Digital Commons Network^™

Long-Acting Antituberculous Therapeutic Nanoparticles Target Macrophage Endosomes, Benson J. Edagwa, Dongwei Guo, Pavan Puligujja, Han Chen, Joellyn Mcmillan, Xinming Liu, Howard Gendelman, Prabagaran Narayanasamy

Nebraska Center for Biotechnology: Faculty and Staff Publications

Eradication of Mycobacterium tuberculosis (MTB) infection requires daily administration of combinations of rifampin (RIF), isoniazid [isonicotinylhydrazine (INH)], pyrazinamide, and ethambutol, among other drug therapies. To facilitate and optimize MTB therapeutic selections, a mononuclear phagocyte (MP; monocyte, macrophage, and dendritic cell)-targeted drug delivery strategy was developed. Long-acting nanoformulations of RIF and an INH derivative, pentenyl- INH (INHP), were prepared, and their physicochemical properties were evaluated. This included the evaluation of MP particle uptake and retention, cell viability, and antimicrobial efficacy. Drug levels reached 6 μg/106 cells in human monocyte-derived macrophages (MDMs) for nanoparticle treatments compared with 0.1 μg/106 cells for native …

A Fish Farmer’S Role In Sustainable Aquaculture: An Overview Of Philippine Aquaculture, Janice A. Ragaza, Jonni Fay C. Teves

Biology Faculty Publications

The expansion of Philippine aquaculture is essential to addressing poverty and food insecurity in the midst of a seemingly irreversible decline in national capture fisheries. Concomitant with its rise, however, are compounding environmental problems caused by climate change, lackluster governance and irresponsible farming practices. It is equally important to ensure aquaculture sustainability so that fish demand from a rapidly growing population is continually met and that fish farmers’ socioeconomic well-being is secured. As such, programs have been developed that aim to enjoin the government and private sectors with fishing communities to realize this goal.

Project Management And Its Relation To Long-Term Project Success : An Empirically Based Theoretical Framework., Youssef Ait Boudlal 1969-

Electronic Theses and Dissertations

Companies implement effective project management to successfully operate in turbulent market cycles and ensure the success of their endeavors. Project management is indispensable for most industrial sectors and is employed in a variety of for-profit and non-profit organizations. It can be considered as a management method that contributes value to a variety of organizations. Many practitioners and researchers have attempted to identify the causes of project failure, the factors of project success, and the criteria to gauge this success. There has been little agreement on what constitutes project success. In response to the widespread debate surrounding project success, several lists …

Investigation Of Transmission Loss Through Double Wall Structures With Varying Small Air Gaps Using Modal Analysis., Richard Michael Phillips 1988-

Electronic Theses and Dissertations

Noise reduction testing is completed for two single steel plate constructions with different thicknesses and for two double wall constructions with different air gap thicknesses that include the same two plates used in the single plate constructions. Results compare favorably with known theory and experimental results from previous literature. These favorable comparisons include the direct relationship between mass per unit area and transmission loss for single plate constructions, the presence of a noise reduction valley near the mass-air-mass frequency, the dependency of the mass-air-mass frequency on the air gap thickness, and the existence of a bridge frequency. Despite the similarities …

Evolutionary Search For Models Of Planarian Regeneration Using Experimental Data, Marianna Viktorovna Budnikova

Boise State University Theses and Dissertations

The ability of science to produce experimental data greatly surpasses our current ability to effectively visualize, conceptualize, and integrate the vast volumes of available data into a unified understanding of how complex biological systems work. This inability is a hindrance to scientific progress, and is particularly daunting when one considers multidimensional and shape-based observations as in the field of regenerative biology. For example, for at least the last 200 years, scientists have been interested in the exceptional ability of Planaria to regenerate lost tissues from damage, and there is a large amount of experimental data available on this organism. However, …

The Tracker: A Proximity Alarm System, Derek Van Riper

Electrical Engineering

No abstract provided.

Wirelessly Controlled Smart Outlet, Andrew Godsil, Ariel Dubinsky

Electrical Engineering

Popularity of home automation devices has increased greatly in recent years due to higher affordability and simplicity through smartphone and tablet connectivity. For the purpose of this experiment, we have developed the Smart Outlet: a stand-alone communication unit, used to connect home outlets to the internet. The Smart Outlet controls lighting and simple appliances throughout the home, remotely, using wireless commands from the web. A Google Calendar interface directly controls the outlets’ function by scheduling them with dedicated calendar events. The calendar’s interface can even be accessed from multiple different platforms (i.e. phones, computers, tablets) for the convenience of all …

Transimpedance Amplifier For Polymer Photodiodes, Sheridan Knighton

Electrical Engineering

Dr. Braun’s students in the Polymer Electronics Lab currently have a way to measure the light intensity from their light emitting devices however it consumes an unnecessary amount of space and power. I offer to improve upon the existing transimpedance circuit that Dr. Braun currently uses, reducing the total space occupied by the circuit and the power consumption of the current setup. The transimpedance circuit measures the incidence light intensity from the polymer-based photo detector and outputs an accurate, discrete, and measurable voltage. The current setup however utilizes two 20V wall warts for the positive and negative rails of the …

Microprocessor Management Of Energy Harvesting Buck Boost Converters, Timothy O'Sullivan

Electrical Engineering

No abstract provided.

High Voltage Pulse-Width Generator For The Algae Biofuel Project, Philip Yu, Stephen Leung

Electrical Engineering

This purpose of this project, sponsored by Boeing and advised by Dr. Arakaki and Dr. Taufik, is to build a high voltage pulse width generator that lyses algae cells to harvest the biofuel within. This project uses Emmanuel Loza's thesis on a cascaded high voltage converter with variable control to build a portable pulse width generator with independent control on the peak voltage, pulse width, and frequency. The project focuses on creating a pulse width generator capable of finding the most optimal pulsed electric field to lyse algae. The pulse width module ranges from 10V-80V peak voltage, 60Hz-100 kHz frequency, …

December 2014 News Releases, University Of Montana--Missoula. Office Of University Relations

University of Montana News Releases, 1928, 1956-present

No abstract provided.

Feedlot Manure Management Considerations Including Anaerobic Digestion Potential And Mineral Retention, Andrea K. Watson

Department of Animal Science: Dissertations, Theses, and Student Research

Three anaerobic digestion trials were conducted to evaluate methane production from feedlot manure. As organic matter content of manure decreased, degradation of manure and methane production also linearly decreased (P ≤ 0.02). Quality, or organic matter content of manure, had a greater impact on anaerobic digestion than diet (with and without distillers grains) fed to cattle. Minerals are concentrated in effluent removed from anaerobic digesters.

Knowing mineral retention within cattle allows for more accurate calculation of mineral excretion in manure. Three serial slaughter trials measured mineral retention in growing and finishing cattle. During a growing phase, beef cattle gaining …

Suppression Of Invasion And Metastasis Of Triple-Negative Breast Cancer Lines By Pharmacological Or Genetic Inhibition Of Slug Activity., Giovanna Ferrari-Amorotti, Claudia Chiodoni, Fei Shen, Sara Cattelani, Angela Rachele Soliera, Gloria Manzotti, Giulia Grisendi, Massimo Dominici, Francesco Rivasi, Mario Paolo Colombo, Alessandro Fatatis, Bruno Calabretta

Department of Cancer Biology Faculty Papers

Most triple-negative breast cancers (TNBCs) exhibit gene expression patterns associated with epithelial-to-mesenchymal transition (EMT), a feature that correlates with a propensity for metastatic spread. Overexpression of the EMT regulator Slug is detected in basal and mesenchymal-type TNBCs and is associated with reduced E-cadherin expression and aggressive disease. The effects of Slug depend, in part, on the interaction of its N-terminal SNAG repressor domain with the chromatin-modifying protein lysine demethylase 1 (LSD1); thus, we investigated whether tranylcypromine [also known as trans-2-phenylcyclopropylamine hydrochloride (PCPA) or Parnate], an inhibitor of LSD1 that blocks its interaction with Slug, suppresses the migration, invasion, and metastatic …

The Miscommunication Of Standardized Education, Eliott James Walker

Communication Studies

No abstract provided.

Online Experiences Of Adolescents With Asperger’S Syndrome And High-Functioning Autism, Shin Ruu Ko

All-Inclusive List of Electronic Theses and Dissertations

This study investigated the online experiences of 10 adolescents with Asperger's Disorder (AD). This study was exploratory in nature and employed a qualitative approach. Three research questions guided this study: (a) What are the positive and negative online experiences of youth with ASD?, (b) What are the perceptions of online interactions in comparison to offline interactions held by youth with ASD?, and (c) What experiences with social connectedness and cyberbullying do youth with ASD have as a result of Internet usage? Four themes and 14 subthemes emerged during the process of analyzing the data: (a) Benefits of Internet Usage (Social, …

Listening To Shells And Discovering A Lost World; Epiphanic Experiences At The Museum, Catherine M.C. Closet-Crane

Proceedings from the Document Academy

This paper aims to entertain the possibilities for analysis, interpretation, and learning offered by evocative autoethnographic texts for LAM and LIS user studies. The focus in this paper is on storytelling as autoethnographic writing. To illustrate facets of a particular cultural experience and start a conversation about the transformative power of museum objects as documents, the story told in this paper recounts a series of events and experiences from the life of two visitors after their museum encounter with an engraved shell artifact from the archeological site of Spiro Mounds in Oklahoma.

Full Issue, The Mcnair Team

McNair Scholars Research Journal

No abstract provided.

Alumni Earning Doctorates, The Mcnair Team

McNair Scholars Research Journal

No abstract provided.

Flexible R Functions For Processing Accelerometer Data, With Emphasis On Nhanes 2003–2006, Dane R. Van Domelen, W. Stephen Pittard

The R Journal

Accelerometers are a valuable tool for measuring physical activity (PA) in epidemiological studies. However, considerable processing is needed to convert time-series accelerometer data into meaningful variables for statistical analysis. This article describes two recently developed R packages for processing accelerometer data. The package accelerometry contains functions for performing various data processing procedures, such as identifying periods of non-wear time and bouts of activity. The functions are flexible, computationally efficient, and compatible with uniaxial or triaxial data. The package nhanesaccel is specifically for processing data from the National Health and Nutrition Examination Survey (NHANES), years 2003–2006. Its primary function generates measures …

Compact Antennas And Arrays For Unmanned Air Systems, James Arthur Eck

Theses and Dissertations

A simple and novel dual-CP printed antenna is modelled and measured. The patch antennais small and achieves a low axial ratio without quadrature feeding. The measured pattern showsaxial ratio pattern squinting over frequency. Possible methods of improving the individual element are discussed, as well as an array technique for improving the axial ratio bandwidth. Three endfire printed antenna structures are designed, analyzed, and compared. The comparison includes an analysis of costs of production for the antenna structures in addition to their performance parameters. This analysis concludes that cost of materials primarily reduces the size of antennas for a given gain …

Replication And Knowledge Production In Empirical Software Engineering Research, Jonathan L. Krein

Theses and Dissertations

Although replication is considered an indispensable part of the scientific method in software engineering, few replication studies are published each year. The rate of replication, however, is not surprising given that replication theory in software engineering is immature. Not only are replication taxonomies varied and difficult to reconcile, but opinions on the role of replication contradict. In general, we have no clear sense of how to build knowledge via replication, particularly given the practical realities of our research field. Consequently, most replications in software engineering yield little useful information. In particular, the vast majority of external replications (i.e., replications performed …

Microchip Thermal Gradient Gas Chromatography, Anzi Wang

Theses and Dissertations

Although the airbath oven is a reliable heating method for gas chromatography (GC), resistive heating is needed for higher analytical throughput and on-site chemical analysis because of size, heating rate and power requirements. In the last thirty years, a variety of resistive heating methods were developed and implemented for both benchtop and portable GC systems. Although fast heating rates and low power consumption have been achieved, losses in column efficiency and resolution, complex construction processes and difficulties experienced in recovering damaged columns have also become problematic for routine use of resistively heated columns. To solve these problems, a new resistively …

Framework To Implement Authentication, Authorization And Secure Communications In A Multiuser Collaborative Cax Environment, Francis Mensah

Theses and Dissertations

Computer Aided Design (CAD) applications have historically been based on a single user per application architecture. Although this architecture is still popular to date, it does have several drawbacks. First of all the single user CAD architecture inhibits a concurrent engineering design process where several designers can work on the same model simultaneously. This limitation introduces time inefficiency especially when a project involves geographically dispersed designers. A solution to these drawbacks could be a transition from the traditional single user CAD architecture to a multiuser collaborative architecture. Advances in computer networking technologies, especially relating to the Internet, have provided the …

Characterization Of Smoothness In Wrist Rotations, Layne Hancock Salmond

Theses and Dissertations

Smoothness is a hallmark of healthy movement and has the potential to be used as a marker of recovery in rehabilitation settings. While much past research has focused on shoulder and elbow movements (reaching), little is known about movements of the wrist despite its importance in everyday life and its impairment in many neurological and biomechanical disorders. Our current lack of knowledge regarding wrist movement prevents us from improving current models, diagnosis, and treatment of wrist disorders. In particular, while movement smoothness is a well-known characteristic of reaching movements and may potentially be used to diagnose and monitor recovery from …

Modeling And Testing Of Bistable Waterbomb Base Configurations, Brandon Holbrook Hanna

Theses and Dissertations

Origami is making an impact in engineering as solutions to problems are being found by applying origami principles (eg. flat-foldability) and using specific crease patterns as inspiration. This thesis presents an in-depth analysis of a particular origami fold -- the waterbomb base -- to facilitate its use in future engineering problems. The watebomb base is of interest due to its familiarity to the origami community, simple topology (can be made by folding a single sheet of paper four times), scalability, generalizability, and interesting kinetic behavior. It can behave as a nonlinear spring as well as a one- or two-way bistable …

The Bioluminescence Heterozygous Genome Assembler, Jared Calvin Price

Theses and Dissertations

High-throughput DNA sequencing technologies are currently revolutionizing the fields of biology and medicine by elucidating the structure and function of the components of life. Modern DNA sequencing machines typically produce relatively short reads of DNA which are then assembled by software in an attempt to produce a representation of the entire genome. Due to the complex structure of all but the smallest genomes, especially the abundant presence of exact or almost exact repeats, all genome assemblers introduce errors into the final sequence and output a relatively large set of contigs instead of full-length chromosomes (a contig is a DNA sequence …

Crash Prediction Modeling For Curved Segments Of Rural Two-Lane Two-Way Highways In Utah, Casey Scott Knecht

Theses and Dissertations

This thesis contains the results of the development of crash prediction models for curved segments of rural two-lane two-way highways in the state of Utah. The modeling effort included the calibration of the predictive model found in the Highway Safety Manual (HSM) as well as the development of Utah-specific models developed using negative binomial regression. The data for these models came from randomly sampled curved segments in Utah, with crash data coming from years 2008-2012. The total number of randomly sampled curved segments was 1,495. The HSM predictive model for rural two-lane two-way highways consists of a safety performance function …

A Hybrid Method For Sensitivity Optimization With Application To Radio-Frequency Product Design, Abraham Lee

Theses and Dissertations

A method for performing robust optimal design that combines the efficiency of experimental designs and the accuracy of nonlinear programming (NLP) has been developed, called Search-and-Zoom. Two case studies from the RF and communications industry, a high-frequency micro-strip band-pass filter (BPF) and a rectangular, directional patch antenna, were used to show that sensitivity optimization could be effectively performed in this industry and to compare the computational efficiency of traditional NLP methods (using fmincon solver in MATLAB R2013a) and they hybrid method Search-and-Zoom. The sensitivity of the BPF's S11 response was reduced from 0.06666 at the (non-robust) nominal optimum to 0.01862 …

The Practice Of Neogeography In Community-Based Organizations, Patrick Oberle

Theses - ALL

Neogeography and Volunteered Geographic Information (VGI) are two terms that have emerged recently to describe the practice of geography by those not formally trained in it as a discipline and spatial data provided by individuals through social media and other Web-based tools. Both neogeography and VGI can be directly linked to the growth of various online mapping websites and applications that allow for the creation of electronic maps that are interactive, adaptable, and easily shared via the Internet and Web. As recent phenomena, the practice of neogeography and VGI is not well understood, nor are the links these new fields …

The Effect Of Surface Roughness On The Fretting Corrosion Of 316l Stainless Steel Biomaterial Surfaces, Aarti Shenoy

Theses - ALL

The medical device industry is still seeking answers to the mechanically-assisted corrosion (MAC) problem, which becomes increasingly important due to modularity in design. MAC manifests in various forms, some of which are fretting corrosion, crevice corrosion and stress corrosion. Several studies have been conducted to understand the causes and the factors that affect fretting corrosion. Some of the factors are the applied load, surface potential, oxide film characteristics and solution chemistry near the interface. Surface properties such as surface roughness determine the topography of the surface and the nature of asperity-asperity contact, which is a factor that would determine the …