Digital Commons Network^™

Sox11 Is Required To Maintain Proper Levels Of Hedgehog Signaling During Vertebrate Ocular Morphogenesis, Lakshmi Pillai-Kastoori, Wen Wen, Stephen G. Wilson, Erin Strachan, Adriana Lo-Castro, Marco Fichera, Sebastiano A. Musumeci, Ordan J. Lehmann, Ann C. Morris

Biology Faculty Publications

Ocular coloboma is a sight-threatening malformation caused by failure of the choroid fissure to close during morphogenesis of the eye, and is frequently associated with additional anomalies, including microphthalmia and cataracts. Although Hedgehog signaling is known to play a critical role in choroid fissure closure, genetic regulation of this pathway remains poorly understood. Here, we show that the transcription factor Sox11 is required to maintain specific levels of Hedgehog signaling during ocular development. Sox11-deficient zebrafish embryos displayed delayed and abnormal lens formation, coloboma, and a specific reduction in rod photoreceptors, all of which could be rescued by treatment with the …

Behavioral Observation And Paternal Investment Of Eastern Kingbirds At Malheur National Wildlife Refuge, Christopher Michael Chutter

Dissertations and Theses

We have been studying the population of Eastern Kingbirds breeding in riparian habitats in Malheur National Wildlife Refuge (eastern Oregon) since 2002. These efforts have created an ideal research environment wherein most adults in the population have been color banded and DNA sampled and, as part of other research projects, nearly all broods since 2003 have been paternity tested. I decided to use behavioral video recordings of parental nest behavior undertaken between 2003 and 2010 for two unrelated projects. First, I tested the effectiveness of video sampling nesting behavior (see below and chapter 2). Second, I tested whether male kingbirds …

Hiv-Positive Parents, Hiv-Positive Children, And Hiv-Negative Children’S Perspectives On Disclosure Of A Parent’S And Child’S Illness In Kenya, Grace Gachanja, Gary J. Burkholder Jr, Aimee Ferraro

Walden Faculty and Staff Publications

HIV disclosure from parent to child is complex and challenging to HIV-positive parents and healthcare professionals. The purpose of the study was to understand the lived experiences of HIV-positive parents and their children during the disclosure process in Kenya. Sixteen HIV-positive parents, seven HIV-positive children, and five HIV-negative children completed semistructured, in-depth interviews. Data were analyzed using the Van Kaam method; NVivo 8 software was used to assist data analysis. We present data on the process of disclosure based on how participants recommended full disclosure be approached to HIV-positive and negative children. Participants recommended disclosure as a process starting at …

Pioglitazone Treatment Reduces Adipose Tissue Inflammation Through Reduction Of Mast Cell And Macrophage Number And By Improving Vascularity, Michael L. Spencer, Lin Yang, Akosua Adu, Brian S. Finlin, Beibei Zhu, Lindsey Rae Shipp, Neda Rasouli, Charlotte A. Peterson, Philip A. Kern

Internal Medicine Faculty Publications

Context and Objective

Adipose tissue in insulin resistant subjects contains inflammatory cells and extracellular matrix components. This study examined adipose pathology of insulin resistant subjects who were treated with pioglitazone or fish oil.

Design, Setting and Participants

Adipose biopsies were examined from nine insulin resistant subjects before/after treatment with pioglitazone 45 mg/day for 12 weeks and also from 19 subjects who were treated with fish oil (1,860 mg EPA, 1,500 mg DHA daily). These studies were performed in a clinical research center setting.

Results

Pioglitazone treatment increased the cross-sectional area of adipocytes by 18% (p = 0.01), and also increased …

Using The Stable Carbon And Nitrogen Isotope Compositions Of Vervet Monkeys (Chlorocebus Pygerythrus) To Examine Questions In Ethnoprimatology, James E. Loudon, J. Paul Grobler, Matt Sponheimer, Kimberly Moyer, Joseph G. Lorenz, Trudy R. Turner

All Faculty Scholarship for the College of the Sciences

This study seeks to understand how humans impact the dietary patterns of eight free-ranging vervet monkey (Chlorocebus pygerythrus) groups in South Africa using stable isotope analysis. Vervets are omnivores that exploit a wide range of habitats including those that have been anthropogenically-disturbed. As humans encroach upon nonhuman primate landscapes, human-nonhuman primate interconnections become increasingly common, which has led to the rise of the field of ethnoprimatology. To date, many ethnoprimatological studies have examined human-nonhuman primate associations largely in qualitative terms. By using stable carbon (δ¹³C) and nitrogen (δ¹⁵N) isotope analysis, we use quantitative data …

Research Program Has Staying Power, Barbara Lago

University of Mississippi News

UM search for antifungal antibiotics marks 30th year

Targeting Of Receptors For Advanced Glycation End-Products (Rage) Diminishes Acute Secondhand Smoke-Induced Inflammation In Mice, Tyler Thomas Wood

Theses and Dissertations

The receptor for advanced glycation end-products (RAGE) has increasingly been demonstrated to be an important modulator of inflammation in cases of pulmonary disease. Published reports involving tobacco smoke exposure have demonstrated increased expression of RAGE, its participation in pro-inflammatory signaling and its role in irreversible pulmonary remodeling. The current research evaluated for the first time the in vivo effects of short-term tobacco smoke exposure in RAGE null and control mice compared to identical animals exposed to room air only. Quantitative real time PCR, immunoblotting, and immunohistochemistry revealed elevated RAGE expression in controls after four weeks of exposure and an anticipated …

Most Soil Trophic Guilds Increase Plant Growth: A Meta-Analytical Review, Andrew Kulmatiski, Andrew Anderson-Smith, Karen H. Beard, Stephen Doucette-Riise, Michael Mazzacavallo, Nicole E. Nolan, Ricardo A. Ramirez, John R. Stevens

Wildland Resources Faculty Publications

Trophic cascades are important drivers of plant and animal abundances in aquatic and aboveground systems, but in soils trophic cascades have been thought to be of limited importance due to omnivory and other factors. Here we use a meta-analysis of 215 studies with 1526 experiments that measured plant growth responses to additions or removals of soil organisms to test how different soil trophic levels affect plant growth. Consistent with the trophic cascade hypothesis, we found that herbivores and plant pathogens (henceforth pests) decreased plant growth and that predators of pests increased plant growth. The magnitude of this trophic cascade was …

Examining Academic Performance Of Polynesian Student-Athletes Using The Theory Of Planned Behavior, Sierra Terina Keung

Theses and Dissertations

This study used Ajzen's (1991) Theory of Planned Behavior (TPB) to explore Polynesian student-athletes' motivation to improve academic performance (AP), while participating in Division I (D1) college football. Specifically, this study examined how attitude, subjective norms and perceived behavioral control influence motivation to achieve a higher GPA. Furthermore, ethnic identity, family obligation and cultural values were examined as potential contributors to subjective norms. The sample consisted of 70 Polynesian football student-athletes at 10 U.S. D1 universities. A modified TPB questionnaire was used to assess the TPB variables (attitude, subjective norms, and perceived behavioral control) as contributors to Polynesian football student-athletes …

Stag2 Promotes Error Correction In Mitosis By Regulating Kinetochore–Microtubule Attachments, Marianna Kleyman, Lilian Kabeche, Duane A. Compton

Dartmouth Scholarship

Mutations in the STAG2 gene are present in ∼20% of tumors from different tissues of origin. STAG2 encodes a subunit of the cohesin complex, and tumors with loss-of-function mutations are usually aneuploid and display elevated frequencies of lagging chromosomes during anaphase. Lagging chromosomes are a hallmark of chromosomal instability (CIN) arising from persistent errors in kinetochore-microtubule (kMT) attachment. To determine whether the loss of STAG2 increases the rate of formation of kMT attachment errors or decreases the rate of their correction, we examined mitosis in STAG2-deficient cells. STAG2 depletion does not impair bipolar spindle formation or delay mitotic progression. Instead, …

Healthy Living Needs Global Governance, Lawrence O. Gostin

Georgetown Law Faculty Publications and Other Works

It may seem counter-intuitive, but the same factors that drive the spread of infectious diseases also contribute to the dominance of non-communicable diseases (NCDs) in the global burden of disease—urbanization, global markets and harmonized cultures. NCDs have overtaken infectious diseases as the leading cause of morbidity and premature mortality worldwide, with deaths concentrated among the poor due to the growing availability and affordability of highly-processed, unhealthy foods, alcohol and tobacco.

The global response to NCDs has been slow and fractured, with the World Health Organization dedicating scant funding and the United Nations waiting until September 2011 to hold a high-level …

Statistical Modeling And Prediction Of Hiv/Aids Prognosis: Bayesian Analyses Of Nonlinear Dynamic Mixtures, Xiaosun Lu

USF Tampa Graduate Theses and Dissertations

Statistical analyses and modeling have contributed greatly to our understanding of the pathogenesis of HIV-1 infection; they also provide guidance for the treatment of AIDS patients and evaluation of antiretroviral (ARV) therapies. Various statistical methods, nonlinear mixed-effects models in particular, have been applied to model the CD4 and viral load trajectories. A common assumption in these methods is all patients come from a homogeneous population following one mean trajectories. This assumption unfortunately obscures important characteristic difference between subgroups of patients whose response to treatment and whose disease trajectories are biologically different. It also may lack the robustness against population heterogeneity …

Chiral Phosphoric Acids And Alkaline Earth Metal Phosphates Chemistry, Tao Liang

USF Tampa Graduate Theses and Dissertations

Asymmetric synthesis and catalysis is one of the leading research areas in chemistry society, for its versatility and efficiency in obtaining chiral molecules that found the vast majority in natural active compounds and synthetic drugs. Developing asymmetric catalytic methodology is at the frontier in both industrial and academic research laboratories. Enantioselective organocatalysis has emerged as a powerful synthetic tool that is complementary to metal-catalyzed transformations. The development of chiral phosphoric acid and metal phosphate as catalysts has been a breakthrough in recent years. Chiral phosphoric acids have been shown to be powerful catalysts in many organic transformations. Moreover, chiral metal …

Development Of An Efficient Human Hepatocyte Culture Platform For Assessing Novel Therapeutic Efficacy Against Plasmodium Liver Parasites, Steven Patrick Maher

USF Tampa Graduate Theses and Dissertations

Malaria is a critical and global public health problem, affecting over 200 million people every year, resulting in over 500,000 deaths. A vaccine is not currently available and only one drug, primaquine, is effective against the dormant stages of Plasmodium vivax. Preclinical assessment of novel therapeutic drugs and vaccines is hampered by the lack of an in vitro liver model for P. falciparum and P. vivax. To provide a stable human hepatocyte-based culture platform for parasite development, we engineered a microfluidic bilayer device capable of both simple and complex culture methods, including perfusion and co-culture, to better understand the requirements …

Connecting Institutional Discourses And Everyday Understandings Of Climate Change: Viewpoints From A Suburban Neighborhood In Tampa, Florida, Christopher Metzger

USF Tampa Graduate Theses and Dissertations

Despite a general consensus regarding anthropogenic global climate change across the international scientific community, many of the major greenhouse gas producers in the world, especially the United States, are hesitant to implement strict emissions regulations. According to some prominent atmospheric scientists, such as James Hansen and Michael Mann, if industrialized countries continue to produce carbon emissions at current rates, an irreversible planetary tipping point of raising temperatures 2°C above pre-industrial levels could be reached in less than 40 years. Societies have a wealth of information from the natural sciences to understand the climate problem and currently possess the technological means …

A Comparison Of Five Malaria Transmission Models: Benchmark Tests And Implications For Disease Control, Dorothy I. Wallace, Ben S. Southworth, Xun Shi, Jonathan W. Chipman, Andrew K. Githeko

Dartmouth Scholarship

Background: Models for malaria transmission are usually compared based on the quantities tracked, the form taken by each term in the equations, and the qualitative properties of the systems at equilibrium. Here five models are compared in detail in order to develop a set of performance measures that further illuminate the differences among models.

Methods: Five models of malaria transmission are compared. Parameters are adjusted to correspond to similar biological quantities across models. Nine choices of parameter sets/initial conditions are tested for all five models. The relationship between malaria incidence in humans and (1) malaria incidence in vectors, (2) man-biting …

Full Issue

Colby Magazine

Colby Magazine vol. 91, no. 2 (Spring 2002): full issue

From The Hill

Colby Magazine

The Liberal Art of Giving
William D. Adams, President

Colby to the Corps: Colby tops list for Peace Corps volunteers per capita

'Nijikai to follow'

Gourley's Collected Works: Colby's retiring museum director praised for his legacy

WMHB's New Wave

wit & wisdom

The Tooth, the Whole Tooth and Nothing But...

Q&A: Bets Brown on carrying a torch for the Olympics and science

Raising Hardy Girls: Lyn Mikel Brown and Karen Heck '74 create spaces where girls can thrive

How We Teach

No Time to Wait: Student activists press for change- now

Jan Plan Goes South

Internship Fund is the Jan …

Better To Give: A Surge In Community Service Reflects Colby Tradition And National Trends, Gerry Boyle

Colby Magazine

It was a sunny afternoon in January and, like a bus driver making a stop, Nick Snyder '05 pulled his Blazer up in front of Foss Hall. Snyder picked up Shawn Sato '05 and then drove downtown to the Albert S. Hall School, where, in the library, fifth graders were waiting.

Within minutes, Snyder, Sato and several other Colby mentors taking part in the Colby Cares About Kids program were talking about Play Station games, movies like Dumb and Dumber, the perils of having younger siblings. Snyder's friend Roy, who is 11, showed him his class picture. "There you are," …

Full Issue

Colby Magazine

Colby Magazine vol. 90, no. 3 (Summer 2001): full issue

The D Word: A Reexamination Of Diversity At Colby Opens The Door To New Possibilities, Stephen Collins

Colby Magazine

When Tennessee Watson '03 arrived at Colby two years ago from a suburb of Rochester, N.Y., she confidently threw herself into tough academic courses and settled on a double major in Latin American studies and government. In her first semester she played soccer on weekends with international students and made up for relative inexperience on the field with tenacity. In the winter she won competitions at Sugarloaf in the boardercross- a sort of snowboard-race-meets-roller-derby event. Almost instantly, Colby was her oyster. "I saw it as a pretty homogenous environment and realized it was comfortable for me," she recalled this spring. …

Full Issue

Colby Magazine

Colby Magazine vol. 88, no. 3 (Summer 1999): full issue

Readers Write

Colby Magazine

The Beanie That Wouldn't Die

Remembering Colby

One Click Away From Untangling The Web: The United States Food And Drug Administration & Interactive Promotional Media, Abraham Gitterman

Health Law and Policy Brief

No abstract provided.

From The Hill, Gerry Boyle, Milan Babik, Stephen Collins, Alicia Nemiccolo Macleay

Colby Magazine

September 11: Colby Reacts

Giving Victims a Voice: Oak Fellow Sevdie Ahmetti chronicles travails of Kosovo casualties

Following Lovejoy: Award winners Pat and Tom Gish stand on principle at The Mountain Eagle

A Formula for Fun

wit & wisdom

Professional Life After Death

Q&A: Frances York

The Fruits of HIs Labor: Professor Russell Johnson brings science to community service

A Bigger Better Canvas: Colby artists stretch out in Crawford Art Studios

IM me on AOL

On the Bison Track: Matthew Testa documents the controversy surrounding Yellowstone's roving herds

Ghostliness and Grief

Recent Releases:
Plan B, by After 8
Colby College …

Full Issue

Colby Magazine

Colby Magazine vol. 89, no. 2 (Spring 2000): full issue

The Birdman Of Colby: Eagle-Eyed Professor Herb Wilson Is Winging His Way Into The Hearts Of Students And Birders Alike, Robert Gillespie

Colby Magazine

Professor Herb Wilson's passion for ornithology is contagious- at Colby and in the community.

Readers Write

Colby Magazine

Tissue Reissue

Gay-Lesbian Films Available

No "PC," Just an Invite

Correction

Full Issue

Colby Magazine

Colby Magazine vol. 88, no. 4 (Fall 1999): full issue

Faculty File, Stephen B. Collins

Colby Magazine

Who's running for Congress and who's not; studying francophone women.