Digital Commons Network^™

Thyroid Autoimmunity As A Window To Autoimmunity: An Explanation For Sex Differences In The Prevalence Of Thyroid Autoimmunity, Stephen Merrill, Ying Mu

Mathematics, Statistics and Computer Science Faculty Research and Publications

Autoimmune thyroid diseases (AITDs), predominately Graves׳ disease and Hashimoto׳s thyroiditis, comprise the most common autoimmune diseases in humans. Both have the production of anti-thyroid antibody as an important aspect and both are much more prevalent in females, being at least 10 times more common than in males. Using these two clues, a hypothesis for the initiation of thyroid autoimmunity is proposed that helps to make the case that the thyroid is one of the most sensitive sites for autoimmunity and helps account for the prevalence and the observed sex differences in AITDs and associated diseases, such as type 1 diabetes …

Serials Solutions Click-Through Statistics By Provider And Database 2014-2015, Andree Rathemacher

Technical Services Reports and Statistics

Statistics on the total number of database and journal-level clicks, by provider and database, of Serials Solutions tools at the University of Rhode Island Libraries by month for 2014-2015. Clicks may have originated from the A-Z full text electronic journal list (at http://zu4tq4pb5v.search.serialssolutions.com/), from OpenURL links ("360 Link"), or the 856 fields of Serials Solutions-generated MARC records ("360 MARC Updates").

Serials Solutions Subject Search Report 2014-2015, Andree Rathemacher

Technical Services Reports and Statistics

Statistics on the total number of Serials Solutions subject searches at the University of Rhode Island Libraries by month for 2014-2015. Shows how many times the A-Z full text electronic journal list (at http://zu4tq4pb5v.search.serialssolutions.com/) was browsed by specific subjects.

Serials Solutions Click-Through Statistics By Journal Title And Issn 2014-2015, Andree Rathemacher

Technical Services Reports and Statistics

Statistics on the total number of journal-level clicks, by journal title (on all platforms), of Serials Solutions tools at the University of Rhode Island Libraries by month for 2014-2015. Clicks may have originated from the A-Z full text electronic journal list (at http://zu4tq4pb5v.search.serialssolutions.com/), from OpenURL links ("360 Link"), or the 856 fields of Serials Solutions-generated MARC records ("360 MARC Updates").

The “Stratospheric Cricket Keeper” – Developing A Simple“Life-Support” Payload For High-Altitude Balloon Missions, Lucas Kramer, Chad Serba, James Flaten

2017 Academic High Altitude Conference

Exposure to the environmental conditions of “near-space” (AKA the stratosphere) is quickly fatal to nearly all forms of animal life. It is even challenging to build a sealable enclosure that can keep insects (crickets) alive through the dramatic and simultaneous pressure and temperature drops experienced during a high-altitude balloon mission. This poster describes the development of a rugged “cricket keeper” in which we were able to fly crickets to the stratosphere and, quoting the words of JFK, “return (them) safely to the earth!” This “life-support” payload had large windows (for the view!) and included Arduino-logged temperature and pressure sensors, an …

June 20, 2015 (Pages 3193-3300), Pennsylvania Legislative Reference Bureau

Volume 45 (2015)

No abstract provided.

Rna Nanoparticle As A Vector For Targeted Sirna Delivery Into Glioblastoma Mouse Model, Tae Jin Lee, Farzin Haque, Dan Shu, Ji Young Yoo, Hui Li, Robert A. Yokel, Craig Horbinski, Tae Hyong Kim, Sung-Hak Kim, Chang-Hyuk Kwon, Ichiro Nakano, Balveen Kaur, Peixuan Guo, Carlo M. Croce

Pharmaceutical Sciences Faculty Publications

Systemic siRNA administration to target and treat glioblastoma, one of the most deadly cancers, requires robust and efficient delivery platform without immunogenicity. Here we report newly emerged multivalent naked RNA nanoparticle (RNP) based on pRNA 3-way-junction (3WJ) from bacteriophage phi29 to target glioblastoma cells with folate (FA) ligand and deliver siRNA for gene silencing. Systemically injected FA-pRNA-3WJ RNPs successfully targeted and delivered siRNA into brain tumor cells in mice, and efficiently reduced luciferase reporter gene expression (4-fold lower than control). The FA-pRNA-3WJ RNP also can target human patient-derived glioblastoma stem cells, thought to be responsible for tumor initiation and deadly …

In Vitro And In Vivo Evaluation Of Infestation Deterrents Against Lice, Kyong-Sup Yoon, Jennifer K. Ketzis, Samuel W. Andrewes, Christopher S. Wu, Kris Honraet, Dorien Staljanssens, Bart Rossel, J Marshall Clark

SIUE Faculty Research, Scholarship, and Creative Activity

The human head louse is a cosmopolitan ectoparasite and frequently infests many people, particularly school-age children. Due to widespread pyrethroid resistance and the lack of efficient resistance management, there has been a considerable interest in the protection of uninfested people and prevention of reinfestation by disrupting lice transfer. In this study, two nonclinical model systems (in vitro and in vivo) were used to determine the efficacy of the infestation deterrents, Elimax lotion and Elimax shampoo, against human head lice or poultry chewing lice, respectively. With in vitro assessments, female head lice exhibited significantly higher avoidance responses to hair tufts treated …

Slavic Village Neighborhood Retail Market Study, Kirby Date

All Maxine Goodman Levin School of Urban Affairs Publications

Slavic Village is a revitalizing urban neighborhood in the southeast area of the City of Cleveland. A historic neighborhood that was once home to 75,000 immigrants of Polish and Slavic descent, it has seen steady decline since the 1960’s, along with other Cleveland neighborhoods, and was especially hard hit during the housing and foreclosure crisis of 2007-2010. However, in the present day, it has many assets and opportunities that make it poised to become one of the vibrant Cleveland neighborhoods of the future.

This study was done as part of a student project to look at the potential to re-invigorate …

Feeding Behavior Of Tonkean Macaques (Macaca Tonkeana) In Schmutzer Primates Center And Ragunan Zoo, Jakarta, Fery Dwi Riptianingsih, Dyah Perwitasari Farajallah, Dewi Apri Astuti

Makara Journal of Science

Tonkean macaques are one of seven endemic macaque species on Sulawesi Island. Feeding management in captivity should pay attention to the quality, palatability, and feeding behavior patterns of animals. The goal of this study was to compare the feeding behavior of two social groups of Tonkean macaques at Schmutzer Primates Center (SPC) and Ragunan Zoo (RZ) with different captive management, which was expected to affect feeding behavior. Ad libitum sampling was used to observe daily behavior and hierarchy, while focal animal sampling was used to observe feeding behavior and feed preference. Data were collected from September 2013 until March 2014 …

Xylooligosaccharide Production From Tobacco Stalk Xylan Using Xylanase Streptomyces Sp. Bo 3.2, Muhammad Nur Kholis, Yopi, Anja Meryandini

Makara Journal of Science

Tobacco stalk (TS), which is one type of lignocellulosic material, has a xylan content of up to 21.9%. Lignocellulose can be used to produce xylooligosaccharides (XOs). XOs are dietary fibers that have prebiotic activity. This study aimed to produce XOs from tobacco stalk xylan using xylanase from Streptomyces sp. BO 3.2. After the TS was delignified, the xylan was extracted using the alkali method. The delignification process, which used 1% natrium hypoclorite (NaOCl), decreased the lignins from 32.93% to 18.15%. Xylan extraction was conducted using 10% natrium hydoroxide (NaOH); this extraction produced xylan of 15.53% (w/w). The xylanase produced by …

Obituaries

Colby Magazine

No abstract provided.

Class Notes

Colby Magazine

No abstract provided.

World-Class Research: Biomedical Science Beyond Experimentation

Colby Magazine

Faculty and relationships with Maine’s big-three research labs propel Colby’s opportunities in biomedical science

Could childhood nutrition set late-life brain function?

Hitting the lab running

Ahmad wins grant for study of neurodegenerative disease

Media

Colby Magazine

Audience Engagement and the Role of Arts Talk in the Digital Era, by Lynne Conner (Theater and Dance)

Negotiating Privilege and Identity in Educational Contexts, by Adam Howard (Education), Aimee Polimeno ’14, and Brianne Wheeler ’14

The Tree in the Mind, by Ronald Moran ’58

The Americans, by David Roderick ’92

Transcultural Aesthetics in the Plays of Gao Xingjian, by Todd Coulter (Theater and Dance)

Mama Gone Geek: Calling on My Inner Science Nerd to Help Navigate the Ups and Downs of Parenthood, by Lynn Brunelle ’85

The Sustainable University, by James Martin ’70, James E. Samuels & Associates

Understanding …

Activation And Inhibition Of Pannexin 1 Channels, David George Jackson

Open Access Dissertations

Pannexin 1 is one of three pannexins, a vertebrate protein family related to the invertebrate innexins. Unlike its innexin relatives, Pannexin 1 does not form gap junctions in vivo, but it does form plasma membrane channels that act as ATP release channels. ATP release through Pannexin 1 serves multiple physiological roles throughout the body, including in the central nervous system, or CNS. Pannexin 1 also plays a pathophysiological role in CNS injury as part of the cell death-inducing P2X7-Pannexin 1 complex. During CNS injury, increased extracellular K+ activates Pannexin 1 by an unknown mechanism. Since Pannexin 1 block might ameliorate …

Go On Take Another Little Piece Of My Heart, Christopher Citro

Booth

One of the reasons I’m loathe in general to crack

the bedroom door and scurry many-legged out

is hearing praying mantises were never endangered...

The Effects On Physical Exercises To Improve Social Communication Skills Of Adolescents With Autism, Christopher Fox

Theses and Dissertations

The purpose of this study was to examine the effects of fitness activities on communication skills of adolescents with Autism Spectrum Disorder (ASD). Over the course of 12 weeks, 3 middle school students with ASD participated in a wellness program focusing on learning social and conversational skills through practicing verbal language in a 1:1 situation, paired with peers, and whole group instruction. The initiation and maintenance of their conversation through reciprocal responses, and responses to questions and comments were evaluated. Participants gained social communication (e.g. requests, responses, and making comments), as well as conversational skills (e.g. reciprocity, listener knowledge, verbosity, …

Non-Operative Management Of Hip Osteoarthritis, Ray Marks

Publications and Research

This paper reviews several non-operative and non-pharmacologic management strategies advocated for alleviating the pain and disability experienced by people with hip osteoarthritis. It analyzes whether painful debilitating hip osteoarthritis, which has no effective cure and is often progressive, may be affected positively by non-operative interventions designed to control osteoar- thritis pain. Finally, it provides an integrated plan of management for ameliorating hip osteoar- thritis pain and disability in light of this knowledge.

Assessing The Carcinogenic Potential Of Low-Dose Exposures To Chemical Mixtures In The Environment: The Challenge Ahead, William H. Goodson, Leroy Lowe, David O. Carpenter, Michael Gilbertson, Abdul Manaf Ali, Adela Lopez De Cerain Salsamendi, Ahmed Lasfar, Amancio Carnero, Amaya Azqueta, Amedeo Amedei, Amelia K. Charles, Andrew R. Collins, Andrew Ward, Anna C. Salzberg, Annamaria Colacci, Ann-Karin Olsen, Arthur Berg, Barry J. Barclay, Binhua P. Zhou, Carmen Blanco-Aparicio, Debasish Roy

Publications and Research

Summary Low-dose exposures to common environmental chemicals that are deemed safe individually may be combining to instigate carcinogenesis, thereby contributing to the incidence of cancer. This risk may be overlooked by current regulatory practices and needs to be vigorously investigated.

Diary Of A Cataract Surgeon 2045, Claire E. Mcdonnell

Articles

No abstract provided.

Procollagen C-Endopeptidase Enhancer Protein 2 (Pcpe2) Reduces Atherosclerosis In Mice By Enhancing Scavenger Receptor Class B1 (Sr-Bi)-Mediated High-Density Lipoprotein (Hdl)-Cholesteryl Ester Uptake, Ricquita D. Pollard, Christopher N. Blesso, Manal Zabalawi, Brian Fulp, Mark Gerelus, Xuewei Zhu, Erica W. Lyons, Nebil Nuradin, Omar L. Francone, Xiang-An Li, Daisy Sahoo, Michael J. Thomas, Mary G. Sorci-Thomas

Pediatrics Faculty Publications

Studies in human populations have shown a significant correlation between procollagen C-endopeptidase enhancer protein 2 (PCPE2) single nucleotide polymorphisms and plasma HDL cholesterol concentrations. PCPE2, a 52-kDa glycoprotein located in the extracellular matrix, enhances the cleavage of C-terminal procollagen by bone morphogenetic protein 1 (BMP1). Our studies here focused on investigating the basis for the elevated concentration of enlarged plasma HDL in PCPE2-deficient mice to determine whether they protected against diet-induced atherosclerosis. PCPE2-deficient mice were crossed with LDL receptor-deficient mice to obtain LDLr^-/-, PCPE2^-/- mice, which had elevated HDL levels compared with LDLr^-/- mice with similar …

Estimation Of Optimal Productivity In Labor-Intensive Construction Operations, Krishna Prasad Kisi

Department of Construction Engineering and Management: Dissertations, Theses, and Student Research

In an attempt to evaluate the efficiency of labor-intensive construction operations, project managers typically compare actual with historical productivity for equivalent operations. However, this approach toward examining productivity only provides a relative benchmark for efficiency and may lead to the characterization of operations as objectively efficient when in reality such operations might simply be comparably efficient.

Optimal productivity is the highest sustainable productivity achievable under good management and typical field conditions. Optimal productivity is useful in the determination of the absolute efficiency of construction operations because an accurate estimate of optimal labor productivity allows for the comparison of actual vs. …

The Integration Of Play Into The First-Grade Language Arts Curriculum For English Language Learners, Cheryl Jean Sanderson

School of Education and Leadership Student Capstone Theses and Dissertations

The research question addressed in this project was, can the integration of play and games with rules into the first-grade Language Arts curriculum improve the oral speaking and reading skills for English language learners? To investigate the answer to that question, I studied how a child’s first language develops. For children who learn a second language, Krashen’s models were utilized in learning how a second language is acquired. Play and games with rules are defined. Looking primarily to Piaget and Vigotsky, I learned about the development of the child, play, games with rules and how a child learns through play. …

Message For New Dads (And Dads-To-Be), Neal Deroo

Faculty Work Comprehensive List

"You’ll realize that you’ve come to love this kid more than you previously thought possible, and you will feel that love deep down in your soul."

Posting about ­­­­­­­­the joys and challenges of parenting from In All Things - an online hub committed to the claim that the life, death, and resurrection of Jesus Christ has implications for the entire world.

http://inallthings.org/a-message-for-new-dads-and-dads-to-be/

Issues Encountered In Development Of Enzymelinked Immunosorbent Assay For Use In Detecting Influenza A Virus Subtype H5n1 Exposure In Swine, Jason Buehler, Kelly Lager, Amy Vincent, Cathy Miller, Eileen Thacker, Bruce Janke

United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications

A potential mechanism by which highly pathogenic avian Influenza A virus subtype H5N1 could more readily infect human beings is through the infection of and adaptation in pigs. To detect the occurrence of such infection, monitoring of pig populations through serological screening would be highly desirable. In the current study, hemagglutination inhibition assays were able to detect antibodies against H5N1 developed in pigs, but because of antigenic variation between clades, the use of multiple virus strains were required. Whole recombinant virus and recombinant hemagglutinin antigen enzymelinked immunosorbent assays (ELISAs) were generated that could detect antibody against multiple H5N1 strains, but …

α7 And β2 Nicotinic Acetylcholine Receptor Subunits Form Heteromeric Receptor Complexes That Are Expressed In The Human Cortex And Display Distinct Pharmacological Properties, Morten Skott Thomsen, Ruud Zwart, Daniel Ursu, Majbrit Myrup Jensen, Lars Hageman Pinborg, Gary Gilmour, Jie Wu, Emanuele Sher, Jens Damsgaard Mikkelsen

Translational Neuroscience

The existence of α7β2 nicotinic acetylcholine receptors (nAChRs) has recently been demonstrated in both the rodent and human brain. Since α7-containing nAChRs are promising drug targets for schizophrenia and Alzheimer's disease, it is critical to determine whether α7β2 nAChRs are present in the human brain, in which brain areas, and whether they differ functionally from α7 nAChR homomers. We used α-bungarotoxin to affinity purify α7-containing nAChRs from surgically excised human temporal cortex, and found that α7 subunits co-purify with β2 subunits, indicating the presence of α7β2 nAChRs in the human brain. We validated these results by demonstrating co-purification of β2 …

Loris Malaguzzi And The Teachers: Dialogues On Collaboration And Conflict Among Children, Reggio Emilia 1990, Carolyn Edwards, Lella Gandini, John Nimmo

Zea E-Books Collection

In 1990, three American scholars participated in an extraordinary research experience with Loris Malaguzzi and the educators of the Diana School in Reggio Emilia, Italy. They were studying “cooperation”— how preschool educators promoted collaboration and community in their classrooms and schools—and they used videotapes of classroom episodes to provoke teachers to reflect on the meanings suggested by the actions of themselves and others. In October 1990 the three traveled to Reggio Emilia and spent several days with the Italian educators.

The Diana School faculty viewed these encounters as powerful opportunities for their own professional development through the documentation process, rather …

Chromatin To Clinic: The Molecular Rationale For Parp1 Inhibitor Function., Felix Y. Feng, Johann S. De Bono, Mark A. Rubin, Karen E Knudsen

Department of Cancer Biology Faculty Papers

Poly(ADP-ribose) polymerase 1 (PARP1) inhibitors were recently shown to have potential clinical impact in a number of disease settings, particularly as related to cancer therapy, treatment for cardiovascular dysfunction, and suppression of inflammation. The molecular basis for PARP1 inhibitor function is complex, and appears to depend on the dual roles of PARP1 in DNA damage repair and transcriptional regulation. Here, the mechanisms by which PARP-1 inhibitors elicit clinical response are discussed, and strategies for translating the preclinical elucidation of PARP-1 function into advances in disease management are reviewed.

2015-June-18-New Species Of Turtle Nicknamed ‘Old Stinky’ Found At Gray Fossil Site, University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.