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Hiv And Minority Youth, Mandakini Sadhir, Hatim A. Omar

Pediatrics Faculty Publications

Human Immunodeficiency virus (HIV) infection is a major public health problem with the burden of disease increasing in adolescents and young adults particularly among black males and males who have sex with males (MSM).

Paper I: Stress In Adolescents, Stephanie Stockburger, Hatim A. Omar

Pediatrics Faculty Publications

It is well known that adolescents experience stress. In this article, sources of adolescent stress will be discussed as well as the physiological effects of stress on the body. Stress disorders will also be briefly reviewed. Mainly, research on stress management strategies that have been evaluated in adolescents will be presented. Many studies have a small number of participants and lack control groups. Therefore, there is a need for ongoing research in this important area.

Part Ii - Stress And Stress Management Strategies In Adolescents, Stephanie Stockburger, Hatim A. Omar

Pediatrics Faculty Publications

It is well known that adolescents experience stress. In this article, sources of adolescent stress will be discussed as well as the physiological effects of stress on the body. Stress disorders will also be briefly reviewed. Mainly, research on stress management strategies that have been evaluated in adolescents will be presented. Many studies have a small number of participants and lack control groups. Therefore, there is a need for ongoing research in this important area.

Workplace Well-Being: Examining The Mental And Psychological Health And Safety Of Non-Unionised And Unionised Employees, Peter O'Mahony

Theses

A quantitative case study was conducted to gain a deeper understanding of the mental and psychological health and safety of non-unionised and unionised employees within the researcher's organisation, a multi-national pharmaceutical company based in Ireland. One hundred and sixty-seven employees and seven senior managers were surveyed to explore their perspectives of psychological health and safety risks in the workplace across thirteen different psychosocial factors which are known to either have positive or negative effects on the psychological health and well-being of an employee.

The Guarding Minds at Work (GM@W) online survey resources were considered appropriate methods to collect the necessary …

Maritime Exposure And Economic Prosperity: Why Location Matters, Jesse M. Lane

Theses

No abstract provided.

Determining The Role Of The Ahr In Immunoglobulin Expression And Class Switch Recombination, Bassam Fawaz Kashgari

Browse all Theses and Dissertations

The aryl hydrocarbon receptor (AhR) is a ligand-activated cytosolic transcription factor that regulates xenobiotic-metabolizing enzymes. It mediates the toxicity of various environmental chemicals such as 2,3,7,8-tetracholorodibenzo-p-dioxin (TCDD). TCDD inhibits the differentiation of B cells into antibody-secreting cells and inhibits immunoglobulin (Ig) expression in various animal models. We have previously determined that TCDD-induced inhibition of the mouse Ig heavy chain gene (mo-Igh) is AhR-dependent. This inhibition may be mediated by binding of the AhR to dioxin response elements (DREs) within the 3'Igh regulatory region (3'IghRR) and inhibition of 3'IghRR activity, a significant transcriptional regulator of Ig expression. However, there are structural …

Vitamin D Receptor And 1Α, 25-Dihydroxyvitamin D3 Mediated Regulation Of Δnp63Α, Hill Tremayne Natasha

Browse all Theses and Dissertations

1alpha, 25-dihydroxyvitamin D3 (VD3), the ligand for the Vitamin D Receptor (VDR), functions to both inhibit cell growth and promote cell survival. High-dose VD3 is being utilized as a cancer preventive therapy for melanoma, breast and colorectal cancers, without a complete understanding of VD3/VDR signaling. DeltaNp63alpha, considered to be a proto-oncogene, is overexpressed in non-melanoma skin cancers (NMSCs), induces VDR gene expression and promotes keratinocyte proliferation, and may serve to exacerbate non-melanoma skin cancer. The objective of this dissertation was to determine whether VDR/VD3 signaling promotes keratinocyte proliferation by up-regulating DeltaNp63alpha. I showed that VDR increases DeltaNp63alpha expression at both …

Whole-Lake Primary Production Calculator, Colin D. Leong

Browse all Theses and Dissertations

This work describes an implementation of a model for estimation of both benthic and phytoplanktonic primary production in lakes. The web application makes use of interpolation techniques to allow estimates of primary production using values for photosynthesis/irradiance parameters at only 5 depths. These estimates compare favorably in accuracy with estimates using values listed at over one hundred depths. Validation of the implementation was done by comparison with primary production results from the Northern Temperate Lakes Long Term Ecological Research database.

Left Ventricle Volume Reconstruction To Minimize Scanning Time: Slice-Fitting Method, Prateek Kalra

Browse all Theses and Dissertations

Assessment of left ventricle volume is usually done for diagnosis and prognosis of heart diseases. Slice-summation method is a standard method used to compute left ventricle volume where region of interest from several short axis (SA) slices are added. There are some limitations to this method, however. It requires short-axis slices to be taken parallel to the mitral valve plane from the base to apex. Moreover, scanning several short-axis slices is a tedious and time consuming process especially for studies that require several hundreds datasets. There are some existing methods to reconstruct left ventricle volume but most of them depend …

The Role Of Nkcc2a On The Nervous System Activity, Kavya Annu

Browse all Theses and Dissertations

The NKCC2A is a splice variant of the Na+K+2Cl- co-transporter 2 (Slc12a1), which is abundantly expressed in macula densa and in the apical membrane of the tubular cells in the kidney. Most of our knowledge regarding NKCC2 function is limited to the kidney, the organ where NKCC2 is abundantly expressed. However, recent studies have demonstrated that NKCC2 is also expressed in extra-renal tissues. This study was designed to determine if NKCC2A, a splice variant of NKCC2 has an impact on behavior and nervous system activity of mice. To these ends, we used mice (wild type, WT), lacking a single or …

Method Development For Mass Spectrometric Characterization Of Ultra-Small Nanomolecules And Mass Spectrometry Imaging Of Selected Biomolecules, Nuwan K. Kothalawala

Electronic Theses and Dissertations

High sensitivity, selectivity and remarkable identification capabilities facilitate the applicability of mass spectrometry (MS) in diverse fields. This dissertation outlines how this cutting edge technology is used to determine the chemical composition of the ultra-small nanomolecules (NMs) to atomic precision and obtain spatial resolution of selected biomolecules using mass spectrometry imaging (MSI). Chapter I includes introduction to electrospray ionization (ESI) and matrix assisted laser desorption ionization (MALDI) MS used in my PhD research. Chapter II explains how high resolution ESI-MS methods were developed to analyze the polar water-soluble NMs. These new methods express how ESI-MS parameters need to be optimized …

Systems Biology Approach To Understanding The Control Of Glucose Metabolism In Healthy And Apoptotic Neurons, Hoda Gebril

Electronic Theses and Dissertations

Apoptosis plays a crucial role in sculpting the developing central nervous system (CNS) but can, under certain conditions, contribute to neurodegeneration in the mature CNS. Metabolic disturbances have long been associated with apoptosis-inducing agents, however, the mechanism underlying such changes remains controversial. In this study, our hypotheses was that decreased ATP turnover may bring about other metabolic changes in apoptotic neurons. Accordingly, change in metabolic reactions other than ATP turnover may not be important in the study of apoptotic mechanism. In a living cell, metabolic reactions are highly connected and thus are highly sensitive to kinetic change in one or …

Carbon Dioxide Capture With Amine Functionlized Graphene Oxide, Renee Zeleszki

Electronic Theses and Dissertations

Abstract: amine functionalized graphene oxide was used as sorbent in order to achieve carbon dioxide capture. In this study, micro size graphite flakes was prepared according to modified hummers method and "hummers' method with additional kmno4." Graphene oxide was then functionalized with ethylenediamine (eda). Different purification methods for graphene oxide were studied as well as different functionalization method times. Graphite oxide and functionalized graphene oxide has been analyzed with fourier transform infrared spectroscopy (ftir) for chemical structure. Thermal gravimetric analysis (tga) was used to test co2 capture capacity. Functionalized graphene oxide that has been purified with 30 washes via centrifuge …

Empirical Modeling Of Piping Along Mississippi River Levees In Southwestern Illinois, Rebecca F. Shields

Electronic Theses and Dissertations

No abstract provided.

Speaking In Wild Tongues: The Borderlands Of Eudora Welty And Alice Walker, Sara Gabler Thomas

Electronic Theses and Dissertations

In Borderlands/La Frontera Gloria Anzaldúa describes her experience undergoing a dental procedure as a battle between her wild tongue and the dentist. Beginning with a discussion of Anzaldúa’s concept of the wild tongue, this project asks how writers across the US South depict unruly tongues and infelicitous speech. Methodologically, this thesis inverts the comreading model in literary studies of reading Third World writers through First World theorists. Instead, beginning with Anzaldúa, I propose to reverse this process and assert a new reading methodology of reading First World writers through Third World theorists. The trope of the wild tongue will mobilize …

Is This Fire, Gregory Sherl

Electronic Theses and Dissertations

Is This Fire is a collection of poems dealing with the themes of faith and loss. In one section, "The Third Testament," parts of the Bible have been reimagined. There are poems about Joan of Arc, as well as poems that touch on miscarriages, as well as the Columbine massacre. There are, of course, also love poems.

Evaluation Of Novel Ligands For Opioid Receptors, Amer Hussien Tarawneh

Electronic Theses and Dissertations

No abstract provided.

Design, Synthesis And Cannabinoid Receptor Activity Of Benzofuran Ligands, Eric William Bow

Electronic Theses and Dissertations

The endocannabinoid system is a complex homeostatic signaling system controlled through the actions of two g-protein coupled receptors, cannabinoid receptor 1 (cb1) and cannabinoid receptor 2 (cb2). Significant neuronal expression and distribution of cb1 throughout the brain establishes its function as a major synaptic signaling receptor, and in regards to the actions of cannabis sativa, it is the primary mediator of the psychotropic effects of marijuana. Conversely, cb2 expression is confined to microglial cells in the brain and predominantly peripheral immune cells. The expression of cb2 provides a pharmacological basis for the well-documented immunomodulatory effects of cannabis, providing a potential …

Biomolecular Folding Rates As Understood From Single-Reaction-Coordinate Langevin Dynamics And Kramers’ Theory, Md Adnan Kabir

Electronic Theses and Dissertations

Langevin dynamics was used to model the folding and unfolding of simple, hairpin-like biomolecules whose ends are attached to laser-trapped beads, as occurs in optical tweezers experiments. The Langevin process was evolved numerically, using parameters motivated by real experimental systems. Folding trajectories were generated and analyzed to extract the folding rate as a function of the force applied to the beads. The observed rate was compared to the analytical predictions of Kramers' theory. Strong discrepancies were noted. The failure of the Kramers' theory was attributed to the slow dynamical response of the beads, which it does not account for. The …

The Dead Rise The Dead And Walk Among The Living: An Examination Of The Haunting South, Queerness, And Grotesqueries In Truman Capote's "Other Voices, Other Rooms" And "Local Color", Jordan Alexis Savage

Electronic Theses and Dissertations

This project is conceptualized through a multitude of intersecting and overlapping theories that work together to allow an examination of circulations and intersections of queerness, grotesqueries, and the haunting South. Throughout this reading of Truman Capote’s Other Voices, Other Rooms and Local Color I want to think through the ways in which images and moments in the text can be queer and grotesque while also lending themselves to the images and eruptions that make up the haunting South. My reading of grotesqueries and the haunting South purposefully moves away from the Southern Gothic, rooting itself instead in a space that …

L’Identité Libanaise Dans La Mémoire Littéraire De La Guerre Civile, Sarah J. Rockford

Honors Theses

Sampling prominent works of Lebanese literature, this paper seeks to unpack the legacy of the Lebanese Civil War (1975- 1990) in the collective memory and identity of Lebanese.

Preaching As A Cultural Formation Tool, Jason P. Esposito

All Electronic Theses and Dissertations

The problem addressed by this project is a lack of awareness some pastors have of the power their preaching has to shape their church culture. In response to this problem the researcher explored the biblical foundations of preaching with a special interest in the Hebrew understanding of learning and its role as a culture creator. He reviewed literature related to homiletics and communication theory with special attention to cultural formation in organizations and churches. He conducted case studies by way of interviews to determine whether members of his church, Crossway, perceived this connection between preaching and cultural formation. He interviewed …

A Petition For God's Forgiveness In Gambella Ethiopia, Omot Olopk Aganya

All Electronic Theses and Dissertations

This thesis project explored the root causes of the ethnic conflicts in the Gambella region of Ethiopia. It examined the issues of ethnic, social, political, and historical conflict occurring at the regional level, which are vital to comprehensively understanding the nature and outcome of the local conflicts. These are embedded in geopolitics, the politics of established administrative agencies established in Gambella by different empires and governments, militarization, ethnicity, socio-economics, deprivation, inequality, marginalization, discrimination, racism, and the undemocratic institutions of the region, as well as the absence of effective mechanisms for national and sub-regional dispute resolution. The lack of implementation and …

The Relationship Between Adhd And Trait Facets Of The Five-Factor Model, Todd William Bennett

PCOM Psychology Dissertations

Facets of the Five-Factor Model (FFM) were examined in order to understand its interaction with Attention Deficit Hyperactivity Disorder (ADHD)-symptoms. By utilizing archival data, in a correlational design, adults between the ages of 18-66 were tested for the presence of ADHD, which was then compared with data gathered from the NEO-PI-R. Comorbid psychiatric conditions often associated with ADHD were accounted for in the design. Results partially supported the hypotheses, specifically, that altruism was inversely related to Impulsivity, as predicted. However, other findings largely did not support a relationship between other specific NEO-PI-R facets and ADHD. Other significant relationships that were …

The Frequency And Competency Of Executive Functions Assessment And Intervention Among Practicing School Psychologists, Meghan A. Garrett

PCOM Psychology Dissertations

This study surveyed school psychologists (N = 167) primarily from six different states about their perceptions, knowledge, frequency, and application of executive functions assessment and interventions. The purpose of this study was to explore school psychologists’ practices in executive functions assessment and interventions. Results of the study indicated that school psychologists vary in their knowledge of executive functions, but the majority of them do not include the assessment of and intervention in executive functions deficits in their regular practice. However, school psychologists tended to report executive functions assessment and intervention more frequently when presented with specific disability classifications (e.g. autism, …

An Exploration Of Social Connectedness As A Predictor Of Quality Of Life In Acquired Brain Injury Survivors, Jennifer Oyekanmi

PCOM Psychology Dissertations

Research on quality of life in ABI survivors has focused on four domains: psychological, physical, social, and cognitive (Upadhyay, 2007). Social relationships, in particular, can help ABI survivors more effectively cope with changes in their lives, help maintain a healthy outlook, and can help with seeking further understanding of the consequences of sustaining a ABI (Hibbard et al, 2002). The current study sought to examine if social connectedness is predictive of quality of life in ABI survivors. Participants were 71 individuals who have sustained a ABI and who currently or in the past participated in a long term rehabilitation program. …

Dawn Of The Intercontinental Sniper: The Drone's Cascading Contribution To The Modern Battlefield's Complexity: A Re-View Essay Of Predator: The Secret Origins Of The Drone Revolution, By Richard Whittle, Steven L. Schooner, Nathaniel E. Castellano

GW Law Faculty Publications & Other Works

This review essay discusses a unique book that chronicles the UAV (unmanned aerial vehicle) or "drone" revolution with a focus on the Predator weapon system. Although brought to market by a mainstream publisher, the book offers a thought-provoking, heavily researched, non-fiction case study involving national security, defense acquisition, and international law. We congratulate author Richard Whittle for crafting a thrilling and highly informative history of technological innovation, government contracting, and weapons system development and deployment, while introducing complex issues of national security and international law, that nonetheless left us eagerly anticipating a forthcoming action movie.

This review essay introduces prospective …

Cross-Talk Between The Tumor Suppressors Par-4 And P53, Tripti Shrestha Bhattarai

Theses and Dissertations--Toxicology and Cancer Biology

This work describes the fascinating interplay between two tumor suppressors Prostate apoptosis response-4 (Par-4) and p53. The guardian of the genome, p53, is frequently mutated in human cancers, and may contribute to therapeutic resistance. However, p53 is intact and functional in normal tissues, and we observed that specific activation of p53 in normal fibroblasts could induce apoptosis selectively in p53-deficient cancer cells. This paracrine apoptotic effect was executed by Par-4 secreted in response to p53 activation. Accordingly, activation of p53 in wild-type mice, but not in p53^-/- or Par-4^-/- mice, caused systemic elevation of Par-4 that induced apoptosis …

Demographic Disparities In Children With Behavioral Or Conduct Disorders, Caitlin Dunworth

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

This study examines the demographic disparities in children with externalizing behavior disorders, such as oppositional defiant disorder and conduct disorder, utilizing secondary data from the 2011/2012 National Survey of Children’s Health (NSCH). Current literature suggests that children with externalizing behavior disorders are more likely to be male, live in a low-­‐income family, receive lower grades in school, and to develop later conditions such as depression. Chi square tests and logistic regression were used to examine the associations of presence of a current behavioral or conduct problems with age group, race/ethnicity, sex, household income level, and insurance type. Additionally, associations were …

Fatal Injuries Among Young Workers In Kentucky, 2005-2014, Allison Christian

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Background: Young workers have been more vulnerable to fatal and nonfatal work injuries. To gain a comprehensive understanding of the injuries that led to fatalities in younger workers, the goal of this study was to compare characteristics of young worker fatal injuries in those aged 16-24 to all workers aged 25 and older in Kentucky using a descriptive analysis.

Methods: A retrospective analysis of fatalities among workers under the age of 25 compared to workers aged 25 and older was performed over a ten-year period from 2005-2014 using Kentucky Fatality Assessment and Control Evaluation (FACE) program data.

Results …