Digital Commons Network^™

Bro Reflects: Adams Reveals His Private Thoughts On His Presidency

Colby Magazine

Retiring President William D. Adams speaks with candor on topics ranging from stresses of the job to the future of the liberal arts.

Full Issue

Colby Magazine

Colby Magazine vol. 102, no. 3 (Fall 2013): full issue

Do-Gooders-Really: Inspired At Colby, These Alumni Choose To Face Society’S Problems Head On, Gerry Boyle

Colby Magazine

Inspired at Colby, these alumni, including Catherine McDonough ’99 (above), tackle society’s most daunting problems.

Colby News

Colby Magazine

David A. Greene Named Colby’s 20th President

Environmental Fellow: Food Is Window to Society’s Challenges

2013 Lovejoy Award Goes to Truth Teller

Smoking Banned on Campus

Ethnic Violence Means Open Season on Burma’s Muslims

A Tome of Epic Proportions

Concussion Study Expands to Include Alumni

Meet the Class of 2017, Complete with Vexillologist

Museum Is Big News

Anonymous Alum Funds Nonprofit Course for Local Causes

From The Hill

Colby Magazine

Options for Adams: Planning committee drafts comprehensive report as basis for strategic planning

Brody Judicial Award Established

Taking Stock

Adams Inauguration Set

wit & wisdom

Shirley Swipes Again

Perfect Pitch: Colby musicians excel in and out of the performance hall

Angling for Answers

A Fulbright and a Goldwater

To: [email protected]
From: jonnybamboo

How We Teach

If You Hate Shakespeare, Have We Got a Play For You

Breathing Life into Music: Eric Thomas finds harmony and inspiration in teaching and performing

Citizen Wayne and the French Guy

Q&A: Professor James Finney Boylan on writing, teaching and bowling with Billy

La Esperanza …

Full Issue

Colby Magazine

Colby Magazine vol. 87, no. 1 (Winter 1998): full issue

From The Hill

Colby Magazine

Shelter From The Storm: Colby weathers the Great Ice Storm of '98

Assessing the Damage

They Ate Hearty

Making Things Right

Yeterian Will Be Dean

New Pub on Tap

Knock It Off

Self-Adjusting Biofeedback With A Dynamic Feedback Signal Set (Dyfss), Laurence I. Sugarman, Brian L. Garrison, Anna E. Hope, Stephen Jacobs, Alex J. Glade, Michael R. Wezalis, Kelsey L. Williford

Annual Effective Access Technology Conference

A lack of control over their autonomic nervous system presents a major challenge for many children with Autism Spectrum Disorder (ASD). Autonomic biofeedback training is a promising treatment for managing anxiety and ASD symptoms more generally. We describe software that tunes four autonomic measurements to the best abilities and needs of each individual patient. Using this dynamic feedback signal set (DyFSS), a strength-based, self-customizing algorithm, we aim to address the autonomic heterogeneity of youth with ASD. The DyFSS may improve autonomic biofeedback training for the user by making it more understandable and easier to accomplish. Because it is self-adjusting, it …

Self-Adjusting Biofeedback With A Dynamic Feedback Signal Set (Dyfss), Laurence I. Sugarman, Brian L. Garrison, Anna E. Hope

Annual Effective Access Technology Conference

Abstract - A lack of control over their autonomic nervous system presents a major challenge for many children with Autism Spectrum Disorder (ASD). Autonomic biofeedback training is a promising treatment for managing anxiety and ASD symptoms more generally. We describe software that tunes four autonomic measurements to the best abilities and needs of each individual patient. Using this dynamic feedback signal set (DyFSS), a strength-based, self-customizing algorithm, we aim to address the autonomic heterogeneity of youth with ASD. The DyFSS may improve autonomic biofeedback training for the user by making it more understandable and easier to accomplish. Because it is …

Get Mobile Captioning Anywhere, Michael Stinson, Donna Easton, Lisa Elliot, Justin Mahar, Pamela Francis

Annual Effective Access Technology Conference

Abstract - This paper describes the C-Print technology and highlights a recent development, C-Print Mobile, which is currently being evaluated with National Science Foundation funding. The C-Print captioning technology is used to produce a text display of spoken information for individuals who are deaf or hard of hearing (or other individuals who may have difficulty understanding speech). The C-Print service has most often been provided in educational settings, primarily to provide communication access for a deaf student enrolled in a class with primarily hearing students. C-Print may also be used in business and community meetings, presentations, and many other situations. …

Developing An Atrial Activity-Based Algorithm For Detection Of Atrial Fibrillation, Steven Ladavich, Behnaz Ghoraani

Annual Effective Access Technology Conference

Abstract - In this study we propose a novel atrial activity based method for atrial fibrillation (AF) identification that detects the absence of normal sinus rhythm (SR) P-waves from the surface ECG. The proposed algorithm extracts nine features from P-waves during SR and develops a statistical model to describe the distribution of the features. The Expectation- Maximization algorithm is applied to a training set to create a multivariate Gaussian Mixture Model (GMM) of the feature space. This model is used to identify P-wave absence (PWA) and, in turn, AF. An optional post-processing stage, which takes a majority vote of successive …

Parts Of The Whole: Strategies For The Spread Of Quantitative Literacy: What Models Can Tell Us, Dorothy Wallace

Numeracy

Two conceptual frameworks, one from graph theory and one from dynamical systems, have been offered as explanations for complex phenomena in biology and also as possible models for the spread of ideas. The two models are based on different assumptions and thus predict quite different outcomes for the fate of either biological species or ideas. We argue that, depending on the culture in which they exist, one can identify which model is more likely to reflect the survival of two competing ideas. Based on this argument we suggest how two strategies for embedding and normalizing quantitative literacy in a given …

How Does One Design Or Evaluate A Course In Quantitative Reasoning?, Bernard L. Madison

Numeracy

In the absence of generally accepted content standards and with little evidence on the learning for long-term retrieval and transfer, how does one design or evaluate a course in quantitative reasoning (QR)? This is a report on one way to do so. The subject QR course, which has college algebra as a prerequisite and has been taught for 8 years, is being modified slightly to be offered as an alternative to college algebra. One modification is adding a significant formal writing component. As the modification occurs, the current course and the modified one are judged according to six sets of …

Development Of Helical Chiral Catalysts And Their Applications In Asymmetric Catalysis, Zhili Peng

Open Access Dissertations

The design and development of novel chiral catalysts for efficient construction of carbon-carbon bonds, especially in an enantioselective manner, stays as a major goal for organic chemists. In the last two decades, various organocatalysts have been developed to solve important problems in asymmetric organic synthesis. Novel chiral catalysts based on previously unexplored 1-azahelicenes have been developed by our group and found great applications in mechanistically unrelated reactions. As part of Ph.D. research projects, the design and development of new helical chiral catalysts based on 11, 12-benzo-1-aza[6]helicene N-oxide and their applications in asymmetric synthesis are presented in this thesis. First, the …

Genetic Determinants Of Amidating Enzyme Activity And Its Relationship With Metal Cofactors In Human Serum, Eric D. Gaier, Alison Kleppinger, Martina Ralle, Jonathan Covault, Richard E. Mains, Anne M. Kenny, Betty A. Eipper

UCHC Articles - Research

Abstract

BACKGROUND:

α-amidation is a final, essential step in the biosynthesis of about half of all peptide hormones and neurotransmitters. Peptidylglycine α-amidating monooxygenase (PAM), with enzymatic domains that utilize Cu and Zn, is the only enzyme that catalyzes this reaction. PAM activity is detected in serum, but its significance and utility as a clinical biomarker remain unexplored.

METHODS:

We used well-established enzymatic assays specific for the peptidylglycine-α -hydroxylating monooxygenase (PHM) and peptidyl-α-hydroxyglycine α-amidating lyase (PAL) domains of PAM to quantify amidating activity in the sera of 144 elderly men. Relationships between PHM and PAL activity and serum levels of their …

Reduced Major Axis Regression: Teaching Alternatives To Least Squares, William V. Harper

Mathematics Faculty Scholarship

The theoretical underpinnings of standard least squares regression analysis are based on the assumption that the independent variable (often thought of as x) is measured without error as a design variable. The dependent variable (often labeled y) is modeled as having uncertainty or error. Both independent and dependent measurements may have multiple sources of error. Thus the underlying least squares regression assumptions can be violated. Reduced Major Axis (RMA) regression is specifically formulated to handle errors in both the x and y variables. It is an excellent topic to teach students the importance of understanding the assumptions underlying the statistical …

Rpl24: A Potential Therapeutic Target Whose Depletion Or Acetylation Inhibits Polysome Assembly And Cancer Cell Growth., Kathleen A. Wilson-Edell, Amanuel Kehasse, Gary K. Scott, Christina Yau, Daniel E. Rothschild, Birgit Schilling, Bianca S Gabriel, Mariya A. Yevtushenko, Ingrid M. Hanson, Jason M. Held, Bradford W. Gibson, Christopher C. Benz

Natural Sciences and Mathematics | Student Professional Publications

Partial loss of large ribosomal subunit protein 24 (RPL24) function is known to protect mice against Akt or Myc-driven cancers, in part via translational inhibition of a subset of cap(eIF4E)-dependently translated mRNAs. The role of RPL24 in human malignancies is unknown. By analyzing a public dataset of matched human breast cancers and normal mammary tissue, we found that breast cancers express significantly more RPL24 than matched normal breast samples. Depletion of RPL24 in breast cancer cells by >70% reduced cell viability by 80% and decreased protein expression of the eIF4E-dependently translated proteins cyclin D1 (75%), survivin (46%) and NBS1 (30%) …

Population And Demographic Structure Of Ixodes Scapularis Say In The Eastern United States., Joyce M. Sakamoto, Jerome Goddard, Jason L. Rasgon

CALS Publications

INTRODUCTION: The most significant vector of tick-borne pathogens in the United States is Ixodes scapularis Say (the blacklegged tick). Previous studies have identified significant genetic, behavioral and morphological differences between northern vs. southern populations of this tick. Because tick-borne pathogens are dependent on their vectors for transmission, a baseline understanding of the vector population structure is crucial to determining the risks and epidemiology of pathogen transmission. METHODS: We investigated population genetic variation of I. scapularis populations in the eastern United States using a multilocus approach. We sequenced and analyzed the mitochondrial COI and 16S genes and three nuclear genes (serpin2, …

Completions 2013-14, Southwestern Oklahoma State University

IPEDS

IPEDS Report created by the SWOSU Office of Institutional Research

Leading Happiness: Leadership And Happiness At Work In Certified B Corporations, A Qualitative Study Of Leaders And Employees To Understand The Influence Of Shared Leadership On Worker Happiness Within Certified Benefit Corporations, Travis Hellstrom

Capstone Collection

The Certified B Corps movement is setting a new standard for businesses, committing to a multiple stakeholder orientation focused on community, environment and the workplace in addition to financial profit. More than 1,000 companies, including well-known companies like Patagonia, Ben & Jerry’s, King Arthur Flour, and Etsy, have joined the ranks of Certified B Corps in over 30 countries.

The B Corps certification is understood to promote a set of organizational practices, which envision improved employee performance and well-being. An important element of that well-being is employee happiness. Previous research has shown that improved business leadership practices can have significant …

Nanoporous Gold Characterization, Structural Modification And Use As A Solid Support For Biomolecule Immobilization, Abeera Sharma

Dissertations

Nanoporous gold (NPG) has immense technological applications owing to a plethora of properties like large surface area to volume ratio, plasmonic properties, stable gold-thiolate bond formation and a wide range of pore sizes. The surface morphology of nanoporous gold has been altered previously by dealloying and thermal annealing to increase/decrease the pore size and change the surface area. We provide a novel electrochemical annealing technique for post dealloying modification wherein electrochemical sweep cycles in different electrolytes at positive potentials leads to a subsequent increase in pore sizes of nanoporous gold as studied using scanning electron microscopy. Tailoring the surface of …

Inactivating Ube2m Impacts The Dna Damage Response And Genome Integrity Involving Multiple Cullin Ligases, Scott Cukras, Nicholas Morffy, Takbum Ohn, Younghoon Kee

Molecular Biosciences Faculty Publications

Protein neddylation is involved in a wide variety of cellular processes. Here we show that the DNA damage response is perturbed in cells inactivated with an E2 Nedd8 conjugating enzyme UBE2M, measured by RAD51 foci formation kinetics and cell based DNA repair assays. UBE2M knockdown increases DNA breakages and cellular sensitivity to DNA damaging agents, further suggesting heightened genomic instability and defective DNA repair activity. Investigating the downstream Cullin targets of UBE2M revealed that silencing of Cullin 1, 2, and 4 ligases incurred significant DNA damage. In particular, UBE2M knockdown, or defective neddylation of Cullin 2, leads to a blockade …

Emu Today, July 15, 2014, Eastern Michigan University

EMU Today

No abstract provided.

Cell Wall And Autolytic Properties Of A Cold-Sensitive Listeria Monocytogenes Mutant Deficient In Branched-Chain Fatty Acid Biosynthesis, Anthony M. Martini

Theses and Dissertations

Cellular membranes modulate several critical functions of bacterial physiology, including solute diffusion and nutrient transport. Biophysical properties of phospholipids, as well as environmental pressures such as temperature, can have a profound effect on these membrane functions and the kinetics of associated enzymes. Listeria monocytogenes is a facultative intracellular pathogen capable of robust low temperature growth, a characteristic thought to be facilitated by a membrane highly enriched in branched-chain fatty acids (BCFA). Mutants deficient in the biosynthesis of these fatty acids exhibit severe growth defects under low temperature and extreme pH conditions. Morphological investigations have also revealed these mutants to undergo …

Designing Viral Product Features For Broader Reach, Sinan Aral, Dylan Walker

Business Faculty Articles and Research

Companies increasingly rely on “network” and “viral” marketing within their communication strategies. This study showed that providing viral products with specific features can increase their diffusion substantially. Products that were enabled to send automated notifications within a user’s local Facebook network upon adoption generated a 450 % higher adoption rate among Facebook friends compared with products without any viral features. Products that enabled adopters to send personal invitations to install the app generated an increase in the adoption rate by friends by 750 % more than in the control group. Although each personalized referral had a much stronger impact, notifications …

Method Of Using Ccr3 Binding Agents To Detect Choroidal Neovascularization, Jayakrishna Ambati, Mark E. Kleinman

Ophthalmology and Visual Science Faculty Patents

The results presented herein demonstrate the specific expression of CCR3 in CNV endothelial cells in humans with AMD, and despite the expression of its ligands, eotaxin-1, -2, and -3, neither eosinophils nor mast cells are present in human CNV. The genetic or pharmacological targeting of CCR3 or eotaxins as disclosed herein inhibited injury-induced CNV in mice. CNV suppression by CCR3 blockade was due to direct inhibition of endothelial cell proliferation, and was uncoupled from inflammation as it occurred in mice lacking eosinophils or mast cells and was independent of macrophage and neutrophil recruitment. CCR3 blockade was more effective at reducing …

The 22nd Annual International Mango Festival, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Ligand-Binding Pocket Bridges Dna-Binding And Dimerization Domains Of The Urate-Responsive Marr Homologue Mftr From Burkholderia Thailandensis, Ashish Gupta, Anne Grove

Faculty Publications

Members of the multiple antibiotic resistance regulator (MarR) family often regulate gene activity by responding to a specific ligand. In the absence of ligand, most MarR proteins function as repressors, while ligand binding causes attenuated DNA binding and therefore increased gene expression. Previously, we have shown that urate is a ligand for MftR (major facilitator transport regulator), which is encoded by the soil bacterium Burkholderia thailandensis. We show here that both mftR and the divergently oriented gene mftP encoding a major facilitator transport protein are upregulated in the presence of urate. MftR binds two cognate sites in the mftR-mftP intergenic …

Luteolin And Diosmin/Diosmetin As Novel Stat3 Inhibitors For Treating Autism, Jun Tan, Deyan Luo, Roland Douglas Shytle

USF Patents

The present invention includes methods for the treatment of autoimmune disorders such as autism, schizophrenia, and type 1 diabetes. Flavonoids, luteolin, diosmin, and diosmin's aglycone form, diosmetin, were found to inhibit activation/phosphorylation of STAT3 induced by IL-6 in cultured neuronal cells. Furthermore, mice treated with diosmin showed a significant reduction of autistic phenotype induced by IL-6 through inhibition of STAT3 activation.

Treatment Of Glycogen Synthase Kinase-Based Disease, Jun Tan, Doug Shytle, Kavon Rezai-Zadeh

USF Patents

The bioflavonoid luteolin reduces amyloid-β peptide (Aβ) generation. Luteolin is also a selective GSK-3 inhibitor that 1) decreases amyloidogenic γ-secretase APP processing, and 2) promotes presenilin-1 (PS1) carboxyl-terminal fragment (CTF) phosphorylation. GSK-3α activity is essential for both PS1 CTF phosphorylation states and PS1-APP interaction. To validate The findings were validated in vivo, using a Tg2576 Alzheimer's Disease model system. Luteolin treatment decreased soluble Aβ levels, reduced GSK-3 activity, and disrupted PS1-APP association.