Digital Commons Network^™

Zbtb20 Is A Sequence-Specific Transcriptional Repressor Of Alpha-Fetoprotein Gene, Hai Zhang, Dongmei Cao, Luting Zhou, Ye Zhang, Xiaoqin Guo, Hui Li, Yuxia Chen, Brett T. Spear, Jia-Wei Wu, Zhifang Xie, Weiping J Zhang

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Alpha-fetoprotein (AFP) represents a classical model system to study developmental gene regulation in mammalian cells. We previously reported that liver ZBTB20 is developmentally regulated and plays a central role in AFP postnatal repression. Here we show that ZBTB20 is a sequence-specific transcriptional repressor of AFP. By ELISA-based DNA-protein binding assay and conventional gel shift assay, we successfully identified a ZBTB20-binding site at -104/-86 of mouse AFP gene, flanked by two HNF1 sites and two C/EBP sites in the proximal promoter. Importantly, mutation of the core sequence in this site fully abolished its binding to ZBTB20 in vitro, as well …

B Lymphocytes Are Required During The Early Priming Of Cd4+ T Cells For Clearance Of Pneumocystis Infection In Mice, Michael M. Opata, Melissa L. Hollifield, Frances E. Lund, Troy D. Randall, Robert Dunn, Beth A. Garvy, David J. Feola

Microbiology, Immunology, and Molecular Genetics Faculty Publications

B cells play a critical role in the clearance of Pneumocystis. In addition to production of Pneumocystis-specific Abs, B cells are required during the priming phase for CD4⁺ T cells to expand normally and generate memory. Clearance of Pneumocystis was found to be dependent on Ag specific B cells and on the ability of B cells to secrete Pneumocystis-specific Ab, as mice with B cells defective in these functions or with a restricted BCR were unable to control Pneumocystis infection. Because Pneumocystis-specific antiserum was only able to partially protect B cell–deficient mice from infection, we …

Corrosion Of Phosphor Bronze In Different Biodiesel Blends / Rathinee Balakumar, Balakumar Rathinee

Student Works (2010-2019)

Biodiesel fuel is gaining rapid recognition around the globe as a reliable alternative to the use of petroleum fuel in the automotive industry. This safer, greener, renewable energy source originates from naturally forming feedstocks such as animal fats and vegetable oils. Biodiesel blends consist of mixtures of biodiesel with diesel at different composition. Biodiesel fuel is much more corrosive when compared to petroleum fuel, thus giving rise to many compatibility issues with the material construction of a typical combustion ignition engine. This research studies the effects of Tert-butylamine and Benzotriazole additive on the corrosion behaviour of phosphor bronze in different …

Serotonergic Regulation Of Prefrontal Cortical Circuitries Involved In Cognitive Processing: A Review Of Individual 5-Ht Receptor Mechanisms And Concerted Effects Of 5-Ht Receptors Exemplified By The Multimodal Antidepressant Vortioxetine, Steven C. Leiser, Yan Li, Alan Pehrson, Elena Dale, Gennady Smagin, Connie Sanchez

Department of Psychology Faculty Scholarship and Creative Works

It has been known for several decades that serotonergic neurotransmission is a key regulator of cognitive function, mood, and sleep. Yet with the relatively recent discoveries of novel serotonin (5-HT) receptor subtypes, as well as an expanding knowledge of their expression level in certain brain regions and localization on certain cell types, their involvement in cognitive processes is still emerging. Of particular interest are cognitive processes impacted in neuropsychiatric and neurodegenerative disorders. The prefrontal cortex (PFC) is critical to normal cognitive processes, including attention, impulsivity, planning, decision-making, working memory, and learning or recall of learned memories. Furthermore, serotonergic dysregulation within …

Green Space, Luralyn M. Helming

Faculty Work Comprehensive List

"Our time spent looking at, experiencing, and engaging with nature improves our lives."

Posting about ­­­­­­­­the psychological benefits of time spent outdoors from In All Things - an online hub committed to the claim that the life, death, and resurrection of Jesus Christ has implications for the entire world.

http://inallthings.org/green-space/

Matrix Compliance And The Regulation Of Cytokinesis, Savitha Sambandamoorthy, Shomita Mathew-Steiner, Scott Varney, Jonathan M. Zuidema, Ryan J. Gilbert, Livingston De Van Water, Susan E. Laflamme

Chemical and Biochemical Engineering Faculty Research & Creative Works

Integrin-mediated cell adhesion to the ECM regulates many physiological processes in part by controlling cell proliferation. It is well established that many normal cells require integrin-mediated adhesion to enter S phase of the cell cycle. Recent evidence indicates that integrins also regulate cytokinesis. Mechanical properties of the ECM can dictate entry into S phase; however, it is not known whether they also can affect the successful completion of cell division. To address this issue, we modulated substrate compliance using fibronectin-coated acrylamide-based hydrogels. Soft and hard substrates were generated with approximate elastic moduli of 1600 and 34,000 Pascals (Pa) respectively. Our …

Abq Free Press, July 15, 2015, Abq Free Press

ABQ Free Press

No abstract provided.

Multiple Myeloma Hides In Bones Like A Wolf In Sheep's Clothing, Jeff Hansen

Browse All News

No abstract provided.

Reel Women: Gender Stereotypes In Film, Kayla Marie Krahn

Master's Theses and Doctoral Dissertations

Horror films portray female characters as sexual, helpless victims. When horror films attempt to portray female characters as the hero, this sends a message to audiences that women can be strong and independent. An experiment was conducted to test an audience's perceptions gender stereotypes of women in the horror film, Scream. Results indicate that stereotypes present in the horror film effected the participants' perception of women as competent heroes. Female participants were also more likely to perceive women as more competent than male participants. Then, from a qualitative standpoint, five individuals were interviewed about their perceptions of characters in their …

Saving The World, One Cadillac At A Time: What Can Be Done When A Religious Or Chartiable Organization Commits Solicitation Fraud?, Nicholas Barborak

Akron Law Review

Recognizing that controversies involving religious and charitable organizations have puzzled the courts throughout this century, this paper will examine specific instances of religious and charitable fraud. It will discuss the potential remedies that are available by donors who fall victim to the perpetrators of this fraud. Finally this paper will suggest a more feasible method by which victims may recover than the conventional approaches.

Gsu View, 2015-07-14, Office Of Marketing And Communications

GSU View

Newsletter published by Governors State University 2007-current.

Epidemiological Associations Between Brachycephaly And Upper Respiratory Tract Disorders In Dogs Attending Veterinary Practices In England, Dan G. O'Neill, Caitlin Jackson, Jonathan H. Guy, David B. Church, Paul D. Mcgreevy, Peter Thomson, Dave C. Brodbelt

Epidemiology Collection

Background: Brachycephalic dog breeds are increasingly common. Canine brachycephaly has been associated with upper respiratory tract (URT) disorders but reliable prevalence data remain lacking. Using primary-care veterinary clinical data, this study aimed to report the prevalence and breed-type risk factors for URT disorders in dogs. Results: The sampling frame included 170,812 dogs attending 96 primary-care veterinary clinics participating within the VetCompass Programme. Two hundred dogs were randomly selected from each of three extreme brachycephalic breed types (Bulldog, French Bulldog and Pug) and three common small-to medium sized breed types (moderate brachycephalic: Yorkshire Terrier and non-brachycephalic: Border Terrier and West Highland …

Interview With Johann M. Mccrackin, Johann M. Mccrackin

South Carolina Mother of the Year Oral History Archives

Interview with Johann M. McCrackin, 1984 South Carolina Mother of the Year.

2015-July-14-‘Trilobite Treasures’ To Be Showcased At Natural History Museum, University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.

Prostate Carcinogenesis Predictor, Mildred Enid Acevedo-Duncan, Hla Y. Win, Raoul Salup

USF Patents

A method of detecting prostate tumorigenesis in a subject, the method including the steps of (a) obtaining a sample from the prostate of the human subject, (b) detecting quantitatively or semi-quantitatively in the sample a level of expression for PKC-ι and (c) comparing the expression level in (b) to a level of expression in a normal control, wherein overexpression of PKC-ι, with respect to the control, indicates the presence of prostate cancer in the subject. The present invention is based upon the discovery that PKC-ι levels are elevated during prostate tumorigenesis. Furthermore, the proliferation rate of the tumor correlates with …

Emdl European Mobile Dome Lab For Artistic Research., Ml Phillips, D Charitos, Mc Poulin, R Schnell, M Kusch, L-P St-Arnault

School of Art, Design and Architecture

This panel describes the activities and presents the outcomes of artistic research carried out on the EMDL European Mobile Dome Lab Project, an international collaboration funded by the European Culture Programme (Strand 1.3.5). E / M / D / L has built an international network for the exchange of artistic and technological expertise, with the goal of researching and documenting a language and grammar unique to the full-dome medium. Bringing together four European and three Canadian institutions and cultural partners, all leaders in this field, the project aimed to share and expand skills, methodologies, strategies and content within this promising …

Interview With Florinette Ford Renfrow, Florinette Ford Renfrow

South Carolina Mother of the Year Oral History Archives

Interview with Florinette Ford Renfrow, 2002 South Carolina Mother of the Year.

Meteorological Conditions, Climate Change, New Emerging Factors, And Asthma And Related Allergic Disorders. A Statement Of The World Allergy Organization., Gennaro D'Amato, Stephen T. Holgate, Ruby Pawankar, Dennis K. Ledford, Lorenzo Cecchi, Mona Al-Ahmad, Fatma Al-Enezi, Saleh Al-Muhsen, Ignacio Ansotegui, Carlos E. Baena-Cagnani, David J. Baker, Hasan Bayram, Karl Christian Bergmann, Louis-Philippe Boulet, Jeroen T M Buters, Maria D'Amato, Sofia Dorsano, Jeroen Douwes, Sarah Elise Finlay, Donata Garrasi, Maximiliano Gómez, Tari Haahtela, Rabih Halwani, Youssouf Hassani, Basam Mahboub, Guy Marks, Paola Michelozzi, Marcello Montagni, Carlos Nunes, Jay Jae-Won Oh, Todor A. Popov, Jay M. Portnoy, Erminia Ridolo, Nelson Rosário, Menachem Rottem, Mario Sánchez-Borges, Elopy Sibanda, Juan José Sienra-Monge, Carolina Vitale, Isabella Annesi-Maesano

Manuscripts, Articles, Book Chapters and Other Papers

The prevalence of allergic airway diseases such as asthma and rhinitis has increased dramatically to epidemic proportions worldwide. Besides air pollution from industry derived emissions and motor vehicles, the rising trend can only be explained by gross changes in the environments where we live. The world economy has been transformed over the last 25 years with developing countries being at the core of these changes. Around the planet, in both developed and developing countries, environments are undergoing profound changes. Many of these changes are considered to have negative effects on respiratory health and to enhance the frequency and severity of …

Efficiency Of Piezotome-Corticision Assisted Orthodontics In Alleviating Mandibular Anterior Crowding - A Randomized Controlled Clinical Trial, Leyla R. Davoody

Master's Theses

No abstract provided.

College Student Understanding Of Informed Consent Terminology, Kishore Garapati

Master's Theses and Doctoral Dissertations

A good, understandable informed consent form (ICF) is key to ethical medical research, and the ICF is necessary according to United States federal regulation. Since they may be written in complex technical language, ICFs are often difficult for subjects to understand. The purpose of this research was to evaluate students' understanding of terminology commonly used in the ICF. An online research survey was sent to active students of Eastern Michigan University (EMU) during the winter 2015 semester. Questions were asked to evaluate the students' understanding of the correct meaning of the terms used in medical research. The majority of students …

Daubert And Judicial Review: How Does An Administrative Agency Distinguish Valid Science From Junk Science?, D. Hiep Truong

Akron Law Review

This broad authority to assess risk, however, leaves too much discretion to administrative agencies. Even more disturbing is the fact that different agencies assess the same risks differently, which leads to inconsistent results. The Environmental Protection Agency (EPA), for example, in determining the cancer risks from pesticides on food, produced an estimated risk of cancer mortality ten times greater than the Food and Drug Administration (FDA). To use a law and economics model, valuing equivalent (or identical) risks differently leaves open the possibility of economic misallocation. For example, if one agency has determined the proper level of risk, and assuming …

Lanthorn, Vol. 50, No. 01, July 13, 2015, Grand Valley State University

Volume 50, July 13, 2015 - June 6, 2016

Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present.

Baboons Might Kidnap Puppies (But Not As Pets), Harold Herzog

'Animals and Us' Blog Posts

A primate expert explains the confusion over baboon "pet-keeping."

Dna-Pkcs-Mediated Transcriptional Regulation Drives Prostate Cancer Progression And Metastasis., Jonathan F Goodwin, Vishal Kothari, Justin M Drake, Shuang Zhao, Emanuela Dylgjeri, Jeffry L. Dean, Matthew J. Schiewer, Christopher Mcnair, Jennifer K. Jones, Alvaro Aytes, Michael S. Magee, Adam E. Snook, Ziqi Zhu, Robert Den, Ruth C. Birbe, Leonard G. Gomella, Nicholas A. Graham, Ajay A. Vashisht, James A. Wohlschlegel, Thomas G. Graeber, R. Jeffrey Karnes, Mandeep Takhar, Elai Davicioni, Scott A. Tomlins, Cory Abate-Shen, Nima Sharifi, Owen N. Witte, Felix Y. Feng, Karen E. Knudsen

Department of Cancer Biology Faculty Papers

Emerging evidence demonstrates that the DNA repair kinase DNA-PKcs exerts divergent roles in transcriptional regulation of unsolved consequence. Here, in vitro and in vivo interrogation demonstrate that DNA-PKcs functions as a selective modulator of transcriptional networks that induce cell migration, invasion, and metastasis. Accordingly, suppression of DNA-PKcs inhibits tumor metastases. Clinical assessment revealed that DNA-PKcs is significantly elevated in advanced disease and independently predicts for metastases, recurrence, and reduced overall survival. Further investigation demonstrated that DNA-PKcs in advanced tumors is highly activated, independent of DNA damage indicators. Combined, these findings reveal unexpected DNA-PKcs functions, identify DNA-PKcs as a potent driver …

Patricia Evankavitch V. Green Tree Servicing Llc

2015 Decisions

USDC for the Middle District of Pennsylvania

Earthquake Stories From Minto And Nenana, Alaska, Carl Tape

Faculty

On Wednesday October 15, 1947 at 4:10pm local time, a magnitude 7.2 earthquake struck Interior Alaska, near Healy. This is a collection of stories of six life-long Alaskan elders who felt this earthquake and shared their recollections in fall of 2014, sixty-seven years after the earthquake. Geraldine Charlie had recently turned 18 years old and worked in the village store in Minto when the earthquake hit. Geraldine was crouching down to weigh a bag of potatoes at the moment the earthquake hit. She felt dizzy and noticed Coleman lanterns swaying from side to side, and items shook off the shelves. …

Bjc Today

BJC Today

No abstract provided.

The Role Of Philornis Downsi In Avian Disease Transmission In The Galápagos Islands, Courtney Lauren Pike

Theses

Philornis downsi is a dipteran fly species known to parasitize passerine birds in the Neotropics. P. downsi is speculated to be a recently introduced species in Galápagos Islands, so it is important to understand its effects on the archipelago’s native and endemic avian species. Avian parasites and pathogens have been previously reported in the Galápagos, leading the Galápagos National Park and the Charles Darwin Foundation to focus efforts on the study and management of potential avian disease vectors. The main goal of this study was to determine whether P. downsi is a host for avian parasites and pathogens found in …

Dumbbell-Pcr: A Method To Quantify Specific Small Rna Variants With A Single Nucleotide Resolution At Terminal Sequences., Shozo Honda, Yohei Kirino

Computational Medicine Center Faculty Papers

Recent advances in next-generation sequencing technologies have revealed that cellular functional RNAs are not always expressed as single entities with fixed terminal sequences but as multiple isoforms bearing complex heterogeneity in both length and terminal sequences, such as isomiRs, the isoforms of microRNAs. Unraveling the biogenesis and biological significance of heterogenetic RNA expression requires distinctive analysis of each RNA variant. Here, we report the development of dumbbell PCR (Db-PCR), an efficient and convenient method to distinctively quantify a specific individual small RNA variant. In Db-PCR, 5'- and 3'-stem-loop adapters are specifically hybridized and ligated to the 5'- and 3'-ends of …

The Mouse That Trolled: The Long And Tortuous History Of A Gene Mutation Patent That Became An Expensive Impediment To Alzheimer's Research, Tania Bubela, Saurabh Vishnubhakat, Robert Cook-Deegan

Faculty Scholarship

This case study presents the tale of the academic discovery of a rare mutation for early-onset Alzheimer's disease that was patented by a sole inventor and licensed to a non-practicing entity (NPE), the Alzheimer's Institute of America (AIA). Our aims are (1) to relate this story about patents, research tools, and impediments to medical progress, and (2) to inform ongoing debates about how patents affect research, disposition of university inventions, and the distribution of benefits from publicly funded research. We present an account of the hunt for Alzheimer's genes, their patenting, assignment, and enforcement based on literature, litigation records and …