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Long Bay Hypoxia Monitoring Consortium, Susan Libes, Michael Trapp, Scott Kindelberger, Danielle Doremus

Journal of South Carolina Water Resources

In October 2011, the coastal municipalities of North Myrtle Beach, Myrtle Beach, Surfside, and Horry County signed a resolution, under the aegis of their Coastal Alliance of mayors, to develop and implement the Long Bay Hypoxia Monitoring Consortium. The goal of this consortium is to support monitoring and studies that further characterize hypoxia and its causes in Long Bay. The baseline data will enable assessments of water quality management efforts. Monitoring stations are to be maintained at three piers, Cherry Grove (NMB), Apache (Horry County), and Second Ave N. Pier (Myrtle Beach). Turbidity and chlorophyll sensors will be deployed at …

Green Infrastructure In Coastal Landscapes: Ecological Design, Hydrological Function, And Sustainable Land Use Guidance, Daniel R. Hitchcock, Anand D. Jayakaran, David L. White

Journal of South Carolina Water Resources

Coastal landscape modification, specifically the conversion of forests to residential and commercial development, coupled with potential climate change impacts, could lead to irretrievable natural resource impairment. An assessment of existing resources (green infrastructure) and their benefits via ecosystem services provides useful guidance for resource protection to enhance community resilience. These landscape elements are complex within and between varying scales; therefore stakeholders need clear, relevant, comparable, and easily accessible information for effective decision-making.

The Effects Of Atp And Adenosine On The Extracellular Matrix Biosynthesis Via Purinergic Pathways, Silvia Daniela Gonzales

Open Access Dissertations

Low back pain causes distress and suffering to patients. The impact of low back pain creates a major socio-economic burden in industrialized societies as well. As the leading cause of disability, low back pain affects more than 80% of the US population at some point in life. Intervertebral disc (IVD) degeneration has been closely associated with low back pain, stimulating interest in finding the causes that lead to IVD degeneration. Therefore, understanding the mechanisms involved in the maintenance of IVD composition may shed light to development of novel therapies for IVD degeneration and low back pain. IVD cells are responsible …

Identification Of Genetic Determinants Of Aging Traits, James Edwin Hicks Jr

Open Access Dissertations

As the population in developed countries ages, the health problems associated with aging will become an increasingly important public health concern. While aging is a complex process that takes place over multiple physiological systems, many aspects of aging are under some amount of genetic control. Identification of the loci underpinning these traits could allow for targeting interventions for the most at-risk individuals in old age, improving both lifespan and quality of life. The Amish represent a uniquely appropriate population for the genetic analysis of aging traits. They live a homogenous lifestyle, with high levels of physical activity throughout their lives. …

Seagrasses In The Age Of Sea Turtle Conservation And Shark Overfishing, Michael Heithaus, Teresa Alcoverro, Rohan Arthur, Derek A. Burkholder, Kathryn A. Coates, Marjolijn J. A. Christianen, Nachiket Kelkar, Sarah A. Manuel, Aaron Wirsing, W. Judson Kenworthy, James W. Fourqurean

HCAS Student Articles

Efforts to conserve globally declining herbivorous green sea turtles have resulted in promising growth of some populations. These trends could significantly impact critical ecosystem services provided by seagrass meadows on which turtles feed. Expanding turtle populations could improve seagrass ecosystem health by removing seagrass biomass and preventing of the formation of sediment anoxia. However, overfishing of large sharks, the primary green turtle predators, could facilitate turtle populations growing beyond historical sizes and trigger detrimental ecosystem impacts mirroring those on land when top predators were extirpated. Experimental data from multiple ocean basins suggest that increasing turtle populations can negatively impact seagrasses, …

Vision 2020: An Analysis Of Policy Implementation And Agrarian Change In Rural Rwanda, Sterling Recker

Dissertations

In 2000, President Paul Kagame introduced a plan to alleviate poverty as well as to maintain political control over the policy process through a decentralized bureaucracy. Since adoption of Vision 2020 in 2000, Rwanda has been reforming its rural sector to commercialize agriculture, reduce pressures on land, and move the country into middle income status by the year 2020. In order to achieve the goals outlined in Vision 2020, the Government of Rwanda (GoR) adopted a policy of administrative decentralization in 2001 to facilitate the transition from subsistence to commercial agriculture. I am addressing two related questions: 1) How has …

Biological Sciences Students & Alumni Present At Joint Meeting Of Ichthyologists And Herpetologists, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Morris Presents ‘Intralocus Tactical Conflict And The Evolution Of “Reversible” Alternative Reproductive Tactics’, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Clinical And Biochemical Function Of Polymorphic Nr0b1 Ggaa-Microsatellites In Ewing Sarcoma: A Report From The Children's Oncology Group., Michael J. Monument, Kirsten M. Johnson, Elizabeth Mcilvaine, Lisa Abegglen, W. Scott Watkins, Lynn B. Jorde, Richard B. Womer, Natalie Beeler, Laura Monovich, Elizabeth R. Lawlor, Julia A. Bridge, Joshua D. Schiffman, Mark D Krailo, R. Lor Randall, Stephen L. Lessnick

Journal Articles: Pathology and Microbiology

BACKGROUND: The genetics involved in Ewing sarcoma susceptibility and prognosis are poorly understood. EWS/FLI and related EWS/ETS chimeras upregulate numerous gene targets via promoter-based GGAA-microsatellite response elements. These microsatellites are highly polymorphic in humans, and preliminary evidence suggests EWS/FLI-mediated gene expression is highly dependent on the number of GGAA motifs within the microsatellite.

OBJECTIVES: Here we sought to examine the polymorphic spectrum of a GGAA-microsatellite within the NR0B1 promoter (a critical EWS/FLI target) in primary Ewing sarcoma tumors, and characterize how this polymorphism influences gene expression and clinical outcomes.

RESULTS: A complex, bimodal pattern of EWS/FLI-mediated gene expression was observed …

August 5, 2014 Finance & Facilities (F&F) Committee Meeting, Evp For Administration

Finance and Facilities Committee

Documents related to the August 5, 2014 Board of Regents' Finance and Facilities Committee Meeting. (Agenda, Minutes, eBook, Notice)

Howey Presents Thermoregulation Energy Expenditures Of Blackhowey Presents ‘Thermoregulation & Energy Expenditures Of Black Racers In Thermally Contrasting, Burned & Unburned Landscapes’ Burned Unburned Landscapes, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Farallo Presents ‘Exploring Below The Undergrowth: The Role Of Microhabitat In The Evolutionary Ecology Of Plethodontid Salamanders’, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Lattanzio Presents Two Papers At Joint Meeting Of Ichthyologists And Herpetologists, Ohio University College Of Arts & Sciences

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No abstract provided.

Phillips Presents ‘Seasonal Movements Of The Sandstone Falls Population Of Lower New River Walleye’, Ohio University College Of Arts & Sciences

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No abstract provided.

D’Amore Presents ‘Maternal Environment Influences Development Of Behavioral Syndrome In Swordtail Fish’, Ohio University College Of Arts & Sciences

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No abstract provided.

Gilbert Presents ‘Relating Thermal Performance To Variation In Resource Use: Implications For Lizards In A Warming World’, Ohio University College Of Arts & Sciences

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No abstract provided.

Associations Between Work-Related Stress In Late Midlife, Educational Attainment, And Serious Health Problems In Old Age: A Longitudinal Study With Over 20 Years Of Follow-Up, Charlotta Nilsen, Ross Andel, Stefan Fors, Bettina Meinow, Alexander D. Mattsson, Ingemar Kåreholt

Aging Studies Faculty Publications

Background: People spend a considerable amount of time at work over the course of their lives, which makes the workplace important to health and aging. However, little is known about the potential long-term effects of work-related stress on late-life health. This study aims to examine work-related stress in late midlife and educational attainment in relation to serious health problems in old age.

Methods: Data from nationally representative Swedish surveys were used in the analyses (n = 1,502). Follow-up time was 20–24 years. Logistic regressions were used to examine work-related stress (self-reported job demands, job control, and job strain) in relation …

Hantak Presents ‘Color Polymorphism In The Eastern Red-Backed Salamander’, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Kitson Presents On ‘Performance Of Malaclemys Terrapin Hatchlings: Variation In Seasonal’, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Advances In Gpcr Modeling Evaluated By The Gpcr Dock 2013 Assessment: Meeting New Challenges, Irina Kufareva, Vsevolod Katritch, Phil Biggin, Minsup Kim, Kichul Park, Sang Won Jung, Art E. Cho, Zara A. Sands, Liliana Ostopovici-Halip, Cristian G. Bologa, Christoffer Norn, Michal Brylinski, Jeffrey Skolnick, Henrik Keränen, Bart E. Lenselink, Gerard Van Westen, John P. Overington, Hugo Gutiérrez De Teráán, Vignir Isberg, Kimberley M. Fidom, Thomas M. Lehto, David E. Gloriam, Anirban Ghosh, Uddhavesh Sonavane, Rajendra Joshi, Jie Xia, Jui Hua Hsieh, Liangren Zhang, Xiang Simon Wang, Horst Vogel, Shuguang Yuan, X. Feng, M. Chen, J. Ambia

Faculty Publications

© 2014 Elsevier Ltd All rights reserved. Despite tremendous successes of GPCR crystallography, the receptors with available structures represent only a small fraction of human GPCRs. An important role of the modeling community is to maximize structural insights for the remaining receptors and complexes. The community-wide GPCR Dock assessment was established to stimulate and monitor the progress in molecular modeling and ligand docking for GPCRs. The four targets in the present third assessment round presented new and diverse challenges for modelers, including prediction of allosteric ligand interaction and activation states in 5-hydroxytryptamine receptors 1B and 2B, and modeling by extremely …

Nucleolar Stress With And Without P53, Allison James, Yubo Wang, Himanshu Raje, Raphyel Rosby, Patrick Dimario

Faculty Publications

Averitable explosion of primary research papers within the past 10 years focuses on nucleolar and ribosomal stress, and for good reason: with ribosome biosynthesis consuming ∼80% of a cell’s energy, nearly all metabolic and signaling pathways lead ultimately to or from the nucleolus. We begin by describing p53 activation upon nucleolar stress resulting in cell cycle arrest or apoptosis. The significance of this mechanism cannot be understated, as oncologists are now inducing nucleolar stress strategically in cancer cells as a potential anti-cancer therapy. We also summarize the human ribosomopathies, syndromes in which ribosome biogenesis or function are impaired leading to …

Methods For Attenuating Dengue Virus Infection, Shyam S. Mohapatra, Weidong Zhang

USF Patents

The present invention pertains to vectors for regulating gene expression having at least one gene expressing cassette and at least one gene suppressing cassette, wherein the gene expression cassette encodes a polypeptide of interest, and wherein the gene suppressing cassette encodes a short interfering RNA (siRNA) molecule that reduces expression of a target gene by RNA interference. The present invention further includes vectors that contain suppressor cassettes in conjunction with cassettes upregulating gene expression regulated by either a constitutive promoter, such as a general CMV promoter, or a tissue specific promoter. The present invention further includes vectors that contain Dengue …

Microbial Cell And Particle Selection System And Method Of Use, Ryan Toomey, Peter George Stroot

USF Patents

The invention comprises two key components: dielectrophoresis (DEP) and reversible binding surfaces. DEP has become an important tool for trapping dielectric particles. Moreover, DEP can manipulate cell movement as dictated by the intrinsic dielectric constant of the cell without modification. DEP therefore provides a mechanism by which to force targets in a flow channel to a reversible binding surface. By building selectivity into the binding surface, the capacity to choose which targets can be held after the dielectric field is turned off, providing a separation strategy that does not suffer from fouling issues, as large foulants can freely pass over …

Recent Shifts In The Occurrence, Cause, And Magnitude Of Animal Mass Mortality Events, Samuel B. Fey, Adam M. Siepielski, Sébastien Nusslé, Kristina Cervantes-Yoshida, Jason L. Hwan, Eric R. Huber, Maxfield J. Fey, Alessandro Catenazzi, Stephanie M. Carlson

Dartmouth Scholarship

Mass mortality events (MMEs) are rapidly occurring catastrophic demographic events that punctuate background mortality levels. Individual MMEs are staggering in their observed magnitude: re- moving more than 90% of a population, resulting in the death of more than a billion individuals, or producing 700 million tons of dead biomass in a single event. Despite extensive documentation of individual MMEs, we have no understanding of the major features characterizing the occurrence and magnitude of MMEs, their causes, or trends through time. Thus, no framework exists for contextualizing MMEs in the wake of ongoing global and regional perturbations to natural systems. Here …

Functionalized Nanoceria Composition For Ophthalmic Treatment Div 2, Sudipta Seal, Manas Haldar, Sanku Mallik, Swanand Patil

UCF Patents

The invention provides a composition comprising a plurality of nanoceria particles, a sufficient amount of at least one inhibitor of human carbonic anhydrase II associated with said plurality of nanoceria particles, and a pharmaceutically acceptable carrier containing said plurality of nanoceria particles with associated inhibitor. One preferred inhibitor of human carbonic anhydrase II comprises 4-carboxybenzene sulfonamide. The disclosed composition is useful in treatment of glaucoma.

Cerium-Oxide-Nanoparticle-Based Device For The Detection Of Reactive Oxygen Species And Monitoring Of Chronic Inflammation Div, J. Manuel Perez Figueroa, Atul Asati, Charalambos Kaittanis, Santimukul Santra

UCF Patents

polymer-coated cerium oxide based device and system is disclosed for detecting reactive oxygen species and monitoring chronic inflammation. The device and system encapsulate free therapeutic nanoparticle elements not present in a living body in a prosthetic or implantable unit. In one embodiment, the unit is a structure with a reactive oxygen species (ROS) scavenging component on one end and at the opposite end is an imaging agent consisting of at least one of the fluorophore capable of fluorescence emission, a chemiluminescent agent, a magnetic relaxation agent and an X-ray contrast agent. In a second embodiment, a single chamber device consisting …

The Effect Of Docosahexaenoic Acid (Dha)-Containing Phosphatidylcholine (Pc) On Liquid-Ordered And Liquid-Disordered Coexistence, Yongwen Gu

Dissertations and Theses

Plasma membranes are essential to both the structure and function of mammalian cells. The first unifying paradigm of membrane structure, the Fluid Mosaic Model, is no longer considered adequate to describe the many non-homogeneous lipid structures that have been observed in both natural and model membranes over the past approximately thirty years. The field of membrane biophysics now appreciates that the complex mixture of different lipid species found in natural membranes produces a range of dynamic, laterally segregated, non-homogeneous structures which exist on time scales ranging from microseconds to minutes.

When sphingomyelin (SM), POPC and cholesterol are all present in …

Summer 2014: New Facilities Heat Up Summer Research Opportunities, St. Norbert College

St. Norbert College Magazine 2013-2018

The transformational environment that will be the new Gehl-Mulva Science Center (GMS) is not set to open fully till July 2015 – but this summer’s faculty-student research teams are enjoying the many customized lab environments already in use.

Annotated Features Of Domestic Cat – Felis Catus Genome, Gaik Tamazian, Serguei Simonov, Pavel Dobrynin, Alexey Makunin, Anton Logachev, Aleksey Komissarov, Andrey Shevchenko, Vladimir Brukhin, Nikolay Cherkasov, Anton Svitin, Klaus-Peter Koepfli, Joan Pontius, Carlos A. Driscoll, Kevin Blackistone, Cristina Barr, David Goldman, Agostinho Antunes, Javier Quilez, Belen Lorente-Galdos, Can Alkan, Tomas Marques-Bonet, Marilyn Menotti-Raymond, Victor A. David, Kristina Narfstrom, Stephen J. O'Brien

Biology Faculty Articles

Background: Domestic cats enjoy an extensive veterinary medical surveillance which has described nearly 250 genetic diseases analogous to human disorders. Feline infectious agents offer powerful natural models of deadly human diseases, which include feline immunodeficiency virus, feline sarcoma virus and feline leukemia virus. A rich veterinary literature of feline disease pathogenesis and the demonstration of a highly conserved ancestral mammal genome organization make the cat genome annotation a highly informative resource that facilitates multifaceted research endeavors.

Findings: Here we report a preliminary annotation of the whole genome sequence of Cinnamon, a domestic cat living in Columbia (MO, USA), …

2014-August-05-Senior Scientist Hired, University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.