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Genomic And Transcriptomic Analyses Of Microbotryum Lychnidis-Dioicae Provide Insights Into The Biology Of A Fascinating Fungal Phytopathogen., Su San Toh

Electronic Theses and Dissertations

This study made use of the Silene latifolia/Microbotryum lychnidis-dioicae phytopathogen system as the focal system to establish the first reference genome for Microbotryum violaceum sensu lato. In silico analysis was performed on the genome assembly to identify various characteristics of the genome. Using RNA-Sequencing technologies on the Illumina platform, we collected transcriptomic data for both in vitro and in planta life stages of the fungus, providing the most comprehensive look at the gene expression and regulation of this fungus. Due to a lack of identifiable domains on the predicted genes, gene set enrichment analysis was done in …

Network Neutrality And Consumer Demand For “Better Than Best Efforts” Traffic Management, Rob Frieden

Fordham Intellectual Property, Media and Entertainment Law Journal

INTRODUCTION The Internet increasingly offers a preferred medium for access to video and other types of high value content that may require Internet Service Providers (“ISPs”) to use special efforts to ensure superior quality of service (“QOS”). ISPs have made substantial investments in infrastructure upgrades to satisfy growing demand for networks capable of delivering bandwidth intensive traffic at higher transmission speeds. Additionally, they work to accommodate consumer expectations of having content access anytime, anywhere, through any medium, via any device, and in any screen presentation format. Early adopters of new video delivery technologies rely on both wireline and wireless alternatives …

Dynamics Of An Sir Model With Nonlinear Incidence And Treatment Rate, Balram Dubey, Preeti Dubey, Uma S. Dubey

Applications and Applied Mathematics: An International Journal (AAM)

In this paper, global dynamics of an SIR model are investigated in which the incidence rate is being considered as Beddington-DeAngelis type and the treatment rate as Holling type II (saturated). Analytical study of the model shows that the model has two equilibrium points (diseasefree equilibrium (DFE) and endemic equilibrium (EE)). The disease-free equilibrium (DFE) is locally asymptotically stable when reproduction number is less than one. Some conditions on the model parameters are obtained to show the existence as well as nonexistence of limit cycle. Some sufficient conditions for global stability of the endemic equilibrium using Lyapunov function are obtained. …

Associations Of Perfluoroalkyl Substances (Pfass) With Lower Birth Weight: An Evaluation Of Potential Confounding By Glomerular Filtration Rate Using A Physiologically Based Pharmacokinetic Model (Pbpk), Marc-André Verner, Anne E. Loccisano, Nils-Halvdan Morken, Miyoung Yoon, Huali Wu, Robin Mcdougall, Mildred Maisonet, Michele Marcus, Reiko Kishi, Chihiro Miyashita, Mei-Huei Chen, Wu-Shiun Hsieh, Melvin E. Andersen, Harvey J. Clewell Iii, Matthew P. Longnecker

ETSU Faculty Works

Background: Prenatal exposure to perfluoroalkyl substances (PFAS) has been associated with lower birth weight in epidemiologic studies. This association could be attributable to glomerular filtration rate (GFR), which is related to PFAS concentration and birth weight.

Objectives: We used a physiologically based pharmacokinetic (PBPK) model of pregnancy to assess how much of the PFAS–birth weight association observed in epidemiologic studies might be attributable to GFR.

Methods: We modified a PBPK model to reflect the association of GFR with birth weight (estimated from three studies of GFR and birth weight) and used it to simulate PFAS concentrations in maternal and cord …

Executive Dysfunction Is Predictive Of Clinical Symptomatology In 22q11.2 Deletion Syndrome, Chinonyere Kemdirim Bello

Loma Linda University Electronic Theses, Dissertations & Projects

By adulthood, 25%- 30% of individuals with 22q11.2 deletion syndrome (22qDS) develop a psychotic disorder, often schizophrenia, and it is not understood why. Given the known genetic etiology of this disorder and the greatly elevated risk for development of schizophrenia, this group offers the possibility of defining a seemingly homogenous maturational pathway to psychosis. Neurocognitive deficits have been increasingly recognized as an important dimension of schizophrenia, particularly in the executive domain. Thus, we assessed multiple aspects of executive cognition in 22qDS, in order to: 1) characterize performance across this domain as compared to age-matched healthy controls; and 2) determine whether …

Online Psychoeducational Therapy For Chronic Pain, Cynthia Marie Nakoski

Loma Linda University Electronic Theses, Dissertations & Projects

The pain experience consists of many factors including biological, psychological, social and spiritual that can exacerbate and perpetuate it, often leading to chronic pain. Provision of an online psychoeducational course, inclusive of social networking capabilities, offers remote access to invaluable information for the enhancement of self-efficacy in the treatment of chronic pain. The focus of this doctoral project was the creation of a website that includes pain management lessons comprised of Cognitive Behavioral Therapy, Acceptance and Commitment Therapy, Family Therapy, and Spirituality modules. The website incorporates psychometrics, automated course tracking, and social network components allowing for research reporting, self-paced interactive …

Dialectical Behavior Therapy And Adolescent Patient Treatment Dropout, Danessa Mayo

Loma Linda University Electronic Theses, Dissertations & Projects

Attrition in mental health treatment is an area of concern among the adolescent population, especially with patients engaged in deliberate self-harm. The purpose of this study was to examine the treatment attrition rate for adolescents with deliberate self-harm in an adapted dialectical behavior therapy intensive outpatient program. A total of 141 adolescents previously enrolled in the program were available for the study. Results demonstrated a 31.9% dropout rate. Graduates indicated greater improvement of overall distress from baseline to post-treatment than dropouts. Dropouts attended an average of 12 treatment sessions. Several factors were examined to identify potential predictors of patient treatment …

Apolipoprotein B Containing Lipoproteins Contribute To Host Innate Immune Pulmonary Defense Against Staphylococcus Aureus, Brett Manifold-Wheeler

Biomedical Sciences ETDs

Circulating lipoproteins are increasingly recognized as innate immune effector molecules. Severe hypolipidemia, which may occur with trauma or critical illness, is clinically associated with bacterial pneumonia. Importantly, pneumonia caused by Staphylococcus aureus is a major cause of morbidity and mortality in both hospital- and community-acquired pneumonia cases. Here we report that lipoprotein deficiency impairs early pulmonary innate defense against S. aureus quorum-sensing dependent pathogenesis. Specifically, apoB levels in the lung early post-infection are significantly reduced with lipoprotein deficiency, coinciding with impaired host control of S. aureus agr-signaling and increased agr-dependent morbidity and inflammation. Given that lipoproteins also inhibit LTA- and …

R-Ketorolac Targets Cdc42 And Rac1 And Alters Ovarian Cancer Behaviors Critical For Invasion And Metastasis, Yuna Guo

Biomedical Sciences ETDs

Cdc42 (cell division control protein 42) and Rac1 (Ras-related C3 botulinum) are attractive therapeutic targets in ovarian cancer based on their established importance in tumor cell migration, adhesion and invasion. Despite a predicted benefit, targeting GTPases has not yet been translated to clinical practice. Based on lead identification through high-throughput screening and computational shape homology approaches, R-ketorolac is identified as a Cdc42 and Rac1 regulator, an activity that is distinct from the anti-inflammatory, cyclooxygenase inhibitory activity of S-ketorolac. In this dissertation, R-ketorolac is established as an allosteric inhibitor of Cdc42 and Rac1. Studies on immortalized human ovarian adenocarcinoma cells (SKOV3ip), …

Exposure Of Neonatal Rats To Alcohol Has Differential Effects On Cytokine Levels In The Cerebellum And Hippocampus: Potential Role Of Microglia And Astrocytes, Lauren Topper

Biomedical Sciences ETDs

Drinking during pregnancy can result in fetal alcohol spectrum disorders (FASD), an umbrella term that encompasses a wide array of symptoms ranging from neurocognitive deficits to physical malformations. The mechanism for FASD is not yet fully understood, however recently, activation of the neuroimmune system has been suggested to play a role. Neuroinflammation, characterized by increased pro-inflammatory cytokine production and glial cell activation, has been observed following exposure to alcohol during the neonatal period. Furthermore, neuroimmune activation has been implicated in alcohol-induced neuronal death and/or damage. The studies herein investigate several components of the relationship between neuronal damage following developmental alcohol …

Mechanisms Of Innate Immune Regulation Of Dermonecrosis During Staphylococcus Aureus Skin Infections, Moriah J. Castleman

Biomedical Sciences ETDs

S. aureus is the dominant cause of skin and soft tissue infections (SSTIs) in humans. The importance of S. aureus as the primary cause of skin infections has increased exponentially over the last few decades since the emergence of resistance to β-lactam antibiotics. Furthermore, the rise of methicillin-resistant S. aureus (MRSA) strains has led to hospitals stays, increased financial burden and increased mortality. A significant proportion of MRSA infections have been attributed to community-acquired strains (CA-MRSA), specifically the USA300 isolates, which can cause deadly disease in otherwise healthy individuals. Due to the increase in antibiotic resistance and the lack of …

Analysis Of Coastal Wetland Geography And Policy In Humboldt Bay: Adapting Wetland Policies For A Changing Climate", Dylan Loudon

Student Projects

No abstract provided.

Orally Delivered Β-Glucans Aggravate Dextran Sulfate Sodium (Dss)-Induced Intestinal Inflammation, Sigrid E.M. Heinsbroek, David L. Williams, Olaf Welting, Sybren L. Meijer, Siamon Gordon, Wouter J. De Jonge

ETSU Faculty Works

β-Glucans have beneficial health effects due to their immune modulatory properties. Oral administration of β-glucans affects tumour growth, microbial infection, sepsis, and wound healing. We hypothesized that pre-treatment with orally delivered soluble and particulate β-glucans could ameliorate the development of aggravate dextran sulfate sodium (DSS) induced intestinal inflammation. To study this, mice were orally pre-treated with β-glucans for 14 days. We tested curdlan (a particulate β-(1,3)-glucan), glucan phosphate (a soluble β-(1,3)-glucan), and zymosan (a particle made from Saccharomyces cerevisiae, which contains around 55% β-glucans). Weight loss, colon weight, and feces score did not differ between β-glucan and vehicle treated groups. …

2015-December-01-Giant Mastodont Skeleton Discovered At Gray Fossil Site, University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.

Effects Of Shrub Encroachment And Removal On South Texas Coastal Prairie Flora, Parker Alex Watson

Theses and Dissertations

Watson, Parker Alex, Effects of shrub encroachment and removal on South Texas coastal prairie flora. Master of Science, December, 2015. 60 pages, 14 tables, 11 figures, 47 references, 5 appendices. Native-invasive honey mesquite (Prosopis glandulosa) and huisache (Acacia farnesiana) are aggressively encroaching onto South Texas coastal prairies, outcompeting Gulf cordgrass (Spartina spartinae) and associated prairie vegetation with potential legacy effects on the landscape. To measure conditions in the presence of shrubs, data loggers were installed for 16 mos in shrub understories and grass cover to monitor light, soil and air temperatures. Vegetation and canopy surveys were also conducted to evaluate …

The Transformative Experiences Of Female Educators As A Catalyst For Social Change In The World, April D. Jordan

Dissertations

As social justice issues become known, one may be moved to act in the hopes of alleviating the conditions that burden marginalized and oppressed people. What is sometimes missing from the discourse when discussing oppressive issues is the role women play in counteracting such subjugation. Also essential, yet missing from the research, are studies that underscore the importance of educators fostering social action change outside of and apart from institutions of learning and curriculum planning. This qualitative study examined the lives of six, nontraditional, female educator intellectuals whose perceptions of self (identity) and the world were transformed by engaging in …

Microcontroller Application For Linear And Rotational Motion Sensing, Zachary Mintzer

Computer Engineering

No abstract provided.

The Production Of Sticky Notes And Bible Quotes: Godly Answers For Sticky Situations A Children’S Musical As Directed By Julie Brinkman, Julie Elizabeth Brinkman

Honors College

This thesis reflects upon a director’s experience while directing her first production: Sticky Notes and Bible Quotes: Godly Answers for Sticky Situations by Dennis and Nan Allen. This children’s musical was produced in cooperation with Wylie United Methodist Church of Abilene, TX. Over forty children, with the help of ten adult volunteers, shared the importance of memorizing scripture and looking to God’s Word in times of trouble through song, skits, and the recitation of scripture. While reflecting upon the production process after each rehearsal, the director makes connections between her experiences as director, the content of her music education undergraduate …

Analysis Of Neuronal Sequences Using Pairwise Biases, Zachary Roth

Department of Mathematics: Dissertations, Theses, and Student Research

Sequences of neuronal activation have long been implicated in a variety of brain functions. In particular, these sequences have been tied to memory formation and spatial navigation in the hippocampus, a region of mammalian brains. Traditionally, neuronal sequences have been interpreted as noisy manifestations of neuronal templates (i.e., orderings), ignoring much richer structure contained in the sequences. This paper introduces a new tool for understanding neuronal sequences: the bias matrix. The bias matrix captures the probabilistic tendency of each neuron to fire before or after each other neuron. Despite considering only pairs of neurons, the bias matrix captures the best …

Prevalence Of Tick-Borne Pathogens In Small Mammals And White-Tailed Deer In Southeast Nebraska, Tim M. Hotaling

School of Veterinary and Biomedical Sciences: Dissertations, Theses, and Student Research

The prevalence of tick-borne diseases has been increasing in the United States for the past couple decades. Studies have been conducted throughout the US identifying tick-borne disease pathogens as well as their hosts and prevalence. Research was conducted in Nebraska to determine the presence of some tick-borne disease pathogens, their vectors, and their hosts, with emphasis made on Borrelia spp., Rickettsia rickettsii, and Ehrlichia chaffeensis.

Small rodents in southeast Nebraska were trapped and sampled at eight study sites using live capture traps. Captured rodents were assessed for active parasitism by ticks which were collected and placed in alcohol. …

Investigation Of Pathways For Complex Sphingolipid Biosynthesis In Arabidopsis Thaliana (L.) Heynh, Kyle Luttgeharm

Department of Biochemistry: Dissertations, Theses, and Student Research

Sphingolipids are essential components of eukaryote membranes. The ceramide backbone of complex sphingolipids is composed of an 18 carbon Long Chain Base (LCB) bound to a 16-26 carbon fatty acid (FA) through an amide linkage. Ceramides are synthesized de novo from a free LCB and fatty acyl coA by ceramide synthase (sphingosine N-acyl transferase, EC 2.3.1.24) which can be inhibited by the fungal mycotoxin Fumonisin B₁. Arabidopsis thaliana contains three ceramide synthases denoted LOH1, LOH2, and LOH3 that have previously been hypothesized to have unique substrate preferences that control the final sphingolipid composition, different susceptibilities to …

Independent Monopoly Size In Graphs, Ahmed M. Naji, N. D. Soner

Applications and Applied Mathematics: An International Journal (AAM)

In a graph G = (V;E), a set D ⊆V (G) is said to be a monopoly set of G if every vertex v ∈V-D has at least d(v)/ 2 neighbors in D. The monopoly size of G, denoted mo(G), is the minimum cardinality of a monopoly set among all monopoly sets in G. The set D ⊆ V (G) is an independent monopoly set in G if it is both a monopoly set and an independent set in G. The number of vertices in a minimum independent monopoly set in a graph G is the independent monopoly size of …

Translating Andrew Kaufman's 'Signs Of The Cross' (Back) Into Spanish, Berenice Ventura Fernandez

Theses and Dissertations

Este trabajo se centra en la traducción al español del poema de Andrew Kaufman “Signs of the Cross”, que se encuentra en su libro Earth’s Ends. El poema presenta una visión familiar, al mismo tiempo que extranjerizante, de los pueblos latinoamericanos a los que describe. Se tratan en él temas como el cambio constante, la desacralización de lo sagrado, la reescritura de la historia, la resiliencia de algunos de los pueblos latinoamericanos, el peso del pasado sobre ellos, así como la presencia del cristianismo y los símbolos de la cruz presentes en acontecimientos históricos importantes, la religión, la vida cotidiana …

Prenatal Exposure To Perfluoroalkyl Acids And Serum Testosterone Concentrations At 15 Years Of Age In Female Alspac Study Participants, Mildred Maisonet, Antonia M. Calafat, Michele Marcus, Jouni J.K. Jaakkola, Hany Lashen

ETSU Faculty Works

Background: Exposure to perfluorooctane sulfonic acid (PFOS) or to perfluorooctanoic acid (PFOA) increases mouse and human peroxisome proliferator–activated receptor alpha (PPARα) subtype activity, which influences lipid metabolism. Because cholesterol is the substrate from which testosterone is synthesized, exposure to these substances has the potential to alter testosterone concentrations.

Objectives: We explored associations of total testosterone and sex hormone–binding globulin (SHBG) concentrations at age 15 years with prenatal exposures to PFOS, PFOA, perfluorohexane sulfonic acid (PFHxS), and perfluoronanoic acid (PFNA) in females.

Methods: Prenatal concentrations of the perfluoroalkyl acids (PFAAs) were measured in serum collected from pregnant mothers at enrollment (1991–1992) …

Economic Feasibility Of Aquaponics In Arkansas, Leah Ashley English

Graduate Theses and Dissertations

Concerns regarding population growth and resource scarcity have led to a recent renaissance of food production research. Over the past few decades, scientists have discovered new and innovative methods for growing food that, cumulatively, may hold the key to efficiently and sustainably feeding an ever-increasing world population. One method, known as aquaponics, has shown promise as being a sustainable solution for producing food locally in all parts of the world. Although many studies have shown aquaponic food production to be technically feasible, there are relatively few studies concerning the economic feasibility of aquaponics in various regions. To determine whether aquaponics …

Montclair Magazine (Fall/Winter 2015), Montclair State University

Montclair: The magazine of Montclair State University

No abstract provided.

The Regulation Of Hpv Late Gene Expression And The Potential Role Of Inkt Cells In Cervical Cancer, Patrice Nolan

Masters

Human papillomaviruses (HPVs) are ubiquitous, sexually transmitted viruses present in 99.7% of all cervical cancers, the second most common cancer in females worldwide. Expression of HPV L1 and L2 late genes is found only in terminally differentiated epithelial cells. As L1 and L2 proteins are highly immunogenic, it is suggested that their suppression may prevent detection of the virus by the immune system, thus acting as a prerequisite for persistence of infection. Therefore, if expression of these proteins in the lower cervical layers was induced, it could lead to clearance of the virus. One aim of this thesis was to …

Olfactory Enrichment In California Sea Lions (Zalophus Californianus), Mystera M. Samuelson

Dissertations

In the wild, California sea lions (Zalophus californianus) are exposed to a wide array of sensory information at all times. However, it is impossible for captive environments to provide this level of complexity. Therefore unique procedures and practices are necessary for the maintenance of physiological and psychological health in captive animals (Wells, 2009). This project aims to explore the behavioral effect of scent added to the environment, with the goal of improving the welfare of captive sea lions by introducing two scent types: 1.) Natural scents, found in their native environment, and 2.) Non-natural scents, not found in …

To Be Or Not To Be Satisfied: Examining Job Satisfaction Of Entry-Level Residence Life Professionals At Historically Black Colleges And Universities, Evingerlean D. Blakney

Dissertations

Research on historically Black college and universities (HBCUs) as institutions of higher education is limited. There is even less scholarship that brings forth an understanding of student affairs at these institutions. A gap in the higher education, student affairs, residence life, and job satisfaction literature suggested a need for research on residence life professionals at HBCUs. Therefore, the goal of this study was to examine job satisfaction of entry-level residence life professionals at HBCUs. For this study, the researcher looked for factors that contributed to overall job satisfaction and further examined the roles of both gender and public or private …

Macrobenthic Communities In The Northern Gulf Of Mexico Hypoxic Zone: Testing The Pearson-Rosenberg Model, Shivakumar Shivarudrappa

Dissertations

The Pearson and Rosenberg (P-R) conceptual model of macrobenthic succession was used to assess the impact of hypoxia (dissolved oxygen [DO] ≤ 2 mg/L) on the macrobenthic community on the continental shelf of northern Gulf of Mexico for the first time. The model uses a stress-response relationship between environmental parameters and the macrobenthic community to determine the ecological condition of the benthic habitat. The ecological significance of dissolved oxygen in a benthic habitat is well understood. In addition, the annual recurrence of bottom-water hypoxia on the Louisiana/Texas shelf during summer months is well documented.

The P-R model illustrates the decreasing …