Digital Commons Network^™

Emotional Urgency And Lack Of Perseverance Are Linked To Anxiety Sensitivity And Improve During Early Recovery From Opioid Use Disorder., Breanna A. Mcnaughton-Long, Abigail J. Pleiman, Carmen Buchfink, Chrysantha B. Davis, Rayus Kuplicki, Martin P. Paulus, Hung-Wen Yeh, Maëlle C M Gueguen, Jennifer L. Stewart

Manuscripts, Articles, Book Chapters and Other Papers

Few studies have identified how facets of impulsivity relate to recovery in opioid use disorder (OUD). Treatment-enrolled individuals with OUD (n = 167) and healthy controls (CTL; n = 46) completed the Urgency, Premeditation, Perseverance, Sensation Seeking, Positive Urgency (UPPS-P) Impulsive Behavior Scale along with demographic and clinical measures at visit 1. Over the next three months, abstinence and return to use were documented for participants with OUD (via self-report, alcohol breathalyzer, urine drug screen, and secondary contact communication). Participants with OUD who returned to use (n = 59) did not complete further study visits, whereas those who remained abstinent …

Managing Collaboration Under Conservation Crisis: Trust, Risk, And Control In The Gulf Of Maine Fishery Management Network, Evelyn Roozee, Owen Temby, Dongkyu Kim, Antonia Sohns, Anthony Rocha Lima, Jasper R. De Vries, Gordon M. Hickey

School of Earth, Environmental, & Marine Sciences Faculty Publications

Transboundary fishery management and the intertwined conservation of critically endangered species represent significant governance challenges that require ongoing inter-organizational communication, collaboration, and collective action to achieve shared objectives. Previous research suggests that inter-organizational collaborative performance depends heavily on different dimensions of trust and complementary control mechanisms to mitigate the perceived risks of collaborating and enable the reciprocal sharing of resources and the coordination of activities. However, it is unclear how proposed relationships between trust, risk, and control are shaped by disruptions to established transboundary management networks. This study presents the results of survey research conducted in the Gulf of Maine …

Fall 2026 Environmental Sciences Seminar Series, Sam Bogan, Sam Bogan

NRESS Seminars

The deep sea is Earth's largest and least-explored habitat, leaving much of its biology unknown. I will present two studies leveraging long-read sequencing to uncover the population dynamics and evolution of deep-sea vertebrates. First, we examined how deep-sea invasions constrained thermal adaptation in  globally distributed fishes. Second, we reconstructed the demography and population health of elusive, deep-foraging whales. In these intractable but important systems, advances in long-read sequencing enabled previously unattainable biological insights.

Evaluating Data-Mining Strategies For Label-Free Raman Microspectroscopic Analysis Of Cellular Processes In Vitro: Dynamic Dimensionality Reduction, Zohreh Mirveis, Nitin Patil, Hugh J. Byrne

Research Outputs: 2025-Present

Understanding dynamic intracellular metabolism is essential for elucidating cellular function and disease mechanisms. However, analysing time-resolved spectral data is challenging due to overlapping signals, high dimensionality, and biological variability. This study evaluates the applicability of Multivariate Curve Resolution-Alternating Least Squares (MCR-ALS) for resolving complex cellular spectral data and introduces a framework that integrates Principal Component Analysis (PCA) of sequential time points as a preprocessing step. PCA was used to extract dominant spectral variance associated with biological kinetics (PC1), and MCR-ALS was subsequently applied to the sequential PC1 loadings to enhance the recovery of kinetic trends. To validate the approach, simulated …

The Antibacterial Properties Of The Infrapatellar Fat Pad Organ, Mark A. Coggins

Summer Research Program Abstracts

No abstract provided.

Engineering Pegylated Chitosan–Gold Nanoparticles For Radiosensitization And Sirna Delivery To Glioblastoma, Wesley Chiu

Summer Research Program Abstracts

No abstract provided.

Ai-Driven Biomarker Discovery & Progression Modeling For Precision Diagnosis Of Glaucoma, Cheng Huang

Computer Science and Engineering Theses and Dissertations

This dissertation presents a comprehensive study on the integration of artificial intelligence (AI) for glaucoma diagnosis and retinal image analysis. Leveraging multimodal imaging data including fundus photography, Optical Coherence Tomography Optical Coherence Tomography (OCT) and Optical Coherence Tomography Angiography (OCTA), the research develops a suite of deep learning frameworks designed to detect early glaucomatous changes with high precision, robustness, and interpretability. A series of novel architectures are introduced, spanning vessel segmentation networks, biomarker discovery pipelines, and multimodal fusion models, all designed to enhance diagnostic accuracy and generalizability across diverse populations. To facilitate reproducible and scalable ophthalmic AI research, this work …

Failed Gay Rights Amendment To Mankato's Human Rights Ordinance In Mankato, Minnesota In 1987, Kellian Clink

Library Services Publications

In 1987, small but passionate people urged the city to pass an amendment to Mankato’s existing human rights ordinance to protect LGBTQ+ communities.   Advocates argued that gays were entitled to the same rights as straight people and were looking for protection in housing and employment, particularly. They demonstrated that people had lost jobs, housing, and access to dance venues. Some opponents equated gays with promiscuity, child molestation, solicitation, sin, and AIDS; some were convinced it was not needed; some pinned their arguments on the existence of laws already on the books.  This narrative is based on articles from the local …

Bile Acid Metabolites And Carotid Intima Media Thickness In The Chronic Kidney Disease In Children (Ckid) Study., Arthur M. Lee, Mark M. Mitsnefes, Jennifer Roem, Bradley A. Warady, Susan L. Furth, Michelle R. Denburg, Ckid Study Investigators

Manuscripts, Articles, Book Chapters and Other Papers

No abstract provided.

The Lender Center For Social Justice Bibliography 2025-2026, The Lender Center For Social Justice

The Lender Center for Social Justice

The Lender Center for Social Justice Bibliography (2025-2026) is a document containing all Lender-Center scholarship written between 2020-2026. The title references the newest entries, which were created in the 2025-2026 academic year.

A Multidimensional Analysis Of Genetic Structure In Canary Rockfish, Sebastes Pinniger, Along The U.S. West Coast, Parker Malhotra

Capstone Projects and Master's Theses

Understanding how genetic structure is distributed across space and influenced by the environment informs basic questions in evolutionary biology and applications for fisheries management. This can be particularly relevant for marine fishes where high dispersal potential, both of drifting larvae and swimming adults, can obscure biologically meaningful subdivision. Canary rockfish (Sebastes pinniger) are commercially important Pacific groundfish that were historically overfished and later rebuilt, yet their population genetic structure remains poorly resolved, across both latitudinal and depth gradients. In this study, reduced-representation genomic (RADseq) data from 171 individuals and 12,726 single nucleotide polymorphisms (SNPs) were used to evaluate coastwide structure …

Intermediate College Writing: Building And Practicing Mindful Writing Skills, Dawn Atkinson, Stacey Corbitt

Writing

No abstract provided.

Clinical Function Assignment Of Nat2 Alleles By The Clinical Pharmacogenetics Implementation Consortium Pharmacogene Curation Expert Panel., Bailey M. Tibben, David W. Hein, Michelle Whirl-Carrillo, Andrea Gaedigk, Michael T. Eadon, Rodney F. Minchin, Sotiria Boukouvala, Adalberto Rezende Santos, Roseann S. Donnelly, José A G Agúndez, Kelly E. Caudle

Manuscripts, Articles, Book Chapters and Other Papers

NAT2 encodes arylamine N-acetyltransferase 2, a key enzyme in the phase II metabolism of arylamines and arylhydrazines. NAT2 is highly polymorphic, resulting in variable distributions of rapid and poor metabolizers across global populations. Here, we detail the process undertaken by the Clinical Pharmacogenetics Implementation Consortium (CPIC) NAT2 Pharmacogene Curation Expert Panel (PCEP) to assign clinical function to NAT2 star (*) alleles using CPIC's standard terminology. Given the observed impact of NAT2 genetic variability on drug response, CPIC convened the NAT2-PCEP to standardize clinical allele function assignments. The NAT2-PCEP is comprised of multidisciplinary and international members, including researchers, clinicians, and implementers …

Investigating The Role Of Gαf In Sperm Storage In The Spermathecae Of Female Drosophila Melanogaster, Aileen Liu

Holster Scholar Projects

Reproductive secretory cells are essential for fertility and have been implicated in diseases such as high-grade serous cancer, yet the molecular mechanisms governing their function remain poorly understood. Using genetic tools available in Drosophila melanogaster, we investigated whether Gαf contributes to reproductive secretory-cell function by examining its role in sperm storage. Gαf is highly expressed in these cells, suggesting a potential role in secretory cell function. Tissue-specific RNAi, trans-heterozygous mutants, and tissue-specific rescue were utilized to examine the role of Gαf in sperm storage. Gαf knockdown consistently reduced sperm storage, supporting a role for Gαf in maintaining normal sperm …

Scientific Innovation, Institutionalization, And Moral Dilemmas: From Chemical Warfare In World War I To Ai In Modern Conflict, Kylie Kiefer

Holster Scholar Projects

This research examines the different American perspectives surrounding the morality and future of chemical warfare during and after World War I. Using primary sources collected at the National Archives at College Park, it argues that the Chemical Warfare Service survived not because Americans agreed that poison gas was morally acceptable, but because wartime mobilization created scientific expertise, military facilities, and relationships that made dismantling the service after the war difficult. While opponents emphasized moral and humanitarian concerns, advocates defended chemical warfare through arguments about preparedness, military necessity, and claims that gas was more humane than conventional weapons. The paper also …

Advanced-Level Writing In The University Classroom And Beyond: Mindful Practices For Technical, Business, And Scientific Communication, Dawn Atkinson, Stacey Corbitt

Writing

No abstract provided.

An Eco-Inspired Emulsion Membrane Harnessed With Waste Vegetable Oil For Effective Separation Of Ibuprofen: Insights Into Stability, Performance, And Kinetics, Huma Warsi Khan, A. Vijaya Bhaskar Reddy, Parvez Alam Khan, Samsur Akm Rahman, Muhammad Moniruzzaman

Publications and Research

Emulsion liquid membranes (ELMs) have emerged as excellent alternatives for the separation and recovery of biologically active drugs (BADs) from industrial waste at trace concentrations. Conventional ELMs generally utilize toxic petroleum-based solvents (PBS) that pose environmental and health risks. Although virgin vegetable oils have been appeared as sustainable alternatives to PBS, their widespread application is limited by economic constraints, resource sustainability, and competition with the food supply. In contrast, waste vegetable oil (WVO) represents an abundant, low-cost, and eco-friendly alternative, yet its potential as a green diluent for ELMs remains largely unexplored. To address this challenge, present study investigated the …

Genetically Driven Lipid Dysfunction And Neuroinflammation: An Agent-Based Model Of Alzheimer's Disease, Anthony Wolfe, Mack Kona, Sela Raisl, Enrique Lopez, Kamila Larripa

IdeaFest 2026

Microglia are immune cells in the brain that switch phenotypes to maintain neural health, but disruptions in this regulation may contribute to Alzheimer’s Disease (AD). We developed an agent-based model to link cell mechanisms to tissue-level patterns, incorporating both individual cell responses to localized signaling and the effects of APOE and TREM2 variants on microglial metabolism and clearance. Through computational experiments, we simulate how impaired lipid clearance and sensing lead to a pro-inflammatory microglial population and chronic inflammation. Our framework offers insight into how local dysfunction progresses to persistent neuroinflammation and promotes conditions like AD.

Impact Of Environmental Stressors On Pinniped Tags: Progress Toward Standardized Testing Protocol, Brodie Lyons, Deeksha Garige, Nathan Vasquez, Sean Shermer, Dr. Frank E. Cappuccio, Dr. Lonny Grafman, Dr. Dawn Goley

IdeaFest 2026

No abstract provided.

Bio 252/254: Genetics Fall 2026, Brian White

OER Textbooks

Bio 252/254 Genetics Fall 2026

This work was created by UMass Boston Professor Brian White using the support and funding from the OER Faculty Incentive Grant Program. This book is also available on LibreTexts, and can be viewed at this link: https://bio.libretexts.org/Courses/University_of_Massachusetts_Boston/Bio_252_254%3A_Genetics

Table of Contents:

• Front Matter (opens in new tab)
• 1: SPOC I - DNA and Chromosome Structure (opens in new tab)
• 2: SPOC II- Genomes (opens in new tab)
• 3: SPOC III - Mitosis and Meiosis (opens in new tab)
• 4: SPOC IV - DNA Replication (opens in new tab)
• 5: SPOC V - Transcription and mRNA Processing …

Growing South Dakota (Fall 2026), College Of Agriculture, Food And, Environmental Sciences

Growing South Dakota (Publication of the College of Agriculture, Food and Environmental Sciences)

[Page] 2 Support from donors helping set SDSU dairy graduates above the rest
[Page] 4 A decade of impact: Celebrating 10 years of cow-calf, swine education and research facilitates
[Page] 8 98-year-old donor keeps decades-long scholarship going in honor of late husband
[Page] 11 Looking back at Michele Dudash's tenure in academia
[Page] 12Giving students opportunities, experience to build their futures
[Page] 16 A Jackrabbit's journey in growing agricultural leadership
[Page] 18 Building South Dakota's next generation of rural veterinarians
[Page] 19 Conservation: A family affair
[Page] 20 South Dakota Water Resources Institute finds solutions to South Dakota's water challenges …

Blue Carbon Ecosystems As Climate Solutions: Sequestration Across Coastal And Marine Environments, Allison K. White, Richard J. Kline, Md. Saydur Rahman

School of Earth, Environmental, & Marine Sciences Faculty Publications

Blue carbon ecosystems (BCEs) such as mangroves, salt marshes, and seagrasses, sequester significant amounts of CO2 from the atmosphere. These ecosystems capture and store carbon in biomass and sediments over long periods. Other marine ecosystems, including the open ocean, kelp forests, bivalve reefs, and coral reefs, have been excluded from the BCEs, but they have the potential to serve as crucial blue carbon sinks or to support adjacent BCEs. Climate change, however, poses severe threats to these ecosystems. Rising sea levels, increasing temperatures, and ocean acidification can lead to habitat loss, reduced biodiversity, and impaired carbon sequestration capacity. Consequently, anthropogenic …

Risks Of Mercury Release From Disturbance Of Blue Carbon Ecosystems, Fan Zhang, Jingrou Hu, Ana Carolina Ruiz-Fernández, Christian J. Sanders, Xinxin Li, Ruotong Chen, Kunshan Bao, Bigyan Neupane, Aidah Baloch, Yanhui Zheng, Oscar Serrano

Research outputs 2022 to 2026

Blue carbon ecosystems (BCEs) function as dual repositories of organic carbon and legacy contaminants. While BCEs are recognized carbon sinks, their role as mercury (Hg) sinks and the risk of their conversion into sources due to human and climatic disturbances remain unexplored. This review synthesizes current knowledge on the drivers and risks of contaminant remobilization from threatened BCEs, with a primary focus on mercury. We explore how natural and human disturbances influence Hg storage, release, and bioavailability, while evaluating the risks posed to ecosystems and human health. Through a three-level meta-analysis, we show that physical disturbance remobilizes approximately 54% (95% …

The Epidemiology Of Kidney And Urinary Tract Infections In Pediatric Chronic Kidney Disease: Prevalence, Risk Factors And Association With Gfr Decline In The Chronic Kidney Disease In Children Study., Derek K. Ng, Andrea R. Molino, Siyao Zhang, Emily J. Stonebrook, Craig S. Wong, Pratyush Gyawali, Kimberly J. Reidy, Susan L. Furth, Bradley A. Warady, Jeffrey J. Fadrowski, Ckid Study Investigators

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Urinary tract and kidney infections are potential complications in pediatric chronic kidney disease (CKD), especially among patients with congenital anomalies of the kidney and urinary tract (CAKUT). We characterized the prevalence of self-reported infections from childhood through young adulthood; evaluated risk factors; and quantified the association with CKD progression.

METHODS: Infections in the past year were self-reported at annual Chronic Kidney Disease in Children (CKiD) study visits. Age-specific infection prevalences were stratified by sex and CKD diagnoses (glomerular, non-glomerular non-CAKUT, CAKUT low-risk for infections, and three CAKUT high-risk categories: reflux nephropathy, obstructive uropathy, and other high-risk). Repeated measures logistic …

Streamlining Diagnosis Of Bardet-Biedl Syndrome: New Diagnostic Algorithm With Updated Criteria., Jeremy J. Pomeroy, Jesse Richards, Brooke Sweeney, Seema Kumar, Katie E. Queen, Joshua Zaritsky, Carl H. Cramer, Elias I. Traboulsi, Brittni A. Scruggs, Erica E. Davis, Ekaterina Keifer, Emma Mcgibbon, Timothy Ogden, Bendert De Graaf, Tonia Hymers, Elizabeth Forsythe, Philip Beales

Manuscripts, Articles, Book Chapters and Other Papers

Considerable advances have been made in our understanding of Bardet-Biedl syndrome (BBS), particularly in its core clinical features and molecular genetics, warranting an update to the existing diagnostic criteria framework. Using a rigorous, evidence-based, and consensus-driven process, a multidisciplinary group of international experts and patient-led organizations developed an updated diagnostic algorithm. This algorithm provides practical, updated guidance for clinicians, including a pathway for accurately incorporating genetic findings into the diagnostic process. We recommend that a clinical diagnosis requires either 4 major criteria or 3 major and 2 minor criteria. Revised major criteria are retinal dystrophy, obesity (or overweight in individuals <  2 years old), congenital anomalies of the kidney and urinary tract or chronic kidney disease, hypogonadism/genital anomalies, neurodevelopmental/neurocognitive manifestations, and postaxial polydactyly. The diagnosis can also be established with a positive genetic testing result in patients exhibiting ≥ 1 major criterion, provided that genetic findings should be interpreted in the context of the patient's clinical presentation, age, family history, and overlap with related ciliopathies. These consensus criteria offer a simple algorithm incorporating updated definitions for major and minor criteria and genetic testing to support a timely and accurate diagnosis of patients with BBS, inform genetic counseling, and potentially facilitate earlier access to treatment. Trial Registration: CRIBBS Registry; ClinicalTrials.gov: NCT02329210.

Faculty Authors & Achievers Bibliography 2026, Luke Vilelle

WRL: Faculty Authors & Achievers Bibliographies

The office of Academic Affairs and the Wyndham Robertson Library congratulate all Hollins faculty who published or presented creative or scholarly works from Fall 2024 - Fall 2026. These pages comprise a list of that work.

Ambulatory Blood Pressure Thresholds And Left Ventricular Hypertrophy In Children Aged 6-12 Years: A Pediatric Nephrology Research Consortium Study., Afsana Jahan, Matthew Schuchman, Mahie Abdullah, Meghan Mclaughlin, Emilia Maria Cadiz, Eshanika Manchanda, Aftab Chishti, Maggie Murphy, Sarah Twichell, Alexandra Mazo, Dmitry Samsonov, Aesha Maniar, Hannah Kim, Francis Lomanta, Ashok Chakravarthy Patibandla, Rachel Frank, Tarak Srivastava, Ikuyo Yamaguchi, Christine Sethna

Manuscripts, Articles, Book Chapters and Other Papers

OBJECTIVE: To evaluate the diagnostic performance of ambulatory blood pressure monitoring (ABPM) thresholds for predicting left ventricular hypertrophy (LVH) in children aged 6-12 years.

STUDY DESIGN: A retrospective, multicenter study was conducted across 11 Pediatric Nephrology Research Consortium sites and included children aged 6-12 years who underwent ABPM and 2-dimensional echocardiography for diagnostic assessment of elevated BP. The diagnostic accuracy of fixed ABPM thresholds and the current 95th percentile for sex and height were assessed using area under the receiver operating characteristic, sensitivity, specificity, and Youden index. Multivariable logistic regression models, adjusted for age, sex, and body mass index z-score, …

Barriers To Veterans Affairs (Va) Healthcare Utilization: Exploring The Underutilization Of Va Healthcare Services Among Rural, West Texas Veterans, Adam G. Rodgers

Electronic Theses and Dissertations

Rural veterans forgo Department of Veterans Affairs (VA) healthcare at disproportionate rates, and this study found that the primary barrier is not enrollment but utilization. Seven of the eight participants were already enrolled yet remained functionally outside the system. The purpose of this qualitative single-case study was to explore why rural West Texas veterans forgo and underutilize Veterans Health Administration (VHA) healthcare. Two research questions examined the perceptions contributing to that decision and the barriers preventing access. Andersen’s behavioral model of health services use provided the framework. Semistructured virtual interviews with eight rural West Texas veterans were analyzed using Braun …

Peritoneal Dialysis Catheter Complications In Neonates With Kidney Failure., Shannon Reinert, Maanasa Yarlagadda, Alexander Bondoc, Donna Claes, Stefanie Riddle, Meredith P. Schuh

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Neonates with kidney failure require placement of a peritoneal dialysis catheter (PD-C) shortly after birth. PD-C malfunction and peritonitis, both common in this population, are associated with PD failure. The aim of this study was to describe our center's PD-C-related practices and outcomes in neonates with kidney failure.

METHODS: We performed a retrospective chart review of neonates who required kidney replacement therapy (KRT) within the first 30 days of life from 01/2018-12/2023. We evaluated for PD-C duration, PD-C replacement or revision, and peritonitis.

RESULTS: Twenty-four neonates had PD-C placed for chronic dialysis at a median of 9.7 days and …

First Evaluation Of Contrast-Enhanced Micro-Xct As A Tool For Organismal And Reproductive Trait Observations In Corals Based On Scans Of Thesea Nivea Deichmann, 1936, Erin E. Easton

School of Earth, Environmental, & Marine Sciences Faculty Publications

Micro-X-ray computed tomography (micro-XCT) with contrast enhancement is considered a non-destructive tool that is increasingly being applied to explore the internal and external structures of vertebrates and invertebrates. Although micro-XCT has been applied to corals to study skeletal features, contrast enhancement has not been applied to evaluate the utility for visualization of soft tissue structures in corals. This study is the first to evaluate the utility of contrast enhancement to visualize internal and external features, including soft tissue features, of octocorals. Contrast staining of a Thesea nivea specimen with 2.5% Lugol's iodine permitted visualization of soft tissues with sufficient density …