and heart failure. By analyzing the PCG, early detection and diagnosis of heart diseases can be accomplished since many pathological conditions of the cardiovascular system cause murmurs or abnormal heart sounds. This thesis presents an algorithm to classify normal and abnormal heart sound signals using PCG. The proposed analysis is based on a framework composed of several statistical signal analysis techniques such as wavelet based de-noising, energy-based segmentation, Hilbert-Huang transform based feature extraction, and Support Vector Machine based classification. The MATLAB …