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2015

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When Is It Mental?, Stuart Glennan Dec 2015

When Is It Mental?, Stuart Glennan

Scholarship and Professional Work - LAS

Most philosophical debate over mental causation has been concerned with reconciling commonsense intuitions that there are causal interactions between the mental and the physical with philosophical theories of the nature of the mental that seem to suggest otherwise. My concern is with a different and more practical problem. We often confront some cognitive, affective, or bodily phenomenon, and wonder about its source – its etiology or its underlying causal basis. For instance, you might wonder whether your queasiness due to something you ate, or whether it is just nervousness, or whether your aunt’s memory loss is a neurological problem or …

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Politics, Labor, And Rebellions Real And Imagined: Slaves, Free People Of Color, And Firearms In North Carolina, 1729-1865, Antwain K. Hunter Dec 2015

Politics, Labor, And Rebellions Real And Imagined: Slaves, Free People Of Color, And Firearms In North Carolina, 1729-1865, Antwain K. Hunter

Scholarship and Professional Work - LAS

For much of North Carolina’s history its General Assembly sought to strike a balance between the undeniable utility of black people’s armed labor and the threat that gun-toting black people were thought to pose. Masters equipped their slaves with firearms much like many other tools and many citizens turned to the Assembly to undertake measures to ensure that this armed labor did not compromise white people’s safety or property. The state’s legislature dictated the terms under which masters could arm their slaves and while some slaveholders defiantly used armed African-descended laborers as they wished most white people believed that armed …

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Cave Talk, December 2015, Robert A. Holt Dec 2015

Cave Talk, December 2015, Robert A. Holt

Cave Talk

Contents: 1965 - Celebrating our 50th Year - 2015 -- Member News -- Deep-Darkness Cave Exploring -- For Sale Crystal Cave, Springfield, Missouri -- Calendar of Events Adventure Opens -- NCA Buyers at the Tennessee Show -- International Association Amusement Parks & Attractions -- Rushmore Cave Brochure Wins International Award -- New Superintendent At Jewel Cave National Monument -- NCA Insurance Column - NCA Members’ Resource for Insurance Information, News, And Education -- Driver Safety – Winter Driving --

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How "Global" Are Global History Teachers? Secondary Social Studies Teachers' Understandings Of Global Awareness And Global Education, Ardyth L. Watson Dec 2015

How "Global" Are Global History Teachers? Secondary Social Studies Teachers' Understandings Of Global Awareness And Global Education, Ardyth L. Watson

Dissertations - ALL

Although global history has been a part of the discipline of social studies in New York State for a number of years, the inclusion of global education and skills has been less prevalent in the discipline. This lack of global perspectives in education has proven to be detrimental to the global awareness of American students. (Roper for National Geographic Foundation, 2006; Harvard University, 2004; Holm and Farber, 2002; Clarke, 2004). Global history teachers play a key role in the dissemination of global content that may contribute to increasing global awareness of students. Yet teachers, themselves, may have limited global awareness …

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Net N2 Fluxes In Muddy Sediments Of Great Peconic Bay: Rates, Pathways & Controls, Stuart Waugh Dec 2015

Net N2 Fluxes In Muddy Sediments Of Great Peconic Bay: Rates, Pathways & Controls, Stuart Waugh

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Abstract of the Dissertation NET N2 FLUXES IN MUDDY SEDIMENTS OF GREAT PECONIC BAY: RATES, PATHWAYS & CONTROLS by Stuart Waugh Doctor of Philosophy in Marine and Atmospheric Sciences Stony Brook University 2015 Depending on its form, nitrogen (N) can exert a dominant control on marine productivity and ecosystem structure. Multiple geochemical processes are involved in redox transformations of nitrogen (N) in marine sediments. In coastal benthic environments, a number of abiotic and biological environmental factors control the extent to which these processes are relevant and therefore the outcomes of sedimentary N transformations. This dissertation seeks to quantify rates of …

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Space Acquisition Strategies Of Zostera Marina, Bradley Thomas Furman Dec 2015

Space Acquisition Strategies Of Zostera Marina, Bradley Thomas Furman

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Seagrasses are a diverse group of clonal marine macrophytes. Their decline in recent decades has been an alarming component of estuarine urbanization, with large portions of historical coverage lost or degraded. Understanding patterns of dispersal and recruitment within and among the remaining populations is now critical to predicting the form and pace of recovery. Working in a developing eelgrass (Zostera marina) meadow in Shinnecock Bay, we combined field manipulations, genotypic surveys and correlative analyses to understand how vegetative growth and seedling recruitment contribute to space acquisition. First, we explored clonal foraging behavior and its effect on patch growth using subterranean …

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Net N2 Fluxes In Muddy Sediments Of Great Peconic Bay: Rates, Pathways & Controls, Stuart Waugh Dec 2015

Net N2 Fluxes In Muddy Sediments Of Great Peconic Bay: Rates, Pathways & Controls, Stuart Waugh

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Abstract of the Dissertation NET N2 FLUXES IN MUDDY SEDIMENTS OF GREAT PECONIC BAY: RATES, PATHWAYS & CONTROLS by Stuart Waugh Doctor of Philosophy in Marine and Atmospheric Sciences Stony Brook University 2015 Depending on its form, nitrogen (N) can exert a dominant control on marine productivity and ecosystem structure. Multiple geochemical processes are involved in redox transformations of nitrogen (N) in marine sediments. In coastal benthic environments, a number of abiotic and biological environmental factors control the extent to which these processes are relevant and therefore the outcomes of sedimentary N transformations. This dissertation seeks to quantify rates of …

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Space Acquisition Strategies Of Zostera Marina, Bradley Thomas Furman Dec 2015

Space Acquisition Strategies Of Zostera Marina, Bradley Thomas Furman

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Seagrasses are a diverse group of clonal marine macrophytes. Their decline in recent decades has been an alarming component of estuarine urbanization, with large portions of historical coverage lost or degraded. Understanding patterns of dispersal and recruitment within and among the remaining populations is now critical to predicting the form and pace of recovery. Working in a developing eelgrass (Zostera marina) meadow in Shinnecock Bay, we combined field manipulations, genotypic surveys and correlative analyses to understand how vegetative growth and seedling recruitment contribute to space acquisition. First, we explored clonal foraging behavior and its effect on patch growth using subterranean …

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Modeling Platelets On Parallel Computers, Seetha Malavika Pothapragada Dec 2015

Modeling Platelets On Parallel Computers, Seetha Malavika Pothapragada

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Mechanical Heart Valves (MHV) provides life-saving solutions to patients suffering from cardiovascular diseases. But these devices are often plagued by non-physiological flow patterns resulting in increased shear stress conditions. This leads to platelet damage, a precursor of thromboembolism, thus impeding the device usability and demanding lifelong anticoagulation treatments. While the flow and stresses are in the micron level, the platelet behavior is at the nm level, thus presenting a major computational challenge for simulating this multiscale multi-physics modeling problem. This dissertation focuses on using parallel computers to develop a computational framework based on n-particle simulations, defined by Coarse Grained Molecular …

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Antibacterial Block Copolymer Thin Films And Growth Characteristics Of Hela Cells, Prafulla Keskar Dec 2015

Antibacterial Block Copolymer Thin Films And Growth Characteristics Of Hela Cells, Prafulla Keskar

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The large number of devices used in medical applications have to be protected from microbial attacks as it leads to serious harm. Further, the current methods of tackling this problem involve using chemicals such as disinfectants which are harmful to us humans. This thesis aims to study the effectiveness of block copolymer thin films against microbes without using traditional harmful methods. We have attempted to prepare anti-bacterial thin films which can kill the bacteria using their surface morphology and thus eliminate the harm posed to us. In the second part of this thesis, we studied the growth characteristics of HeLa …

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Biotinylated Self-Assembled Micelles As Potential Vehicles For Targeted Anti-Cancer Drug Delivery, Weiyi Li Dec 2015

Biotinylated Self-Assembled Micelles As Potential Vehicles For Targeted Anti-Cancer Drug Delivery, Weiyi Li

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Chemotherapy is one of the most commonly used cancer treatments. However, many side effects could occur due to the non-specific bindings of extremely toxic anti-cancer drugs to healthy cells and organs. Targeted delivery has been developed to enhance the selectivity of drug delivery vehicle and minimize side effects of chemotherapy. In this study, the hydrophobically modified glycol chitosan (HGC) micelle was further modified with a biotin-avidin-biotin (B-A-B) strategy to improve the tumor-selective ability of HGC. Firstly, HGC was biotinylated either at the amine groups (NH2) or the hydroxyl groups (OH) on the chitosan main chain. Then the biotin-4-fluorescein, as a …

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Mutilated Bodies And Memories Of Violence: Displacements And Contestations Of Representations Of Violence, In Contemporary Video Art And Photography In Colombia, 1993-1998., Juan Carlos Guerrero Hernandez Dec 2015

Mutilated Bodies And Memories Of Violence: Displacements And Contestations Of Representations Of Violence, In Contemporary Video Art And Photography In Colombia, 1993-1998., Juan Carlos Guerrero Hernandez

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

How do contemporary artworks address and give visibility to the wounded body without reinvigorating trauma, without repeating the spectacular and homogenizing strategies used by the media? How do artworks move beyond denunciation to aesthetically and historically name and rearticulate bodily violence? And fundamentally, how do artworks offer an historical understanding of the political historicity of contemporary violence without uncritically resorting to myth and structural trauma? We intend to answer these questions within the context of art and violence in Colombia in 1990s. In this direction, we examine four artworks produced between 1993 and 1998, by artists Alberto Baraya, Clemencia Echeverri, …

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Designated Pages: Bradbury Thompson's Inspirations For Paper, Mi Seok Huh Dec 2015

Designated Pages: Bradbury Thompson's Inspirations For Paper, Mi Seok Huh

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

How do Bradbury Thompson’s designs in Westvaco Inspirations work as a guide for design and paper? Westvaco Inspirations was a promotional magazine first published in 1925 by the West Virginia Pulp and Paper Company. The main purpose of the magazine was to promote paper and to show an intricate relationship between print, paper and design. Bradbury Thompson was the designer for the magazine from 1939 to its final year of publication in 1962. This thesis shows how Thompson’s designs promoted the quality of each particular paper brand and its effectiveness in presenting a printed image. The thesis aims to show …

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The Role Of Pofut2 In Gastrulation And Axis Elongation Of The Mouse Embryo, Brian Benz Dec 2015

The Role Of Pofut2 In Gastrulation And Axis Elongation Of The Mouse Embryo, Brian Benz

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Protein O-fucosyltransferase 2 (POFUT2) elongates Thrombospondin Type 1 Repeats (TSR) with an O-linked fucose. Forty-nine potential proteins are modified by POFUT2 in the endoplasmic reticulum. Nearly half the POFUT2 targets belong to the A Disintegrin and Metalloprotease with ThromboSpondin type-1 motifs (ADAMTS) or ADAMTS-like family of proteins. One of POFUT2’s target proteins, ADAMTS9, contains 15 TSRs and is reported to be embryonic lethal around the same time as our Pofut2 LoxP mutants. In this study, we compared the Pofut2 and Adamts9 knockout phenotypes and used tissue specific deletion of Pofut2 to define the role of Pofut2 during gastrulation. Knockout of …

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Class Iii Phosphoinositide 3-Kinase Vps34 In Autophagy, Endocytosis, And Nutrient-Induced Signaling, Nadia Jaber Dec 2015

Class Iii Phosphoinositide 3-Kinase Vps34 In Autophagy, Endocytosis, And Nutrient-Induced Signaling, Nadia Jaber

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Vps34 is the sole member of the Class III phosphoinositide 3-kinases (PI3Ks) identified in mammals thus far. It phosphorylates phosphatidylinositol (PI) to generate PI(3)P on intracellular membranes. Previous work has suggested that Vps34 is important for the protein degradation pathways of autophagy and endocytosis, as well as nutrient-induced mTOR signaling. However, due to the pluripotent nature of available PI3K inhibitors, a clear understanding of the functions of mammalian Vps34 remains to be illustrated. To investigate the precise role of Vps34 in these processes, I have generated and characterized mice with conditional genetic ablation of Vps34. Mice with liver or heart-specific …

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The Pirna Pathway In The Somatic Stem Cells Of A Regeneration-Competent Flatworm, Macrostomum Lignano, Xin Zhou Dec 2015

The Pirna Pathway In The Somatic Stem Cells Of A Regeneration-Competent Flatworm, Macrostomum Lignano, Xin Zhou

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

piRNA pathway and its central components, PIWI proteins, are essential for transposon silencing and some aspects of gene regulation. Although they predominantly function in the animal germline, increasing evidence has pointed to their involvement in somatic cells. Some flatworms possess a unique somatic stem cell system named neoblasts. These totipotent cells are the only dividing cell population thus critical for postembryonic development, adult homeostasis and the remarkable regeneration ability. In the study led by Kaja A. Wasik and me, we identify and characterize piRNAs and PIWI proteins in the emerging regenerative flatworm model, Macrostomum lignano, combining targeted gene knockdown and …

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The Role Of The Scribble Protein Complex In The Regulation Of Dendrite Formation, Bingru Sun Dec 2015

The Role Of The Scribble Protein Complex In The Regulation Of Dendrite Formation, Bingru Sun

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

During neuronal development, the neuronal cell polarizes to specify the structures of axons and dendrites. This polarized architecture regulates the input/output functions of the neuronal cell. In my thesis, I studied the molecular mechanisms of dendrite formation. My main hypothesis was that dendrite specification results from local elevation of the cGMP signal. Soluble guanylyl cyclase (sGC) is the major enzyme for the synthesis of cGMP in the embryonic brain. I study the molecular mechanism that activates sGC and leads to dendrite specification during neuronal polarization.Scribble is a scaffold protein, part of a polarity complex that establish apical-basal polarity in epithelial …

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Three-Dimensional Macroporous All-Carbon Scaffolds For Tissue Engineering Applications, Gaurav Lalwani Dec 2015

Three-Dimensional Macroporous All-Carbon Scaffolds For Tissue Engineering Applications, Gaurav Lalwani

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Assembly of carbon nanomaterials into three-dimensional (3D) architectures is necessary to harness their unique physiochemical properties for tissue engineering and regenerative medicine applications. In this dissertation, fabrication and characterization of 3D chemically crosslinked macro-sized (5-8 mm height and 4-6 mm diameter) porous carbon nanotube (CNT) scaffolds, their in vitro cytocompatibility and interactions with human mesenchymal stem cells (hMSCs) are reported. Single- or multi-walled carbon nanotubes (SWCNTs or MWCNTs) scaffolds were fabricated using a novel radical initiated thermal crosslinking and annealing method using SWCNTs or MWCNTs as nanoscale building blocks. The scaffolds possess macroscale interconnected pores, robust structural integrity, stability, and …

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Comparison Of Sustained Cognitive Training Vs. Cardiovascular Exercise On Cognitive Decline And Pathology In A Vascular Model Of Alzheimer’S Disease | Comparison Of Sustained Cognitive Training Vs. Cardiovascular Exercise On Cognitive Decline And Pathology In A Vascular Model Of Alzheimer’S Disease, Maria Elizabeth Anderson Dec 2015

Comparison Of Sustained Cognitive Training Vs. Cardiovascular Exercise On Cognitive Decline And Pathology In A Vascular Model Of Alzheimer’S Disease | Comparison Of Sustained Cognitive Training Vs. Cardiovascular Exercise On Cognitive Decline And Pathology In A Vascular Model Of Alzheimer’S Disease, Maria Elizabeth Anderson

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Despite numerous advances in our understanding of the mechanisms that underlie Alzheimer’s disease (AD), there is still no cure, and the disease continues to pose a severe public health problem. It has become clear that many factors, including certain lifestyle practices, may contribute to the development of the disease; however, much remains to be learned about how lifestyle factors may prevent or delay cognitive decline. Unlike human epidemiological studies, murine models can provide clearer inferences about causality. The present studies focus on two lifestyle factors: cognitive enrichment and cardio-vascular exercise. Specifically, the effects of lifestyle interventions on behavioral performance and …

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Synthesis Of Carbon-11 Labeled Organic Molecules For Pet Studies, So Jeong Lee Dec 2015

Synthesis Of Carbon-11 Labeled Organic Molecules For Pet Studies, So Jeong Lee

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

PET has played a key role in the field of molecular imaging and nuclear medicine over the past decades. PET represents a non-invasive molecular imaging technique to study and visualize human physiology by detecting positron-emitting radiopharmaceuticals labeled with short half-live radioisotopes (i.e. | 11C, 13N, 15O, and 18F) that visualize in vivo biochemical processes and metabolic pathways (i.e. | glycolysis and protein/DNA synthesis). PET is also an emerging method for measuring body function and tailoring disease treatment in living human by detecting biochemical changes preceding anatomical changes occurring a disease. The capability of imaging quantitatively and with high sensitivity without …

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Topical Treatment Of Actinic Keratosis And Non-Melanoma Skin Cancer With Phospho-Sulindac And Difluoromethylornithine, Yajing Sun Dec 2015

Topical Treatment Of Actinic Keratosis And Non-Melanoma Skin Cancer With Phospho-Sulindac And Difluoromethylornithine, Yajing Sun

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Actinic keratosis (AK), a cutaneous lesion resulting from the proliferation of atypical epidermal keratinocytes, has an incidence of 11%-26% and its prevalence is 58 million in the US alone. AK is a precursor to non-melanoma skin cancer (NMSC). NMSC, consisting of squamous cell and basal cell carcinomas, represents the most frequent human cancer. Current treatment for AK and NMSC is often limited by low efficacy, side effects, high cost, and undesirable cosmetic outcomes. Thus new agents for the treatment of AK are urgently needed. In an effort to develop an efficacious, safe and patient-acceptable approach to both AK and NMSC, …

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Targeting The Enoyl-Acp Reductase In Mycobacterium Tuberculosis: Mechanism Of Time Dependent Inhibition And Cellular Consequence Of Target Engagement, Weixuan Yu Dec 2015

Targeting The Enoyl-Acp Reductase In Mycobacterium Tuberculosis: Mechanism Of Time Dependent Inhibition And Cellular Consequence Of Target Engagement, Weixuan Yu

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Tuberculosis (TB) infection is the single most lethal bacterial infections in the world. Isoniazid (INH), one of the most effective anti-TB drugs is usually administered to treat latent TB infection and is used in combination therapy to treat active TB. However resistance to INH is common and the emergence of multi-drug-resistant, extensively drug-resistant and now totally drug-resistant strains of TB, has resulted in an urgent need to develop novel anti-TB drugs. INH targets InhA, the enoyl-ACP reductase (FabI) from the Type II fatty acid biosynthesis pathway, and resistance to INH usually results from mutations in KatG, the enzyme that activates …

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Antecedents And Outcomes Associated With Altered Neuroendocrine Coupling In A Young Adolescent Sample, Sarah Rose Black Dec 2015

Antecedents And Outcomes Associated With Altered Neuroendocrine Coupling In A Young Adolescent Sample, Sarah Rose Black

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Previous research has identified puberty as a time of marked vulnerability to negative psychological outcomes, despite the fact that most individuals navigate this transition with little disturbance. The current study investigated neuroendocrine coupling, or the extent to which hormone reactivity is correlated, as a potential mechanism explaining the relationship between puberty and negative outcomes, as well as investigating early life stressors that may influence hormone coupling patterns. Cortisol, DHEA, and testosterone levels were collected from 394 9-year-old children as part of a larger longitudinal study investigating temperament and psychopathology; previously collected information about parenting styles, parental psychopathology, and parental marital …

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In Defense Of Magic: Using Fantasy Literature In The Classroom, Marisa Florence Cignarella Dec 2015

In Defense Of Magic: Using Fantasy Literature In The Classroom, Marisa Florence Cignarella

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

This thesis argues for the greater inclusion of fantasy literature in high school and middle school English classrooms. Through an analysis of the popularity of fantasy series, including recent movies and their widespread pop cultural appeal, this thesis illustrates that fantasy resonates with many readers. A close examination of various works of fantasy literature appropriate to be read in full or excerpted in the classroom demonstrates that fantasy usefully illustrates various literary concepts, such as symbolism, metaphor, allusion, allegory, and character foils; provides clear examples of the hero's journey, which appear in various canonical texts as well as other media; …

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Heroes In Patrick Mchale's Over The Garden Wall, Justine Nicole Wilson Dec 2015

Heroes In Patrick Mchale's Over The Garden Wall, Justine Nicole Wilson

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The presented Thesis asserts Patrick McHale’s Over the Garden Wall as a Modern Epic. It identifies the piece as Dantesque in its structure of a journey through an underworld, while noting that Dante is not the hero of his own epic. The argument is made that while Dante is too inactive in determining his fate to be given the title of epic Hero, McHale’s protagonists Wirt and Greg follow the structure of epic heroes, of the ancient tradition. The purpose of two protagonist on the same personal journey that is a spiritual odyssey, is maintained as a catalyst that allows …

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The Function Of Pqbp1, A Causative Gene For Renpenning Syndrome, During Early Neural Development In Xenopus, Jamina Oomen-Hajagos Dec 2015

The Function Of Pqbp1, A Causative Gene For Renpenning Syndrome, During Early Neural Development In Xenopus, Jamina Oomen-Hajagos

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The pqbp1 (polyglutamine tract-binding protein 1) gene has been associated with a number of developmental and neurodegenerative disorders, such as Huntington’s disease, spinocerebellar ataxia type 1, and a variety of X-linked intellectual disabilities grouped together under the umbrella term Renpenning Syndrome. Renpenning Syndrome is an X-linked recessive disorder involving intellectual disability, as well as physical features such as microcephaly, micropthalmia, lean build, short stature, and small testes. Work in the Thomsen Lab previously determined that a disruption in cellular levels of PQBP1 can impact crucial developmental processes such as gastrulation and neural tube closure. A reduction in PQBP1 levels was …

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Tgf-Β /Smad Signaling Through Dock4 Facilitates Lung Adenocarcinoma Metastasis, Jia-Ray Yu Dec 2015

Tgf-Β /Smad Signaling Through Dock4 Facilitates Lung Adenocarcinoma Metastasis, Jia-Ray Yu

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The mechanisms by which transforming growth factor beta (TGF-beta) promotes lung adenocarcinoma (ADC) metastasis are largely unknown. Here, we report that in lung ADC cells TGF-beta potently induces expression of dedicator of cytokinesis 4 (DOCK4), but not other DOCK-family members, via the Smad pathway, and that DOCK4 induction mediates TGF-beta's pro-metastatic effects by enhancing tumor cell extravasation. TGF-beta-induced DOCK4 stimulates lung ADC cell protrusion, motility, and invasion, without affecting epithelial-to-mesenchymal transition (EMT). These processes, which are fundamental to tumor cell extravasation, are driven by DOCK4-mediated Rac1 activation, unveiling a novel link between TGF-beta and Rac1. Thus, our findings uncover the …

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Community Belonging And Community Building: Women In Early Modern Granada, Nichole Suzanne Prescott Dec 2015

Community Belonging And Community Building: Women In Early Modern Granada, Nichole Suzanne Prescott

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

This dissertation addresses community belonging, community building, and community identity of women in the city of Granada during the early modern period, showing how women made use of their Granadan social context. It situates the women of Granada in the context of the economic and social turmoil throughout the early modern period, and in particular of the seventeenth century. Non-elite urban women in early modern Granada actively shaped the civic economy, culture, and religious life of the city and, in turn, their lives were shaped by the interplay of these elements. Women played indispensable commercial roles in the market economy, …

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Ecology Of Qpx Disease In The Hard Clam Mercenaria Mercenaria, Soren Dahl Dec 2015

Ecology Of Qpx Disease In The Hard Clam Mercenaria Mercenaria, Soren Dahl

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

There is increasing recognition of the role of suspension-feeding bivalves in providing important ecosystem services (e.g. | water clarity, benthic-pelagic coupling, and habitat structure) within estuarine systems. Mercenaria mercenaria (aka hard clams, quahogs) are frequently the dominant suspension-feeder in estuarine systems across the US east coast and have had significant commercial fishery importance and a steadily growing mariculture industry. M. mercenaria have generally not had disease problems which contrasts the microbial infections that have plagued oyster fisheries. Quahog Parasite Unknown (QPX) is the first substantial infectious microbial pathogen affecting hard clams across both wild populations and cultured stocks. QPX is …

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Primary Cilia Modulate Functionality Of Dentate Granule Cells In The Adult Brain, Soyoung Rhee Dec 2015

Primary Cilia Modulate Functionality Of Dentate Granule Cells In The Adult Brain, Soyoung Rhee

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Adult born neurons in the hippocampal dentate gyrus start to assemble primary cilia at 14 days after their birth. At 21 days, all newborn neurons show a typical primary cilium. Although this small microtubule-based structure has been shown to be important for early neuronal development, its physiological/behavioral roles remain elusive. Therefore, I set out to investigate both behavioral and physiological functions of primary cilia in immature and mature dentate granule cells (DGCs) of the adult brain. After selectively knocking out IFT20 to ablate primary cilia from mature DGCs, I found defects of hippocampal spatial and cognitive memory, suggesting a crucial …

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