Digital Commons Network^™

2014-July-15-Susan Chambers, University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.

Impact Of The English Advanced Placement (Ap) Program On College Grade Point Average Among Rural Appalachian Students, Shannon Deaton

The Rural Educator

This study explored the impact of the English Advanced Placement (AP) program on college success among rural Appalachian students attending four private colleges in central and eastern Kentucky: Alice Lloyd College, Georgetown College, Lindsey Wilson College, and University of the Cumberlands. A Pearson Product-Moment Correlation r and an independent-samples t-test were conducted. With respect to rural Appalachian students, statistical analyses revealed that the English ACT score is a better predictor of first-semester college grade point average than the English AP score. Analyses also revealed no statistically significant difference between first-semester college GPAs of rural Appalachian students with English AP credit …

Determination Of Thiamine In Solution By Uv-Visible Spectrophotometry: The Effect Of Interactions With Gold Nanoparticles, Michael Vincent Zielinski

Master's Theses and Doctoral Dissertations

The method presented here provides the foundation for a simple and selective qualitative determination of thiamine in solution. Gold nanoparticles in the presence of thiamine results in the formation of a secondary peak in the absorbance spectrum of the mixture. This peak can be used as an indicator of thiamine, which is useful for the qualitative analysis of solutions, and may provide an alternative to other methods for evaluating thiamine in blood and other biological systems. This method uses gold nanoparticles of a size around 20 to 30 nm and involves their selective interaction with thiamine, compared to selected amino …

Shape And Position Of The Node And Notochord Along The Bilateral Plane Of Symmetry Are Regulated By Cell-Extracellular Matrix Interactions., Maria Pulina, Dong Liang, Sophie Astrof

Center for Translational Medicine Faculty Papers

The node and notochord (and their equivalents in other species) are essential signaling centers, positioned along the plane of bilateral symmetry in developing vertebrate embryos. However, genes and mechanisms regulating morphogenesis of these structures and their placement along the embryonic midline are not well understood. In this work, we provide the first evidence that the position of the node and the notochord along the bilateral plane of symmetry are under genetic control and are regulated by integrin α5β1 and fibronectin in mice. We found that the shape of the node is often inverted in integrin α5-null and fibronectin-null mutants, and …

Infectious Diseases, Bert Chapman

Libraries Faculty and Staff Scholarship and Research

Provides information about the role of infectious diseases in the early years of U.S. History, with particular emphasis on how they impacted injuries sustained in military conflict.

July 15, 2014, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Pneumonia Disease Research In India: A Scientometric Study During 2004-13, Brij Mohan Gupta, Ritu Gupta

Library Philosophy and Practice (e-journal)

Examines 2508 publications in Indian pneumonia research, as indexed in Scopus database during 2004-13, witnessing an annual average growth rate of 19.86%, an average citation impact per paper of 2.85 and international collaborative publication share of 14.19%. The global share of Indian pneumonia research was 2.74% during 2004-13, which increased from 1.83% to 3.39% from 2004-08 to 2009-13. Medicine contributed the largest publications share (76.28%) in Indian pneumonia research, followed by pharmacology, toxicology & pharmaceutics (16.27%), biochemistry, genetics & molecular biology (13.12%), immunology & microbiology (7.19%) and chemistry (3.99%) during 2004-13. The 15 most productive Indian organizations and authors in …

A Conservation Status Index, As An Auxiliary Tool For The Management Of Cave Environments, Christiane Ramos Donato, Adauto De Souza Ribeiro, Leandro De Sousa Souto

International Journal of Speleology

The conservation of the Speleological Heritage involves bioecological, geomorphological and anthropogenic studies, both from inside the caves and from the external environments that surround them. This study presents a method to rank caves according to their priority for conservation and restoration. Nine caves were evaluated: indicators related to the environmental impacts and the vulnerability status presented by those caves (intrinsic features) and the values scored in a ‘Cave Conservation Index’ (CCI) were established. We also used a rapid assessment protocol to measure cave vulnerability for prioritization of conservation/restoration actions (RAP-cr) comparing natural cavities with the same lithology, due …

Combinatorial Therapeutic Vaccination Strategies For Hematologic Malignancies In The Early Period Following Experimental Autologous Hematopoietic Stem Cell Transplantation, Robert G. Newman

Open Access Dissertations

Tumor relapse is the primary cause of mortality in patients with hematologic cancers following autologous hematopoietic stem cell transplantation (HSCT). Vaccination early post-HSCT can exploit both the state of lymphopenia and minimal residual disease for the generation of anti-tumor immunity. Here, multiple vaccinations utilizing lymphoma cells engineered to secrete the heat shock protein fusion gp96-Ig within two weeks of T cell replete syngeneic HSCT led to antigen cross-presentation and increased survival of lymphoma bearing mice. To enhance vaccine efficacy, IL-2 was directed to predominantly memory phenotype CD8+ T lymphocytes and natural killer cells via administration bound to anti-IL-2 monoclonal antibody …

Simple Signaling Molecules For Inductive Bone Regenerative Engineering, Bret D. Ulery, Stephen J. Nelson, Meng Deng, Kevin W. H. Lo, Yusuf M. Khan, Cato T. Laurencin

UCHC Articles - Research

Abstract

With greater than 500,000 orthopaedic procedures performed in the United States each year requiring a bone graft, the development of novel graft materials is necessary. We report that some porous polymer/ceramic composite scaffolds possess intrinsic osteoinductivity as shown through their capacity to induce in vivo host osteoid mineralization and in vitro stem cell osteogenesis making them attractive synthetic bone graft substitutes. It was discovered that certain low crystallinity ceramics partially dissociate into simple signaling molecules (i.e., calcium and phosphate ions) that induce stem cells to endogenously produce their own osteoinductive proteins. Review of the literature has uncovered a variety …

Identification Of A Cytotoxic Form Of Dimeric Interleukin-2 In Murine Tissues, Lucile E. Wrenshall, Suzanne E. Clabaugh, David R. Cool, Prakash Arumugam, William C. Grunwald Jr., Deandra R. Smith, Gino C. Liu, John D. Miller

Department of Surgery Faculty Publications

Interleukin-2 (IL-2) is a multi-faceted cytokine, known for promoting proliferation, survival, and cell death depending on the cell type and state. For example, IL-2 facilitates cell death only in activated T cells when antigen and IL-2 are abundant. The availability of IL-2 clearly impacts this process. Our laboratory recently demonstrated that IL-2 is retained in blood vessels by heparan sulfate, and that biologically active IL-2 is released from vessel tissue by heparanase. We now demonstrate that heparanase digestion also releases a dimeric form of IL-2 that is highly cytotoxic to cells expressing the IL-2 receptor. These cells include “traditional” IL-2 …

The Statesman, V. 58, I. 01, Stony Brook University

Stony Brook Statesman-Sucolian

v. 58, i. 01

Long-Term Health Effects Of Neutering Dogs: Comparison Of Labrador Retrievers With Golden Retrievers, Benjamin L. Hart, Lynette A. Hart, Abigail P. Thigpen, Neil H. Willits

Endocrinology Collection

Our recent study on the effects of neutering (including spaying) in Golden Retrievers in markedly increasing the incidence of two joint disorders and three cancers prompted this study and a comparison of Golden and Labrador Retrievers. Veterinary hospital records were examined over a 13-year period for the effects of neutering during specified age ranges: before 6 mo., and during 6–11 mo., year 1 or years 2 through 8. The joint disorders examined were hip dysplasia, cranial cruciate ligament tear and elbow dysplasia. The cancers examined were lymphosarcoma, hemangiosarcoma, mast cell tumor, and mammary cancer. The results for the Golden Retriever …

Paxistima Canbyi: Ohio’S Rarest Plant?, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Preparation And Biological Properties Of Ring-Substituted Naphthalene-1-Carboxanilides, Eoghan Nevin, Rodeney Govender, Jim O'Mahony, Aidan Coffey, Et. Al.

Department of Biological Sciences Publications

In this study, a series of twenty-two ring-substituted naphthalene-1-carboxanilides were prepared and characterized. Primary in vitro screening of the synthesized carboxanilides was performed against Mycobacterium avium subsp. paratuberculosis. N-(2-Methoxyphenyl)naphthalene-1-carboxamide, N-(3-methoxy-phenyl)naphthalene-1-carboxamide, N-(3-methylphenyl)naphthalene-1-carboxamide, N-(4-methylphenyl)naphthalene-1-carboxamide and N-(3-fluorophenyl)naphthalene-1-carboxamide showed against M. avium subsp. paratuberculosis two-fold higher activity than rifampicin and three-fold higher activity than ciprofloxacin. The most effective antimycobacterial compounds demonstrated insignificant toxicity against the human monocytic leukemia THP-1 cell line. The testing of biological activity of the compounds was completed with the study of photosynthetic electron transport (PET) inhibition in isolated spinach (Spinacia oleracea L.) chloroplasts. The PET-inhibiting activity expressed by IC50 value …

2014-July-14-Dr. Aruna Kilaru News, University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.

Design, Synthesis And Evaluation Of Small Molecules As Inhibitors Of Plasminogen Activator Inhibitor-1, Darshani Avanthi Weerakoon

Master's Theses and Doctoral Dissertations

Plasminogen activator inhibitor type-1 (PAI-1) is a member of the serine protease inhibitor (serpin) superfamily. Excessive levels of PAI-1 inhibit urokinase-type plasminogen activator (uPA) and tissue-type plasminogen activator (tPA), which regulates fibrinolysis as well as the development of different pathological diseases like obesity, metabolic syndrome, tumor invasion and metastasis, and coronary heart disease. Currently, there is no Food and Drug Administration approval for inactivating higher levels of PAI-1. Therefore, PAI-1 is considered an attractive drug target. Due to PAI-1’s different structural conformations and multiple binding domains, development of PAI-1 inhibitors is a challenging situation. In this research study, we describe …

The Effects Of Opedix < Sup > Tm < / Sup > Knee Support System, Philip Mathew

Theses and Dissertations

INTRODUCTION: Knee supports are often employed to decrease adductor angle and/or adductor moment and thus medial knee joint loading in persons with medial knee osteoarthritis. It is compelling that these gait alterations would also be considered beneficial in healthy individuals from a prophylactic application. While the Opedix product was designed specifically as a knee support system, in the present study lower extremity kinematic chain with emphasis on hip and knee were investigated.

PURPOSE: The purpose of this study was to test Opedix garments and describe the changes in sagittal (X), frontal (Y), and transverse (Z) planes for both kinematic and …

Comorbidity Of Infectious Diseases And Anxiety Disorders In Adults And Its Association With Quality Of Life: A Community Study, Cornelia Witthauer, Andrew T. Gloster, Andrea Hans Meyer, Renee D. Goodwin, Roselind Lieb

Publications and Research

Objective: Infectious diseases and anxiety disorders are common and both are associated with substantial burden to individual, families, and society. A better understanding of their association may be helpful in explicating possible etiological mechanisms related to both. The goal of the current study was to investigate the relationship between specific infectious diseases and anxiety disorders among adults in the community, and to examine whether the co-occurrence of the two is associated with poorer quality of life compared to subjects with one or neither condition.

Methods: We used data from the 1998 German Mental Health survey with 4181 subjects aged 18–65. …

Informing Flood Plain Wetland Restoration Using Amphibian Monitoring, Ashley Vanderham

School of Natural Resources: Dissertations, Theses, and Student Research

Wetlands are among the most important and complex ecosystems in the world. They contribute to nutrient cycling, the hydrologic cycle, and provide critical habitat for many plants, fish, and wildlife. Channelization of Missouri River resulted in the loss of many floodplain wetlands. Despite ongoing restoration efforts, there are few ecologically-based performance guidelines, and managers need methods to quantify and assess the success of restored riverine wetland systems.

In 2008 a multi-institutional herpetofauna monitoring project, funded by the U.S. Army Corps of Engineers, was initiated in four states (Kansas, Missouri, Iowa, and Nebraska). The main goal of the project is to …

Iron Porphyrin Carbenes As Catalytic Intermediates: Structures, Mössbauer And Nmr Spectroscopic Properties, And Bonding, Rahul L. Khade, Wenchao Fan, Yan Ling, Liu Yang, Eric Oldfield, Yong Zhang

Faculty Publications

Iron porphyrin carbenes (IPCs) are thought to be intermediates involved in the metabolism of various xenobiotics by cytochrome P450, as well as in chemical reactions catalyzed by metalloporphyrins and engineered P450s. While early work proposed IPCs to contain Fe^II, more recent work invokes a double-bond description of the iron–carbon bond, similar to that found in Fe^IV porphyrin oxenes. Reported herein is the first quantum chemical investigation of IPC Mössbauer and NMR spectroscopic properties, as well as their electronic structures, together with comparisons to ferrous heme proteins and an Fe^IV oxene model. The results provide the first …

Identification Of Research Trends At Physical Research Laboratory (Prl), Ahmedabad, India, Nishtha Anilkumar Dr

Library Philosophy and Practice (e-journal)

Several investigators have conducted bibliometric analysis of research productivity of different countries in the world. A few studies have also been carried out to assess the productivity and impact of a single institute. As no bibliometric study on Physical Research Laboratory, India has been done before, the researcher thought it appropriate to carry out the study for her doctoral research with the following objectives:

1. To study the division wise output of research
2. To identify the thrust areas of research at PRL

The present bibliometric study aims to measure the research output of Physical Research Laboratory (PRL) during a 10 year …

Emission Of Volatile Organic Compounds After Land Application Of Cattle Manure, Bryan Woodbury, John E. Gilley, David B. Parker, David B. Marx, Daniel N. Miller, Roger A. Eigenberg

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Beef cattle manure can serve as a valuable source of nutrients for crop production. However, emissions of volatile organic compounds (VOCs) after land application may pose an odor nuisance to downwind populations. This study was conducted to evaluate the effects of land application method, diet, soil moisture content, and time since manure application on VOC emissions. Manure was collected from feedlot pens where cattle were fed diets containing 0, 10, or 30% wet distillers grains with solubles (WDGS). Land application methods included surface-applying manure (i.e., no-tillage) or incorporating manure using disk tillage. The effects of soil moisture content on VOC …

Application Of A Modified Backwards Lagrangian Stochastic Model To Estimate Particulate Matter Emissions From A Dairy, Kori Moore, Michael Wojcik, Randy Martin, Richard Pfeiffer, John Prueger, Jerry Hatfield

Space Dynamics Laboratory Publications

Background

• SDL, USU, and ARS have assembled sensors to measure PM and NH₃ concentrations around area sources
• Point and remote sensors, including a PM calibrated scanning lidar
• Emissions estimated using concentration measurements
• Mass balance (lidar only)
• Inverse modeling

Land-Use Legacies Regulate Decomposition Dynamics Following Bioenergy Crop Conversion, Cynthia M. Kallenbach, A. Stuart Grandy

Faculty Publications

Land-use conversion into bioenergy crop production can alter litter decomposition processes tightly coupled to soil carbon and nutrient dynamics. Yet, litter decomposition has been poorly described in bioenergy production systems, especially following land-use conversion. Predicting decomposition dynamics in postconversion bioenergy production systems is challenging because of the combined influence of land-use legacies with current management and litter quality. To evaluate how land-use legacies interact with current bioenergy crop management to influence litter decomposition in different litter types, we conducted a landscape-scale litterbag decomposition experiment. We proposed land-use legacies regulate decomposition, but their effects are weakened under higher quality litter and …

Structural Differentiation Of Graphs Using Hosoya-Based Indices, Matthias Dehmer, Abbe Mowshowitz, Yongtang Shi

Publications and Research

In this paper, we introduce the Hosoya-Spectral indices and the Hosoya information content of a graph. The first measure combines structural information captured by partial Hosoya polynomials and graph spectra. The latter is a graph entropy measure which is based on blocks consisting of vertices with the same partial Hosoya polynomial. We evaluate the discrimination power of these quantities by interpreting numerical results.

Advances In Aquatic Target Localization With Passive Sonar, John Thomas Gebbie

Dissertations and Theses

New underwater passive sonar techniques are developed for enhancing target localization capabilities in shallow ocean environments. The ocean surface and the seabed act as acoustic mirrors that reflect sound created by boats or subsurface vehicles, which gives rise to echoes that can be heard by hydrophone receivers (underwater microphones). The goal of this work is to leverage this "multipath" phenomenon in new ways to determine the origin of the sound, and thus the location of the target. However, this is difficult for propeller driven vehicles because the noise they produce is both random and continuous in time, which complicates its …

Mentoring High School Students, Robin L. Cooper

Kaleidoscope

Dr. Robin Cooper is a faculty member in the Department of Biology and teaches physiology and neurobiology courses at the University of Kentucky. His research is in comparative physiology. He received a double major with a B.S. in Chemistry and Zoology from Texas Tech in 1983 and a PhD in Physiology from Texas Tech Medical School in 1989. He has had postdoctoral training in Switzerland and Canada for 7 years before joining the University of Kentucky in 1996.

Democratizing The Food System- The Food Policy Council Movement, Garrett Spear

Kaleidoscope

The increasing complexity of our modern food system has changed the landscape of American agriculture and diet, and has increasingly consolidated decision-making abilities in a concentrated group of organizations. Local food movements are re-appropriating their food supply chains through a variety of methods, including the democratic-minded food policy council organization. Food policy councils organize community stakeholders into a network of organizations which can collectively grapple with food issues affecting and on behalf of the local community. This study consisted of research on the history and methods of the food policy council movement, directed ultimately at the council-less context in Lexington …

A Tragedy Exposed? Clear Growth Medium Reveals Competing Roots, Christopher H. Karounos, Deric Miller, Philip Crowley, Nicholas Mcletchie

Kaleidoscope

Abstract

Tragedy of the Commons (ToC) is the exploitation of an open-access resource that is exploited by selfish individuals to the detriment of all. Examples include open sea fisheries, cattle grazing, pollution, deforestation and plants competing over shared soil nutrients and space. Tragically, these resources become depleted and plants become severely resource limited. Our study seeks to determine if a ToC causes two plants sharing resources to reproduce less successfully than two plants owning the equivalent amount of personal resources. We predict that plant root competition creates a ToC by increasing root mass while reducing reproductive mass. Our study uses …