Digital Commons Network^™

Mtor And Mek1/2 Inhibition Differentially Modulate Tumor Growth And The Immune Microenvironment In Syngeneic Models Of Oral Cavity Cancer, Harrison Cash, Sujay Shah, Ellen Moore, Andria Caruso, Ravindra Uppaluri, Carter Van Waes, Clint Allen

Open Access Publications

No abstract provided.

Valproic Acid Enhances The Efficacy Of Radiation Therapy By Protecting Normal Hippocampal Neurons And Sensitizing Malignant Glioblastoma Cells, Dinesh Thotala, Rowan M. Karvas, John A. Engelbach, Joel R. Garbow, Andrew N. Hallahan, Todd A. Dewees, Andrei Laszlo, Dennis E. Hallahan

Open Access Publications

No abstract provided.

Hypomagnesemia In Critically Ill Sepsis Patients, Dimitrios Velissaris, Vassilios Karamouzos, Charalampos Pierrakos, Diamanto Aretha, Menelaos Karanikolas

Open Access Publications

No abstract provided.

Strengths And Weaknesses Of A Planar Whole-Body Method Of 153sm Dosimetry For Patients With Metastatic Osteosarcoma And Comparison With Three-Dimensional Dosimetry, Donika Plyku, David M. Loeb, Andrew Prideaux, Sébastien Baechler, Richard L. Wahl, George Sgouros, Robert F. Hobbs

Open Access Publications

No abstract provided.

Dnam-1 Controls Nk Cell Activation Via An Itt-Like Motif, Zhanguang Zhang, Ning Wu, Yan Lu, Dominique Davidson, Marco Colonna, Andre Veillette

Open Access Publications

No abstract provided.

The Pancreas Anatomy Conditions The Origin And Properties Of Resident Macrophages, Boris Calderon, Javier A. Carrero, Stephen T. Ferris, Dorothy K. Sojka, Lindsay Moore, Slava Epelman, Kenneth M. Murphy, Wayne M. Yokoyama, Gwendalyn J. Randolph, Emil R. Unanue

Open Access Publications

No abstract provided.

Identification Of High-Efficiency 3′Gg Grna Motifs In Indexed Fasta Files With Ngg2, Elisha D. Roberson

Open Access Publications

No abstract provided.

Ultrasound-Aided Multi-Parametric Photoacoustic Microscopy Of The Mouse Brain, Bo Ning, Naidi Sun, Ruimin Chen, K Kirk Shung, John A. Hossack, Jin-Moo Lee, Qifa Zhou, Song Hu, Rui Cao

Open Access Publications

No abstract provided.

Treatment-Resistant Major Depression: Rationale For Nmda Receptors As Targets And Nitrous Oxide As Therapy, Charles F. Zorumski, Peter Nagele, Steven Mennerick, Charles R. Conway

Open Access Publications

No abstract provided.

Tourette Syndrome Research Highlights 2014, Cheryl A. Richards, Kevin J. Black

Open Access Publications

No abstract provided.

The Atf6 Pathway Of The Er Stress Response Contributes To Enhanced Viability In Glioblastoma, David Y A Dadey, Vaishali Kapoor, Arpine Khudanyan, Fumihiko Urano, Albert H. Kim, Dinesh Thotala, Dennis E. Hallahan

Open Access Publications

No abstract provided.

Caenorhabditis Elegans Glp-4 Encodes A Valyl Aminoacyl Trna Synthetase, Suchita Rastogi, Ben Borgo, Nanette Pazdernik, Paul Fox, Elaine R. Mardis, Yuji Kohara, Jim Havranek, Tim Schedl

Open Access Publications

No abstract provided.

Exome Sequencing Identifies A Rare Hspg2 Variant Associated With Familial Idiopathic Scoliosis, Erin E. Baschal, Cambria I. Wethey, Kandice Swindle, Robin M. Baschal, Katherine Gowan, Nelson L.S. Tang, David M. Alvarado, Gabe E. Haller, Matthew B. Dobbs, Matthew R.G. Taylor, Christina A. Gurnett, Kenneth L. Jones, Nancy H. Miller

Open Access Publications

No abstract provided.

Butyrate And Mucosal Inflammation: New Scientific Evidence Supports Clinical Observation, Kelly Cushing, David M. Alvarado, Matthew A. Ciorba

Open Access Publications

No abstract provided.

A Review Of Gene Therapy In Canine And Feline Models Of Lysosomal Storage Disorders, Allison M. Bradbury, Brittney L. Gurda, Margret L. Casal, Katherine P. Ponder, Charles H. Vite, Mark E. Haskins

Open Access Publications

No abstract provided.

Molecular Approaches For Improving Desiccation Tolerance : Insights From The Brine Shrimp Artemia Franciscana., Steven Hand, Michael Menze

Faculty and Staff Scholarship

Main conclusion We have evaluated the endogenous expression and molecular properties of selected Group 3 LEA proteins from Artemia franciscana , and the capacity of selected Groups 1 and 3 proteins transfected into various desiccation-sensitive cell lines to improve tolerance to drying. Organisms inhabiting both aquatic and terrestrial ecosystems frequently are confronted with the problem of water loss for multiple reasons—exposure to hypersalinity, evaporative water loss, and restriction of intracellular water due to freezing of extracellular fluids. Seasonal desiccation can become severe and lead to the production of tolerant propagules and entry into the state of anhydrobiosis at various stages …

Exploring The Meaning Of Cohabitation: A Relationship Dialectics Perspective, Lindsey J. Thomas, Kristina M. Scharp

Iowa Journal of Communication

This study employed relational dialectics theory to investigate what cohabitation means to cohabiters. Cohabitation is an ambiguous relationship state (e.g., perceived as "more than dating" but "less than marriage") associated with negative outcomes. Scholars have empirically investigated cohabitation; however, little research explores what cohabitation means using a qualitative approach. Exploring the meaning of cohabitation can illuminate perceptions that might coincide with negative outcomes. Framed by Relational Dialectics Theory, a contrapuntal analysis of cohabiters' online stories (n=27) revealed three counter-discourses: Narratives of Cohabitation as a Normal Relationship, Cohabitation as an Easy Relationship, and Cohabitation as a Worthwhile Struggle. Each counter-discourse resisted …

A General Equilibrium Theory Of Contracts In Community Supported Agriculture, Thomas W. Sproul, Jaclyn D. Kropp

Environmental and Natural Resource Economics Faculty Publications

Community Supported Agriculture (CSA) contracts allow consumers to buy claims on a farm's future production. In turn, the consumer provides working capital to the farm during the growing season. CSA contracts also provide risk management for farmers with limited access to Federal crop insurance by transferring part of the farm's risk to the consumer. We derive a theory of CSA contract pricing for the two most prevalent types of CSA contracts: yield contracts, in which consumers receive a percentage of the farm's production, and weight contracts, in which consumers receive fixed quantities. We develop a two-period model in which expected …

The Recreational Use Of Provincetown Harbor And Attitudes Towards Shellfish Aquaculture, Daniel Maggio

Open Access Master's Theses

Aquaculture refers to the breeding, rearing, and harvesting of plants and animals in all types of water environments including ponds, rivers, lakes, and the ocean (NOAA, 2014). In the United States shellfish aquaculture of mollusks experienced significant economic growth from 2005-2013. In 2005 the mollusk shellfish aquaculture industry was worth approximately $203,183,000, which grew to $328,567,000 in 2013 (USDA;NASS, 2013). In Provincetown, Massachusetts the interest of growth and development of shellfish aquaculture from local fishermen and town officials is increasing (Wisbauer, 2015).

Surveys were administered to four categories of users, as defined by the town's definitions: residents, non-residents, occupants, and …

The Impact Of Hyped Ipo's On The Market, Elias Escobedo

Honors Program Theses

Increasingly, finance researchers are including irrationality into their understanding of the stock market, including emotions (Tetlock, 2007) or misunderstanding of available information (Huberman & Regev, 2007). The popularity of the recent Alibaba IPO demonstrates that investors can get excited.1 Is excitement an important determinant of the behavior of stock market investors? Empirical evidence suggests that investors “herd” into similar stocks (Wermers, 1999) and may experience common feelings of optimism and pessimism (Tetlock, 2007). If investor’s emotions correlate, what about excitement? Can the excitement for a particular stock spill over into the excitement of other stocks?

To analyze the impact excitement …

C3d Adjuvant Effects Are Mediated Through The Activation Of C3d-Specific Autoreactive T Cells, Anne S. De Groot, Ted M. Ross, Lauren Levitz, Timothy J. Messitt, Ryan Tassone, Christine M. Boyle, Amber J. Vincelli, Leonard Moise, William Martin, Paul M. Knopf

Institute for Immunology and Informatics Faculty Publications

Complement fragment C3d covalently attached to antigens enhances immune responses, particularly for antigens lacking T cell epitopes. Enhancement has been attributed to receptor cross-linking between complement receptor CR2 (CD21) and polysaccharide antigen to surface IgM on naïve B cells. Paradoxically, C3d has still been shown to increase immune responses in CD21 KO mice, suggesting that an auxiliary activation pathway exists. In prior studies, we demonstrated the CD21-independent C3d adjuvant effect might be due to T cell recognition of C3d T helper epitopes processed and presented by MHC class II on the B cell surface. C3d peptide sequences containing concentrated clusters …

Ivax: An Integrated Toolkit For The Selection And Optimization Of Antigens And The Design Of Epitope-Driven Vaccines, Leonard Moise, Andres H. Gutierrez, Farzana Kibria, Rebecca Martin, Ryan Tassone, Rui Liu, Francis Terry, William Martin, Anne S. De Groot

Institute for Immunology and Informatics Faculty Publications

Computational vaccine design, also known as computational vaccinology, encompasses epitope mapping, antigen selection and immunogen design using computational tools. The iVAX toolkit is an integrated set of tools that has been in development since 1998 by De Groot and Martin. It comprises a suite of immunoinformatics algorithms for triaging candidate antigens, selecting immunogenic and conserved T cell epitopes, eliminating regulatory T cell epitopes, and optimizing antigens for immunogenicity and protection against disease. iVAX has been applied to vaccine development programs for emerging infectious diseases, cancer antigens and biodefense targets. Several iVAX vaccine design projects have had success in pre-clinical studies …

A Plasmid-Based Reporter System For Live Cell Imaging Of Dengue Infected Cells, Carey L. Medin, Sierra Valois, Chinmay G. Patkar, Alan Rothman

Institute for Immunology and Informatics Faculty Publications

Cell culture models are used widely to study the effects of dengue virus (DENV) on host cell function. Current methods of identification of cells infected with an unmodified DENV requires fixation and permeablization of cells to allow DENV-specific antibody staining. This method does not permit imaging of viable cells over time. In this report, a plasmid-based reporter was developed to allow non-destructive identification of DENV-infected cells. The plasmid-based reporter was demonstrated to be broadly applicable to the four DENV serotypes, including low-passaged strains, and was specifically cleaved by the viral protease with minimal interference on viral production. This study reveals …

Quasi-Subjectivity And Ethics In Non-Modernity, Justin T. Simpson

UNF Graduate Theses and Dissertations

The inspiration behind this philosophical endeavor is an ethical one: interested in what it means to flourish as a human being – how to live well and authentically. Similar to medicine and how the ability to prescribe the appropriate treatment depends on first making a diagnosis, the focus of this work will to be understand the human condition and the ways in which subjectivity, one’s sense of self, is constituted. Given the general dissatisfaction with the modern metaphysical picture of the world, which analyzes the world in terms of the mutually exclusive and completely separate categories of nature/objects and society/subjects, …

Human Origins, Dispersal And Associated Environments: An African Perspective, Amanuel Beyin

Faculty and Staff Scholarship

Africa’s position as the cradle of humanity is widely accepted, supported by rich fossil and archaeological discoveries from different parts of the continent. Drawing on the Out-of-Africa theory of human origins, this article provides a condensed narrative of the major milestones in human evolution and associated environmental settings. The underlying hypothesis is that changes in global climate played an important role in fueling early modern human origins and dispersals within and outside of Africa. As one will discover in this article, the history of humanity is a tale of small events that merged together into major milestones over a long …

Environmental Privacy, Katrina Fischer Kuh

Hofstra Law Faculty Scholarship

No abstract provided.

Molecular Identification And Functional Characteristics Of Peptide Transporter 1 (Pept1) In The Bonnethead Shark (Sphyrna Tiburo), Hannah Hart

UNF Graduate Theses and Dissertations

Many elasmobranchs are considered top predators with worldwide distribution, and in general these fish play an important role in the transfer of energy from the lower to the upper trophic levels within the marine ecosystem. Despite this, little research has been done regarding the rates of prey ingestion, digestion, and the processes of energy and nutrient absorption. Specifically understudied is enzymatic digestion within the intestinal brush border, which functions to break down macromolecules into smaller subunits for luminal absorption across the gastrointestinal epithelium. Given their carnivorous diet, the present study sought to expand knowledge on nutrient intake in elasmobranchs by …

The Regulation Of Vitamin A Metabolism, Mark Adams

All ETDs from UAB

Bioactive vitamin A takes form as several molecules, among them all-trans-retinoic acid (RA) is the major form and influences a wide range of biological processes. RA must be synthesized through a two-step mechanism, where all-trans-retinol is first oxidized to all-trans-retinaldehyde by retinol dehydrogenases (RDHs) and retinaldehyde is further oxidized to RA by retinaldehyde dehydrogenases (RALDHs). The first step, retinol to retinaldehyde conversion is the rate limiting step and therefore a likely target of mechanisms that modulate RA synthesis. Despite this, many of the enzymes that are involved in retinol and retinaldehyde interconversion have yet to be identified and thus many …

Competition From New Neurons Drives Circuit Refinement In The Adult Dentate Gyrus, Elena W. Adlaf

All ETDs from UAB

The hippocampus encodes sensory information into memories. The dentate gyrus (DG) region is viewed as the entry point into the hippocampus, receiving sensory and spatial signals from perforant path axons of the entorhinal cortex (EC). Ever since researchers discovered a neurogenic niche in the subgranular zone (SGZ) of the DG in adult animals and humans, many studies have been aimed at discovering how these continually proliferating granule cells (GCs) contribute to the network. Immature GCs have dendrites that project densely into the molecular layer alongside mature GCs and there is morphological evidence that immature excitatory spines preferentially synapse onto existing …

Pathophysiology And Metabolic Dysfunction Following Polytrauma, Robert Mackay Akscyn

All ETDs from UAB

Polytrauma, a combination of injuries to more than one body part or organ system, is common in modern warfare and in automobile and industrial accidents. The combination of injuries can include burn, fracture, hemorrhage, trauma to the extremities, and trauma to specific organ systems. These injuries are highly survivable when occurring singly. However, when they occur in combination the prognosis is worsened. To investigate the effects of combined injuries, we have developed a new and highly reproducible model of polytrauma. This model combines burn injury with soft tissue and gastrointestinal (GI) tract trauma. Male Sprague Dawley rats were subjected to …