Digital Commons Network^™

Deep-Sea Octopus (Graneledone Boreopacifica) Conducts The Longest-Known Egg-Brooding Period Of Any Animal, Bruce Robison, Brad A. Seibel, Jeffrey Drazen

Biological Sciences Faculty Publications

Octopuses typically have a single reproductive period and then they die (semelparity). Once a clutch of fertilized eggs has been produced, the female protects and tends them until they hatch. In most shallow-water species this period of parental care can last from 1 to 3 months, but very little is known about the brooding of deep-living species. In the cold, dark waters of the deep ocean, metabolic processes are often slower than their counterparts at shallower depths. Extrapolations from data on shallow-water octopus species suggest that lower temperatures would prolong embryonic development periods. Likewise, laboratory studies have linked lower temperatures …

Volume 51, Number 50: July 30, 2014, University Of North Dakota

University Letter Archive

No abstract provided.

High School Students Participate In Inaugural Science Academy At Gardner-Webb, Office Of University Communications

Gardner-Webb NewsCenter Archive

For over a dozen high school students from Thomas Jefferson Classical Academy (TJCA) in Mooresboro, N.C., one of the first weeks of their summer vacation has given them new insight into the practical application of scientific principles they have learned in the classroom. Through a grant from the Stonecutter Foundation (Spindale, N.C.), 14 teens participated in the first annual Science Academy, a brand new program designed to offer them enrichment in the subject of science. “I think this academy caused the students to think about science beyond the classroom and opened their eyes to the many different careers in the …

Sheep Updates 2014, James Kynge, David Lindsay, Johan Greeff, John Young, Luke Stephen, Graham Gardner, Stephen Lee, Bindi Murray, James Rowe

Sheep Updates

This session covers nine papers from different authors:

Genetic Research: A brave new world of opportunities

1. "China's Appetite" - The implications for WA, James Kynge, Chairman, FT Confidential Research, Emerging Markets Editor, Financial Times, London.

2. The genetics warm-up - the secret language of genetic research and its impacts on WA's sheep flock, Professor David Lindsay, University of Western Australia, Perth WA

The strength of genetic data: is it really valuable?

3. Genetic research in Western Australia - What have the compromises in production been? Johan Greeff, Senior Geneticist, Department of Agriculture and Food Western Australia

4. Show …

Supporting Representation-Rich Problem-Solving In High School Physics, Lyrica L. Lucas

Department of Teaching, Learning, and Teacher Education: Theses and Other Student Research

The literature on physics education research (PER) promotes the use of multiple representations (such as pictures, diagrams, written explanations, and mathematical expressions) to enhance the problem-solving ability of students through instruction. The purpose of this study was to explore the use of a scaffolding strategy that involved the use of multiple representation tasks in problem-solving in a modeling physics class in high school. Another class with similar background was selected as a comparison group. In 12 in-depth problem-solving interviews of students drawn from the two classes, I investigated in detail how the students responded to the multiple representations tasks and …

2014-July-30-Plant Biochemistry Research, University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.

Making A Decision About Trial Participation: The Feasibility Of Measuring Deliberation During The Informed Consent Process For Clinical Trials, Katie Gillies, Glyn Elwyn, Jonathan Cook

Dartmouth Scholarship

Background:

Informed consent of trial participants is both an ethical and a legal requirement. When facing a decision about trial participation, potential participants are provided with information about the trial and have the opportunity to have any questions answered before their degree of ‘informed-ness’ is assessed, usually subjectively, and before they are asked to sign a consent form. Currently, standardised methods for assessing informed consent have tended to be focused on aspects of understanding and associated outcomes, rather than on the process of consent and the steps associated with decision-making.

Methods:

Potential trial participants who were approached regarding participation in …

Psychosocial Food-Related Behavior And Food Intake Of Adult Main Meal Preparers Of Food For 9-10 Year-Old Children Participating In Icook, A Five-State Childhood Obesity Pilot Prevention Study, Ashley A. Miller

College of Education and Human Sciences: Dissertations, Theses, and Student Research

Understanding adult outcomes of programs aimed at childhood obesity prevention is necessary because parents/caregivers are the most important influence on a child’s physical activity and eating habits. Based on the principles of the social cognitive theory, the iCook 4-H pilot study taught dyads consisting of 9-10 year-old children and their primary meal preparers cooking skills, healthy shopping and meal habits, and easy ways to incorporate physical activity as a family. The program took place in five states, Maine, Nebraska, South Dakota, Tennessee, and West Virginia. In each state, adult-youth dyads (n = 54) were recruited by 4-H programs and nutrition …

Executive Control In Hispanic Children: Considering Linguistic And Sociocultural Factors, Miriam M. Martinez

Department of Psychology: Dissertations, Theses, and Student Research

Executive control represents a collection of high-order cognitive processes that are associated with important child outcomes, including academic achievement and social competencies. Despite the burgeoning interest in examining the development of executive control, less is known about the development of these skills among ethnic minority children. Hispanic children are currently the largest ethnic minority group in the United States and their diverse sociocultural and linguistic backgrounds provide an excellent context to study the influence of linguistic and sociocultural factors on the development of child executive control. The purpose of the three complementary studies reported in this dissertation is to contribute …

Neutral Sphingomyelinase-3 Mediates Tnf-Stimulated Oxidant Activity In Skeletal Muscle, Jennifer S. Moylan, Jeffrey D. Smith, Erin M. Wolf Horrell, Julie B. Mclean, Gergana M. Deevska, Mark R. Bonnell, Mariana N. Nikolova‑Karakashian, Michael B. Reid

Physiology Faculty Publications

AIMS: Sphingolipid and oxidant signaling affect glucose uptake, atrophy, and force production of skeletal muscle similarly and both are stimulated by tumor necrosis factor (TNF), suggesting a connection between systems. Sphingolipid signaling is initiated by neutral sphingomyelinase (nSMase), a family of agonist-activated effector enzymes. Northern blot analyses suggest that nSMase3 may be a striated muscle-specific nSMase. The present study tested the hypothesis that nSMase3 protein is expressed in skeletal muscle and functions to regulate TNF-stimulated oxidant production.

RESULTS: We demonstrate constitutive nSMase activity in skeletal muscles of healthy mice and humans and in differentiated C2C12 myotubes. nSMase3 ( …

Johnson Spends The Summer At Harvard Forest, University Relations

Campus News Archive

Alayna is examining the relationship between climate and deforestation.

Equality, Trust And Universalism In Europe, Canada And The United States: Implications For Health Care Policy, P. Christopher Palmedo

Dissertations and Theses

A number of theoretical explanations seek to describe the factors that have led to the position of the United States as the last industrialized Western nation without a universal health care program. Theories focus on institutional arrangement, historic precedent, and the influence of the private sector and market forces. This study explores another factor: the role of underlying social values. The research examines differences in values among ten European countries, the United States and Canada, and analyzes the associations between the values that have been seen to contribute the individualism-collectivism dynamic in the United States. The hypothesis that equality and …

Mir-143 Acts As A Tumor Suppressor By Targeting N-Ras And Enhances Temozolomide-Induced Apoptosis In Glioma., Lin Wang, Zhu-Mei Shi, Cheng-Fei Jiang, Xue Liu, Qiu-Dan Chen, Xu Qian, Dong-Mei Li, Xin Ge, Xie-Feng Wang, Ling-Zhi Liu, Yong-Ping You, Ning Liu, Bing-Hua Jiang

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Therapeutic applications of microRNAs (miRNAs) in RAS-driven glioma were valuable, but their specific roles and functions have yet to be fully elucidated. Here, we firstly report that miR-143 directly targets the neuroblastoma RAS viral oncogene homolog (N-RAS) and functions as a tumor-suppressor in glioma. Overexpression of miR-143 decreased the expression of N-RAS, inhibited PI3K/AKT, MAPK/ERK signaling, and attenuated the accumulation of p65 in nucleus of glioma cells. In human clinical specimens, miR-143 was downregulated where an adverse with N-RAS expression was observed. Furthermore, overexpression of miR-143 decreased glioma cell migration, invasion, tube formation and slowed tumor growth and angiogenesis in …

Patrick Mclane, Patrick Mclane, Francine Krieger 2015

All oral histories

Mr. McLane worked in IWU's Information Technology office starting in 1991 and retired in 2014. He discusses the changes in technology and personnel he witnessed and also provides career highlights prior to IWU.

The Bg News July 30, 2014, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. July 30, 2014. Volume 93-Issue 110.

Atherosclerosis: A Longue Durée Approach, L. Samuel Wann, Randall C. Thompson, Adel H. Allam, Caleb E. Finch, Albert Zink, Hillard Kaplan, Bruno Frohlich, Guido P. Lombardi, M. Linda Sutherland, James D. Sutherland, Lucia Watson, Samantha L. Cox, Michael I. Miyamoto, Alexandre F. R. Stewart, Jagat Narula, Gregory S. Thomas

ESI Publications

Fernand Braudel popularized the longue durée approach to scholarly investigation in the mid-20th century. The longue durée approach can be loosely translated to mean “look for the big picture, synthesize data collected using all available methodology over the long periods of time to identify fundamental principles, rather than becoming preoccupied with isolated observations.” Braudel, a historian and economist, emphasized observation of enduring historical structures and analysis of long-term, panoramic economic trends rather than concentrating on detailed descriptions of particular events or individuals. He also urged the use of insight gained from many scholarly disciplines to identify the essential underpinnings of …

Why Did Ancient People Have Atherosclerosis?: From Autopsies To Computed Tomography To Potential Causes, Gregory S. Thomas, L. Samuel Wann, Adel H. Allam, Randall C. Thompson, David E. Michalik, M. Linda Sutherland, James D. Sutherland, Guido P. Lombardi, Lucia Watson, Samantha L. Cox, Clide M. Valladolid, Gomaa Abd El-Maksoud, Muhammad Al-Tohamy Soliman, Ibrahem Badr, Abd El-Halim Nur El-Din, Emily M. Clarke, Ian G. Thomas, Michael I. Miyamoto, Hillard Kaplan, Bruno Frohlich, Jagat Narula, Alexandre F. R. Stewart, Albert Zink, Caleb E. Finch

ESI Publications

Computed tomographic findings of atherosclerosis in the ancient cultures of Egypt, Peru, the American Southwest and the Aleutian Islands challenge our understanding of the fundamental causes of atherosclerosis. Could these findings be true? Is so, what traditional risk factors might be present in these cultures that could explain this apparent paradox? The recent computed tomographic findings are consistent with multiple autopsy studies dating as far back as 1852 that demonstrate calcific atherosclerosis in ancient Egyptians and Peruvians. A nontraditional cause of atherosclerosis that could explain this burden of atherosclerosis is the microbial and parasitic inflammatory burden likely to be present …

Genomic Correlates Of Atherosclerosis In Ancient Humans, Albert Zink, L. Samuel Wann, Randall C. Thompson, Andreas Keller, Frank Maixner, Adel H. Allam, Caleb E. Finch, Bruno Frohlich, Hillard Kaplan, Guido P. Lombardi, M. Linda Sutherland, James D. Sutherland, Lucia Watson, Samantha L. Cox, Michael I. Miyamoto, Jagat Narula, Alexandre F. R. Stewart, Gregory S. Thomas, Johannes Krause

ESI Publications

Paleogenetics offers a unique opportunity to study human evolution, population dynamics, and disease evolution in situ. Although histologic and computed x-ray tomographic investigations of ancient mummies have clearly shown that atherosclerosis has been present in humans for more than 5,000 years, limited data are available on the presence of genetic predisposition for cardiovascular disease in ancient human populations. In a previous whole-genome study of the Tyrolean Iceman, a 5,300-year-old glacier mummy from the Alps, an increased risk for coronary heart disease was detected. The Iceman’s genome revealed several single nucleotide polymorphisms that are linked with cardiovascular disease in genome-wide association …

Funerary Artifacts, Social Status, And Atherosclerosis In Ancient Peruvian Mummy Bundles, M. Linda Sutherland, Samantha L. Cox, Guido P. Lombardi, Lucia Watson, Clide M. Valladolid, Caleb E. Finch, Albert Zink, Bruno Frohlich, Hillard Kaplan, David E. Michalik, Michael I. Miyamoto, Adel H. Allam, Randall C. Thompson, L. Samuel Wann, Jagat Narula, Gregory S. Thomas, James D. Sutherland

ESI Publications

Background: Evidence of atherosclerotic plaques in ancient populations has led to the reconsideration of risk factors for heart disease and of the common belief that it is a disease of modern times.

Methods: Fifty-one wrapped mummy bundles excavated from the sites of Huallamarca, Pedreros, and Rinconada La Molina from the Puruchuco Museum collection in Lima, Peru, were scanned using computed tomography to investigate the presence of atherosclerosis. Funerary artifacts contained within the undisturbed mummy bundles were analyzed as an attempt to infer the social status of the individuals to correlate social status with evidence of heart disease in …

Population Connectivity And Larval Dispersal Of Caribbean Spiny Lobster, Andrew Sebastian Kough

Open Access Dissertations

Studies of movement, fundamental to most life on earth, become complicated in the ocean. Many marine organisms have a complex lifecycle with a larval phase, giving them vast dispersal potential from powerful ocean currents while obscuring direct observation by virtue of their minute size. These research challenges are beginning to be circumvented through biophysical modeling of larval transport. Modeling simulates the potential pathways of larvae, but not fine-scale spatial movements. Despite their small size, larvae actively participate in their dispersive journey, detecting and responding to environmental cues. Orientation behavior has a great impact on a larva’s survival and journey, and …

The Role Of Class I Histone Deacetylases In The Transcriptional Repression Of Estrogen Receptor In Response To Hmapk Signaling, Amy Jayne Plotkin

Open Access Dissertations

Estrogen receptor negative (ER-) breast cancer is more aggressive and associated with both shorter disease-free and overall survival than ER positive breast cancer. Anti-estrogen therapies are not effective in ER- breast cancers, thus identifying mechanisms underlying lack of ER expression in ER- breast cancers is imperative. We have previously demonstrated that hyperactivation of MAPK (hMAPK) downstream of overexpressed EGFR or overexpression/amplification of Her2 represses ER protein and mRNA expression. Abrogation of hMAPK in ER- breast cancer cell lines and primary cultures causes re-expression of ER and restoration of anti-estrogen responses. In investigating the mechanisms underlying hMAPK repression of ER mRNA, …

The Impact Of Negative Mood On Cognitive Control, Joshua D. Rooks

Open Access Theses

The current study aimed to determine the effect of both negative and positive mood on working memory (WM). Using a sample of undergraduates (N = 104), we investigated three specific topics: 1) if differences in trait affect and induced mood revealed specific impairments in WM; 2) the interplay between trait affect, induced mood, and dynamic adjustments in cognitive control; 3) the impact of baseline WM capacity on emotion manipulation and subsequent task performance. Participants completed one of three (Positive, Neutral, or Negative) 10-minute mood induction phases prior to a WM delayed-recognition task. Demand levels (high vs. low) of WM maintenance …

Deafdigest: Gold Edition, July 29, 2014, Barry Strassler

DeafDigest Gold 2014

No abstract provided.

Demonstrating The Use Of High-Volume Electronic Medical Claims Data To Monitor Local And Regional Influenza Activity In The Us, Cecile G. Viboud, Vivek Charu, Donald R. Olson, Sebastien Ballesteros, Julia R. Gog, Farid Khan, Bryan T. Grenfell, Lone Simonsen

Global Health Faculty Publications

Introduction

Fine-grained influenza surveillance data are lacking in the US, hampering our ability to monitor disease spread at a local scale. Here we evaluate the performances of high-volume electronic medical claims data to assess local and regional influenza activity.

Material and Methods

We used electronic medical claims data compiled by IMS Health in 480 US locations to create weekly regional influenza-like-illness (ILI) time series during 2003–2010. IMS Health captured 62% of US outpatient visits in 2009. We studied the performances of IMS-ILI indicators against reference influenza surveillance datasets, including CDC-ILI outpatient and laboratory-confirmed influenza data. We estimated correlation in weekly …

Deafdigest: Blue Edition, July 29, 2014, Barry Strassler

DeafDigest Blue 2014

No abstract provided.

Production Of Recombinant Human Coagulation Factor Ix By Transgenic Pig, Weijie Xu

Department of Chemical and Biomolecular Engineering: Dissertations, Theses, and Student Research

Hemophilia B is the congenital bleeding disorder caused by deficiency in functional coagulation factor IX (FIX) and about 28,000 patients worldwide in 2012. And current treatment is restricted to protein-replacement therapy, which required FIX concentrates for patients’ life-time. Approximately 1 billion units FIX were consumed in 2012. However, still about 70-80% patients, mostly in developing countries, received inadequate or no treatment because of the unavailable and/or unaffordable FIX concentrates. Considering safety reasons, e.g. transmission of blood-borne diseases, the recombinant human FIX (rFIX) is recommended other than the plasma-derived FIX. However, only one rFIX is currently available on the market. The …

Adherence Inhibition Of Human Pathogens Campylobacter Jejuni And Campylobacter Coli By Non-Digestible Oligosaccharides, Alejandra Ramirez-Hernandez

Department of Food Science and Technology: Dissertations, Theses, and Student Research

Adherence is the first and one of the most important steps of bacterial pathogenesis. Natural derived components that inhibit the adherence of pathogens to the surface of epithelial cells have received considered interest. The goal of this research was to assess the anti-adherence activity of mannan oligosaccharides (MOS), pectic oligosaccharides (POS) and cranberry high molecular weight component (HMW) against Campylobacter jejuni and Campylobacter coli. First the anti-adherence activity of MOS and their purified fraction (pMOS) was tested against three strains of C. jejuni and two strains of C. coli. Results shown significant reductions in adherence (up to 70%) …

Activatable Nanoprobes For Intracellular Drug Delivery, Swadeshmukul Santra, James Turkson

UCF Patents

An activatable nanoprobe is provided having a core component and an active agent associated with the core component via a bond configured to be cleaved upon exposure to an endogenous compound.

Compositions For Treating Or Delaying The Onset Of Hair Loss (Us), Kiminobu Sugaya, Stephanie Merchant

UCF Patents

Disclosed herein are novel methods and compositions for treating and/or preventing hair loss in patients. Specifically exemplified herein are compositions containing a modified pyrimidine that are topically applied to a scalp of an patient. Typically, the patient has androgenic alopecia, alopecia greata, postpartum alopecia or telogen effluvium.

High-Performance Polymer Monoliths For Capillary Liquid Chromatography, Pankaj Aggarwal

Theses and Dissertations

This dissertation focuses on improving the chromatographic efficiency of polymeric organic monoliths by characterizing and optimizing the bed morphology. In-situ characterization techniques such as capillary flow porometry (CFP), 3-dimensional scanning electron microscopy (3D SEM) and conductivity measurements were developed and implemented to quantitatively characterize the morphology of poly(ethylene glycol) diacrylate (PEGDA) monoliths. The CFP measurements for monoliths prepared by the same procedure in capillaries with different diameters (i.e., 75, 150, and 250 μm) clearly showed a change in average through-pore size with capillary diameter, thus, certifying the need for in-situ measurement techniques. Serial sectioning and imaging of PEGDA monoliths using …