Digital Commons Network^™

Telemetric Blood Pressure Assessment In Angiotensin Ii-Infused Apoe-/- Mice: 28 Day Natural History And Comparison To Tail-Cuff Measurements, Christopher M. Haggerty, Andrea C. Mattingly, Ming C. Gong, Wen Su, Alan Daugherty, Brandon K. Fornwalt

Saha Cardiovascular Research Center Faculty Publications

Abdominal aortic aneurysm (AAA) is a disease of the aortic wall, which can progress to catastrophic rupture. Assessment of mechanical characteristics of AAA, such as aortic distensibility, may provide important insights to help identify at-risk patients and understand disease progression. While the majority of studies on this topic have focused on retrospective patient data, recent studies have used mouse models of AAA to prospectively evaluate the evolution of aortic mechanics. Quantification of aortic distensibility requires accurate measurement of arterial blood pressure, particularly pulse pressure, which is challenging to perform accurately in murine models. We hypothesized that volume/pressure tail-cuff measurements of …

Antibacterial Characterization Of Novel Synthetic Thiazole Compounds Against Methicillin-Resistant Staphylococcus Pseudintermedius, Haroon Mohammad, P.V. N. Reddy, Dennis Monteleone, Abdelrahman S. Mayhoub, Mark S. Cushman, G. Kenitra Hammac, Mohamed N. Seleem

Department of Comparative Pathobiology Faculty Publications

Staphylococcus pseudintermedius is a commensal organism of companion animals that is a significant source of opportunistic infections in dogs. With the emergence of clinical isolates of S. pseudintermedius (chiefly methicillin-resistant S. pseudintermedius (MRSP)) exhibiting increased resistance to nearly all antibiotic classes, new antimicrobials and therapeutic strategies are urgently needed. Thiazole compounds have been previously shown to possess potent antibacterial activity against multidrug-resistant strains of Staphylococcus aureus of human and animal concern. Given the genetic similarity between S. aureus and S. pseudintermedius, this study explores the potential use of thiazole compounds as novel antibacterial agents against methicillin-sensitive S. pseudintermedius (MSSP) and …

A System Dynamics Approach To The Efficacy Of Oxime Therapy In Sub Lethal Exposure To Sarin Gas, Daniel J. Droste

Theses and Dissertations

The 2010 National Security Strategy states, The effective dissemination of a lethal agent would endanger the lives of thousands of people and have unprecedented economic, societal, and political consequences. We must continue to work at home with first responders and health officials to reduce the risk associated with high-consequence threats . Nerve agents, such as Sarin gas, are considered high consequence threats. The threat of use of agents such as Sarin is as much a threat today as any other time in our history. However, the suggested treatment protocol is not as precise as it could be. Debate exists over …

The Murray Ledger And Times, June 18, 2015, The Murray Ledger And Times

The Murray Ledger & Times

No abstract provided.

Relationship Of Phenotypic Variation And Genetic Admixture In The Saltmarsh–Nelson's Sparrow Hybrid Zone, Jennifer Walsh, W. Gregory Shriver, Brian J. Olsen, Kathleen M. O'Brien, Adrienne I. Kovach

New Hampshire Agricultural Experiment Station Publications

Hybridization is influential in shaping species' dynamics and has many evolutionary and conservation implications. Identification of hybrid individuals typically relies on morphological data, but the assumption that hybrids express intermediate traits is not always valid, because of complex patterns of introgression and selection. We characterized phenotypic and genotypic variation across a hybrid zone between 2 tidal-marsh birds, the Saltmarsh Sparrow (Ammodramus caudacutus) and Nelson's Sparrow (A. nelsoni) (n = 290), and we sought to identify morphological traits that could be used to classify admixed individuals. Sparrows were sampled from a total of 34 marshes, including 23 sympatric and 11 putatively …

Structure-Based Redesign Of Lysostaphin Yields Potent Antistaphylococcal Enzymes That Evade Immune Cell Surveillance, Kristina Blazanovic, Hongliang Zhao, Yoonjoo Choi, Wen Li, Regina S. Salvat, Daniel C. Osipovitch, Jennifer Fields, Leonard Moise, Brett L. Berwin, Steven N. Fiering, Chris Bailey-Kellogg, Karl E. Griswold

Institute for Immunology and Informatics Faculty Publications

Staphylococcus aureus infections exert a tremendous burden on the health-care system, and the threat of drug-resistant strains continues to grow. The bacteriolytic enzyme lysostaphin is a potent antistaphylococcal agent with proven efficacy against both drug-sensitive and drug-resistant strains; however, the enzyme’s own bacterial origins cause undesirable immunogenicity and pose a barrier to clinical translation. Here, we deimmunized lysostaphin using a computationally guided process that optimizes sets of mutations to delete immunogenic T cell epitopes without disrupting protein function. In vitro analyses showed the methods to be both efficient and effective, producing seven different deimmunized designs exhibiting high function and reduced …

Encounters With Dead Pets: A Study Of The Evolution Of Grief, Harold Herzog

'Animals and Us' Blog Posts

False recognitions of dead dogs and cats are common among grieving pet owners.

2015-06-17-New Species Nicknamed ‘Old Stinky’ Found At Gray Fossil Site, University Marketing And Communications, East Tennessee State University

Accent [newsletter]

No abstract provided.

Black History Month: An Investigation Of The Impact Of A Curriculum For Increasing The Knowledge Of Elementary Students' Knowledge Of African-American History, Monique Goodwin

Theses and Dissertations

The significance of this current study was to show the importance of Black History being added to the curriculum for elementary students of all ethnicities, but especially with the African-American children. During this study the students were given a pre- and post-test on the Civil Rights Movement for the month of February. The study consisted of 40 students from an upper elementary school located in southern New Jersey. Of the participants 26 were female and 14 were male; there are 4 special needs students and 2 in a reading program called Read 180. All were in the 6th grade with …

Emu Mcnair Scholars Program 2014-2015 Newsletter, Mcnair Scholars Program

EMU McNair Challenger

No abstract provided.

Making The Invisible Challenges And Opportunities Visible, Maureen A. Scully, Lisa Deangelis, Katie Bates

Emerging Leaders Program Team Projects

The 41 fellows in the 2015 Emerging Leaders Program worked with community partners to generate the theme, “Making the Invisible Challenges and Opportunities Visible: Collaborative leadership for economic and social well-being."

The projects provide fellows an opportunity to practice elements of collaborative leadership in peer-led teams working with multiple stakeholders. The projects focus on civic engagement, building a leadership base for Greater Boston that is ready to tackle the big challenges that ensure the broader economic and social well-being of the region. The project sponsor with whom each team works is a nonprofit or governmental organization with big goals. Each …

Living On The Edge: Settlement Patterns By The Symbiotic Barnacle Xenobalanus Globicipitis On Small Cetaceans, Juan M. Carillo, Robin M. Overstreet, Juan A. Raga, Francisco J. Aznar

Faculty Publications

The highly specialized coronulid barnacle Xenobalanus globicipitis attaches exclusively on cetaceans worldwide, but little is known about the factors that drive the microhabitat patterns on its hosts. We investigate this issue based on data on occurrence, abundance, distribution, orientation, and size of X. globicipitis collected from 242 striped dolphins (Stenella coeruleoalba) that were stranded along the Mediterranean coast of Spain. Barnacles exclusively infested the fins, particularly along the trailing edge. Occurrence, abundance, and density of X. globicipitis were significantly higher, and barnacles were significantly larger, on the caudal fin than on the flippers and dorsal fin. …

The Alestle - Vol. 67 No. 42 - 06/17/2015, Southern Illinois University Edwardsville

The Alestle

Vol. 67 No. 42

Neuron-Based Heredity And Human Evolution, Don M. Gash, Andrew S. Deane

Neuroscience Faculty Publications

It is widely recognized that human evolution has been driven by two systems of heredity: one DNA-based and the other based on the transmission of behaviorally acquired information via nervous system functions. The genetic system is ancient, going back to the appearance of life on Earth. It is responsible for the evolutionary processes described by Darwin. By comparison, the nervous system is relatively newly minted and in its highest form, responsible for ideation and mind-to-mind transmission of information. Here the informational capabilities and functions of the two systems are compared. While employing quite different mechanisms for encoding, storing and transmission …

Space Environmental Factor Impacts Upon Murine Colon Microbiota And Mucosal Homeostasis, Lauren E. Ritchie, Stella S. Taddeo, Brad R. Weeks, Florence Lima, Susan A. Bloomfield, M. Andrea Azcarate-Peril, Sara R. Zwart, Scott M. Smith, Nancy D. Turner

Internal Medicine Faculty Publications

Astronaut intestinal health may be impacted by microgravity, radiation, and diet. The aim of this study was to characterize how high and low linear energy transfer (LET) radiation, microgravity, and elevated dietary iron affect colon microbiota (determined by 16S rDNA pyrosequencing) and colon function. Three independent experiments were conducted to achieve these goals: 1) fractionated low LET γ radiation (¹³⁷Cs, 3 Gy, RAD), high Fe diet (IRON) (650 mg/kg diet), and a combination of low LET γ radiation and high Fe diet (IRON+RAD) in male Sprague-Dawley rats; 2) high LET ³⁸Si particle exposure (0.050 Gy), 1/6 G …

Penghou, A New Genus Of Flea Beetles From China (Coleoptera: Chrysomelidae: Galerucinae: Alticini), Yong-Ying Ruan, Alexander S. Konstantinov, Kaniyarikkal Divakaran Prathapan, Si-Qin Ge, Xing‐Ke Yang

United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications

A new genus (Penghou) with a single new species (P. yulongshan) from Yunnan Province in China is described and illus- trated. It is compared to Hespera Weise, Hesperomorpha Ogloblin, Laotzeus Chen, Luperomorpha Weise, Mandarella Duvivier, Omeiana Chen, Stenoluperus Ogloblin and Taiwanohespera Kimoto.

Prokaryotic Diversity In The Rhizosphere Of Organic, Intensive, And Transitional Coffee Farms In Brazil, Adam Caldwell, Livia Silva, Cynthia Da Silva, Cleber Ouverney

Faculty Publications, Biological Sciences

Despite a continuous rise in consumption of coffee over the past 60 years and recent studies showing positive benefits linked to human health, intensive coffee farming practices have been associated with environmental damage, risks to human health, and reductions in biodiversity. In contrast, organic farming has become an increasingly popular alternative, with both environmental and health benefits. This study aimed to characterize and determine the differences in the prokaryotic soil microbiology of three Brazilian coffee farms: one practicing intensive farming, one practicing organic farming, and one undergoing a transition from intensive to organic practices. Soil samples were collected from 20 …

Good Liars Are Neither ‘Dark’ Nor Self-Deceptive, Gordon R.T. Wright, Christopher J. Berry, Caroline Catmur, Geoffrey Bird

School of Psychology

No abstract provided.

Middle East Respiratory Syndrome: A Global Health Challenge, Lawrence O. Gostin, Daniel Lucey

Georgetown Law Faculty Publications and Other Works

Beginning in May 2015, Middle-East respiratory syndrome (MERS) experienced its first publicly reported “super-spreading” event in South Korea. By mid-June, more than 120 cases and 11 deaths in South Korea had been linked to a businessman returning from travel to Bahrain, United Arab Emirates, the Kingdom of Saudi Arabia and Qatar. Globally more than 1200 had been infected of whom more than 450 died—a high fatality rate of 37%.

What are the most effective legal, social, and public health responses to MERS and other emerging diseases? First, the World Health Organization’s International Health Regulations (IHR) did not effectively guide the …

Representing Life In The Earth System With Soil Microbial Functional Traits In The Mimics Model, William R. Wieder, A. Stuart Grandy, Cynthia M. Kallenbach, P. G. Taylor, G. B. Bonan

Faculty Publications

Projecting biogeochemical responses to global environmental change requires multi-scaled perspectives that consider organismal diversity, ecosystem processes, and global fluxes. However, microbes, the drivers of soil organic matter decomposition and stabilization, remain notably absent from models used to project carbon (C) cycle–climate feedbacks. We used a microbial trait-based soil C model with two physiologically distinct microbial communities, and evaluate how this model represents soil C storage and response to perturbations. Drawing from the application of functional traits used to model other ecosystems, we incorporate copiotrophic and oligotrophic microbial functional groups in the MIcrobial-MIneral Carbon Stabilization (MIMICS) model; these functional groups are …

S-Nitrosoglutathione Reductase-Dependent Ppargamma Denitrosylation Participates In Msc-Derived Adipogenesis And Osteogenesis, Yenong Cao

Open Access Dissertations

Osteogenesis and adipogenesis are two closely linked processes that share the same precursor, bone marrow mesenchymal stem cells (MSCs). MSCs are a rare population of non-hematopoietic stromal cells, present in bone marrow and almost every type of connective tissue. It is crucial to understand the signals that govern the specificity of MSC differentiation. Adipogenic transcription factor PPARγ can stimulate adipogenesis while inhibit osteogenesis. However, the role of potential regulators of PPARγ activity in this differentiation shift remains unknown. One potential regulator is nitric oxide (NO). NO enhances adipogenesis of human preadipocytes while decreasing cell proliferation. Studies in mice with a …

Migrating Songbirds On Stopover Prepare For, And Recover From, Oxidative Challenges Posed By Long-Distance Flight, Megan M. Skrip, Ulf Bauchinger, Wolfgang Goymann, Leonida Fusani, Massimiliano Cardinale, Rebecca R. Alan, Scott R. Mcwilliams

Natural Resources Science Faculty Publications

Managing oxidative stress is an important physiological function for all aerobic organisms, particularly during periods of prolonged high metabolic activity, such as long-distance migration across ecological barriers. However, no previous study has investigated the oxidative status of birds at different stages of migration and whether that oxidative status depends on the condition of the birds. In this study, we compared (1) energy stores and circulating oxidative status measures in (a) two species of Neotropical migrants with differing migration strategies that were sampled at an autumn stopover site before an ecological barrier; and (b) a species of trans-Saharan migrant sampled at …

Trust In Science And Scientists And The Acceptance Of Evolution, Louis S. Nadelson, Kimberly K. Hardy

Psychological Sciences Faculty Publications and Presentations

Background: Accepting the concept of evolution is important for the advancement of biological science and has many implications for daily life. However, a large portion of the general public does not currently accept biological evolution. Therefore, it is important to understand what factors are associated with a decline in the acceptance of evolution. Of particular interest for us is the relationship of individuals’ sense of trust in science in relationship to evolution acceptance.

Methods: Using the Trust in Science and Scientists and Inventory of Student Evolution Acceptance we surveyed 159 undergraduate students enrolled in an introductory psychology course. Additionally, we …

Bbc, Usfsp Professor Collaborate On Documentary, June 16, 2015, University Of South Florida St. Petersburg Office Of University Advancement.

USF St. Petersburg Campus News and Press Releases

No abstract provided.

Tissue Specific Reactions To Positional Discontinuities In The Regenerating Axolotl Limb, Malcolm Maden, Daima Avila, Molly Roy, Ashley W. Seifert

Biology Faculty Publications

We investigated cellular contributions to intercalary regenerates and 180^o supernumerary limbs during axolotl limb regeneration using the cell autonomous green fluorescent protein marker and exchanged blastemas between white and green fluorescent protein animals. After distal blastemas were grafted to proximal levels tissues of the intercalary regenerate behaved independently with regard to the law of distal transformation; graft epidermis was replaced by stump epidermis, muscle-derived cells, blood vessels, and Schwann cells of the distal blastema moved proximally to the stylopodium and cartilage and dermal cells conformed to the law. After 180^o rotation, blastemas showed contributions from stump tissues which …

Acute Lung Injury Results From Innate Sensing Of Viruses By An Er Stress Pathway, Eike R. Hrincius, Swantje Liedmann, David Finkelstein, Peter Vogel, Shane Gansebom, Amali E. Samarasinghe, Dahui You, Stephania A. Cormier, Jonathan A. Mccullers

Faculty Publications

© 2015 The Authors. Incursions of new pathogenic viruses into humans from animal reservoirs are occurring with alarming frequency. The molecular underpinnings of immune recognition, host responses, and pathogenesis in this setting are poorly understood. We studied pandemic influenza viruses to determine the mechanism by which increasing glycosylation during evolution of surface proteins facilitates diminished pathogenicity in adapted viruses. ER stress during infection with poorly glycosylated pandemic strains activated the unfolded protein response, leading to inflammation, acute lung injury, and mortality. Seasonal strains or viruses engineered to mimic adapted viruses displaying excess glycans on the hemagglutinin did not cause ER …

Nanoparticle-Mediated Methods For Antimicrobial Susceptibility Testing Of Bacteria, J. Manuel Perez Figueroa, Charalambos Kaittanis, Sudip Nath

UCF Patents

A method of testing bacterial cells for antimicrobial susceptibility includes preparing a suspension of the bacterial cells in a non-nutrient medium, mixing with the suspension an antimicrobial, a carbohydrate usable by the bacterial cells, metallic nanoparticles, and a lectin, and incubating the mixture while monitoring a parameter of the nanoparticles responsive to use of the carbohydrate by the bacterial cells. More broadly stated, the invention includes a method of testing an agent for its effect on cell metabolism by preparing a suspension of cells in a non-nutrient medium, mixing the suspension with the agent, adding a carbohydrate usable by the …

Effects Of Sucroferric Oxyhydroxide Compared To Lanthanum Carbonate And Sevelamer Carbonate On Phosphate Homeostasis And Vascular Calcifications In A Rat Model Of Chronic Kidney Failure, Olivier Phan, Marc Maillard, Hartmut H. Malluche, Jean-Christophe Stehle, Felix Funk, Michel Burnier

Internal Medicine Faculty Publications

Elevated serum phosphorus, calcium, and fibroblast growth factor 23 (FGF23) levels are associated with cardiovascular disease in chronic renal disease. This study evaluated the effects of sucroferric oxyhydroxide (PA21), a new iron-based phosphate binder, versus lanthanum carbonate (La) and sevelamer carbonate (Se), on serum FGF23, phosphorus, calcium, and intact parathyroid hormone (iPTH) concentrations, and the development of vascular calcification in adenine-induced chronic renal failure (CRF) rats. After induction of CRF, renal function was significantly impaired in all groups: uremic rats developed severe hyperphosphatemia, and serum iPTH increased significantly. All uremic rats (except controls) then received phosphate binders for 4 weeks. …

When Nanoparticles Meet Biofilms—Interactions Guiding The Environmental Fate And Accumulation Of Nanoparticles, Kaoru Ikuma, Alan W. Decho, Boris T. Lau

Faculty Publications

Bacteria are essential components of all natural and many engineered systems. The most active fractions of bacteria are now recognized to occur as biofilms, where cells are attached and surrounded by a secreted matrix of “sticky” extracellular polymeric substances. Recent investigations have established that significant accumulation of nanoparticles (NPs) occurs in aquatic biofilms. These studies point to the emerging roles of biofilms for influencing partitioning and possibly transformations of NPs in both natural and engineered systems. While attached biofilms are efficient “sponges” for NPs, efforts to elucidate the fundamental mechanisms guiding interactions between NPs and biofilms have just begun. In …

Low Level Lead Exposure Impairs Attentional Set Shifting Task Performance Depending Upon Sex And Developmental Periods Of Exposure, L.S. Neuwirth, D.W. Anderson, J. S. Schneider

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Introduction

Exposure to low levels of lead (Pb) impairs a variety of cognitive processes. Although children exposed to Pb developmentally present with a variety of cognitive impairments that include deficits in learning, memory, language, and executive functioning, experimental work on Pb toxicity in rats has focused mostly on learning and memory deficits and less on executive functions. However, detrimental effects on executive functioning could lead to or even underlie a variety of other cognitive problems attributed to Pb exposure. In this study, we examined the ability of Long Evans rats (control and Pb-exposed: 150ppm Pb-acetate in food given perinatally (gestation …