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Cd151-Α3Β1 Integrin Complexes Suppress Ovarian Tumor Growth By Repressing Slug-Mediated Emt And Canonical Wnt Signaling, Lauren A. Baldwin, John T. Hoff, Jason Lefringhouse, Michael Zhang, Changhe Jia, Zeyi Liu, Sonia Erfani, Hongyan Jin, Mei Xu, Qing-Bai She, John R. Van Nagell Jr., Chi Wang, Li Chen, Rina Plattner, David M. Kaetzel, Jia Luo, Michael Lu, Dava West, Chunming Liu, Fred R. Ueland, Ronny Drapkin, Binhua P. Zhou, Xiuwei H. Yang

Pharmacology and Nutritional Sciences Faculty Publications

Human ovarian cancer is diagnosed in the late, metastatic stages but the underlying mechanisms remain poorly understood. We report a surprising functional link between CD151-α3β1 integrin complexes and the malignancy of serous-type ovarian cancer. Analyses of clinical specimens indicate that CD151 expression is significantly reduced or diminished in 90% of metastatic lesions, while it remains detectable in 58% of primary tumors. These observations suggest a putative tumor-suppressing role of CD151 in ovarian cancer. Indeed, our analyses show that knocking down CD151 or α3 integrin enhances tumor cell proliferation, growth and ascites production in nude mice. These changes are accompanied by …

Scientizing Culpability: The Implications Of Hall V. Florida And The Possibility Of A “Scientific Stare Decisis”, Christopher Slobogin

William & Mary Bill of Rights Journal

The Supreme Court’s decision in Hall v. Florida held that “clinical definitions” control the meaning of intellectual disability in the death penalty context. In other words, Hall “scientized” the definition of a legal concept. This Article discusses the implications of this unprecedented move. It also introduces the idea of scientific stare decisis—a requirement that groups that are scientifically alike be treated similarly for culpability purposes—as a means of implementing the scientization process.

Usa V. Rodney Miller, Sr.

2014 Decisions

USDC for the District Court of the Virgin Islands

Usa V. Richard Brown

2014 Decisions

USDC for the Western District of Pennsylvania

Michael Lehtonen V. Governor Of The Virgin Islands

2014 Decisions

USDC for the District Court of the Virgin Islands

Usa V. Willie Purdom

2014 Decisions

USDC for the Western District of Pennsylvania

The Influence Of Dx-52-1 And Phosphorylation On The Interactions Of Galectin-3 With Its Binding Partners, Matthew L. Rotondi

Doctoral Dissertations

The Influence of DX-52-1 and Phosphorylation on the Interactions of Galectin-3 with its Binding Partners

Matthew L. Rotondi, PhD

University of Connecticut, 2015

Galectin-3, a member of a large family of animal based β-galactoside-binding lectins has been shown to play a role in a number of cellular and pathogenic processes. This protein has been shown throughout the literature to interact with a diverse multiplicity of proteins, involved in a diverse array of cellular functions, including cell migration and cell proliferation, both of which are of particular in regards to cancer research. Covalent modifications to Galectin-3 that can undermine its binding …

(Un)Wrapping Felix Gonzalez-Torres: The Relational Power And Contagious Wonderment Of Candy And Other Things, Brooke Clark

Honors Theses

Huddled in the corner of the cold, sterile floor of The Art Institute of Chicago, Felix Gonzalez-Torres's Untitled (Portrait of Ross in L.A.), 1991 is a mound of individually wrapped, multihued candy that can be possessed, consumed, and rearranged by the audience (artic.edu). The parenthetical remark within the title suggests the portrait is that of a human. In fact, Ross was the artist's lover, who died of AIDS in the year 1991. The candy spill memorializes Ross at his healthy weight of one hundred seventy-five pounds. Even as Ross's body is implicated in the candy, the candies themselves contain and …

State V. Casad Respondent's Brief Dckt. 41613

Not Reported

No abstract provided.

Introduction, Linda Jackson

William & Mary Journal of Race, Gender, and Social Justice

No abstract provided.

Women In The Crowd Of Corporate Directors: Following, Walking Alone, And Meaningfully Contributing, Joan Macleod Heminway

William & Mary Journal of Race, Gender, and Social Justice

No abstract provided.

Feminist Legal Theory As A Way To Explain The Lack Of Progress Of Women’S Rights In Afghanistan: The Need For A State Strength Approach, Isaac Kfir

William & Mary Journal of Race, Gender, and Social Justice

Cultural and religious practices are critical to explaining Afghanistan’s dreadful reputation concerning the preservation, protection, and promotion of women’s rights. Those advocating misogynistic practices assert that the calls for reforms challenge their religion and culture, while also claiming that many women’s issues exist within the private realm. Accordingly, they assert that reforms that aim at addressing disempowerment are not vital to the state and go beyond the established limits of state authority. Building on feminist legal theory, which distinguishes between the public and private spheres, I argue in Afghanistan misogynistic and discriminatory practices stem from contrived cultural and religious norms. …

Procedurally Criminal: How Peremptory Challenges Create Unfair And Unrepresentative Single-Gender Juries, Chelsea V. King

William & Mary Journal of Race, Gender, and Social Justice

No abstract provided.

A Travesty Of Justice: Revisiting Harris V. Mcrae, Jill E. Adams, Jessica Arons

William & Mary Journal of Race, Gender, and Social Justice

No abstract provided.

Climatic Controls On Organic Matter Decomposition In Boreal Peatlands, Michael J. Philben

Theses and Dissertations

Boreal peatlands currently contain 550 Pg C and are located at high latitudes where mean annual temperatures are expected to increase by as much as 7°C by the end of the century. There is growing concern that warming will stimulate decomposition, transforming peatlands from a sink to a source of atmospheric carbon dioxide and accelerating climate change. A primary goal of this dissertation was to evaluate the effect of climate change on organic matter decomposition in peatlands. This was achieved by developing and employing biochemical tracers to indicate the extent of peat decomposition across a range of naturally occurring climatic …

Independence At Large: Contemporary China's Alternative Music Scenes And The Cultural Practices Of Post-Socialist Urban Youth, Shan Huang

Theses and Dissertations

Using contemporary Beijing’s alternative music scenes as a focal point, this ethnographic research seeks to enrich the understanding of China’s post-socialist urban youth by examining their cultural practices. First, this thesis offers an analytical account of the popularizing embrace of “independent cultures,” which is defined as a collection of experienceable objects and activities in musical, filmic, theatric, and other cultural forms that are well recognized yet believed by advocates as having aesthetic and participatory features that are different from those produced in the popular culture industry. While the vogue for independent cultures is substantially conditioned by the socioeconomic attributes of …

Making Fun Of Franco: Representations And Caricatures Of Spanish Fascism In The Films El Espiritú De La Colmena, Cría Cueros And El Laberinto Del Fauno, Elizabeth Pruchnicki

Renée Crown University Honors Thesis Projects - All

The end of the Spanish Civil War marked the beginning of Francisco Franco’s dictatorship, which lasted more than 35 years. Throughout this time, he systemized terror, executing more than 100,000 republican sympathizers in the first few years of his regime and marginalizing the remainder of the population. Therefore, the Fascist Era lasting from 1940-1975 is one plagued with strained relationships, ambiguous loyalties and distant relatives. The films El espiritú de la colmena by Victor Erice, Cría cuervos by Carlos Saura and El laberinto del fauno by Guillermo del Toro’s illustrate these kinds of challenges, from the point …

Invest For Impact: An Exploration Of The Incongruities In Social Finance, Kelly Marie Thompson

Renée Crown University Honors Thesis Projects - All

Within the impact investing industry, a definition for societal return and how to measure this concept is lacking. Although its potential has been proven, there is still very limited exposure to impact investing within the United States. The present study aims to survey the current status of the impact investment industry in the United States, assess the presence of gaps between investments and their outcomes, and formulate a framework for addressing such shortcomings. The current status of the impact investing industry was examined and evaluated in order to understand how the industry is defined, what is the outcomes social finance, …

Hern V. Idaho Transp. Dept. Appellant's Brief 1 Dckt. 42287

Idaho Supreme Court Records & Briefs, All

No abstract provided.

"The Garden Of Forking Paths": Islamic Legal Transformations In The Ottoman Empire During The Nineteenth Century, John Bugnacki

History & Classics Undergraduate Theses

In the popular imagination, misconceptions abound regarding islamic law. Many outside of the Islamic world believe that Islamic law consists of a discrete series of inviolable, unchanging commands. However, both in historical and contemporary contexts, this characterization is false. The different legal schools within Islamic law have evolved and changed over time in response to surrounding conditions and other legal traditions that have existed alongside it. In the Ottoman Empire this process was particularly evident and, during the nineteenth century, its main tradition of Islamic law underwent an unprecedented transformation that would seek to combine Islamic legal principles within statist …

An Essential Role For Self-Pmhc Throughout The Life Of A Cd4 T Cell: Contributions In The Thymus And Periphery, Stephanie Rodriguez

Arts & Sciences Graduate Student Theses and Dissertations

It is well established that self-peptide Major Histocompatibility Complexes (hereafter self-pMHC) are essential for the development of a broad repertoire of mature, self-tolerant CD4 and CD8 T cells. Despite clear knowledge that the pool of self-ligands is critical for positive and negative selection, the exact kinetics and dynamic nature of thymocyte interaction with self-pMHC class II (self-pMHCII) bearing antigen-presenting cells (APCs) during development is still largely a mystery. The enigmatic nature of selecting self-pMHC is not unique to the thymic environment; increasingly evident is the dependence of peripheral T cells on extra-thymic self-pMHC expression, specifically selecting self-pMHC, for their homeostatic …

Tuning Electronic Correlation With Pressure, Gilberto Fernandes Lopes Fabbris

Arts & Sciences Graduate Student Theses and Dissertations

Strongly correlated electron systems display some of the most exotic ground states in condensed matter. In this thesis high pressure is used to tune the degree of electron correlations in systems of current interest. Their electronic and structural properties were investigated at high pressure using x-ray spectroscopy and scattering as well as transport techniques in a diamond anvil cell. The interplay between short- and long-range structural order, one-dimensional charge ordering, and superconductivity was studied in La_1.875Ba_0.125CuO₄. At ambient pressure, this material displays charge ordering at the onset of a low temperature structural phase transition, …

Power To Appoint: A Model Of Appointments To The United States Federal Judiciary, Alicia Bernice Uribe

Arts & Sciences Graduate Student Theses and Dissertations

This dissertation project considers judicial appointments in a new light. The project, first, considers how appointments to the United States Federal Judiciary might be thought of differently if the appointment to multiple positions were thought of as interdependent decisions rather than independent decisions. I create a simulation based model that matches judges with vacant positions in the judiciary to see how our expectations of appointments should differ for different levels of the judiciary and in different political environments. I then consider how this approach might translate to other selection mechanisms comparing the selection system for the federal judiciary with other …

Zinc And Copper Isotopic Fractionation During Planetary Differentiation, Heng Chen

Arts & Sciences Graduate Student Theses and Dissertations

Zinc and copper are two important transition metal elements that are widely involved in every stage of planetary formation and differentiation. Their isotopic ratios are robust tracers used to understand the origin of the Solar System, planetary formation and differentiation processes. In this thesis, I focus on their isotopic behaviors during magmatic processes. I report the Zn isotopic compositions of representative igneous rocks to determine potential isotopic fractionations associated with magmatic processes, and to estimate the bulk silicate Earth value. I report isotopic compositions of various groups of iron meteorites (samples of which represent the core of asteroids) and discuss …

Nuns In The Newsroom: The Sisters Of Marillac College And U.S. Sisters’ Involvement In Social Justice Reform, Elizabeth D. Nako

History & Classics Undergraduate Theses

"Nuns in the Newsroom: The Sisters of Marillac College and U.S. Sisters' Involvement in Social Justice Reform" is a senior honors history thesis project.  The Second Vatican Council (1962-1965) was guided by the spirit of aggiornamento, or “a bringing up to date” of the Catholic Church.  As a result of Vatican II documents such as Gaudium et Spes, they influenced U.S. sisters to expand their ministry from performing works of mercy to advocating for legal, economic, and social justice in addition to their charitable endeavors.  However, after doing research at the Daughters of Charity Archives in Emmitsburg, Maryland and …

Monnet, The General, And The Community Of Six: French Policy On European Integration In The 1950s And 1960s, Daniel A. Gagnon

History & Classics Undergraduate Theses

This thesis examines the roles of Jean Monnet and General Charles de Gaulle in crafting French policy towards a united Europe during the postwar decades. Monnet strongly supported supranational integration in which the nations of Europe cede power to common governing institutions. But, French policy changed dramatically when de Gaulle came to power in 1958. As a nationalist he refused to sacrifice France’s independence by ceding power to the common institutions. He risked the existence of a united Europe, but after his sudden departure in 1969 it became clear that French popular opinion opposed his limiting policy towards European integration.

Portland Spectrum, December 2014, Portland State University. Student Publications Board

Portland Spectrum

Editor: Corinne Hutfilz

Articles in this issue include: GMO: An Informed Right to Know; Aetna: Is it Worth it?; Torrenting on Campus; Food Insecurity Across College Campuses; Raise the Umbrella: Protests in Hong Kong Continued; A Point of View..... Arrival at Tangier (A Snapshot in Time; Meeting a Writer); and ISIS: A History of Terror;

State V. Cooke Respondent's Brief Dckt. 41833

Not Reported

No abstract provided.

Sovereignty, Economic Development, And Human Security In Native American Nations, W. Gregory Guedel

American Indian Law Journal

No abstract provided.

No Tribal Court Is An Island? Citation Practices Of The Tribal Judiciary, Rose Carmen Goldberg

American Indian Law Journal

No abstract provided.