Digital Commons Network^™

A Western-Fed Diet Increases Plasma Hdl And Ldl-Cholesterol Levels In Apod–/– Mice, Kamilah Ali, Ehab M. Abo-Ali, M. D. Kabir, Bethany Riggins, Susanna Nguy, Lisa Li, Ujala Srivastava, Su Mya Mya Thinn

Publications and Research

Objective Plasma apolipoprotein (apo)D, a ubiquitously expressed protein that binds small hydrophobic ligands, is found mainly on HDL particles. According to studies of human genetics and lipid disorders, plasma apoD levels positively correlate with HDL-cholesterol and apoAI levels. Thus, we tested the hypothesis that apoD was a regulator of HDL metabolism. Methods & Results We compared the plasma lipid and lipoprotein profiles of wild-type (WT) C57BL/6 mice with apoD−/− mice on a C57BL/6 background after receiving a high fat-high cholesterol diet for 12 weeks. ApoD−/− mice had higher HDL-cholesterol levels (61±13-apoD−/− vs. 52±10-WT-males; 37±11-apoD−/− vs. 22±2 WT-female) than WT mice …

Left Ventricular Assist Device As Destination Therapy, Maya Guglin, Leslie W. Miller

The VAD Journal

Mechanical circulatory support is the most rapidly evolving strategy in heart failure management. The growing number of patients who need better results than medical therapy can offer, the limited pool of donors for cardiac transplantation, and several technological breakthroughs have all made the option of implanting a left ventricular assist device (LVAD) as destination therapy more important.

In this review, we outline the indications and decision making process of considering a patient for a destination therapy LVAD, as well as outcomes, complications, and issues related to management of patients on currently approved devices. The future direction of the field will …

System And Method For Dissolving Gases In Fluids And For Delivery Of Dissolved Gases, Gregory S. Osborn, Marty D. Matlock, Shandi S. Teltschik

Patents Granted

Apparatus and methods are disclosed for facilitating dissolution of one or more gases into a liquid. Preferred gases for use with the apparatus are oxygen, air, and ozone. An apparatus of the present invention includes a dissolution tank that includes a pressure vessel, at least one liquid spray nozzle, and a fluid outlet. The apparatus also includes a gas source, an element for passing fluid into the pressure vessel, and a discharge device connected to the fluid outlet, which discharge device is provided with at least one orifice. Preferred applications include wastewater treatment, treatment of drinking water, fermentation, and bioremediation.

The Bubbling Aorta, Hesham R. Omar, Maya Guglin

The VAD Journal

We are presenting the image of the bubbles in the descending aorta in a patient on VA ECMO.

American Society Of Parasitologists Newsletter, V. 36, Nos. 3-4, Fall-Winter 2014, Scott Lyell Gardner

American Society of Parasitologists: Newsletter

No abstract provided.

Minimally Invasive Networked Surgical System And Method, Richard D. Gitlin, Gabriel E. Arrobo, Thomas P. Ketterl

USF Patents

A system for performing non-invasive networked medical procedures including a number of in vivo medical devices, a communication path between at least two of the devices, an ex vivo control unit to control the behavior of the devices, and a wireless communication path between the control unit and at least one of the devices. An associated method for performing non-invasive networked medical procedures is also provided. Further included is a simulation method that utilizes accurate electromagnetic field simulations, using a software based test bench, to determine the maximum allowable transmitted power levels from in vivo devices to achieve a required …

Combination Of Insulin And Ascorbate To Enhance Wound Healing, Kurt Musselmann, John R. Hassell, Brad Kane, Bridgette Alexandrou

USF Patents

Provided is a method of stimulating collagen synthesis and proteoglycan (lumican and keratocan) accumulation. Collagenase isolated keratocytes were cultured with or without insulin with or without ascorbate. Insulin stimulates the synthesis of collagen but does not affect the accumulation of lumican and keratocan. Insulin plus ascorbate, however, stimulates the synthesis of collagen and increased the accumulation of these proteoglycans. The accumulation of PGDS, a KSPG that does not interact with collagen, is not affected by ascorbate. Only the collagen made in the presence of ascorbate was pepsin resistant. EDB overrode the effects of ascorbate on pepsin resistance and proteoglycan accumulation.

Evolutionary Genomics And Adaptive Evolution Of The Hedgehog Gene Family (Shh, Ihh And Dhh) In Vertebrates, Joana Pereira, Warren E. Johnson, Stephen J. O'Brien, Erich D. Jarvis, Guojie Zhang, M. Thomas P. Gilbert, Vitor Vasconcelos, Agostinho Antunes

Biology Faculty Articles

The Hedgehog (Hh) gene family codes for a class of secreted proteins composed of two active domains that act as signalling molecules during embryo development, namely for the development of the nervous and skeletal systems and the formation of the testis cord. While only one Hh gene is found typically in invertebrate genomes, most vertebrates species have three (Sonic hedgehog – Shh; Indian hedgehog – Ihh; and Desert hedgehog – Dhh), each with different expression patterns and functions, which likely helped promote the increasing complexity of vertebrates and their successful diversification. In this study, we …

Classification Of Current Anticancer Immunotherapies., Lorenzo Galluzzi, Erika Vacchelli, José-Manuel Bravo-San Pedro, Aitziber Buqué, Laura Senovilla, Elisa Elena Baracco, Norma Bloy, Francesca Castoldi, Jean-Pierre Abastado, Patrizia Agostinis, Ron N Apte, Fernando Aranda, Maha Ayyoub, Philipp Beckhove, Jean-Yves Blay, Laura Bracci, Anne Caignard, Chiara Castelli, Federica Cavallo, Estaban Celis, Vincenzo Cerundolo, Aled Clayton, Mario P Colombo, Lisa Coussens, Madhav V Dhodapkar, Alexander M Eggermont, Douglas T Fearon, Wolf H Fridman, Jitka Fučíková, Dmitry I Gabrilovich, Jérôme Galon, Abhishek Garg, François Ghiringhelli, Giuseppe Giaccone, Eli Gilboa, Sacha Gnjatic, Axel Hoos, Anne Hosmalin, Dirk Jäger, Pawel Kalinski, Klas Kärre, Oliver Kepp, Rolf Kiessling, John M Kirkwood, Eva Klein, Alexander Knuth, Claire E Lewis, Roland Liblau, Michael T Lotze, Enrico Lugli, Jean-Pierre Mach, Fabrizio Mattei, Domenico Mavilio, Ignacio Melero, Cornelis J Melief, Elizabeth A Mittendorf, Lorenzo Moretta, Adekunke Odunsi, Hideho Okada, Anna Karolina Palucka, Marcus E Peter, Kenneth J Pienta, Angel Porgador, George C Prendergast, Gabriel A Rabinovich, Nicholas P Restifo, Naiyer Rizvi, Catherine Sautès-Fridman, Hans Schreiber, Barbara Seliger, Hiroshi Shiku, Bruno Silva-Santos, Mark J Smyth, Daniel E Speiser, Radek Spisek, Pramod K Srivastava, James E Talmadge, Eric Tartour, Sjoerd H Van Der Burg, Benoît J Van Den Eynde, Richard Vile, Hermann Wagner, Jeffrey S Weber, Theresa L Whiteside, Jedd D Wolchok, Laurence Zitvogel, Weiping Zou, Guido Kroemer

Kimmel Cancer Center Faculty Papers

During the past decades, anticancer immunotherapy has evolved from a promising therapeutic option to a robust clinical reality. Many immunotherapeutic regimens are now approved by the US Food and Drug Administration and the European Medicines Agency for use in cancer patients, and many others are being investigated as standalone therapeutic interventions or combined with conventional treatments in clinical studies. Immunotherapies may be subdivided into "passive" and "active" based on their ability to engage the host immune system against cancer. Since the anticancer activity of most passive immunotherapeutics (including tumor-targeting monoclonal antibodies) also relies on the host immune system, this classification …

Lives In Fiction: Auto/Biographies As Theoretical Narratives, Dennis S. Erasga

Asia-Pacific Social Science Review

Sociological imagination is an open invitation to theorize from the stories we tell about ourselves and others. More than self-expression, the sociological ethos of auto/biographical narration is to extend the reality of a solipsistic and exclusive existence into a common and public experience. In order to achieve this, the narrator must convert biographies into scribed realities. The narrating process, however, has unique epistemic anchorage (memory-based) and stylistic requirement (literary) that encage lived lives in a fictional genre, giving this mode of writing a unique interpretive lens that projects new visions of the social. Consequently for theorizing purposes, auto/biographies are meaning-claims …

National Vs. International Schools: Factors Influencing School Choice In Egypt; The Voices Of Parents And Students., Yasmine Alaa Khorshed

Theses and Dissertations

There are many national and international schools in Cairo today, and every year lots of parents make educational choices for their children. Those choices are based on various factors. This research explores the factors that influence parents to select a certain school type and not the other. It is an initial step into school research as an attempt to help educators and administrators understand parents’ and students’ priorities, needs and expectations when choosing a school. The research questions are: (1) What are the most and least important factors that parents consider when choosing a national/ international school for their children? …

Of Economic Bubbles And Economic Miracles: Notes And Reflections From A Non-Expert, Dennis V. Blanco

Asia-Pacific Social Science Review

No abstract provided.

The Effect Of Non Freeze-Dried Hydrogel-Cha On Fibroblast Proliferation, Ivan A. Wahyudi, Lea M. Nurwadji

Journal of Dentistry Indonesia

Bone damage can be caused by variety of surgical procedures. Bone reconstruction has been developed lately is tissue engineering techniques. One of materials that proved to be effective as a scaffold in tissue engineering is a hydrogel. The addition of carbonate apatite (CHA) will produce a hydrogel-CHA material which is believed to improve the mechanical properties and biological similarities with the original bone. Scaffold is considered an important aspect in the field of tissue engineering, because it’s ability to mimic extracellular matrix of the damaged tissue. Fibroblasts are mesenchymal cells that can be readily cultured in the laboratory and play …

Orofacial Disorders Of Patients With End Stage Renal Disease Undergoing Haemodialysis, Yohana Gowara, Afi S. Sarsito, Parlindungan Siregar, Yuniardini S. Wimardhani

Journal of Dentistry Indonesia

Several orofacial disorders in patients with end stage renal disease (ESRD) undergoing hemodialysis have been reported. However, up to the present, particularly in Indonesia, such data still limited. Objective: the purpose of this study was to assess the orofacial disorders in patients with ESDR undergoing hemodialysis at Cipto Mangunkusumo Hospital, Indonesia. Methods: The study was conducted through observation using a cross-sectional design. The subjects were selected by consecutive sampling. Ninety-three patients fulfilled the inclusion criteria and enrolled in this study. They participated in the structural interview-using questionnaire assessing subjective complaints; clinical examinations; and salivary measurements. Results: Xerostomia (82.8%) dysgeusia (66.7%), …

Measurement Of Tooth Brushing Frequency, Time Of Day And Duration Of Adults And Children In Jakarta, Indonesia, Anton Rahardjo, Diah A. Maharani, Bramma Kiswanjaya, Erik Idrus, Julie Nicholson, Paul J. Cunningham, Fred Schäfer

Journal of Dentistry Indonesia

Epidemiological study of tooth brushing is essential to evaluate dental health of a country. Objective: To obtain data on tooth brushing frequency, time of day and duration from adults and children in Jakarta, Indonesia. Methods: Toothbrushes containing data loggers were distributed to 120 random families in Jakarta to record how many times a day, when and for how long subjects brushed their teeth. The families were each composed of a mother, father and two children aged between 6 and 15 years. Results: The mean brushing frequency of the population was 1.27 times per day. The majority of the tooth brushing …

Uji Stabilitas Fisik Formula Krim Yang Mengandung Ekstrak Kacang Kedelai (Glycine Max), Rosmala Dewi, Effionora Anwar, Yunita Ks

Pharmaceutical Sciences and Research

Soybean extract has known for its antiaging potential. The addition of soybean extract was predicted can influence the physical stability of the cream. Therefore, this research was aimed to test the physical stability of cream contained soybean extract in different concentration (2%, 4%, 6%, and 8%). The physical stability test including the storage for eight weeks at room temperature, high temperature (40°±2°C), and low temperature (4°±2°C). Stability parameters were the organoleptic observation, pH, globul size, viscosity, and cycling test. Those four cream formula showed good stability in organoleptic, pH, globul size, viscosity, and cycling test.

Efek Fraksi N-Heksana Kulit Hylocereus Polyrhizus Terhadapaktivitas Katalase Tikus Stres Oksidatif, Eka Kartika Untari, Sri Wahdaningsih, Agustia Damayanti

Pharmaceutical Sciences and Research

Production of excess free radicals cause oxidative damage and degenerative diseases. Catalase enzyme is one of the endogenous intracellular antioxidant that can be reduced by oxidative stress conditions. The peel of red dragon fruit (Hylocereus polyrhizus) as a potent exogenous antioxidants could support the internal enzyme activity to prevent free radicals. The aim of this research was to determine the effect of n-hexane fraction of H.polyrhizus’s peel and the dose that could increase activity of catalase. The peel was maserated with chloroform, then fractionated by n-hexane. Stress condition was achieved by five days fasting and swimming for 10 mins/day to …

Efek Fraksi N-Heksana Kulit Hylocereus Polyhizus Terhadap Kadar Malondialdehida Tikus Stres Oksidatif, Wirna Maya Sari, Sri Wahdaningsih, Eka Kartika Untari

Pharmaceutical Sciences and Research

Excessive free radical production will lead to oxidative stress. One of the indicators used to determine stress oxidative is malondialdehyde (MDA). Hylocereus polyhizus peel is potential used natural exogenous antioxidant. The aim of this research was to study the effect of n-hexane fraction of H.polyhizus peel on MDA level and to determine the dose that could reduce the MDA level. H.polyhizus peel was macerated with chloroform, fractionated with n-Hexane. Rats were divided into 7 groups : normal, negative, positive control vitamin E (18 mg/ kgbw), positive control quercetin (4 mg/200gbw), H.polyhizus peel extract group treated with dose I (10mg/ 200gbw), …

Antibakteri Fraksi N-Heksana Kulit Hylocereus Polyrhizus Terhadap Staphylococcus Epidermidis Dan Propionibacterium Acnes, Sri Wahdaningsih, Eka Kartika Untari, Yunita Fauziah

Pharmaceutical Sciences and Research

Acne can be caused by Staphylococcus epidermidis and Propionibacterium acnes. By using antibiotic for the acne theraphy in a long term period can cause resistance, organ detriment and imunohypersensitivity. Red dragon fruit’s peel (Hylocereus polyrhizus) is one of natural materials which can be used for alternative antibacterial. This study aims to determine the antibacterial activity of n-Hexane fraction of red dragon fruit’s peel against S. epidermidis dan P. acnes by the method of disc diffusion Kirby-Bauer. Red dragon fruit’s peel powder macerated within chloroform, and macerate then fractionated with n-Hexane. Phytochemical screening result red dragon fruit’s peel contains terpenoid and …

Distaste: Joyce Carol Oates And Food, David Rutledge

Bearing Witness: Joyce Carol Oates Studies

Distaste: Joyce Carol Oates and Food

Abstract

In many of her short stories and novels, Joyce Carol Oates depicts an unhealthy relationship with food. The range of these unhealthy relationships is wide, from overeating to the point of suicide, in Expensive People, to starving oneself in an attempt to deny one’s physical nature, in “Orange” and them. Overindulgence is a means for attempting to fill that space where the soul should be; undereating is often an attempt to deny one’s place in the social world. The eating disorders she portrays are rooted in both personal and social causes. …

Directional Secretory Response Of Double Stranded Rna-Induced Thymic Stromal Lymphopoetin (Tslp) And Ccl11/Eotaxin-1 In Human Asthmatic Airways, Gustavo Nino, Shehlanoor Huseni, Geovanny F. Perez, Krishna Pancham, Humaira Mubeen, Aleeza Abeesi, Justin Wang, Stephen Eng, Anamaris M. Colberg-Poley, Mary C. Rose

Pediatrics Faculty Publications

Background

Thymic stromal lymphoproetin (TSLP) is a cytokine secreted by the airway epithelium in response to respiratory viruses and it is known to promote allergic Th2 responses in asthma. This study investigated whether virally-induced secretion of TSLP is directional in nature (apical vs. basolateral) and/or if there are TSLP-mediated effects occurring at both sides of the bronchial epithelial barrier in the asthmatic state.

Methods

Primary human bronchial epithelial cells (HBEC) from control (n = 3) and asthmatic (n = 3) donors were differentiated into polarized respiratory tract epithelium under air-liquid interface (ALI) conditions and treated apically with dsRNA (viral surrogate) …

Authenticity In Constructivist Inquiry: Assessing An Elusive Construct, Patrick Shannon, Elyse Hambacher

Education

Methodological rigor in constructivist inquiry is established through an assessment of trustworthiness and authenticity. Trustworthiness parallels the positivistic concepts of internal and external validity, focusing on an assessment of the inquiry process. Authenticity, however, is unique to constructivist inquiry and has no parallel in the positivistic paradigm. Authenticity involves an assessment of the meaningfulness and usefulness of interactive inquiry processes and social change that results from these processes. However, the techniques for ascertaining authenticity are in the early stages of development. Therefore, the purpose of this article is to describe a process for assessing authenticity in a constructivist inquiry. A …

Amylin Structure, Aggregation, And Pancreatic Β Cell Toxicity, Sharadrao Patil

MCB Articles

In most type 2 diabetes patients, amyloid plaques have been found juxtaposed with membranes of pancreatic β-cells. These plaques are composed of amyloid fibrils of the 37 residue endocrine hormone amylin and cause distinct changes in cell membrane morphology associated with the destruction of β-cells. Research is still ongoing to identify the toxic species involved and the mechanisms by which mature fibrils or oligomers cause cytotoxicity. The projects undertaken were designed to study the molecular structural features of amylin, mechanism of amyloid aggregation and, to develop cytotoxicity inhibitors. We determined the structure of human amylin bound to SDS micelles using …

Heal Utah, Et. Al., Plaintiffs/Appellants, V. Kane County Water Conservancy District, Et. Al. Defendant/Appellees., Utah Court Of Appeals

Utah Court of Appeals Briefs (2007– 2019)

An appeal from a judgment of the Seventh District Court sitting without a jury Judge George M. Hatmond, Jr.

Modeling Properties Of Deformation Pattern, Yuan Lin

Theses and Dissertations

The human aging process is a complicated topic in the biological sciences. It is human nature to want to keep looking young and interested in one's appearance many years into the future. Some fundamental questions related to this issue are, "How fast are we aging?" Is it a continuous process or is it a process of phases? What will I possibly look like after ten years? To provide an answer to all of these questions, it is necessary to closely monitor the changes taking places in our anatomy. Wrinkles and human face shape deformation, which are the natural signs of …

Authenticity In Constructivist Inquiry: Assessing An Elusive Construct, Patrick Shannon, Elyse Hambacher

The Qualitative Report

Methodological rigor in constructivist inquiry is established through an assessment of trustworthiness and authenticity. Trustworthiness parallels the positivistic concepts of internal and external validity, focusing on an assessment of the inquiry process. Authenticity, however, is unique to constructivist inquiry and has no parallel in the positivistic paradigm. Authenticity involves an assessment of the meaningfulness and usefulness of interactive inquiry processes and social change that results from these processes. However, the techniques for ascertaining authenticity are in the early stages of development. Therefore, the purpose of this article is to describe a process for assessing authenticity in a constructivist inquiry. A …

State V. Vaughn Respondent's Brief Dckt. 42077

Not Reported

No abstract provided.

Tracing The History Of Grounded Theory Methodology: From Formation To Fragmentation, Méabh Kenny, Robert Fourie

The Qualitative Report

There are very few articles, which track the history of Grounded Theory (GT) methodology from its tentative conception to its present divisions. This journal article addresses the dearth by tracing the history of GT methodology from its conception in the 1960’s, discussing the context of its composition, character, and contribution. Subsequently, the article follows the maturation of GT which is characterised by a series of contentious and, at times, antagonistic academic debates. The crux of these debates centres on disputes over core tenets of GT and have resulted in three dominant and divergent configurations of the GT methodology: Classic, Straussian, …

Baseline Survey For Street Dogs In Guam, John D. Boone

Stray and Feral Animal Populations Collection

As is the case for many inhabited islands in Pacific region, dogs are common, including freeroaming street dogs that may be owned or unowned. Reproduction among dogs is largely unchecked, and many owned dogs do not receive adequate levels of basic care in the home or veterinary care when needed. For all of these reasons, Humane Society International (HSI) is exploring options for improving the management of street dog populations and promoting better treatment and care of all dogs on Guam and on the nearby islands of Rota and Saipan. One of the initial steps in this process was to …

Direct Electrochemistry And Glucose Biosensing Of Glucose Oxidase-Gold Nanoparticles Composite Synthesized By Enzyme Method, Fang He, Xiao-Li Qin, Ying-Chun Fu, Chao Chen, Qing-Ji Xie, Shou-Zhuo Yao

Journal of Electrochemistry

Glucose oxidase (GOx)-gold nanoparticles (AuNPs) composite was synthesized by the one-pot enzyme reaction in the mixture solution of NaAuCl₄, GOx and glucose, and a Nafion/GOx-AuNPs/glassy carbon electrode was fabricated by the cast-coating method to examine the direct electrochemistry of GOx and the biosensing performance on this electrode. Such a GOx-AuNPs composite showed good direct-electrochemistry activity and bioactivity of GOx, probably because the enzyme-mediated AuNPs are close to the redox active centers of GOx. This enzyme electrode exhibited a linear amperometric response to glucose concentration (0.54 mmol·L^-1) at -0.4 V (vs. SCE), and a detection limit of …