Digital Commons Network^™

Mechanism Of Type Iii Secretion System-Triggered Killing Of Yersinia In Macrophages, Xiaoying Wang

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The mammalian immune system has the ability to discriminate between pathogens and innocuous microbes by detecting conserved molecular patterns. In addition to conserved microbial patterns, the mammalian immune system may recognize distinct pathogen-induced processes, the mechanism of which is poorly understood. Pathogenic Yersinia species utilize a type III secretion system (T3SS) to translocate various bacterial effectors into target cells, which aim to modify multiple host signaling pathways. Interestingly, previous studies have shown that the T3SS in Yersinia pseudotuberculosis leads to decreased survival of this bacterium in primary murine macrophages, the mechanism of which is unknown. Here, we use colony forming …

The Origin Of Contemporary Drug Contraband: A Global Interpretation From Sinaloa, Froylan Vladimir Enciso Higuera

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

This dissertation charts the longer history of contemporary drug contraband by focusing on the Pacific state of Sinaloa, the cradle of the Mexican drug trade. Historians working on drug trades in Latin America have now produced many accounts of the development of global drug commodity chains, and of the origins of drug prohibition regimes as well as smuggling and illicit flows. This dissertation is different in its attempt to trace the emergence of drug trafficking as a historically specific set of relationships emerging between states—above all, the United States and Mexico--and global markets, all mediated by shifting cultures of medical …

Food Waste And Sustainability: Quantifying Food Waste Disposal And Evaluating The Environmental Impacts Of Technologies And Policies, Krista Lee Thyberg

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

There has been growing interest in establishing food waste prevention and recovery programs throughout the United States. An interdisciplinary systems approach to sustainable food waste management was taken to explore three integrated food waste issues: 1. the quantity of residential, commercial and institutional food waste disposed in the U.S.; 2. the environmental impact of food waste treatment technologies; and, 3. approaches for sustainable waste system planning and the development of food waste management policies. The dissertation begins with a review of the history, contributing factors, impacts, and current practices regarding food waste in the U.S. and globally. The amount of …

On Using Risk-Benefit Analysis To Assess And Manage Controversial Research, Daniel Rozell

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Science research in the twenty-first century increasingly results in powerful and rapidly disseminated technologies that raise concerns over technological risk and public safety. A common recommendation for assessing and managing controversial research is to perform a quantitative risk-benefit analysis (RBA) in order to help determine an appropriate course of action. However, these recommendations lack guidelines on how to perform such an assessment. This dissertation lays out a detailed argument why a quantitative RBA should not be used as a basis for making complex policy decisions. Rather, RBA should be regarded as a tool for exploring the impacts of technology on …

Phylogenetic Systematics And Biogeography Of Lemurs From Madagascar, James Paul Herrera

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The evolutionary mechanisms influencing biodiversity include abiotic and biotic factors, such as climate change, vicariance, ecological adaptation, and competition. I investigated evolutionary mechanisms that may have influenced the diversity of lemurs from Madagascar by testing geographic and ecological hypotheses in a phylogenetic framework. I used total-evidence methods to infer the lemur phylogeny and divergence times of extant and extinct species. I then tested macroevolutionary hypotheses about lemur biogeography based on the phylogeny to shed new light on the causes of lemur diversification. I examined macroevolution and biogeography at four geographic scales: island-wide, regions, localities, and multiple transects within localities. I …

Comparative Morphology Of Primate Distal Phalanges: Implications For Early Primate Evolution And The Origins Of The Primate Nail, Stephanie A. Maiolino

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Human manual dexterity is strongly enhanced by the presence of flattened nails associated with well-developed apical pads. However, the presence of nails is not unique to humans; it is one of the few traits that unite all living primates. Further, the form of the keratinous structure (nail, claw, etc.) on the ends of primate digits is often considered to be a diagnostic trait of major primate clades; strepsirrhines (lemurs, lorises, and galagos) possess a grooming claw (a specialized nail or claw used to scratch and clean the fur around the head and neck) on each second pedal digit; tarsiers possess …

Bmp-2 Gene Delivery Using Electrospun Collagen/Plla Scaffold With Surface Adsorbed Transfection Complexes For Bone Formation, Xia Zhao

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Bone tissue engineering provides an alternative to bone grafting. Our laboratory previously developed two different types of electrospun scaffolds for bone tissue engineering, including a DNA containing PLGA/PELA scaffold for delivering genes and a collagen/PLLA scaffold for delivering cells. For this dissertation research, we firstly fabricated a DNA containing PLGA/PELA electrospun scaffold using the same method as previously developed, with the intent of delivering osteogenic growth factor genes for bone regeneration. However, the scaffold shrunk severely after being submerged into aqueous environment and failed to achieve high transfection efficiency in vitro. Subsequently, we used the collagen/PLLA scaffold (originally developed for …

Design, Synthesis, And Biological Evaluation Of Novel Taxoid-Based Small-Molecule Theranostic Pet/Spect Imaging Agents And Nano-Scale Asymmetric Bow-Tie Dendrimer Drug Conjugates Towards Tumor-Targeted Chemotherapy, Tao Wang

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Cancer remains the second leading cause of death in the United States. Traditional chemotherapy relies on highly potent cytotoxic agents, such as paclitaxel and docetaxel, to kill rapidly dividing cancer cells. But these drugs usually cause undesired side-effects due to lack of tumor-selectivity, and decreased efficacy against MDR cancer cell lines. Accordingly, newer generation taxoids were designed and evaluated showing several orders of magnitude greater potency than paclitaxel and docetaxel. Over the past decade, significant advancement has been made on the development of newer generation taxoids based on SAR study. As a selected example of second generation taxoid, SB-T-1214 was …

Brief For New Mexico Trial Lawyers Association, Montaño V. Frezza As Amicus Curiae, George Bach

Faculty Scholarship

This brief is on whether to extend sovereign immunity to out-of-state doctor in medical malpractice action.

Huntsman Alumni Magazine, Fall 2015, Usu Jon M. Huntsman School Of Business

Huntsman Business Magazine

Alumni magazine for the Jon M. Huntsman School of Business at Utah State University.

The Use Of Lasers For Direct Pulp Capping, Takashi Komabayashi, Arata Ebihara, Akira Aoki

Dental Medicine Faculty Publications

Direct pulp capping helps extend the life of a diseased tooth by maintaining tooth vitality. Nowadays, lasers are more frequently used during direct pulp capping in the clinic, but their use has not been previously reviewed. This review presents the basic properties of currently available lasers, scientific evidence on the effects of laser application on direct pulp capping, and future directions for this technology. An extensive literature search was conducted in various databases for articles published up to January 2015. Original in vitro, in vivo, and clinical studies, reviews, and book chapters published in English were included. Various laser systems …

Présence Francophone, Numéro 85 (2015)

Présence Francophone: Revue internationale de langue et de littérature

No abstract provided.

La Première Couche D’Encre, Abdourahman Waberi

Présence Francophone: Revue internationale de langue et de littérature

The author reexamines his engagement with the Rwandan genocide.

Du Témoin Et De L’Humain Chez Gilbert Gatore : Le Passé Devant Soi, Jean-Pierre Karegeye

Présence Francophone: Revue internationale de langue et de littérature

This article revisits Gatore’s novel, The past ahead, in analyzing the idea of witnessing. Some critics estimate that the novel does not make a clear distinction between the perpetrator and the victim. While recognizing the danger, the article extends the debate on the notion of the human beyond the categories of “perpetrator” and “victim”. Without excusing acts of the former, the author of this article affirms that the perpetrator and the victim belong to the same humanity. While they remain extreme and inexcusable, crime against humanity and genocides are not a contingent acts, which opens a meditation on the fragility …

La Bande Dessinée À L’Épreuve Du Génocide Au Rwanda : État Des Lieux Critique D’Un Mode D’Expression Original, Markus Arnold, Karel Plaiche

Présence Francophone: Revue internationale de langue et de littérature

20 years after the genocide of the Tutsis, one observes within the artistic production dealing with these traumatic events the presence of several comics (or bande dessinée). Yet is this specific mode of expression which often remains associated with lightness, humour and caricature capable to address in a credible fashion such delicate topics as pain, cruelty and death ? How do comics “translate” this 1994 tragedy for the purpose of critically raising awareness and providing memorial accounts while respecting the reader’s sensitivity ? Is there an “appropriate” depiction and where is the frontier between sensational, reliable and emotionally convincing portrayal …

Vision, Winter 2015 (2)

Vision

A newsletter published for Deaf Catholics in USA

VisionFinding Aid

Chadbourn Mill, Michael O. Lee, Robert Hayes, Brandon Yarusi, Lin "Kevin" Liu

Master of Real Estate Development

No abstract provided.

Estimating The Water Quality Condition Of River And Lake Water In The Midwestern United States From Its Spectral Characteristics, Jing Tan

Open Access Dissertations

This study focuses on developing/calibrating remote sensing algorithms for water quality retrieval in Midwestern rivers and lakes. In the first part of this study, the spectral measurements collected using a hand-held spectrometer as well as water quality observations for the Wabash River and its tributary the Tippecanoe River in Indiana were used to develop empirical models for the retrieval of chlorophyll (chl) and total suspended solids (TSS). A method for removing sky and sun glint from field spectra for turbid inland waters was developed and tested. Empirical models were then developed using a subset of the field measurements with the …

Nicholas Of Lyra, Literal Commentary On Galatians, Edward Arthur Naumann

TEAMS Commentary Series

Though little-known today, Nicholas of Lyra's commentaries are arguably among the most widely-read and influential commentaries of all time. For more than two hundred years, from the time of their composition, well into the Reformation era, they were copied and recopied, printed and reprinted, as an indispensable guide to the meaning of scripture. Naumann presents here a complete translation of Lyra's literal commentary on Galatians in English for the first time, with a freshly-edited Latin text, and provides ample notes on its significance in relation to the works of previous authors.

December Agenda, Wku Graduate Council

Graduate School

Meeting agenda.

Oral History Project/ Robert Leslie Smith, Joe S. Mixon

Korean War

This is simply an interview of a Korean War veteran by his grandson. It includes stories of times before, during, and after the war. Robert L. Smith, the veteran interviewed for this piece, gives valuable information for the public on Korea and the United States military during the years of the Korean War. Veterans are becoming increasingly scarce as age takes them away. However, thanks to interviews like this, we can preserve their legacy.

Entrepreneurship, Creativity, And Local Food Systems: Essays On Regional Economic Development In South Carolina, Kristen Lientz

All Dissertations

Within the existing economic development literature, there is a well-established linkage between the presence of skilled human capital and economic growth. A subset of this literature has focused on the role that a specific type of skilled human capital, known as the “creative class,” may play in facilitating regional economic development. This dissertation builds upon the existing creative class literature by examining the factors that have attracted the creative class to the state of South Carolina. In addition, this research gives special attention to the entrepreneurial activities of creative class professionals who engage in small-scale farming. Recent interest surrounding the …

The History Of The Guitar, Júlio Ribeiro Alves

Music Faculty Research

Conceived as instructional material for the guitar students at Marshall University (or anyone interested in the subject), it presents the historical process of the guitar in a clear and attainable fashion. Several topics related to the guitar will be discussed in detail throughout the book: the postulates associated with its origins, its evolution through the centuries, its repertoire, composers, performers, techniques, etc., culminating with the achievement of the privileged status of a respected concert instrument which it currently possesses.

Fort St. Joseph Archaeological Project Annual Report, 2015, Michael S. Nassaney

Fort St. Joseph Archaeological Project

This year the Fort St. Joseph Archaeological Project (hereafter the “Project”) established new standards in research, teaching, and public outreach in the study of the fur trade and colonialism in southwest Michigan. The Project continues to collaborate in the generation and dissemination of knowledge under the auspices of the Fort St. Joseph Archaeology Advisory Committee (FSJAAC), Western Michigan University (WMU) faculty and students, interested stakeholders, supporters, members, and community volunteers. Highlights of 2015 include:

• Fort St. Joseph was featured in the exhibit “Evidence Found” at the Kalamazoo Valley Museum in 2015, enjoyed by some 60,000 visitors.
• The Register of Professional …

Creating Tomorrow, Fall 2015, College Of Engineering

College of Engineering Magazines

Annual magazine for the College of Engineering at Utah State University.

Adverse Effects Of Perinatal Nicotine Exposure On Reproductive Outcomes, Michael K. Wong, Nicole G. Barra, Nadia Alfaidy, Daniel B. Hardy, Alison C. Holloway

Paediatrics Publications

Nicotine exposure during pregnancy through cigarette smoking, nicotine replacement therapies or e-cigarette use continues to be a widespread public health problem, impacting both fetal and postnatal health. Yet, at this time, there remains limited data regarding the safety and efficacy in using these nicotine products during pregnancy. Notably, reports assessing the effect of nicotine exposure on postnatal health outcomes in humans, including reproductive health, are severely lacking. Our current understanding regarding the consequences of nicotine exposure during pregnancy is limited to a few animal studies, which do not comprehensively address the underlying cellular mechanisms involved. This paper aims to critically …

Linking Energetics And Overwintering In Temperate Insects., Brent J Sinclair

Biology Publications

Overwintering insects cannot feed, and energy they take into winter must therefore fuel energy demands during autumn, overwintering, warm periods prior to resumption of development in spring, and subsequent activity. Insects primarily consume lipids during winter, but may also use carbohydrate and proteins as fuel. Because they are ectotherms, the metabolic rate of insects is temperature-dependent, and the curvilinear nature of the metabolic rate-temperature relationship means that warm temperatures are disproportionately important to overwinter energy use. This energy use may be reduced physiologically, by reducing the slope or elevation of the metabolic rate-temperature relationship, or because of threshold changes, such …

Review: City Choreographer: Lawrence Halprin In Urban Renewal America, Anthony Raynsford

Faculty Publications

No abstract provided.

Redwood Highway/Save The Redwoods Movement, Susie Van Kirk

Susie Van Kirk Papers

Susie Van Kirks research notes for the State Parks project. Resources includes books, web pages, newspaper references from various periodicals (1910-1970), timelines and more.

Reporter - December 2015, Rit Reporter Staff

University Publications

No abstract provided.