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Articles 134671 - 134700 of 135657
Full-Text Articles in Entire DC Network
Modeling Nitroglycerin-Induced Migraine In Rats, Stephanie Staszko
Modeling Nitroglycerin-Induced Migraine In Rats, Stephanie Staszko
Honors Theses
The present research sought to determine whether nitroglycerin (NTG) produced changes in clinically relevant endophenotypes of migraine. Rats were given a single injection of NTG or vehicle with the following dependent measures recorded: Rat Grimace Scale, hot and cold tail flick latency, Rotor-Rod performance, and photophobia and movement in traditional and modified light/dark boxes. NTG increased rat grimace scores but did not produce thermal allodynia nor photophobia. Further, NTG produced paradoxical increases in Rotor-Rod performance and movement. These results demonstrate that a single injection of NTG does not produce behaviors that parallel clinical symptoms of migraine.
Valuation And Financial Statement Analysis For Activision-Blizzard, Inc., Stephen Wittmann
Valuation And Financial Statement Analysis For Activision-Blizzard, Inc., Stephen Wittmann
Honors Theses
Activision-Blizzard (ATVI), a market-leading publisher and developer in the videogame industry, represents a fascinating case study of a player in a relatively new industry as it struggles to find a permanent place among entrenched entertainment staples such as music, television, and movies. The company in its present form is the product of a 2008 merger between Activision Inc. and Vivendi Games, thus creating a massive publisher with rights to several of the industry's most popular franchises, including World of Warcraft, StarCraft, and Call of Duty. This industry domination has not gone unnoticed, and as of March 2013, ATVI's share price …
The Effects Of Adrenergic Antagonists On Spatial Memory In The Zebra Finch (Taeniopygia Guttata), Taylor Williams
The Effects Of Adrenergic Antagonists On Spatial Memory In The Zebra Finch (Taeniopygia Guttata), Taylor Williams
Honors Theses
The adrenergic system appears to be involved in the consolidation and reconsolidation of hippocampally dependent spatial memories in mammals. Based on connectivity, cell types, ontogeny and receptor distribution, the avian hippocampus is thought to be a homolog to the mammalian hippocampus. The adrenergic system appears to be fairly conserved but may show some species specializations. To determine if the adrenergic system plays a role in spatial learning and memory in birds, we used a series of experiments to investigate the role of α- and β-adrenergic receptors on spatial navigation and memory in an avian species, zebra finches, using the Day …
Developing The Marine Energy Sector In Scotland: A View From The Islands, Thomas Neal Mcmillin
Developing The Marine Energy Sector In Scotland: A View From The Islands, Thomas Neal Mcmillin
Honors Theses
In a world searching for environmentally-friendly alternative energy options, some people are looking to the ocean for answers. Through cutting-edge technology, engineers are devising ways to capture electricity from the power of the waves and tides. More than any other nation, Scotland is trying to develop a vibrant, domestic marine renewable energy hub. Instead of following the extraction-only model, Scotland seeks to achieve the entire ocean energy supply chain within the nation. An important first step towards this goal was the creation of the European Marine Energy Center (EMEC) in Orkney. The center hosts the leading test berths for tidal …
The Currency Union Effect On Trade: The Role Of Financial Development, Walker Lee Messer
The Currency Union Effect On Trade: The Role Of Financial Development, Walker Lee Messer
Honors Theses
The effect of currency union formation on trade growth may depend on an economy's level of financial development. Economies with lower levels of financial development have less capacity to hedge exchange rate risk, are susceptible to hysteresis, and have little to overcome the large fixed costs of entering foreign markets. These barriers may be partially overcome through the use of common currencies. Economies with high levels of financial development may already be capable of overcoming these barriers to trade and will likely not gain significant trade from common currency formation. This paper tests the hypothesis that the currency union effect …
Noninvasive Imaging Of Focal Atherosclerotic Lesions Using Fluorescence Molecular Tomography, Dolonchampa Maji, Metasebya Solomon, Annie Nguyen, Richard A. Pierce, Pamela K. Woodard, Walter J. Akers, Samuel Achilefu, Joseph P. Culver, Dana R. Abendschein, Monica Shokeen
Noninvasive Imaging Of Focal Atherosclerotic Lesions Using Fluorescence Molecular Tomography, Dolonchampa Maji, Metasebya Solomon, Annie Nguyen, Richard A. Pierce, Pamela K. Woodard, Walter J. Akers, Samuel Achilefu, Joseph P. Culver, Dana R. Abendschein, Monica Shokeen
Open Access Publications
No abstract provided.
Nephrotic Syndrome In Acute Promyelocytic Leukemia, Borhan Moradveisi, Armin Rashidi, Samin Alavi, Alireza Eskandarifar
Nephrotic Syndrome In Acute Promyelocytic Leukemia, Borhan Moradveisi, Armin Rashidi, Samin Alavi, Alireza Eskandarifar
Open Access Publications
No abstract provided.
Neuronal Activity Regulates Extracellular Tau In Vivo, Kaoru Yamada, Jerrah K. Holth, Fan Liao, Floy R. Stewart, Thomas E. Mahan, Hong Jiang, John R. Cirrito, Tirth K. Patel, Katja Hochgräfe, Eva-Maria Mandelkow, David M. Holtzman
Neuronal Activity Regulates Extracellular Tau In Vivo, Kaoru Yamada, Jerrah K. Holth, Fan Liao, Floy R. Stewart, Thomas E. Mahan, Hong Jiang, John R. Cirrito, Tirth K. Patel, Katja Hochgräfe, Eva-Maria Mandelkow, David M. Holtzman
Open Access Publications
Tau is primarily a cytoplasmic protein that stabilizes microtubules. However, it is also found in the extracellular space of the brain at appreciable concentrations. Although its presence there may be relevant to the intercellular spread of tau pathology, the cellular mechanisms regulating tau release into the extracellular space are not well understood. To test this in the context of neuronal networks in vivo, we used in vivo microdialysis. Increasing neuronal activity rapidly increased the steady-state levels of extracellular tau in vivo. Importantly, presynaptic glutamate release is sufficient to drive tau release. Although tau release occurred within hours in response to …
Potential Role Of Orexin And Sleep Modulation In The Pathogenesis Of Alzheimer's Disease, Jee Hoon Roh, Hong Jiang, Mary Beth Finn, Floy R. Stewart, Thomas E. Mahan, John R. Cirrito, Ashish Heda, B. Joy Snider, Mingjie Li, Masashi Yanagisawa, Luis De Lecea, David M. Holtzman
Potential Role Of Orexin And Sleep Modulation In The Pathogenesis Of Alzheimer's Disease, Jee Hoon Roh, Hong Jiang, Mary Beth Finn, Floy R. Stewart, Thomas E. Mahan, John R. Cirrito, Ashish Heda, B. Joy Snider, Mingjie Li, Masashi Yanagisawa, Luis De Lecea, David M. Holtzman
Open Access Publications
Age-related aggregation of amyloid-β (Aβ) is an upstream pathological event in Alzheimer's disease (AD) pathogenesis, and it disrupts the sleep-wake cycle. The amount of sleep declines with aging and to a greater extent in AD. Poor sleep quality and insufficient amounts of sleep have been noted in humans with preclinical evidence of AD. However, how the amount and quality of sleep affects Aβ aggregation is not yet well understood. Orexins (hypocretins) initiate and maintain wakefulness, and loss of orexin-producing neurons causes narcolepsy. We tried to determine whether orexin release or secondary changes in sleep via orexin modulation affect Aβ pathology. …
Endothelial Cells Use Dynamic Actin To Facilitate Lymphocyte Transendothelial Migration And Maintain The Monolayer Barrier, Olivia L. Mooren, Jinmei Li, Julie Nawas, John A. Cooper
Endothelial Cells Use Dynamic Actin To Facilitate Lymphocyte Transendothelial Migration And Maintain The Monolayer Barrier, Olivia L. Mooren, Jinmei Li, Julie Nawas, John A. Cooper
Open Access Publications
No abstract provided.
High-Coverage Sequencing And Annotated Assemblies Of The Budgerigar Genome, Ganeshkumar Ganapathy, Wesley C. Warren, Et Al
High-Coverage Sequencing And Annotated Assemblies Of The Budgerigar Genome, Ganeshkumar Ganapathy, Wesley C. Warren, Et Al
Open Access Publications
No abstract provided.
A Central Support System Can Facilitate Implementation And Sustainability Of A Classroom-Based Undergraduate Research Experience (Cure) In Genomics, David Lopatto, Jeremy Buhler, Elaine Mardis, Wilson Leung, Christopher D. Shaffer, Jennifer Threlfall, Et Al
A Central Support System Can Facilitate Implementation And Sustainability Of A Classroom-Based Undergraduate Research Experience (Cure) In Genomics, David Lopatto, Jeremy Buhler, Elaine Mardis, Wilson Leung, Christopher D. Shaffer, Jennifer Threlfall, Et Al
Open Access Publications
No abstract provided.
Treatment Of Metastatic Spinal Lesions With A Navigational Bipolar Radiofrequency Ablation Device: A Multicenter Retrospective Study, Praveen R. Anchala, Winston D. Irving, Travis J. Hillen, Michael V. Friedman, Bassem A. Georgy, Douglass M. Coldwell, Nam D. Tran, Frank D. Vrionis, Allan Brook, Jack W. Jennings
Treatment Of Metastatic Spinal Lesions With A Navigational Bipolar Radiofrequency Ablation Device: A Multicenter Retrospective Study, Praveen R. Anchala, Winston D. Irving, Travis J. Hillen, Michael V. Friedman, Bassem A. Georgy, Douglass M. Coldwell, Nam D. Tran, Frank D. Vrionis, Allan Brook, Jack W. Jennings
Open Access Publications
No abstract provided.
The Cavefish Genome Reveals Candidate Genes For Eye Loss, Suzanne E. Mcgaugh, Patrick Minx, Wesley C. Warren, Et Al
The Cavefish Genome Reveals Candidate Genes For Eye Loss, Suzanne E. Mcgaugh, Patrick Minx, Wesley C. Warren, Et Al
Open Access Publications
No abstract provided.
Integrated Analysis Of Germline And Somatic Variants In Ovarian Cancer, Krishna L. Kanchi, Kimberly J. Johnson, Charles Lu, Michael D. Mclellan, Michael C. Wendl, Qunyuan Zhang, Daniel C. Koboldt, Mingchao Xie, Cyriac Kandoth, Joshua F. Mcmichael, Matthew A. Wyczalkowski, David E. Larson, Heather K. Schmidt, Christopher A. Miller, Robert S. Fulton, Elaine R. Mardis, Todd E. Druley, Timothy A. Graubert, Richard K. Wilson, Li Ding, Et Al
Integrated Analysis Of Germline And Somatic Variants In Ovarian Cancer, Krishna L. Kanchi, Kimberly J. Johnson, Charles Lu, Michael D. Mclellan, Michael C. Wendl, Qunyuan Zhang, Daniel C. Koboldt, Mingchao Xie, Cyriac Kandoth, Joshua F. Mcmichael, Matthew A. Wyczalkowski, David E. Larson, Heather K. Schmidt, Christopher A. Miller, Robert S. Fulton, Elaine R. Mardis, Todd E. Druley, Timothy A. Graubert, Richard K. Wilson, Li Ding, Et Al
Open Access Publications
No abstract provided.
Secondhand Smoke Exposure And Severity Of Attention-Deficit/Hyperactivity Disorder In Preschoolers: A Pilot Investigation, Mini Tandon, Christina N. Lessov-Schlaggar, Rebecca Tillman, Melbourne F. Hovell, Joan Luby
Secondhand Smoke Exposure And Severity Of Attention-Deficit/Hyperactivity Disorder In Preschoolers: A Pilot Investigation, Mini Tandon, Christina N. Lessov-Schlaggar, Rebecca Tillman, Melbourne F. Hovell, Joan Luby
Open Access Publications
No abstract provided.
Patents At Issue: The Data Behind The Patent Troll Debate, Jonathan H. Ashtor, Michael J. Mazzeo, Samantha Zyontz
Patents At Issue: The Data Behind The Patent Troll Debate, Jonathan H. Ashtor, Michael J. Mazzeo, Samantha Zyontz
Faculty Scholarship
The debate over "patent trolls"' is raging at full tilt and its fury is stoked by fundamental questions about patent assertion. Both sides are struggling to understand which patent assertion practices are consistent with the purpose of patent rights and which are abusive and result in net social costs. This Article addresses patent assertion concretely through empirical analysis of actual infringement awards. In particular, this Article studies all awards granted for findings of patent infringement in U.S. district courts between 1995 and 2011, and, with targeted analyses, focuses on cases involving patent assertion entities ("PAEs"). This Article specifically investigates certain …
Genome-Wide Mapping Of The Distribution Of Card, Rnap Σa, And Rnap Β On The Mycobacterium Smegmatis Chromosome Using Chromatin Immunoprecipitation Sequencing, Robert Landick, Azra Krek, Michael S. Glickman, Nicholas D. Socci, Christina L. Stallings
Genome-Wide Mapping Of The Distribution Of Card, Rnap Σa, And Rnap Β On The Mycobacterium Smegmatis Chromosome Using Chromatin Immunoprecipitation Sequencing, Robert Landick, Azra Krek, Michael S. Glickman, Nicholas D. Socci, Christina L. Stallings
Open Access Publications
No abstract provided.
Illustrated Techniques For Performing The Cox-Maze Iv Procedure Through A Right Mini-Thoracotomy, Jason O. Robertson, Lindsey L. Saint, Jeremy E. Leidenfrost, Ralph J. Damiano Jr.
Illustrated Techniques For Performing The Cox-Maze Iv Procedure Through A Right Mini-Thoracotomy, Jason O. Robertson, Lindsey L. Saint, Jeremy E. Leidenfrost, Ralph J. Damiano Jr.
Open Access Publications
No abstract provided.
Cell Type-Specific Expression Analysis To Identify Putative Cellular Mechanisms For Neurogenetic Disorders, Xiaoxiao Xu, Alan B. Wells, David R. O'Brien, Arye Nehorai, Joseph D. Dougherty
Cell Type-Specific Expression Analysis To Identify Putative Cellular Mechanisms For Neurogenetic Disorders, Xiaoxiao Xu, Alan B. Wells, David R. O'Brien, Arye Nehorai, Joseph D. Dougherty
Open Access Publications
No abstract provided.
An Improved Predictive Recognition Model For Cys2-His2 Zinc Finger Proteins, Ankit Gupta, Ryan G. Christensen, Heather A. Bell, Mathew Goodwin, Ronak Y. Patel, Manishi Pandey, Metewo Selase Enuameh, Amy L. Rayla, Cong Zhu, Stacey Thibodeau-Beganny, Michael H. Brodsky, J Keith Joung, Scot A. Wolfe, Gary D. Stormo
An Improved Predictive Recognition Model For Cys2-His2 Zinc Finger Proteins, Ankit Gupta, Ryan G. Christensen, Heather A. Bell, Mathew Goodwin, Ronak Y. Patel, Manishi Pandey, Metewo Selase Enuameh, Amy L. Rayla, Cong Zhu, Stacey Thibodeau-Beganny, Michael H. Brodsky, J Keith Joung, Scot A. Wolfe, Gary D. Stormo
Open Access Publications
No abstract provided.
Comparison Of The Stand-Alone Cox-Maze Iv Procedure To The Concomitant Cox-Maze Iv And Mitral Valve Procedure For Atrial Fibrillation, Christopher P. Lawrance, Matthew C. Henn, Jacob R. Miller, Laurie A. Sinn, Richard B. Schuessler, Ralph J. Damiano Jr.
Comparison Of The Stand-Alone Cox-Maze Iv Procedure To The Concomitant Cox-Maze Iv And Mitral Valve Procedure For Atrial Fibrillation, Christopher P. Lawrance, Matthew C. Henn, Jacob R. Miller, Laurie A. Sinn, Richard B. Schuessler, Ralph J. Damiano Jr.
Open Access Publications
No abstract provided.
The Semiotics Of Film In Us Supreme Court Cases, Jessica Silbey, Meghan Hayes Slack
The Semiotics Of Film In Us Supreme Court Cases, Jessica Silbey, Meghan Hayes Slack
Faculty Scholarship
This chapter explores the treatment of film as a cultural object among varied legal subject matter in US Supreme Court jurisprudence. Film is significant as an object or industry well beyond its incarnation as popular media. Its role in law – even the highest level of US appellate law – is similarly varied and goes well beyond the subject of a copyright case (as a moving picture) or as an evidentiary proffer (as a video of a criminal confession). This chapter traces the discussion of film in US Supreme Court cases in order to map the wide-ranging and diverse relations …
Hippocampal Long-Term Potentiation Is Disrupted During Expression And Extinction But Is Restored After Reinstatement Of Morphine Place Preference, George S. Portugal, Ream Al-Hasani, Amanda K. Fakira, Jose L. Gonzalez-Romero, Zare Melyan, Jordan G. Mccall, Michael R. Bruchas, Jose A. Moron
Hippocampal Long-Term Potentiation Is Disrupted During Expression And Extinction But Is Restored After Reinstatement Of Morphine Place Preference, George S. Portugal, Ream Al-Hasani, Amanda K. Fakira, Jose L. Gonzalez-Romero, Zare Melyan, Jordan G. Mccall, Michael R. Bruchas, Jose A. Moron
Open Access Publications
No abstract provided.
Electronic Health Record: Integrating Evidence-Based Information At The Point Of Clinical Decision Making, Susan A. Fowler, Lauren H. Yaeger, Feliciano Yu, Dwight Doerhoff, Paul Schoening
Electronic Health Record: Integrating Evidence-Based Information At The Point Of Clinical Decision Making, Susan A. Fowler, Lauren H. Yaeger, Feliciano Yu, Dwight Doerhoff, Paul Schoening
Open Access Publications
No abstract provided.
Whole-Genome Sequencing Of Salmonella Enterica Subsp. Enterica Serovar Cubana Strains Isolated From Agricultural Sources, George Weinstock, Et Al
Whole-Genome Sequencing Of Salmonella Enterica Subsp. Enterica Serovar Cubana Strains Isolated From Agricultural Sources, George Weinstock, Et Al
Open Access Publications
No abstract provided.
Targeting The Programmed Cell Death 1: Programmed Cell Death Ligand 1 Pathway Reverses T Cell Exhaustion In Patients With Sepsis, Katherine Chang, Catherine Svabek, Cristina Vazquez-Guillamet, Bryan Sato, David Rasche, Strother Wilson, Paul Robbins, Nancy Ulbrandt, Joann Suzich, Jonathan Green, Andriani C. Patera, Wade Blair, Subramaniam Krishnan, Richard Hotchkiss
Targeting The Programmed Cell Death 1: Programmed Cell Death Ligand 1 Pathway Reverses T Cell Exhaustion In Patients With Sepsis, Katherine Chang, Catherine Svabek, Cristina Vazquez-Guillamet, Bryan Sato, David Rasche, Strother Wilson, Paul Robbins, Nancy Ulbrandt, Joann Suzich, Jonathan Green, Andriani C. Patera, Wade Blair, Subramaniam Krishnan, Richard Hotchkiss
Open Access Publications
No abstract provided.
Tax Inflicts Dna Damage Through Activation Of Nitric Oxide Production, Hicham H. Baydoun, Lee Ratner
Tax Inflicts Dna Damage Through Activation Of Nitric Oxide Production, Hicham H. Baydoun, Lee Ratner
Open Access Publications
No abstract provided.
Economic Evaluation Of Access To Musculoskeletal Care: The Case Of Waiting For Total Knee Arthroplasty, Richard C. Mather Iii, Kevin T. Hug, Lori A. Orlando, Tyler Steven Watters, Lane Koenig, Ryan M. Nunley, Michael P. Bolognesi
Economic Evaluation Of Access To Musculoskeletal Care: The Case Of Waiting For Total Knee Arthroplasty, Richard C. Mather Iii, Kevin T. Hug, Lori A. Orlando, Tyler Steven Watters, Lane Koenig, Ryan M. Nunley, Michael P. Bolognesi
Open Access Publications
No abstract provided.
Novel Treatment Option For Muc16-Positive Malignancies With The Targeted Trail-Based Fusion Protein Meso-Tr3, Gunjal Garg, Jesse Gibbs, Brian Belt, Matthew A. Powell, David G. Mutch, Peter Goedegebuure, Lynne Collins, David Piwnica-Worms, William G. Hawkins, Dirk Spitzer
Novel Treatment Option For Muc16-Positive Malignancies With The Targeted Trail-Based Fusion Protein Meso-Tr3, Gunjal Garg, Jesse Gibbs, Brian Belt, Matthew A. Powell, David G. Mutch, Peter Goedegebuure, Lynne Collins, David Piwnica-Worms, William G. Hawkins, Dirk Spitzer
Open Access Publications
No abstract provided.